Search
People

Professor Rainer Ebel

Professor Rainer Ebel
Professor Rainer Ebel
Professor Rainer Ebel

Personal Chair

About
Email Address
r.ebel@abdn.ac.uk
Telephone Number
+44 (0)1224 272930
Office Address
G23 Meston Building
Old Aberdeen Campus
Meston Walk
AB24 3UE

View on Map

School/Department
School of Natural and Computing Sciences

Internal Memberships

Safety Adviser for the Chemistry Department, Member of the University Health & Safety Committee

Latest Publications

View My Publications

Research

Research Overview

Biologically Active Natural Products

  • Structure elucidation of biologically active marine and terrestrial-derived natural products with the aid of modern spectroscopic methods, including one- and two-dimensional NMR spectroscopy and various mass spectrometric techniques.

     
  • Characterisation of natural products with regard to biological activity in pharmacologically relevant assay systems.

    An endophytic fungus is a fungus that spends the whole or part of its life cycle colonizing inside the healthy tissue of the host plant, typically without causing any apparent symptoms of disease, but forming a relationship between latent phytopathogenesis to mutualistic symbiosis.

    Endophytic fungi associated with plants represent a potential new source of novel chemistry and biology to assist in solving not only human, but also animal and plant health problems.

    Current research of our group explores endophytes isolated from different medicinal plants and mangroves for pharmacologically active natural products which might prove to be suitable for specific medicinal or agrochemical applications. By the use of advanced cultivation and investigation procedures as well as chemical technology, novel natural product leads will be optimized on the basis of their biological activities to yield effective chemotherapeutic and other bioactive agents.

 

  • Marine microbiology, especially cultivation of marine fungi for analysis of secondary metabolite profiles.

The marine environment serves as a source not only of untapped taxonomical diversity of fungi, but also unique chemical structures of novel fungal metabolites. Marine fungi have been gaining increased attention in recent decades because of their potential as producers of biologically active secondary metabolites with therapeutic potential. Moreover, the exploration of fungi could also solve the problem of supply of marine-derived pharmacologically active substances, which normally are produced in a limited amount. Cephalosporine C is a first classical example of a b-lactam antibiotic isolated from a marine derived fungus (Cephalosporium acremonium).

  • Molecular taxonomy of marine-derived fungi as well as endophytic fungi

Isolation of endophytic or endosymbiontic fungi is limited by the phenomenon that more than 99.8 % of micro-organisms existing in nature are not amenable to currently available cultivation methods. Molecular biology techniques can be used to overcome these limitations. Fungi strains may be identified by total DNA isolation, amplification of the so-called ITS region, sequencing of the product and database search.  Complex samples consisting of multiple fungi will result in a mixture of amplification products that cannot be sequenced together. Separation, traditionally performed by cloning, nowadays can be achieved by denaturing gradient gel electrophoresis that separates PCR products by their sequence-based melting behaviour.

Teaching

Programmes

Courses

Teaching Responsibilities

Professor Ebel teaches in the following courses: 

  • CM1020 Chemistry for the Life Sciences 1
  • CM1021 Chemistry for the Physical Sciences 1
  • CM1022 Elements of Chemistry 1CM1512 Chemistry for the Life Sciences 2
  • CM1522 Elements Of Chemistry 2
  • CM2016 Analytical Chemistry and Spectroscopy
  • CM2514 Organic and Biological Chemistry
  • CM3534 Organic and Biological Chemistry
  • CM4537 Advanced Honours Chemistry, module "Natural Products"
  • CM4538 Integrated Chemistry
  • CM5003 MChem Chemistry Applications
Publications

Page 2 of 3 Results 51 to 100 of 115

  • Does Osmotic Stress Affect Natural Product Expression in Fungi?

    Overy, D., Correa, H., Roullier, C., Chi, W. C., Pang, K. L., Rateb, M., Ebel, R., Shang, Z., Capon, R., Bills, G., Kerr, R.
    Marine Drugs, vol. 15, no. 8, 254
    Contributions to Journals: Articles

  • Dual Induction of New Microbial Secondary Metabolites by Fungal Bacterial Co-cultivation

    Wakefield, J., Hassan, H. M., Jaspars, M., Ebel, R., Rateb, M. E.
    Frontiers in Microbiology, vol. 8, pp. 1-10
    Contributions to Journals: Articles

  • Targeted Dereplication of Microbial Natural Products by High-Resolution MS and Predicted LC Retention Time

