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Health Economics Research Unit (HERU)

Professor Graeme MacLennan

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Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

About
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge. 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)

    Cotton, S., Devereux, G., Abbas, H., Briggs, A. H., Campbell, K., Chaudhuri, R., Choudhury, G., Dawson, D., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lang, C. C., Lee, A., MacLennan, G., MacNee, W., McCormack, K., McMeekin, N., Mills, N. L., Morice, A., Norrie, J., Petrie, L., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J. A., Wilson, A., Lipworth, B. J.
    Trials, vol. 23, no. 1, 307
    Contributions to Journals: Articles

  • The development of theory-informed participant-centred interventions to maximise participant retention in randomised controlled trials

    Newlands, R., Duncan, E., Treweek, S., Elliott, J., Presseau, J., Bower, P., MacLennan, G., Ogden, M., Wells, M., Witham, M. D., Young, B., Gillies, K.
    Trials, vol. 23, no. 1, 268
    Contributions to Journals: Articles

  • Pulpotomy for the Management of Irreversible Pulpitis in Mature Teeth (PIP): a feasibility study

    Hamilton, A., Clarkson, J. E., Ramsay, C. R., Mannocci, F., Jarad, F., Albadri, S., Ricketts, D., Tait, C., Banerjee, A., Deery, C., Boyers, D., Marshman, Z., Goulao, B., Hamilton, A. R., Banister, K., Bell, R., Brown, L., Conway, D. I., Donaldson, P., Duncan, A., Dunn, K., Fee, P., Forrest, M., Glenny, A. M., Gouick, J., Gupta, E., Jacobsen, E., Kettle, J., MacLennan, G., Macpherson, L., McGuff, T., Mitchell, F., van der Pol, M., Moazzez, R., Roberston, D., Wojewodka, G., Young, L., Lamont, T.
    Pilot and Feasibility Studies, vol. 8, 77
    Contributions to Journals: Articles

  • Single-Incision Mini-Slings for Stress Urinary Incontinence in Women

    Abdel-Fattah, M., Cooper, D., Davidson, T., Kilonzo, M., Hossain, M., Boyers, D., Bhal, K., Wardle, J., N'Dow, J., MacLennan, G., Norrie, J.
    The New England Journal of Medicine, vol. 386, no. 13, pp. 1230-1243
    Contributions to Journals: Articles

  • Shockwave lithotripsy compared with ureteroscopic stone treatment for adults with ureteric stones: the TISU non-inferiority RCT

    Dasgupta, R., Cameron, S., Aucott, L., MacLennan, G., Kilonzo, M. M., Lam, T. B., Thomas, R., Norrie, J., McDonald, A., Anson, K., N'Dow, J., Burgess, N., Clark, C. T., Keeley, F. X., MacLennan, S. J., Starr, K., McClinton, S.
    Health technology assessment (Winchester, England), vol. 26, no. 19, pp. 1-70
    Contributions to Journals: Articles

  • A peer-delivered intervention to reduce harm and improve the well-being of homeless people with problem substance use: the SHARPS feasibility mixed-methods study

    Parkes, T., Matheson, C., Carver, H., Foster, R., Budd, J., Liddell, D., Wallace, J., Pauly, B., Fotopoulou, M., Burley, A., Anderson, I., MacLennan, G.
    Health technology assessment (Winchester, England), vol. 26, no. 14, pp. 1-128
    Contributions to Journals: Articles

  • Assessing the feasibility, acceptability and accessibility of a peer-delivered intervention to reduce harm and improve the well-being of people who experience homelessness with problem substance use: the SHARPS study

    Parkes, T., Matheson, C., Carver, H., Foster, R., Budd, J., Liddell, D., Wallace, J., Pauly, B., Fotopoulou, M., Burley, A., Anderson, I., Price, T., Schofield, J., MacLennan, G.
    Harm Reduction Journal, vol. 19, 10
    Contributions to Journals: Articles

  • The ALLEGRO trial: a placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery

    Paterson, H., Cotton, S., Norrie, J., Nimmo, S., Foo, I., Balfour, A., Speake, D., MacLennan, G., Stoddart, A., Innes, K., Cameron, S., Aucott, L., McCormack, K.
    Trials, vol. 23, no. 1, 84
    Contributions to Journals: Articles

  • Eye Movement Patterns Can Distinguish Schizophrenia From the Major Affective Disorders and Healthy Control Subjects

    St Clair, D., MacLennan, G., Beedie, S. A., Nouzová, E., Lemmon, H., Rujescu, D., Benson, P. J., McIntosh, A., Nath, M.
    Schizophrenia Bulletin Open, vol. 3, no. 1, sgac032
    Contributions to Journals: Articles

