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Dr Renato Coelho Dos Santos

Dr Renato Coelho Dos Santos
Dr Renato Coelho Dos Santos
Dr Renato Coelho Dos Santos

Advanced Research Fellow

About
Email Address
renato.santos@abdn.ac.uk
Telephone Number
+44 (0)1224 438577
Office Address

Liberty Building, Room GD07

Foresterhill Road

AB25 2ZP

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD
Scopus
Google Scholar
Pure

Biography

I obtained the BSc in Biology in 2008, and the Doctorate degree (Cell Biology) in 2014 from the Faculty of Sciences and Technology, University of Coimbra, Portugal. My work was focused on numerous aspects of cellular and, particularly, mitochondrial biology, namely, mitochondrial biogenesis, mitochondrial fission and fusion and also autophagy/mitophagy. The main subject of my work was to understand the relation between diabetes and the propensity do develop dementia, particularly Alzheimer's disease. In 2017, I joined the team of Dr. Charles Harrington at the Institute of Medical Sciences, University of Aberdeen. My research interests include the understanding of neuropathological processes, uncovering of therapeutic targets and study of efficient therapeutic approaches to tackle progression of neurodegenerative diseases.  

Qualifications

  • BSc Biology 
    2008 - University of Coimbra, Portugal 
  • PhD Cell Biology 
    2014 - University of Coimbra, Portugal 

Internal Memberships

03/2023-02/2025: Board Member - School Ethics Review Board (SERB), for the School of Medicine, Medical Sciences and Nutrition

Latest Publications

View My Publications

Research

Research Overview

Neurodegeneration

Alzheimer's disease

Tau protein

Mitochondria

Oxidative Stress

Autophagy/Mitophagy

Therapeutics

Publications

Page 1 of 6 Results 1 to 10 of 56

  • Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain

    Coelho Dos Santos, R., Lee, S. H., Lofthouse, R. A., Melis, V., Strachan, L., Leith, M., Dreesen, E., Armstrong, P., Vorley, T., Goatman, E., Hull, C., Riedel, G., Wischik, C., Harrington, C.
    FEBS Journal, vol. 292, no. 10, pp. 2602-2623
    Contributions to Journals: Articles

  • Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

    Kondak, C., Leith, M., Baddeley, T. C., Santos, R. X., Harrington, C. R., Wischik, C. M., Riedel, G., Klein, J.
    International Journal of Molecular Sciences, vol. 24, no. 13, 10810
    Contributions to Journals: Articles

  • HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

    Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.
    Biomedicines, vol. 10, no. 4, 867
    Contributions to Journals: Articles

  • Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

    Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R., Wischik, C. M.
    Current Alzheimer Research, vol. 17, no. 3, pp. 285-296
    Contributions to Journals: Articles

  • Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

    Candeias, E., Duarte, A. I., Sebastião, I., Fernandes, M. A., Plácido, A. I., Carvalho, C., Correia, S., Santos, R. X., Seiça, R., Santos, M. S., Oliveira, C. R., Moreira, P. I.
    Molecular Neurobiology, vol. 54, no. 8, pp. 6471-6489
    Contributions to Journals: Articles

  • Brain intracellular signaling, oxidative stress and Alzheimer’s disease-related hallmarks upon type 2 diabetes are differentially influenced by gender

    Duarte, A. I., Candeias, E., Sebastião, I., Carvalho, C., Correia, S. C., Plácido, A. I., Coelho Dos Santos, R. X., Fernandes, M. A., Seiça, R., Santos, M. S., Oliveira, C. R., da Silva Moreira, P. I.
    12th International Conference on Alzheimer's and Parkinson's diseases (AD/PD)
    Contributions to Conferences: Posters

  • Gender Influences Type 2 Diabetic-Related Intracellular Brain Signaling and Neurodegeneration Markers

    Duarte, A. I., Candeias, E., Sebastião, I., Plácido, A. I., Coelho Dos Santos, R. X., Carvalho, C., Correia, S. C., Fernandes, M. A., Seiça, R., Santos, M. S., Oliveira, C. R., da Silva Moreira, P. I.
    XIV Meeting of the Portuguese Society for Neuroscience
    Contributions to Conferences: Posters

  • Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

    Santos, R. X., Correia, S. C., Alves, M. G., Oliveira, P. F., Cardoso, S., Carvalho, C., Seiça, R., Santos, M. S., Moreira, P. I.
    Molecular & Cellular Biochemistry, vol. 394, no. 1-2, pp. 13-22
    Contributions to Journals: Articles

  • The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease

    Plácido, A., Pereira, C., Duarte, A., Candeias, E., Correia, S., Santos, R., Carvalho, C., Cardoso, S., Oliveira, C., Moreira, P.
    Biochimica et Biophysica Acta, vol. 1842, no. 9, pp. 1444-1453
    Contributions to Journals: Articles

  • Type 2 diabetic female rat brains are less vulnerable to oxidative stress and AD-related hallmarks: a role for insulin/IGF-1/estrogen signaling?

    Duarte, A. I., Candeias, E., Sebastião, I., Carvalho, C., Correia, S. C., Plácido, A. I., Coelho Dos Santos, R. X., Fernandes, M. A., Seiça, R., Santos, M. S., Oliveira, C. R., da Silva Moreira, P. I.
    9th FENS Forum of Neuroscience
    Contributions to Conferences: Posters
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