    Chervin, J., Stierhof, M., Tong, M. H., Peace, D., Hansen, K. ?., Urgast, D. S., Andersen, J. H., Yu, Y., Ebel, R., Kyeremeh, K., Paget, V., Cimpan, G., Wyk, A. V., Deng, H., Jaspars, M., Tabudravu, J. N.
    Journal of Natural Products, vol. 80, no. 5, pp. 1370-1377
    Contributions to Journals: Articles

  • Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040

    Sonnenschein, E. C., Stierhof, M., Goralczyk, S., Vabre, F. M., Pellissier, L., Hanssen, K. ?., de la Cruz, M., Díaz, C., de Witte, P., Copmans, D., Andersen, J. H., Hansen, E., Kristoffersen, V., Tormo, J. R., Ebel, R., Milne, B. F., Deng, H., Gram, L., Jaspars, M., Tabudravu, J. N.
    Tetrahedron, vol. 73, no. 18, pp. 2633-2637
    Contributions to Journals: Articles

  • Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

    Wichner, D., Idris, H., Houssen, W. E., McEwan, A. R., Bull, A. T., Asenjo, J. A., Goodfellow, M., Jaspars, M., Ebel, R., Rateb, M. E.
    The Journal of antibiotics, vol. 70, pp. 448-453
    Contributions to Journals: Articles

  • Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation

    Sánchez, J. A., Alfonso, A., Rodriguez, I., Alonso, E., Cifuentes, J. M., Bermudez, R., Rateb, M. E., Jaspars, M., Houssen, W. E., Ebel, R., Tabudravu, J., Botana, L. M.
    Frontiers in Immunology, vol. 7, 452
    Contributions to Journals: Articles

  • Identification of Spongionella compounds as cyclosporine A mimics

    Sánchez, J. A., Alfonso, A., Leirós, M., Alonso, E., Rateb, M. E., Jaspars, M., Houssen, W. E., Ebel, R., Tabudravu, J., Botana, L. M.
    Pharmacological Research, vol. 107, pp. 407-414
    Contributions to Journals: Articles

  • NMR characterisation of natural products derived from under-explored microorganisms

    Rateb, M. E., Tabudravu, J., Ebel, R.
    Nuclear Magnetic Resonance. Ramesh, V. (ed.). Royal Society of Chemistry, pp. 240-268, 29 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Solamargine production by a fungal endophyte of Solanum nigrum

    El-Hawary, S. S., Mohammed, R., Abouzid, S. F., Bakeer, W., Ebel, R., Sayed, A. M., Rateb, M. E.
    Journal of Applied Microbiology, vol. 120, no. 4, pp. 900-911
    Contributions to Journals: Articles

  • A Comparative biochemical study on two marine endophytes bacterium SRCnm and bacillus sp. JS, isolated from red sea algae

    Ahmed, E. F., Hassan, H. M., Rateb, M. E., Abdel-Wahab, N., Sameer, S., Ebel, R., Taie, H. A. A., Hameed, M. S. A., Hammouda, O.
    Pakistan Journal of Pharmaceutical Sciences, vol. 29, no. 1, pp. 17-26
    Contributions to Journals: Articles

  • Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps

    Huang, S., Elsayed, S. S., Lv, M., Tabudravu, J., Rateb, M. E., Gyampoh, R., Kyeremeh, K., Ebel, R., Jaspars, M., Deng, Z., Yu, Y., Deng, H.
    Chemistry & Biology, vol. 22, no. 12, pp. 1633-1642
    Contributions to Journals: Articles

  • Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins

    Huang, S., Tabudravu, J., Elsayed, S. S., Travert, J., Peace, D., Tong, M. H., Kyeremeh, K., Kelly, S. M., Trembleau, L., Ebel, R., Jaspars, M., Yu, Y., Deng, H.
    Angewandte Chemie International Edition, vol. 54, no. 43, pp. 12697-12701
    Contributions to Journals: Articles

  • Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert

    Elsayed, S. S., Trusch, F., Deng, H., Raab, A., Prokes, I., Busarakam, K., Asenjo, J. A., Andrews, B. A., van West, P., Bull, A. T., Goodfellow, M., Yi, Y., Ebel, R., Jaspars, M., Rateb, M. E.
    Journal of Organic Chemistry, vol. 80, no. 20, pp. 10252-10260
    Contributions to Journals: Articles