  • How common are complications following polypropylene mesh, biological xenograft and native tissue surgery for pelvic organ prolapse?: A secondary analysis from the PROSPECT trial

    Reid, F. M., Elders, A., Breeman, S., Freeman, R. M., Glazener, C. M., Hemming, C., Cooper, K. G., Smith, A. R., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J., PROSPECT study group
    BJOG: An International Journal of Obstetrics and Gynaecology, vol. 128, no. 13, pp. 2180-2189
    Contributions to Journals: Articles

  • Primary trabeculectomy versus primary glaucoma eye drops for newly diagnosed advanced glaucoma: TAGS RCT

    King, A. J., Fernie, G., Hudson, J., Kernohan, A., Azuara-Blanco, A., Burr, J., Homer, T., Shabaninejad, H., Sparrow, J. M., Garway-Heath, D., Barton, K., Norrie, J., McDonald, A., Vale, L., MacLennan, G.
    Health Technology Assessment, vol. 25, no. 72, pp. 1-194
    Contributions to Journals: Articles

  • Primary trabeculectomy versus primary glaucoma eye drops for newly diagnosed advanced glaucoma: TAGS RCT

    King, A. J., Fernie, G., Hudson, J., Kernohan, A., Azuara-Blanco, A., Burr, J., Homer, T., Shabaninejad, H., Sparrow, J. M., Garway-Heath, D., Barton, K., Norrie, J., McDonald, A., Vale, L., Maclennan, G.
    Health Technology Assessment, vol. 25, no. 72, pp. i-158
    Contributions to Journals: Articles

  • Female Urgency, Trial of Urodynamics as Routine Evaluation (FUTURE study): a superiority randomised clinical trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms

    Abdel-fattah, M., Chapple, C., Guerrero, K., Dixon, S., Cotterill, N., Ward, K., Hashim, H., Monga, A., Brown, K., Drake, M. J., Gammie, A., Mostafa, A., Bladder Health, U. K., Breeman, S., Cooper, D., MacLennan, G., Norrie, J.
    Trials, vol. 22, no. 1, 745
    Contributions to Journals: Articles

  • The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study

    Khadhouri, S., Gallagher, K. M., MacKenzie, K., Shah, T. T., Gao, C., Moore, S., Zimmermann, E., Edison, E., Jefferies, M., Nambiar, A. K., Mannas, M., Lee, T., Marra, G., Lillaz, B., Gómez Rivas, J., olivier, J., Assmus, M., Uçar, T., Claps, F., Boltri, M., Burnhope, T., Nkwam, N., Tanasescu, G., Boxall, N., Downey, A., Lal, A., Antón-Juanilla, M., Clarke, H., Lau, D., Gillams, K., Crockett, M., Nielsen, M. E., Takwoingi, Y., Chuchu, N., O'Rourke, J., MacLennan, G., McGrath, J., Kasivisvanathan, V., The IDENTIFY Study Group
    BJU International, vol. 128, no. 4, pp. 440-450
    Contributions to Journals: Articles

  • Why trials lose participants: a multi-trial investigation of participants’ perspectives using the theoretical domains framework

    Newlands, R., Duncan, E., Presseau, J., Treweek, S., Lawrie, L., Bower, P., Elliott, J., Francis, J. J., MacLennan, G., Ogden, M., Wells, M., Witham, M. D., Young, B., Gillies, K.
    Journal of Clinical Epidemiology, vol. 137, pp. P1-13
    Contributions to Journals: Articles

  • Selective Caries Removal in Permanent Teeth (SCRiPT) for the treatment of deep carious lesions: a randomised controlled clinical trial in primary care

    Clarkson, J. E., Ramsay, C. R., Ricketts, D., Banerjee, A., Deery, C., Lamont, T., Boyers, D., Marshman, Z., Goulao, B., Banister, K., Conway, D., Dawett, B., Baker, S., Sherriff, A., Young, L., van der Pol, M., MacLennan, G., Floate, R., Braid, H., Fee, P., Forrest, M., Gouick, J., Mitchell, F., Gupta, E., Dakri, R., Kettle, J., McGuff, T., Dunn, K.
    BMC Oral Health, vol. 21, 336
    Contributions to Journals: Articles

  • Have you had bleeding from your gums?: Self-report to Identify giNGival inflammation (The SING diagnostic accuracy and diagnostic model development study)

    Goulao, B., MacLennan, G., Ramsay, C.
    Journal of Journal of Clinical Periodontology, vol. 48, no. 7, pp. 919-928
    Contributions to Journals: Articles

  • Shockwave Lithotripsy Versus Ureteroscopic Treatment as Therapeutic Interventions for Stones of the Ureter (TISU): A Multicentre Randomised Controlled Non-inferiority Trial

