Advanced Research Fellow
- About
-
- Email Address
- renato.santos@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438577
- Office Address
Liberty Building, Room GD07
Foresterhill Road
AB25 2ZP
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I obtained the BSc in Biology in 2008, and the Doctorate degree (Cell Biology) in 2014 from the Faculty of Sciences and Technology, University of Coimbra, Portugal. My work was focused on numerous aspects of cellular and, particularly, mitochondrial biology, namely, mitochondrial biogenesis, mitochondrial fission and fusion and also autophagy/mitophagy. The main subject of my work was to understand the relation between diabetes and the propensity do develop dementia, particularly Alzheimer's disease. In 2017, I joined the team of Dr. Charles Harrington at the Institute of Medical Sciences, University of Aberdeen. My research interests include the understanding of neuropathological processes, uncovering of therapeutic targets and study of efficient therapeutic approaches to tackle progression of neurodegenerative diseases.
Qualifications
- BSc Biology2008 - University of Coimbra, Portugal
- PhD Cell Biology2014 - University of Coimbra, Portugal
Internal Memberships
03/2023-02/2025: Board Member - School Ethics Review Board (SERB), for the School of Medicine, Medical Sciences and Nutrition
Latest Publications
Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain
FEBS Journal, vol. 292, no. 10, pp. 2602-2623Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/febs.70021
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/372a1f89-dc2a-4be5-a64e-19083dc6d8d6/download
- [ONLINE] View publication in Scopus
Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice
International Journal of Molecular Sciences, vol. 24, no. 13, 10810Contributions to Journals: ArticlesHMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
Biomedicines, vol. 10, no. 4, 867Contributions to Journals: ArticlesMechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model
Current Alzheimer Research, vol. 17, no. 3, pp. 285-296Contributions to Journals: ArticlesMiddle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology
Molecular Neurobiology, vol. 54, no. 8, pp. 6471-6489Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s12035-016-0155-1
- Research
-
Research Overview
Neurodegeneration
Alzheimer's disease
Tau protein
Mitochondria
Oxidative Stress
Autophagy/Mitophagy
Therapeutics
- Publications
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Page 2 of 6 Results 11 to 20 of 56
Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats.
Biochimica et Biophysica Acta, vol. 1842, no. 7, pp. 1154-1166Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bbadis.2014.04.011
- [ONLINE] http://europepmc.org/abstract/med/24747740
Role of Mitochondria and Oxidative stress in Parkinson's disease
Role of Oxidative Stress in Chronic Diseases. Dichi, I., Breganó, J. W., Colado Simão, A. N., Cecchini, R. (eds.). CRC Press, pp. 521-548, 28 pagesChapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)The Janus Face of Insulin in Brain
Metabolic Syndrome and Neurological Disorders. Farooqui, T., Farooqui, A. A. (eds.). John Wiley & Sons Ltd., pp. 85-113, 29 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1002/9781118395318.ch5
Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease
Antioxidants & Redox Signaling, vol. 18, no. 18, pp. 2444–2457Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1089/ars.2012.5039
- [ONLINE] http://europepmc.org/abstract/med/23216311
Type 2 diabetic and Alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies.
Journal of Alzheimer's Disease, vol. 35, no. 3, pp. 623-635Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3233/JAD-130005
- [ONLINE] http://europepmc.org/abstract/med/23478310
Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins
Current molecular medicine, vol. 13, no. 4, pp. 586-601Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2174/1566524011313040010
- [ONLINE] http://europepmc.org/abstract/med/22934852
Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease.
Current Alzheimer Research, vol. 10, no. 4, pp. 406-419Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2174/1567205011310040006
- [ONLINE] http://europepmc.org/abstract/med/23061885
Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
Biochimica et Biophysica Acta, vol. 1832, no. 4, pp. 527-541Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bbadis.2013.01.008
- [ONLINE] http://europepmc.org/abstract/med/23314196
Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance
Neurobiology of Disease, vol. 49, pp. 1-12Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.nbd.2012.08.008
- [ONLINE] http://europepmc.org/abstract/med/22940631
A insulina diminui os níveis de proteína tau fosforilada e modula a dinâmica mitocondrial no cérebro de ratos diabéticos tipo 1
Annual Meeting of the Portuguese Society of DiabetologyContributions to Conferences: Posters