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Dr Renato Coelho Dos Santos

Dr Renato Coelho Dos Santos
Dr Renato Coelho Dos Santos
Dr Renato Coelho Dos Santos

Advanced Research Fellow

About
Email Address
renato.santos@abdn.ac.uk
Telephone Number
+44 (0)1224 438577
Office Address

Liberty Building, Room GD07

Foresterhill Road

AB25 2ZP

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD
Scopus
Google Scholar
Pure

Biography

I obtained the BSc in Biology in 2008, and the Doctorate degree (Cell Biology) in 2014 from the Faculty of Sciences and Technology, University of Coimbra, Portugal. My work was focused on numerous aspects of cellular and, particularly, mitochondrial biology, namely, mitochondrial biogenesis, mitochondrial fission and fusion and also autophagy/mitophagy. The main subject of my work was to understand the relation between diabetes and the propensity do develop dementia, particularly Alzheimer's disease. In 2017, I joined the team of Dr. Charles Harrington at the Institute of Medical Sciences, University of Aberdeen. My research interests include the understanding of neuropathological processes, uncovering of therapeutic targets and study of efficient therapeutic approaches to tackle progression of neurodegenerative diseases.  

Qualifications

  • BSc Biology 
    2008 - University of Coimbra, Portugal 
  • PhD Cell Biology 
    2014 - University of Coimbra, Portugal 

Internal Memberships

03/2023-02/2025: Board Member - School Ethics Review Board (SERB), for the School of Medicine, Medical Sciences and Nutrition

Latest Publications

View My Publications

Research

Research Overview

Neurodegeneration

Alzheimer's disease

Tau protein

Mitochondria

Oxidative Stress

Autophagy/Mitophagy

Therapeutics

Publications

Page 2 of 3 Results 26 to 50 of 56

  • Diabetes disturbs autophagy and mitochondrial dynamics in the brain

    Coelho Dos Santos, R. X., Santos, M. S., Seiça, R., Oliveira, C. R., da Silva Moreira, P. I.
    26th Meeting of the Portuguese group for the study of brain aging and dementia
    Contributions to Conferences: Posters

  • Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities

    Carvalho, C., Cardoso, S., Correia, S. C., Santos, R. X., Santos, M. S., Baldeiras, I., Oliveira, C. R., Moreira, P. I.
    Diabetes, vol. 61, no. 5, pp. 1234-1242
    Contributions to Journals: Articles

  • Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation

    Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Candeias, E., Santos, M. S., Oliveira, C. R., Moreira, P. I.
    Brain Research, vol. 1441, pp. 64-78
    Contributions to Journals: Review articles

  • Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1α

    Correia, S. C., Santos, R. X., Cardoso, S. M., Santos, M. S., Oliveira, C. R., Moreira, P. I.
    Neurobiology of Disease, vol. 45, no. 1, pp. 206-218
    Contributions to Journals: Articles

  • Diabetes unbalances autophagy and mitochondrial dynamics in the brain

    Coelho Dos Santos, R. X., Correia, S. C., Santos, M. S., Seiça, R., Oliveira, C. R., da Silva Moreira, P. I.
    12th FENS Forum
    Contributions to Conferences: Posters

  • Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases

    Correia, S. C., Santos, R. X., Perry, G., Zhu, X., Moreira, P. I., Smith, M. A.
    Advances in Experimental Medicine and Biology, vol. 724, pp. 205-221
    Contributions to Journals: Review articles

  • Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

    Santos, R. X., Correia, S. C., Zhu, X., Lee, H., Petersen, R. B., Nunomura, A., Smith, M. A., Perry, G., Moreira, P. I.
    FREE RADICAL RESEARCH, vol. 46, no. 4, pp. 565-576
    Contributions to Journals: Review articles

  • Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease

    Santos, R. X., Correia, S. C., Cardoso, S., Carvalho, C., Santos, M. S., Moreira, P. I.
    Journal of Neurochemistry, vol. 117, no. 6, pp. 927-936
    Contributions to Journals: Articles

  • Mitophagy in neurodegeneration: an opportunity for therapy?

    Santos, R. X., Correia, S. C., Carvalho, C., Cardoso, S., Santos, M. S., Moreira, P. I.
    Current Drug Targets, vol. 12, no. 6, pp. 790-799
    Contributions to Journals: Articles

  • Hyperglycemia potentiates apoptosis and autophagy in primary cortical neurons

    Coelho Dos Santos, R. X., Santos, M. S., Oliveira, C. R., da Silva Moreira, P. I.
    XII Meeting of the Portuguese Society for Neuroscience
    Contributions to Conferences: Posters

  • Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?

