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Health Economics Research Unit (HERU)

Professor Graeme MacLennan

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Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

About
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge. 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • A randomized double-blind placebo-controlled trial of Dipeptidyl Peptidase-1 inhibition in hospitalized patients with COVID-19: the STOP-COVID19 trial

    Keir, H. R., Long, M. B., Abo-Leyah, H., Giam, Y. H., Vadiveloo, T., Pembridge, T., Hull, R. C., Delgado, L., Band, M. M., McLaren-Neil, F., Adamson, S., Lahnsteiner, E., Gilmour, A., Hughes, C., New, B. J., Connell, D., Dowey, R., Turton, H., Richardson, H., Cassidy, D., Cooper, J., Suntharalingam, J., Diwakar, L., Russell, P., Underwood, J., Hicks, A., Dosanjh, D. P., Sage, B., Dhasmana, D. J., Spears, M., Thompson, A. R., Brightling, C. E., Smith, A., Patel, M. I., George, J., Condliffe, A. M., Shoemark, A., MacLennan, G., Chalmers, J. D.
    American Thoracic Society International Conference, A5055
    Contributions to Journals: Abstracts

  • Visualising harms in publications of randomised controlled trials: consensus and recommendations

    Phillips, R., Cro, S., Wheeler, G., Bond, S., Morris, T. P., Creanor, S., Hewitt, C., Love, S., Lopes, A., Schlackow, I., Gamble, C., MacLennan, G., Habron, C., Gordon, A. C., Vergis, N., Li, T., Qureshi, R., Everett, C. C., Holmes, J., Kirkham, A., Peckitt, C., Pirrie, S., Ahmed, N., Collett, L., Cornelius, V.
    BMJ (Clinical research ed.), vol. 377, e068983
    Contributions to Journals: Articles

  • The effectiveness and cost-effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) for trauma patients with uncontrolled torso haemorrhage: study protocol for a randomised clinical trial (the UK-REBOA trial)

    Jansen, J. O., Cochran, C., Boyers, D., Gillies, K., Lendrum, R., Sadek, S., Lecky, F., MacLennan, G., Campbell, M. K., UK-REBOA Trial grantholders
    Trials, vol. 23, no. 1, 384
    Contributions to Journals: Articles

  • Digital smartphone intervention to recognise and manage early warning signs in schizophrenia to prevent relapse: the EMPOWER feasibility cluster RCT

    Gumley, A. I., Bradstreet, S., Ainsworth, J., Allan, S., Alvarez-Jimenez, M., Birchwood, M., Briggs, A., Bucci, S., Cotton, S., Engel, L., French, P., Lederman, R., Lewis, S., Machin, M., Maclennan, G., McLeod, H., McMeekin, N., Mihalopoulos, C., Morton, E., Norrie, J., Reilly, F., Schwannauer, M., Singh, S. P., Sundram, S., Thompson, A., Williams, C., Yung, A., Aucott, L., Farhall, J., Gleeson, J.
    Health Technology Assessment, vol. 26, no. 27, pp. v-122
    Contributions to Journals: Articles

  • ScotCap - A large observational cohort study

    MacLeod, C., Hudson, J., Brogan, M., Cotton, S., Treweek, S., MacLennan, G., Watson, A. J. M.
    Colorectal Disease, vol. 24, no. 4, pp. 411-421
    Contributions to Journals: Articles

  • Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)

    Cotton, S., Devereux, G., Abbas, H., Briggs, A. H., Campbell, K., Chaudhuri, R., Choudhury, G., Dawson, D., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lang, C. C., Lee, A., MacLennan, G., MacNee, W., McCormack, K., McMeekin, N., Mills, N. L., Morice, A., Norrie, J., Petrie, L., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J. A., Wilson, A., Lipworth, B. J.
    Trials, vol. 23, no. 1, 307
    Contributions to Journals: Articles

  • The development of theory-informed participant-centred interventions to maximise participant retention in randomised controlled trials

    Newlands, R., Duncan, E., Treweek, S., Elliott, J., Presseau, J., Bower, P., MacLennan, G., Ogden, M., Wells, M., Witham, M. D., Young, B., Gillies, K.
    Trials, vol. 23, no. 1, 268
    Contributions to Journals: Articles

  • Pulpotomy for the Management of Irreversible Pulpitis in Mature Teeth (PIP): a feasibility study

    Hamilton, A., Clarkson, J. E., Ramsay, C. R., Mannocci, F., Jarad, F., Albadri, S., Ricketts, D., Tait, C., Banerjee, A., Deery, C., Boyers, D., Marshman, Z., Goulao, B., Hamilton, A. R., Banister, K., Bell, R., Brown, L., Conway, D. I., Donaldson, P., Duncan, A., Dunn, K., Fee, P., Forrest, M., Glenny, A. M., Gouick, J., Gupta, E., Jacobsen, E., Kettle, J., MacLennan, G., Macpherson, L., McGuff, T., Mitchell, F., van der Pol, M., Moazzez, R., Roberston, D., Wojewodka, G., Young, L., Lamont, T.
    Pilot and Feasibility Studies, vol. 8, 77
    Contributions to Journals: Articles

  • Single-Incision Mini-Slings for Stress Urinary Incontinence in Women

    Abdel-Fattah, M., Cooper, D., Davidson, T., Kilonzo, M., Hossain, M., Boyers, D., Bhal, K., Wardle, J., N'Dow, J., MacLennan, G., Norrie, J.
    The New England Journal of Medicine, vol. 386, no. 13, pp. 1230-1243
    Contributions to Journals: Articles

  • Shockwave lithotripsy compared with ureteroscopic stone treatment for adults with ureteric stones: the TISU non-inferiority RCT

    Dasgupta, R., Cameron, S., Aucott, L., MacLennan, G., Kilonzo, M. M., Lam, T. B., Thomas, R., Norrie, J., McDonald, A., Anson, K., N'Dow, J., Burgess, N., Clark, C. T., Keeley, F. X., MacLennan, S. J., Starr, K., McClinton, S.
    Health technology assessment (Winchester, England), vol. 26, no. 19, pp. 1-70
    Contributions to Journals: Articles
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