  • Spongionella Secondary Metabolites Regulate Store Operated Calcium Entry Modulating Mitochondrial Functioning in SH-SY5Y Neuroblastoma Cells

    Andoni Sanchez, J., Alfonso, A., Leiros, M., Alonso, E., Rateb, M. E., Jaspars, M., Houssen, W. E., Ebel, R. P., Botana, L. M.
    Cellular Physiology and Biochemistry, vol. 37, no. 2, pp. 779-792
    Contributions to Journals: Articles

  • Gracilins: Spongionella-derived promising compounds for Alzheimer disease

    Leiros, M., Alonso, E., Rateb, M. E., Houssen, W. E., Ebel, R. P., Jaspars, M., Alfonso, A., Botana, L. M.
    Neuropharmacology, vol. 93, pp. 285-293
    Contributions to Journals: Articles

  • Bromoalkaloids Protect Primary Cortical Neurons from Induced Oxidative Stress

    Leiros, M., Alonso, E., Rateb, M. E., Houssen, W. E., Ebel, R., Jaspars, M., Alfonso, A., Botana, L. M.
    ACS Chemical Neuroscience, vol. 6, no. 2, pp. 331-338
    Contributions to Journals: Articles

  • Diversity of organic structures of marine microbial origin with drug potential

    Jaspars, M., Ebel, R. P., Deng, H.
    Phycotoxins: Chemistry and Biochemistry. Botana, L., Alfonso, A. (eds.). 2 edition. Blackwell Science, pp. 361-380, 20 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces Isolate

    Rateb, M. E., Zhai, Y., Ehrner, E., Rath, C., Wang, X., Tabudravu, J., Ebel, R. P., Bibb, M., Kyeremeh, K., Dorrestein, P., Hong, K., Jaspars, M., Deng, H.
    Organic & Biomolecular Chemistry, vol. 13, no. 37, pp. 9585-9592
    Contributions to Journals: Articles

  • New rocaglamide derivatives from Vietnamese Aglaia species

    Duong, N. T., Edrada-Ebel, R., Ebel, R., Lin, W., Duong, A. T., Dang, X. Q., Nguyen, N. H., Proksch, P.
    Natural Product Communications, vol. 9, no. 6, pp. 833-834
    Contributions to Journals: Articles

  • Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum

    Rateb, M. E., Hassan, H. M., Arafa, E. A., Jaspars, M., Ebel, R., Rateb, M. E. M.
    Natural Product Communications, vol. 9, no. 4, pp. 473-476
    Contributions to Journals: Articles

  • Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments

    Wagner, M., Abdel-Mageed, W. M., Ebel, R., Bull, A. T., Goodfellow, M., Fiedler, H., Jaspars, M.
    Journal of Natural Products, vol. 77, no. 2, pp. 416-420
    Contributions to Journals: Articles

  • Hymenoscyphus pseudoalbidus and Hymenoscyphus albidus: Viridiol concentration and virulence do not correlate

    Junker, C., Mandey, F., Pais, A., Ebel, R., Schulz, B.
    Forest Pathology, vol. 44, no. 1, pp. 39-44
    Contributions to Journals: Articles

  • Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress

    Leirós, M., Sánchez, J. A., Alonso, E., Rateb, M. E., Houssen, W. E., Ebel, R., Jaspars, M., Alfonso, A., Botana, L. M., Rateb, M. E. M.
    Marine Drugs, vol. 12, no. 2, pp. 700-718
    Contributions to Journals: Articles

  • Mitigation of ROS Insults by Streptomyces Secondary Metabolites in Primary Cortical Neurons

    Leirós, M., Alonso, E., Sanchez, J. A., Rateb, M. E. M., Ebel, R., Houssen, W. E., Jaspars, M., Alfonso, A., Botana, L. M.
    ACS Chemical Neuroscience, vol. 5, no. 1, pp. 71-80
    Contributions to Journals: Articles

  • Induction of diverse secondary metabolites in Aspergillus fumigatus by microbial co-culture

    Rateb, M., Hallyburton, I., Houssen, W. E., Bull, A., Goodfellow, M., Santhanam, R., Jaspars, M., Ebel, R.
    RSC Advances, vol. 34, no. 3, pp. 14444-14450
    Contributions to Journals: Articles

  • Comprehensive analysis of lipophilic arsenic species in a brown alga (Saccharina latissima)

