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Dr Roger Staff

Dr Roger Staff
Dr Roger Staff
Dr Roger Staff

BSc MSc PhD MIPEM

Honorary Professor

About
Email Address
r.staff@abdn.ac.uk
Office Address

Nuclear Medicine ARI Foresterhill Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Roger Staff was born in London and studied physics at UEA.  He moved to Aberdeen in 1988 and completed his PhD in medical physics in 1994.  He has worked for the NHS since 1991 and currently leads the clinical physics imaging team at NHS-Grampian. His other interests include Intelligence and social mobility.

Research

Research Overview

(Since 1999) founding member of the Aberdeen 1921 & 1936 birth cohort study group with three critical responsibilities for (1) hypothesis generation and hypothesis testing; (2) brain imaging and image analysis; (3) Advance data modelling of complex databases; (Since 2003 with Taurx) the imaging the effects tau aggregation inhibition and the use of surrogate imaging measures in drug development; (Since 2008) the development of structural and temporal (fMRI) complexity measures for use in ageing and neurodegenerative disease; (Since 2012) The prognostic value of automated analysis of sequential retinal images in diabetic retinopathy. The use of external quality assurance programs in diabetic retinopathy.   

Publications

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  • Klotho, APOEε4, cognitive ability, brain size, atrophy and survival: A study in the Aberdeen Birth Cohort of 1936

    de Vries, C. F., Staff, R. T., Harris, S. E., Chapko, D., Williams, D. S., Reichert, P., Ahearn, T., McNeil, C. J., Whalley, L. J., Murray, A. D.
    Neurobiology of Aging, vol. 55, pp. 91-98
    Contributions to Journals: Articles

  • Sexual dimorphism in changes of cortical complexity associated with cognitive decline in late life

    Sandu-Giuraniuc, A., Staff, R., McNeil, C. J., Stringer, M. S., Ahearn, T., Whalley, L., Murray, A. D.
    Alzheimer's Research UK
    Contributions to Conferences: Abstracts

  • A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)

    Job, D. E., Dickie, D. A., Rodriguez, D., Robson, A., Pernet, C., Bastin, M. E., Boardman, J. P., Murray, A. D., Ahearn, T., Waiter, G. D., Staff, R. T., Deary, I. J., Shenkin, S. D., Wardlaw, J. M.
    Neuroimage, vol. 144, no. Part B, pp. 299–304
    Contributions to Journals: Articles

  • Distinct anatomical subtypes of behavioural variant frontotemporal dementia and involvement of intrinsic brain networks: a clustering study

    Vuksanovic, V., Staff, R., Ahearn, T. S., Morson, S. M., Bentham, P., Murray, A. D., Wischik, C. M.
    Alzheimer Research UK (2017)
    Contributions to Conferences: Abstracts

  • Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

    Gauthier, S., Feldman, H. H., Schneider, L. S., Wilcock, G. K., Frisoni, G. B., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Wischik, D. J., Schelter, B. O., Davis, C. S., Staff, R. T., Bracoud, L., Shamsi, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    The Lancet, vol. 388, no. 10062, pp. 2873-2884
    Contributions to Journals: Articles

  • Late-life deficits in cognitive, physical and emotional functions, childhood intelligence and occupational profile: a life-course examination of the Aberdeen 1936 Birth Cohort (ABC1936)

    Chapko, D., Staff, R. T., McNeil, C. J., Whalley, L. J., Black, C., Murray, A. D.
    Age and Ageing, vol. 45, no. 4, pp. 486-493
    Contributions to Journals: Articles

  • Brain hyperintensity location determines outcome in the triad of impaired cognition, physical health and depressive symptoms: A cohort study in late life

    Murray, A., McNeil, C., Salarirad, S., Deary, I., Phillips, L., Whalley, L., Staff, R.
    Archives of Gerontology and Geriatrics, vol. 63, pp. 49-54
    Contributions to Journals: Articles

  • Cerebral correlates of cognitive reserve

    Whalley, L. J., Staff, R. T., Fox, H. C., Murray, A. D.
    Psychiatry Research, vol. 247, pp. 65-70
    Contributions to Journals: Articles

  • Neural correlates of cognitive and behavioural impairments in behavioural variant of frontotemporal dementia: A voxel based morphometry analysis

    Vuksanovic, V., Staff, R., Ahearn, T., Morson, S. M., Bentham, P., Murray, A. D., Wischik, C. M.
    SINAPSE Annual Scientific Meeting (2016)
    Contributions to Conferences: Abstracts

  • QUALITY ASSURANCE IN DIABETIC RETINAL SCREENING IN SOUTH AFRICA: A BASELINE AND FOLLOW-UP STUDY

    Staff, R. T., Cook, S., Paxton, J., Philip, S., Sharp, P., Goatman, K., Olson, J.
    26th Meeting of the European Association for the Study of Diabetes Eye Complications Study Group (EASDec), pp. E102-E102
    Contributions to Journals: Abstracts

