Professor Graeme MacLennan

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Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

About
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Catheter II Team
    European Association of Urology Annual Congress 2025
    Contributions to Conferences: Abstracts
  • The PUrE Randomised Controlled Trial (RCT) 1:: Clinical and cost-effectiveness of Flexible Ureterorenoscopy and Extracorporeal Shockwave Lithotripsy for lower pole stones ≤10mm.

    Wiseman, O. J., Smith, D., Starr, K., Aucott, L., Hernández, R. A., Thomas, R., MacLennan, S., Clark, C. T., MacLennan, G., McRae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., McClinton, S.
    European Urology
    Contributions to Journals: Articles
  • Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery: A Health Economic Evaluation of the ALLEGRO Randomised Clinical Trial

    Atter, M., Stoddart, A., Cotton, S., Vadiveloo, T., Innes, K., Balfour, A., Arnott, R., Aucott, L., Batham, Z., Foo, I., MacLennan, G., Nimmo, S., Speake, D., Norrie, J., Paterson, H.
    BMJ Open
    Contributions to Journals: Articles
  • Updated Systematic Review and Meta-analysis of Extracorporeal Shock Wave Lithotripsy, Flexible Ureterenoscopy, and Percutaneous Nephrolithotomy for Lower Pole Renal Stones

    MacLennan, S., Wiseman, O. J., Smith, D., Starr, K., Aucott, L., Hernández, R. A., Manson, P., Thomas, R., Clark, C. T., MacLennan, G., McRae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., McClinton, S.
    European Urology
    Contributions to Journals: Articles
  • Intravenous lidocaine for gut function recovery in colonic surgery: A Randomized Clinical Trial

    Paterson, H., Vadiveloo, T., Innes, K., Balfour, A., Atter, M., Cotton, S., Stoddart, A., Arnott, R., Aucott, L., Batham, Z., Foo, I., MacLennan, G., Nimmo, S., Speake, D., Norrie, J.
    JAMA, vol. 333, no. 1, pp. 39-48
    Contributions to Journals: Articles
  • Complexity of Trials on Pain Management in Acute Pancreatitis: An Ongoing Challenge

    Kamarajah, S. K., Maclennan, G., Pandanaboyana, S.
    Clinical Gastroenterology and Hepatology, vol. 23, no. 1
    Contributions to Journals: Letters
  • A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease

    Devereux, G., Cotton, S., Nath, M., McMeekin, N., Campbell, K., Chaudhuri, R., Choudhury, G., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lee, A., MacLennan, G., Morice, A., Norrie, J., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J. A., Wilson, A., Wu, O., Lipworth, B. J.
    Health Technology Assessment
    Contributions to Journals: Articles
  • CATHETER II: a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Dimitropoulos, K., Evans, S., Granitsiotis, P., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., Murchie, P., Myint, P. K., N'Dow, J., Paterson, C., Powell, K., Scotland, G., Thiruchelvam, N., Young, A. J., Cotton, S., Norrie, J., MacLennan, G.
    BMJ Open, vol. 14, no. 12, e087203
    Contributions to Journals: Articles
  • Clinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT

    Thompson, L., Tanner, J., Breckons, M., Young, N., Ternent, L., Vadiveloo, T., Wilson, P., Wight, D., Marryat, L., McGowan, I., MacLennan, G., MacBeth, A., McTaggart, J., Allison, T., Norrie, J.
    Public Health Research, vol. 12, no. 17
    Contributions to Journals: Articles
  • Laparoscopic cholecystectomy versus conservative management for uncomplicated symptomatic gallstones: economic evaluation based on the C-GALL trial

    Hernández, R. A., Ahmed, I., Edwards, K., Hudson, J., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J. M., Brazzelli, M., Cotton, S., Croal, B. L., MacLennan, G., Murchie, P., Ramsay, C.
    British Journal of Surgery
    Contributions to Journals: Articles
  • The UK resuscitative endovascular balloon occlusion of the aorta in trauma patients with life-threatening torso haemorrhage: The (UK-REBOA) multicentre RCT

    Jansen, J. O., Hudson, J., Kennedy, C., Cochran, C., Maclennan, G., Gillies, K., Lendrum, R., Sadek, S., Boyers, D., Ferry, G., Lawrie, L., Nath, M., Cotton, S., Wileman, S., Forrest, M., Brohi, K., Harris, T., Lecky, F., Moran, C., Morrison, J. J., Norrie, J., Paterson, A., Tai, N., Welch, N., Campbell, M. K., UK-REBOA Study Group
    Health Technology Assessment, vol. 28, no. 54
    Contributions to Journals: Articles
  • RCT comparing the clinical and cost effectiveness of various catheter washout policies

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
    RCOG World Congress 2024
    Contributions to Conferences: Posters
  • RCT comparing the clinical and cost effectiveness of various catheter washout policies

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
    The International Continence Society
    Contributions to Conferences: Posters
  • Public perspective on potential treatment intervention harm in clinical trials-terminology and communication

    Phillips, R., Bi, D., Goulão, B., Miller, M., El-Askary, M., Fagbemi, O., Freeborn, C., Giammetta, M., El Masri, N., Flockhart, P., Kumar, M., Melvin, M., Murray, D., Myhill, A., Saeid, L., Thomas, S., MacLennan, G., Cornelius, V.
    Trials, vol. 25, no. 1, 573
    Contributions to Journals: Articles
  • Feasibility of in-home monitoring for people with glaucoma: the I-TRAC mixed-methods study

