Dr Louie Van de Lagemaat

Dr Louie Van de Lagemaat
Dr Louie Van de Lagemaat
Dr Louie Van de Lagemaat


Office Address
G16 23 St. Machar Drive
Old Aberdeen Campus
23 St. Machar Drive
AB24 3RY

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School of Medicine, Medical Sciences and Nutrition


Louie van de Lagemaat joined the Centre for Genome-Enabled Biology and Medicine as a bioinformatician in October 2021. He completed his PhD in Genetics at the University of British Columbia, Canada in 2006. Subsequent positions focused on diverse subjects, including molecular neuroscience of the mammalian excitatory synapse and developmental and malignant haematopoiesis. He has used varied analytical methods such as linear and mixed effects models and has broad experience with short-read sequencing technologies including ChIP-seq, bulk and low-cell-count RNA-seq, mRNA splicing, ribosomal profiling (Ribo-seq), transcript methylation (meRIP-seq), poly-A tail length (tail-seq) and transcript half-life (SLAM-seq). He has also performed analysis of survival and loss of HLA allele heterozygosity in cancers.


Research Specialisms

  • Genomics
  • Behavioural Biology
  • Bioinformatics

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.


Page 1 of 4 Results 1 to 10 of 35

  • Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.

    Woodley, K., Dillingh, L., Giotopoulos, G., Madrigal, P., Rattigan, K., Philippe, C., Dembitz, V., Magee, A., Asby, R., van de Lagemaat, L. N., Mapperley, C., James, S., Prehn, J., Tzelepis, K., Rouault-Pierre, K., Vassiliou, G., Kranc, K., Helgason, G. V., Huntly, B., Gallipoli, P.
    Nature Communications, vol. 14, 2132
    Contributions to Journals: Articles
  • Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis

    Young, C., Russell, J. R., van de Lagemaat, L. N., Lawson, H., Mapperley, C., Kranc, K. R., Christophorou, M. A.
    Open Biology, vol. 11, no. 6, bio059143
    Contributions to Journals: Articles
  • CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation

    Lawson, H., van de Lagemaat, L. N., Barile, M., Tavosanis, A., Durko, J., Villacreces, A., Bellani, A., Mapperley, C., Georges, E., Martins-Costa, C., Sepulveda, C., Allen, L., Campos, J., Campbell, K. J., O'Carroll, D., Göttgens, B., Cory, S., Rodrigues, N. P., Guitart, A. V., Kranc, K. R.
    Stem Cell Reports, vol. 16, no. 11, pp. 2784-2797
    Contributions to Journals: Articles
  • NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells

    Codino, A., Turowski, T., van de Lagemaat, L. N., Ivanova, I., Tavosanis, A., Much, C., Auchynnikava, T., Vasiliauskaitė, L., Morgan, M., Rappsilber, J., Allshire, R. C., Kranc, K. R., Tollervey, D., O'Carroll, D.
    iScience, vol. 24, no. 7, pp. 102762
    Contributions to Journals: Articles
  • The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function

    Mapperley, C., van de Lagemaat, L. N., Lawson, H., Tavosanis, A., Paris, J., Campos, J., Wotherspoon, D., Durko, J., Sarapuu, A., Choe, J., Ivanova, I., Krause, D. S., von Kriegsheim, A., Much, C., Morgan, M., Gregory, R. I., Mead, A. J., O'Carroll, D., Kranc, K. R.
    Journal of Experimental Medicine, vol. 218, no. 3
    Contributions to Journals: Articles
  • JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells

    Lawson, H., Sepulveda, C., van de Lagemaat, L. N., Durko, J., Barile, M., Tavosanis, A., Georges, E., Shmakova, A., Timms, P., Carter, R. N., Allen, L., Campos, J., Vukovic, M., Guitart, A. V., Giles, P., O'Shea, M., Vernimmen, D., Morton, N. M., Rodrigues, N. P., Göttgens, B., Schofield, C. J., Lengeling, A., O'Carroll, D., Kranc, K. R.
    Blood Advances, vol. 5, no. 3, pp. 889-899
    Contributions to Journals: Articles
  • Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

    Paris, J., Morgan, M., Campos, J., Spencer, G. J., Shmakova, A., Ivanova, I., Mapperley, C., Lawson, H., Wotherspoon, D. A., Sepulveda, C., Vukovic, M., Allen, L., Sarapuu, A., Tavosanis, A., Guitart, A. V., Villacreces, A., Much, C., Choe, J., Azar, A., van de Lagemaat, L. N., Vernimmen, D., Nehme, A., Mazurier, F., Somervaille, T. C. P., Gregory, R. I., O'Carroll, D., Kranc, K. R.
    Cell stem cell, vol. 25, no. 1, pp. 137-148.e6
    Contributions to Journals: Articles
  • CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands.

    van de Lagemaat, L. N., Flenley, M., Lynch, M., David, G., Tomlinson, S., Kranc, K., Vernimmen, D.
    Epigenetics & Chromatin, vol. 11, 59
    Contributions to Journals: Articles
  • A combinatorial postsynaptic molecular mechanism converts patterns of nerve impulses into the behavioral repertoire

    Kopanitsa, M. V., van de Lagemaat, L. N., Afinowi, N. O., Strathdee, D. J., Strathdee, K. E., Fricker, D. G., Tuck, E. J., Elsegood, K. A., Croning, M. D. R., Komiyama, N. H., Grant, S. G. N.
    Working Papers: Preprint Papers
  • Synaptic combinatorial molecular mechanisms generate repertoires of innate and learned behavior

    Komiyama, N. H., van de Lagemaat, L. N., Stanford, L. E., Pettit, C. M., Strathdee, D. J., Strathdee, K. E., Fricker, D. G., Tuck, E. J., Elsegood, K. A., Ryan, T. J., Nithianantharajah, J., Skene, N. G., Croning, M. D. R., Grant, S. G. N.
    Working Papers: Preprint Papers
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