Advanced Research Fellow
- About
-
- Email Address
- renato.santos@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438577
- Office Address
Liberty Building, Room GD07
Foresterhill Road
AB25 2ZP
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I obtained the BSc in Biology in 2008, and the Doctorate degree (Cell Biology) in 2014 from the Faculty of Sciences and Technology, University of Coimbra, Portugal. My work was focused on numerous aspects of cellular and, particularly, mitochondrial biology, namely, mitochondrial biogenesis, mitochondrial fission and fusion and also autophagy/mitophagy. The main subject of my work was to understand the relation between diabetes and the propensity do develop dementia, particularly Alzheimer's disease. In 2017, I joined the team of Dr. Charles Harrington at the Institute of Medical Sciences, University of Aberdeen. My research interests include the understanding of neuropathological processes, uncovering of therapeutic targets and study of efficient therapeutic approaches to tackle progression of neurodegenerative diseases.
Qualifications
- BSc Biology2008 - University of Coimbra, Portugal
- PhD Cell Biology2014 - University of Coimbra, Portugal
Internal Memberships
03/2023-02/2025: Board Member - School Ethics Review Board (SERB), for the School of Medicine, Medical Sciences and Nutrition
Latest Publications
Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain
FEBS Journal, vol. 292, no. 10, pp. 2602-2623Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/febs.70021
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/372a1f89-dc2a-4be5-a64e-19083dc6d8d6/download
- [ONLINE] View publication in Scopus
Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice
International Journal of Molecular Sciences, vol. 24, no. 13, 10810Contributions to Journals: ArticlesHMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
Biomedicines, vol. 10, no. 4, 867Contributions to Journals: ArticlesMechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model
Current Alzheimer Research, vol. 17, no. 3, pp. 285-296Contributions to Journals: ArticlesMiddle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology
Molecular Neurobiology, vol. 54, no. 8, pp. 6471-6489Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s12035-016-0155-1
- Research
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Research Overview
Neurodegeneration
Alzheimer's disease
Tau protein
Mitochondria
Oxidative Stress
Autophagy/Mitophagy
Therapeutics
- Publications
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Page 5 of 6 Results 41 to 50 of 56
Mitochondrial preconditioning: a potential neuroprotective strategy
Frontiers in Genetics, vol. 2, 138Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fnagi.2010.00138
- [ONLINE] http://europepmc.org/abstract/med/20838473
Mitochondrial reactive oxygen species preconditioning protects brain cells against hyperglycemia
Alzheimer's Association International Conference on Alzheimer's Disease (ICAD)Contributions to Conferences: PostersAutophagy in Alzheimer's disease
Expert Review Neurotherapeutics, vol. 10, no. 7, pp. 1209-1218Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1586/ern.10.84
- [ONLINE] http://europepmc.org/abstract/med/20586699
Effects of Estrogen in the Brain: Is it a Neuroprotective Agent in Alzheimers Disease?
Current Aging Science, vol. 3, no. 2, pp. 113-126Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2174/1874609811003020113
- [ONLINE] http://europepmc.org/abstract/med/20167003
A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease
Journal of Alzheimer's Disease, vol. 20, no. s2, pp. S401-S412Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3233/JAD-2010-100666
- [ONLINE] http://europepmc.org/abstract/med/20463393
Alzheimer's disease: diverse aspects of mitochondrial malfunctioning
International journal of clinical and experimental pathology, vol. 3, no. 6, pp. 570-581Contributions to Journals: ArticlesTargeting autophagy in the brain: a promising approach?
Central nervous system agents in medicinal chemistry, vol. 10, no. 2, pp. 158-168Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2174/187152410791196350
- [ONLINE] http://europepmc.org/abstract/med/20518730
Diabetes as a trigger of neurodegeneration: from pathophysiological mechanisms to therapeutic approaches
Advances in Molecular Mechanisms and Pharmacology of Diabetic Complications. Stefek, M. (ed.). Research Signpost, pp. 175-198, 24 pagesChapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)Mitochondrial Uncoupling Proteins: Therapeutic Targets in Neurodegeneration?
Neurodegeneration: Theory, Disorders and Treatments. McNeill, A. S. (ed.). Nova Science Publishers Inc, pp. 107-124, 18 pagesChapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)Insulin is a Two-Edged Knife on the Brain
Journal of Alzheimer's Disease, vol. 18, no. 3, pp. 483-507Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3233/JAD-2009-1155
- [ONLINE] http://europepmc.org/abstract/med/19542630