    Stewart, C., Wu, H., Alagappan, U., Azuara-Blanco, A., King, A. J., Tatham, A. J., Hernández, R., Lowe, B., Shotton, D., Appiah, N., Coffey, T., Vadiveloo, T., MacLennan, G., Gillies, K.
    Health technology assessment (Winchester, England), vol. 28, no. 44, pp. 1-163
    Contributions to Journals: Articles
  • Text Messages With Financial Incentives for Men With Obesity: A Randomized Clinical Trial

    Hoddinott, P., O'Dolan, C., Macaulay, L., Dombrowski, S. U., Swingler, J., Cotton, S., Avenell, A., Getaneh, A. M., Gray, C., Hunt, K., Kee, F., MacLean, A., McKinley, M., Torrens, C., Turner, K., van der Pol, M., MacLennan, G.
    JAMA, vol. 332, no. 1, pp. 31-40
    Contributions to Journals: Articles
  • Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study

    King, A. J., Hudson, J., Azuara-Blanco, A., Burr, J., Kernohant, A., Homer, T., Shabaninejad, H., Sparrow, J. M., Garway-Heath, D., Barton, K., Norrie, J., Davidson, T., Vale, L., MacLennan, G., TAGS Study Group
    Ophthalmology, vol. 131, no. 7, pp. 759-770
    Contributions to Journals: Articles
  • Assessment of depth of sedation using Bispectral Index™ monitoring in patients with severe traumatic brain injury in UK intensive care units

    Kaye, C., Rhodes, J., Austin, P., Casey, M., Gould, R., Sira, J., Treweek, S., MacLennan, G.
    BJA Open, vol. 10, 100287
    Contributions to Journals: Articles
  • Laparoscopic cholecystectomy versus conservative management for adults with uncomplicated symptomatic gallstones: the C-GALL RCT

    Innes, K., Ahmed, I., Hudson, J., Hernández, R. A., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J. M., Brazzelli, M., Cotton, S., Croal, B., Forrest, M., MacLennan, G., Murchie, P., Wileman, S., Ramsay, C.
    Health Technology Assessment, vol. 28, no. 26, pp. 1-151
    Contributions to Journals: Articles
  • Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial

    Devereux, G., Cotton, S., Nath, M., McMeekin, N., Campbell, K., Chaudhuri, R., Choudhury, G., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lee, A. J., MacLennan, G., Morice, A., Norrie, J., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J., Wilson, A., Wu, O., Lipworth, B. J.
    JAMA, vol. 332, no. 6, pp. 462-470
    Contributions to Journals: Articles
  • Prevalencia del cáncer del tracto urinario. Análisis de la cohorte española del estudio IDENTIFY

    Toribio-Vázquez, C., Gómez Rivas, J., Amigo, F., Carrión, D. M., Yebes, , Alonso-Bartolomé, M., Ayllon, H., Aguilera, A., Martinez-Pineiro, L., Antón-Juanilla, M., Crespo-Atín, V., Otaola-Arca, H., Herranz-Yague, J. A., Munoz Rivero, M. V., MacKenzie, K. R., Shah, T. T., Gao, C., Zimmermann, E., Jefferies, M., Nambiar, A., Gallagher, K. M., Khadhouri, S., Kasivisvanathan, V., Moore, S., Zimmermann, E. F., Edison, E., Mannas, M. P., Lee, T., Marra, G., Lillaz, B., Olivier, J., Assmus, M. A., Uçar, T., Claps, F., Boltri, M., Burnhope, T., Nkwam, N., Tanasescu, G., Boxall, N. E., Downey, A. P., Ahmed Lal, A., Clarke, H., HW Lau, D., Gillams, K., Crockett, M., Nielsen, M., Takwoingi, Y., Chuchu, N., O'Rourke, J., MacLennan, G., IDENTIFY Study group
    Actas Urologicas Espanolas, vol. 48, no. 3, pp. 228-237
    Contributions to Journals: Articles
  • Resuscitative Endovascular Balloon Occlusion of the Aorta in Patients With Exsanguinating Hemorrhage-Reply

    Jansen, J. O., MacLennan, G. S., Campbell, M. K.
    JAMA, vol. 331, no. 11, pp. 981-982
    Contributions to Journals: Comments and Debates
  • PUrE RCT 1: Clinical and cost-effectiveness of flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones ≤10 mm

    Wiseman, O., Smith, R., Starr, K., Aucott, L., Hernández, R., Thomas, R., Maclennan, S., Clark, T., Maclennan, G., Mcrae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., Mcclinton, S.
    European Urology, vol. 85, no. Supplement 1, pp. S529
    Contributions to Journals: Abstracts
  • PUrE RCT 2: Clinical and cost-effectiveness of FURS and percutaneous nephrolithotomy for lower pole stones 10-25mm

    Smith, R., Wiseman, O., Starr, K., Aucott, L., Hernández, R., Thomas, R., Maclennan, S., Clark, T., Maclennan, G., Mcrae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., Mcclinton, S.
    European Urology, vol. 85, no. Supplement 1, pp. S537
    Contributions to Journals: Abstracts
  • Reply to Arnulf Stenzl, Morgan Rouprêt, J. Alfred Witjes, Paolo Gontero. High-quality Transurethral Resection of Bladder Tumour Needs Additional Forms of Tumour Delineation. Eur Urol 2023;83:193–4

    Heer, R., Tan, W. S., Gravestock, P., Vadiveloo, T., Lewis, R., Penegar, S., Vale, L., MacLennan, G., Hall, E., PHOTO Trial Team
    European Urology, vol. 85, no. 3, pp. 309-312
    Contributions to Journals: Comments and Debates
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