    Raab, A., Newcombe, C., Pitton, D., Ebel, R., Feldmann, J.
    Analytical Chemistry, vol. 85, no. 5, pp. 2817-2824
    Contributions to Journals: Articles

  • Natural products from marine-derived fungi

    Ebel, R.
    Marine Fungi and Fungal-like Organisms. de Gruyter, pp. 411-440, 30 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Pullularins E and F, two new peptides from the endophytic fungus Bionectria ochroleuca isolated from the mangrove plant Sonneratia caseolaris

    Ebrahim, W., Kjer, J., El Amrani, M., Wray, V., Lin, W., Ebel, R., Lai, D., Proksch, P.
    Marine Drugs, vol. 10, no. 5, pp. 1081-1091
    Contributions to Journals: Articles

  • Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment

    Rateb, M. E., Houssen, W. E., Harrison, W. T. A., Deng, H., Okoro, C. K., Asenjo, J. A., Andrews, B. A., Bull, A. T., Goodfellow, M., Ebel, R., Jaspars, M.
    Journal of Natural Products, vol. 74, no. 9, pp. 1965-1971
    Contributions to Journals: Articles

  • Chaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp

    Rateb, M. E., Houssen, W. E., Arnold, M., Abdelrahman, M. H., Deng, H., Harrison, W. T. A., Okoro, C. K., Asenjo, J. A., Andrews, B. A., Ferguson, G., Bull, A. T., Goodfellow, M., Ebel, R., Jaspars, M.
    Journal of Natural Products, vol. 74, no. 6, pp. 1491-1499
    Contributions to Journals: Articles

  • Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus Aspergillus ustus

    Liu, H., Edrada-Ebel, R., Ebel, R., Wang, Y., Schulz, B., Draeger, S., Müller, W. E., Wray, V., Lin, W., Proksch, P.
    Helvetica Chimica Acta, vol. 94, no. 4, pp. 623-631
    Contributions to Journals: Articles

  • Isolation, characterization, and bioactivity of endophytic fungi of Tylophora indica

    Kumar, S., Kaushik, N., Edrada-Ebel, R., Ebel, R., Proksch, P.
    World Journal of Microbiology and Biotechnology, vol. 27, no. 3, pp. 571-577
    Contributions to Journals: Articles

  • Antimicrobial activities of marine fungi from Malaysia

    Zainuddin, N., Alias, S., Lee, C., Ebel, R., Othman, N., Mukhtar, M., Awang, K.
    Botanica Marina, vol. 53, no. 6, pp. 507-513
    Contributions to Journals: Articles

  • Terpenes from marine-derived fungi

    Ebel, R.
    Marine Drugs, vol. 8, no. 8, pp. 2340-2368
    Contributions to Journals: Literature Reviews

  • Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa

    Ibrahim, S., Min, C., Teuscher, F., Ebel, R., Kakoschke, C., Lin, W., Wray, V., Edrada-Ebel, R., Proksch, P.
    Bioorganic & Medicinal Chemistry, vol. 18, no. 14, pp. 4947-4956
    Contributions to Journals: Articles

  • Natural product diversity from marine fungi

    Ebel, R.
    Comprehensive Natural Products II: Chemistry and Biology. Elsevier Ltd, pp. 223-262, 40 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Dermacozines, a new phenazine family from deep-sea dermacocci isolated from a Mariana Trench sediment

    Abdel-Mageed, W. M., Milne, B. F., Wagner, M., Schumacher, M., Sandor, P., Pathom-aree, W., Goodfellow, M., Bull, A. T., Horikoshi, K., Ebel, R. P., Diederich, M., Fiedler, H., Jaspars, M.
    Organic & Biomolecular Chemistry, vol. 8, no. 10, pp. 2352-2362
    Contributions to Journals: Articles

  • Bioactive Diterpene Derivatives from the Marine Sponge Spongionella sp.