    Dasgupta, R., Cameron, S., Aucott, L., MacLennan, G., Thomas, R., N'Dow, J., Norrie, J., Anson, K., Keeley Jr, F. X., MacLennan, S., Starr, K., McClinton, S., Kilonzo, M., Lam, T.
    European Urology, vol. 80, no. 1, pp. 46-54
    Contributions to Journals: Articles

  • The arabin pessary to prevent preterm birth in women with a twin pregnancy and a short cervix: The STOPPIT 2 RCT

    Norman, J. E., Norrie, J., Maclennan, G., Cooper, D., Whyte, S., Chowdhry, S., Cunningham-Burley, S., Neilson, A. R., Mei, X. W., Smith, J. B., Shennan, A., Robson, S. C., Thornton, S., Kilby, M. D., Marlow, N., Stock, S. J., Bennett, P. R., Denton, J., on behalf of the STOPPIT collaborative group
    NIHR Health Technology Assessment programme. 94 pages
    Books and Reports: Other Reports

  • Outcomes of a non-inferiority randomised controlled trial of surgery for men with urodynamic stress incontinence after prostate surgery (MASTER)

    Abrams, P., Constable, L., Cooper, D., MacLennan, G., Drake, M. J., Harding, C., Mundy, A., McCormack, K., McDonald, A., Norrie, J., Ramsay, C., Smith, R., Cotterill, N., Kilonzo, M., Glazener, C., MASTER trial team
    European Urology, vol. 79, no. 6, pp. 812-823
    Contributions to Journals: Articles

  • Tibial nerve stimulation compared with sham to reduce incontinence in care home residents: ELECTRIC RCT

    Booth, J., Aucott, L., Cotton, S., Davis, B., Fenocchi, L., Goodman, C., Hagen, S., Harari, D., Lawrence, M., Lowndes, A., Macaulay, L., MacLennan, G., Mason, H., McClurg, D., Norrie, J., Norton, C., O'Dolan, C., Skelton, D., Surr, C., Treweek, S.
    Health technology assessment (Winchester, England), vol. 25, no. 41, pp. 1-109
    Contributions to Journals: Articles

  • TISU (Therepeutic Intervention for Stones in the Ureter): ESWL versus Ureteroscopy, a multicentre RCT

    Dasgupta, R., Cameron, S., Aucott, L., Maclennan, G., Thomas, R. E., N'dow, J., Norrie, J., Anson, K., Keeley, F. X., Maclennan, S., Starr, K., Mcclinton, S.
    European Urology, vol. 79, no. S1, pp. S390-S390
    Contributions to Journals: Abstracts

  • Primary trabeculectomy for advanced glaucoma: pragmatic multicentre randomised controlled trial (TAGS)

    King, A., Hudson, J., Fernie, G., Kernohan, A., Azuara-Blanco, A., Burr, J., Homer, T., Shabaninejad, H., Sparrow, J. M., Garway-Heath, D., Barton, K., Norrie, J., McDonald, A., Vale, L., MacLennan, G., King, A., Agrawal, P., Stead, R., Broadway, D. C., Strouthidis, N., Chew, S., Sng, C., Toth, M., Gazzard, G., Elkarmouty, A., Nikita, E., Triolo, G., Aguilar-Munoa, S., Goyal, S., Lim, S., Sung, V., Masood, I., Wride, N., Sandhu, A., Hill, E., Sparrow, J., Grey, F., Bourne, R., Nithyanandarajah, G., Willshire, C., Bloom, P., Ahmed, F., Cordeiro, F., Crawley, L., Normando, E., Ameen, S., Tryfinopoulou, J., Porteous, A., Azuara-Blanco, A., Sidiki, S., TAGS Study Group
    BMJ, vol. 373, n1014
    Contributions to Journals: Articles

  • Equity of access to critical care services in Scotland: A Bayesian spatial analysis

    Emerson, P., Green, D. R., Stott, S., Maclennan, G., Campbell, M. K., Jansen, J. O.
    Journal of the Intensive Care Society, vol. 22, no. 2, pp. 127-135
    Contributions to Journals: Articles

  • Evaluation of the Arabin cervical pessary for prevention of preterm birth in women with a twin pregnancy and short cervix (STOPPIT-2): An open-label randomised trial and updated meta-analysis

    Norman, J. E., Norrie, J., MacLennan, G., Cooper, D., Whyte, S., Chowdhry, S., Cunningham-Burley, S., Mei, X. W., Smith, J. B. E., Shennan, A., Robson, S. C., Thornton, S., Kilby, M. D., Marlow, N., Stock, S. J., Bennett, P. R., Denton, J., STOPPIT-2 collaborative group
    PLoS Medicine, vol. 18, no. 3, e1003506
    Contributions to Journals: Articles
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