    Correia, S. C., Santos, R. X., Perry, G., Zhu, X., Moreira, P. I., Smith, M. A.
    Ageing Research Reviews, vol. 10, no. 2, pp. 264-273
    Contributions to Journals: Articles

  • Oxidative stress, mitochondria and insulin signaling dysfunction: a redoubtable trio in Alzheimer’s disease pathogenesis

    Correia, S. C., Coelho Dos Santos, R. X., Carvalho, C., Cardoso, S., da Silva Moreira, P. I.
    Dementia. McNamara, P. (ed.). ABC-CLIO Greenwood
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)

  • Association of Mitochondrial Signaling in Alzheimer’s Disease and Hypoxia

    Carvalho, C., Correia, S. C., Coelho Dos Santos, R. X., Cardoso, S., da Silva Moreira, P. I., Zhu, X., Smith, M. A., Perry, G.
    Molecular Aspects of Neurodegeneration and Neuroprotection. Farooqui, A. A., Farooqui, T. (eds.). Bentham Science Publishers B.V., pp. 50-61, 12 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)

  • Diabetes, Mitochondria and brain endothelium dysfunction: a dangerous triad for neurodegeneration?

    Carvalho, C., Correia, S. C., Coelho Dos Santos, R. X., Cardoso, S., Santos, M. S., da Silva Moreira, P. I.
    Mitochondria: Structure, Functions and Dysfunctions. Svensson, O. L. (ed.). Nova Science Publishers Inc, pp. 553-578, 26 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)

  • New Insights into the Mechanisms of Mitochondrial Preconditioning-Triggered Neuroprotection

    Correia, S. C., Cardoso, S., Santos, R. X., Carvalho, C., Santos, M. S., Perry, G., Smith, M. A., Moreira, P. I.
    Current Pharmaceutical Design, vol. 17, no. 31, pp. 3381-3389
    Contributions to Journals: Articles

  • Mitochondrial preconditioning: a potential neuroprotective strategy

    Correia, S. C., Carvalho, C., Cardoso, S., Santos, R. X., Santos, M. S., Oliveira, C. R., Perry, G., Zhu, X., Smith, M. A., Moreira, P. I.
    Frontiers in Genetics, vol. 2, 138
    Contributions to Journals: Articles

  • Mitochondrial reactive oxygen species preconditioning protects brain cells against hyperglycemia

    Correia, S. C., Coelho Dos Santos, R. X., Santos, M. S., Moreira, P. I.
    Alzheimer's Association International Conference on Alzheimer's Disease (ICAD)
    Contributions to Conferences: Posters

  • Autophagy in Alzheimer's disease

    Moreira, P. I., Santos, R. X., Zhu, X., Lee, H., Smith, M. A., Casadesus, G., Perry, G.
    Expert Review Neurotherapeutics, vol. 10, no. 7, pp. 1209-1218
    Contributions to Journals: Articles

  • Effects of Estrogen in the Brain: Is it a Neuroprotective Agent in Alzheimers Disease?

    Correia, S. C., Santos, R. X., Cardoso, S., Carvalho, C., Santos, M. S., Oliveira, C. R., Moreira, P. I.
    Current Aging Science, vol. 3, no. 2, pp. 113-126
    Contributions to Journals: Articles

  • A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease

    Santos, R. X., Correia, S. C., Wang, X., Perry, G., Smith, M. A., Moreira, P. I., Zhu, X.
    Journal of Alzheimer's Disease, vol. 20, no. s2, pp. S401-S412
    Contributions to Journals: Articles

  • Alzheimer's disease: diverse aspects of mitochondrial malfunctioning

    Santos, R. X., Correia, S. C., Wang, X., Perry, G., Smith, M. A., Moreira, P. I., Zhu, X.
    International journal of clinical and experimental pathology, vol. 3, no. 6, pp. 570-581
    Contributions to Journals: Articles

  • Targeting autophagy in the brain: a promising approach?

    Santos, R., Cardoso, S., Correia, S., Carvalho, C., Santos, M., Moreira, P.
    Central nervous system agents in medicinal chemistry, vol. 10, no. 2, pp. 158-168
    Contributions to Journals: Articles

  • Diabetes as a trigger of neurodegeneration: from pathophysiological mechanisms to therapeutic approaches

    Correia, S. C., Carvalho, C., Coelho Dos Santos, R. X., Cardoso, S., Santos, M. S., da Silva Moreira, P. I.
    Advances in Molecular Mechanisms and Pharmacology of Diabetic Complications. Stefek, M. (ed.). Research Signpost, pp. 175-198, 24 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)

  • Mitochondrial Uncoupling Proteins: Therapeutic Targets in Neurodegeneration?

    Cardoso, S., Carvalho, C., Correia, S. C., Coelho Dos Santos, R. X., Santos, M. S., da Silva Moreira, P. I.
    Neurodegeneration: Theory, Disorders and Treatments. McNeill, A. S. (ed.). Nova Science Publishers Inc, pp. 107-124, 18 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)

  • Insulin is a Two-Edged Knife on the Brain

    Cardoso, S., Correia, S., Santos, R. X., Carvalho, C., Santos, M. S., Oliveira, C. R., Perry, G., Smith, M. A., Zhu, X., Moreira, P. I.
    Journal of Alzheimer's Disease, vol. 18, no. 3, pp. 483-507
    Contributions to Journals: Articles
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