  • Phenothiazine compounds for treating mild cognitive impairment

    Wischik, C. M., Harbaran, D. V., Riedel, G., Deiana, S., Goatman, E. A., Wischik, D. J., Murray, A. D., Staff, R. T.
    Patents: Patents

  • Fuzzy approximate entropy analysis of resting state fMRI signal complexity across the adult life span

    Sokunbi, M. O., Cameron, G. G., Ahearn, T. S., Murray, A. D., Staff, R. T.
    Medical Engineering & Physics, vol. 37, no. 11, pp. 1082-1090
    Contributions to Journals: Articles

  • A longitudinal study of cognitive and hippocampal ageing in late life

    Sandu-Giuraniuc, A., Rana, A., Robertson, K. L., Ahearn, T., McNeil, C. J., Staff, R., Murray, A. D.
    British Neuroscience Association, 2015 Festival of Neuroscience
    Contributions to Conferences: Abstracts

  • Mapping the cortical complexity and cognitive decline in late life

    Sandu-Giuraniuc, A., McNeil, C. J., Stringer, M., Ahearn, T., Whalley, L., Staff, R., Murray, A. D.
    Alzheimer's research UK 2015
    Contributions to Conferences: Abstracts

  • Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

    Wischik, C. M., Staff, R. T., Wischik, D. J., Bentham, P., Murray, A. D., Storey, J. M. D., Kook, K. A., Harrington, C. R.
    Journal of Alzheimer's Disease, vol. 44, no. 2, pp. 705-720
    Contributions to Journals: Articles

  • Structural brain complexity and cognitive decline in late life: A longitudinal study in the Aberdeen 1936 Birth Cohort

    Sandu-Giuraniuc, A., Staff, R. T., McNeil, C. J., Mustafa, N., Ahearn, T., Whalley, L. J., Murray, A. D.
    Neuroimage, vol. 100, pp. 558-563
    Contributions to Journals: Articles

  • Improving the cost-effectiveness of photographic screening for diabetic macular oedema: a prospective, multi-centre, UK study

    Prescott, G., Sharp, P., Goatman, K., Scotland, G., Fleming, A., Philip, S., Staff, R., Santiago, C., Borooah, S., Broadbent, D., Chong, V., Dodson, P., Harding, S., Leese, G., Megaw, R., Styles, C., Swa, K., Wharton, H., Olson, J.
    British Journal of Ophthalmology, vol. 98, no. 8, pp. 1042-1049
    Contributions to Journals: Articles

  • A longitudinal study of human brain complexity and cognitive decline in ageing

    Sandu-Giuraniuc, A., Staff, R., McNeil, C. J., Mustafa, N., Ahearn, T., Whalley, L., Murray, A. D.
    Organization of Human Brain Mapping meeting (OHBM)
    Contributions to Conferences: Abstracts

  • Nonlinear complexity analysis of brain FMRI signals in schizophrenia

    Sokunbi, M. O., Gradin, V. B., Waiter, G. D., Cameron, G. G., Ahearn, T. S., Murray, A. D., Steele, D. J., Staff, R. T.
    PloS ONE, vol. 9, no. 5, e95146
    Contributions to Journals: Articles

  • Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities: A Population Based Cohort Study

    Murray, A. D., McNeil, C. J., Salarirad, S., Whalley, L. J., Staff, R. T.
    PloS ONE, vol. 9, no. 2, e88969
    Contributions to Journals: Articles

  • Homocysteine, antioxidant micronutrients and late onset dementia

    Whalley, L. J., Duthie, S. J., Collins, A. R., Starr, J. M., Deary, I. J., Lemmon, H., Duthie, A. C., Murray, A. D., Staff, R. T.
    European Journal of Nutrition, vol. 53, no. 1, pp. 277-285
    Contributions to Journals: Articles

  • Depressive symptoms in late life and cerebrovascular disease: the importance of intelligence and lesion location

    Murray, A. D., Staff, R. T., McNeil, C. J., Salarirad, S., Phillips, L. H., Starr, J., Deary, I. J., Whalley, L. J.
    Depression and Anxiety, vol. 30, no. 1, pp. 77-84
    Contributions to Journals: Articles

  • Genetic and environmental factors in late onset dementia: possible role for early parental death

    Whalley, L. J., Staff, R. T., Murray, A. D., Deary, I. J., Starr, J. M.
    International Journal of Geriatric Psychiatry, vol. 28, no. 1, pp. 75-81
    Contributions to Journals: Articles

  • Brain structural complexity and life course cognitive change

    Mustafa, N., Ahearn, T. S., Waiter, G. D., Murray, A. D., Whalley, L. J., Staff, R. T.
    Neuroimage, vol. 61, no. 3, pp. 694-701
    Contributions to Journals: Articles

  • Do brain image databanks support understanding of normal ageing brain structure?: A systematic review

    Dickie, D. A., Job, D. E., Poole, I., Ahearn, T. S., Staff, R. T., Murray, A. D., Wardlaw, J. M.
    European Radiology, vol. 22, no. 7, pp. 1385-1394
    Contributions to Journals: Articles
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