    Rateb, M., Houssen, W. E., Schumacher, M., Harrison, W. T. A., Diederich, M., Ebel, R. P., Jaspars, M.
    Journal of Natural Products, vol. 72, no. 8, pp. 1471-1476
    Contributions to Journals: Articles

  • A new tetrahydrofuran derivative from the Endophytic Fungus Chaetomium sp. isolated from Otanthus maritimus

    Aly, A., Debbab, A., Edrada-Ebel, R., Wray, V., Müller, W., Lin, W., Ebel, R., Proksch, P.
    Zeitschrift für Naturforschung - C, vol. 64, no. 5-6, pp. 350-354
    Contributions to Journals: Articles

  • Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium

    Debbab, A., Aly, A., Proksch, P., Edrada-Ebel, R., Wray, V., Müller, W., Totzke, F., Zirrgiebel, U., Schächtele, C., Kubbutat, M., Wen, H., Mosaddak, M., Hakiki, A., Ebel, R.
    Journal of Natural Products, vol. 72, no. 4, pp. 626-631
    Contributions to Journals: Articles

  • Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation

    Wätjen, W., Debbab, A., Hohlfeld, A., Chovolou, Y., Kampkötter, A., Edrada, R. A., Ebel, R., Hakiki, A., Mosaddak, M., Totzke, F., Kubbutat, M. H. G., Proksch, P.
    Molecular Nutrition & Food Research, vol. 53, no. 4, pp. 431-440
    Contributions to Journals: Articles

  • Bioactive secondary metabolites from the endophytic fungus Chaetomium sp isolated from Salvia officinalis growing in Morocco

    Debbab, A., Aly, A. H., Edrada-Ebel, R. A., Mueller, W. E. G., Mosaddak, M., Hakiki, A., Ebel, R., Proksch, P.
    Biotechnologie Agronomie Societe et Environnement, vol. 13, no. 2, pp. 229-234
    Contributions to Journals: Articles

  • Chemical constituents of the endophytic fungus Lecythophora sp. isolated from Alyxia reinwardtii

    Sugijanto, N. E., Diesel, A., Ebel, R., Indrayanto, G., Zaini, N. C.
    Natural Product Communications, vol. 4, no. 11, pp. 1485-1488
    Contributions to Journals: Articles

  • Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula

    Liu, H., Edrada-Ebel, R., Ebel, R., Wang, Y., Schulz, B., Draeger, S., Müller, W., Wray, V., Lin, W., Proksch, P.
    Journal of Natural Products, vol. 72, no. 9, pp. 1585-1588
    Contributions to Journals: Articles

  • Xanalteric acids I and II and related phenolic compounds from an endophytic Alternaria sp. isolated from the Mangrove plant Sonneratia alba

    Kjer, J., Wray, V., Edrada-Ebel, R., Ebel, R., Pretsch, A., Lin, W., Proksch, P.
    Journal of Natural Products, vol. 72, no. 11, pp. 2053-2057
    Contributions to Journals: Articles

  • Diacarperoxides, norterpene cyclic peroxides from the sponge Diacarnus megaspinorhabdosa

    Ibrahim, S., Ebel, R., Wray, V., Müller, W., Edrada-Ebel, R., Proksch, P.
    Journal of Natural Products, vol. 71, no. 8, pp. 1358-1364
    Contributions to Journals: Articles

  • Sponge-associated fungi and their bioactive compounds: The Suberites case

    Proksch, P., Ebel, R., Edrada, R., Riebe, F., Liu, H., Diesel, A., Bayer, M., Li, X., Han Lin, W., Grebenyuk, V., Müller, W., Draeger, S., Zuccaro, A., Schulz, B.
    Botanica Marina, vol. 51, no. 3, pp. 209-218
    Contributions to Journals: Articles

  • Metabolic profiling of lignan varibality in Linum species of section syllinum native to Bulgaria

    Vasilev, N., Ebel, R., Edrada, R., Fuss, E., Alfermann, A. W., Ionkova, I., Petrova, A., Repplinger, M., Schmidt, T. J.
    Planta Medica, vol. 74, no. 3, pp. 273-280
    Contributions to Journals: Articles

  • Pyrazolinone analgesics prevent the antiplatelet effect of aspirin and preserve human platelet thromboxane synthesis

    Hohlfeld, T., Zimmermann, N., Weber, A., Jessen, G., Weber, H., Schrör, K., Höltje, H., Ebel, R.
    Journal of Thrombosis and Haemostasis, vol. 6, no. 1, pp. 166-173
    Contributions to Journals: Articles

  • UDP-glucose: (6-methoxy)podophyllotoxin 7-O-glucosyltransferase from suspension cultures of Linum nodiflorum

    Berim, A., Ebel, R., Schneider, B., Petersen, M.
    Phytochemistry, vol. 69, no. 2, pp. 374-381
    Contributions to Journals: Articles
Show 10 | 25 | 50 | 100 results per page

Refine

Chapters in Books, Reports and Conference Proceedings

Contributions to Conferences

Contributions to Journals

Working Papers

Update