![Dr Fergal Waldron Dr Fergal Waldron](/img/200x200/staffpages/uploads/s03fw2/avatar/6QoBSpdf6lxDV4Gfd4Rtm0a3F9oLE417naLNDiS5.jpeg)
BSc MSc MRes PhD (Cantab.)
Advanced Research Fellow
- About
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- Email Address
- fergal.waldron@abdn.ac.uk
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
My research focuses on the roles of immunity, inflammation, and the gut-brain axis in ALS. I also work on biomarker developement in neurodegenerative disease but for ALS in particular. I am interested in heterogeneity, and early detection of disease, and my work involves a combination of experimental, molecular, histological, bioinformatics and meta-analytical approaches to answer fundamental questions in ALS research.
I obtained my PhD in Evolutionary Genetics from the University of Cambridge before undertaking postdoctoral work at the Institute of Evolutionary Biology at the University of Edinburgh.
Qualifications
- BSc Zoology2003 - National University of Ireland, Galway
- MRes Zoology2006 - National University of Ireland, Galway
- MSc Evolutionary Genetics and Genome Analysis2008 - University of Edinburgh
- PhD Evolutionary Genetics2013 - University of Cambridge
Internal Memberships
The Genetics Society
The Pathological Society of Great Britain and Ireland
Latest Publications
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
Acta Neuropathologica, vol. 147, 50Contributions to Journals: ArticlesSOP and tick-sheet for using TDP-43 RNA aptamer (TDP-43APT) to detect pathological TDP-43 in FFPE-preserved human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica) v1
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.eq2lyjo4mlx9/v1
Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts
Brain, vol. 146, no. 12, pp. 5124-5138Contributions to Journals: ArticlesRNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides withSTMN-2cryptic splicing and precedes clinical manifestation in ALS
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2023.10.24.563701
Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: Using systematic reviews to inform expert consensus
BMJ Open, vol. 13, no. 2, e064169Contributions to Journals: Articles
- Research
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Funding and Grants
A Laboratory Model for Antiviral Immunity in Molluscs (co-writer); £201,732 | 2018-06 to 2021-10 | Grant | The Leverhulme Trust (London, GB)
Establishment of a Laboratory Model for Antiviral Immunity in Molluscs (co-writer); £44,364 | 2017-04 to 2017-12 | Grant | Wellcome Trust ISSF (London, GB)
Antiviral immune expression in the mollusc Lymnaea stagnalis (co-writer); £1,791 | 2017-02 to 2017-06 | Grant | University of Edinburgh Moray Endowement Fund (Edinburgh, GB)
Next Generation Sequencing workshop hosted by the Vienna Graduate School of Population Genetics Registration and Travel Award; €1,000 | 2011-05 to 2011-06 | AwardEuropean Science Foundation (Strasbourg, FR)
St. John’s College, Cambridge Learning and Research Fund; £1,000 | 2010-06 to 2010-07 | Award | St. John's College, University of Cambridge (Cambridge, GB)
Summer Institute in Statistics and Modelling in Infectious Diseases workshop hosted by The University of Washington Registration and Travel Award; $4,000 | 2010-06 to 2010-07 | Award | National Institutes of Health (Bethesda, Maryland, US)
Marie Curie Early Stage Research Fellowship; £24,055 | 2007-09 to 2008-08 | Salary award | Marie Curie (London, GB)
Embark Initiative Thermadapt Programme Research Fellowship; €38,012 | 2003-09 to 2005-08 | Salary award | Irish Research Council (Dublin, IE)
- Publications
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Page 1 of 2 Results 1 to 25 of 27
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
Acta Neuropathologica, vol. 147, 50Contributions to Journals: ArticlesSOP and tick-sheet for using TDP-43 RNA aptamer (TDP-43APT) to detect pathological TDP-43 in FFPE-preserved human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica) v1
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.eq2lyjo4mlx9/v1
Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts
Brain, vol. 146, no. 12, pp. 5124-5138Contributions to Journals: ArticlesRNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides withSTMN-2cryptic splicing and precedes clinical manifestation in ALS
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2023.10.24.563701
Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: Using systematic reviews to inform expert consensus
BMJ Open, vol. 13, no. 2, e064169Contributions to Journals: ArticlesALS and the Gut-Brain Axis: A protocol for a systematic review and meta-analysis assessing the relationship between amyotrophic lateral sclerosis, the gut and its microbiome.
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.5qpvorqpzv4o/v1
Distinct neuroinflammatory signatures exist across genetic and sporadic ALS cohorts
Working Papers: Preprint PaperspTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data
Journal of Pathology: Clinical Research, vol. 9, no. 1, pp. 44-55Contributions to Journals: ArticlesA Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease
Working Papers: Preprint PapersInterferon signalling as a potentional therapeutic target in amyotrophic lateral sclerosis and frontotemporal dementia – protocol for a systematic review and meta-analysis
protocols.io.Other Contributions: Other ContributionspTDP-43 aggregates accumulate in the gut and other non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2022.03.17.484805
pTDP-43 aggregates accumulate in the gut and other non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis
Working Papers: Preprint PapersBuilding a Systematic Online Living Evidence Summary of COVID-19 Research
Journal of EAHIL, vol. 17, no. 2, pp. 21-26Contributions to Journals: ArticlesTesting evolutionary explanations for the lifespan benefit of dietary restriction in fruit flies (Drosophila melanogaster)
Evolution, vol. 75, no. 2, pp. 450-463Contributions to Journals: Articles- [ONLINE] https://doi.org/10.5061/dryad.80gb5mkq2
- [ONLINE] DOI: https://doi.org/10.1111/evo.14146
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/20298/1/Charter_etal_RRH_The_Word_That_VOR.pdf
- [ONLINE] View publication in Scopus
Unlocking Spatial Molecular & Cellular Relationships of SARS-CoV-2 in Archived Human Tissue
protocols.io.Other Contributions: Other ContributionsTesting evolutionary explanations for the lifespan benefit of dietary restriction in Drosophila melanogaster
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2020.06.18.159731
- [ONLINE] http://europepmc.org/abstract/PPR/PPR178319
Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta-Analysis of Preclinical Research
Frontiers in Neuroscience, vol. 14, no. 2020, 511Contributions to Journals: ArticlesCorrection: Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes
PLoS Genetics, vol. 16, no. 3, e1008679Contributions to Journals: ArticlesTargeting mitochondrial dysfunction in amyotrophic lateral sclerosis: a systematic review and meta-analysis
Brain Communications, vol. 1, no. 1, fcz009Contributions to Journals: ArticlesCreation and maintenance of Ashworth outcrossed DGRP population V.1
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.zbuf2nw
Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes.
PLoS Genetics, vol. 14, no. 7, e1008679Contributions to Journals: ArticlesThe virome of Drosophila suzukii, an invasive pest of soft fruit
Virus Evolution, vol. 4, no. 1, vey009Contributions to Journals: ArticlesThe virome of Drosophila suzukii, an invasive pest of soft fruit
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/190322
Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/166488
- [ONLINE] http://dx.doi.org/10.1101/166488
Protocol for a systematic review and meta-analysis of experimental models of amyotrophic lateral sclerosis
Evidence-based Preclinical Medicine, vol. 3, no. 2, pp. 17-19Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ebm2.23
- [ONLINE] https://onlinelibrary.wiley.com/doi/10.1002/ebm2.23