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Professor Marion Campbell

Professor Marion Campbell
Professor Marion Campbell
Professor Marion Campbell

BSc (Hons), MSc, PhD, CStat, FSS, FFPH, FSCT, FRSE, FMedSci

Chair in HSRU

About
Email Address
m.k.campbell@abdn.ac.uk
Telephone Number
+44 (0)1224 273161
Office Address
Aberdeen Centre for Evaluation, Health Sciences Building
Foresterhill Campus
Foresterhill
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition
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Biography

Professor Marion Campbell is Professor of Health Services Research at the University of Aberdeen. She is also Director of the Royal College of Surgeons (RCSEngland) Aberdeen Surgical Trials Centre. Marion is a medical statistician by training, a clinical trialist and methodologist. Her main research interests are in the design, conduct and analysis of clinical trials of complex interventions and of surgical, device and critical care trials. She has published widely on clinical trials methodology including on cluster randomised trials, design of trials of surgical interventions, pragmatic trials and trials reporting. She has served on many national and international funding agencies and committees and is an elected Fellow of the Academy of Medical Sciences, the Royal Society of Edinburgh, the Faculty of Public Health, and the International Society for Clinical Trials and is a previous NIHR senior investigator.

Previously Marion was Vice-Principal (Research) for the University of Aberdeen. In this role, she had primary responsibility for promoting the University's research ambitions, ensuring effective delivery of the University's strategic objectives for research. and for enabling a research context for academic colleagues to deliver world-leading, impactful research.  She also led on the establishment of interdisciplinary research across the institution.  Prior to this, Marion was Dean of Research for Life Sciences and Medicine following ten years as Director of the Scottish Government core-funded Health Services Research Unit.

Marion graduated with an honours degree in Statistics from the University of Aberdeen and subsequently gained an MSc in Statistics and PhD in Public Health.  Following early career appointments within the National Health Service in the fields of Operational Research and Statistics of Medical Audit, she joined the University of Aberdeen in 1993.  

 

External Memberships

Chair. NIHR/MRC Better Methods Better Research Panel

Member, MRC Training and Careers Strategy Board

Member of REF2021 UoA2 sub-panel

Research

Research Overview

Marion’s main research interests are in the design, conduct and analysis of clinical trials especially complex trial design and the design and conduct of surgical and device trials.  She has also published widely on clinical trials methodology including on cluster randomised trials, design of trials of non-pharmacological interventions, pragmatic trials and trials reporting. 

Some examples of current and recent research include:

REINFORCE: The NIHR-funded REINFORCE study aims to evaluation the introduction and scale up of robot-assisted surgery across the NHS.  Further information is available at: https://www.abdn.ac.uk/hsru/what-we-do/research/projects/reinforce-291

UK-REBOA: The NIHR-funded UK-REBOA trial aims to establish the clinical and cost-effectiveness of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), in addition to standard major trauma centre treatment, for the treatment of patients with life-threatening torso haemorrhage.  The trial results have been published in JAMA  (https://jamanetwork.com/journals/jama/fullarticle/2810757) and found that REBOA did not reduce and may increase mortality.  

TOPKAT: The NIHR-funded TOPKAT trial is investigating the clinical and cost effectiveness of partial (PKR) vs total (THR) knee replacements.  The trial recruited 528 patients from across the UK.  Five year results have been published in the Lancet (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31281-4/fulltext) and showed that PKR has similar, if not a slightly better clinical outcome than TKR. More importantly, the economic benefit of using PKR is substantial.  Patients are now being followed up to 10 years.

CLASS: The NIHR-funded CLASS trial is assessing the clinical and cost-effectiveness of three treatment modalities for the treatment of varicose veins: a) foam; b) EVLA with subsequent foam to varicosities when required; and c) surgery.  A total of 798 adult patients were recruited into the trial and randomised to one of the treatment options.  Early results (http://www.nejm.org/doi/full/10.1056/NEJMoa1400781) and five year follow-up results (https://www.nejm.org/doi/full/10.1056/NEJMoa1805186 were published in the New England Journal of Medicine.

KAT: The NIHR-funded KAT trial, explores different knee replacement surgery options (the effects of patellar resurfacing, mobile bearings and metal backing were investigated). A total of 116 surgeons in 34 UK centres participated and 2352 participants were randomised.  Ten year outcomes were previously published (https://www.journalslibrary.nihr.ac.uk/hta/hta18190/#/abstract); long term follow up to 20 years is underway.

Research Areas

Applied Health Sciences

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Research Specialisms

  • Healthcare Science
  • Medical Statistics

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Publications

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  • A pragmatic randomised, controlled trial of intensive care follow up programmes in improving longer-term outcomes from critical illness: the PRACTICAL study

    Cuthbertson, B., Rattray, J., Johnston, M., Wildsmith, J. A., Wilson, E., Hernandez, R., Ramsay, C., Hull, A. M., Norrie, J., Campbell, M., PRaCTICaL Study Group
    BMC Health Services Research, vol. 7, 116
    Contributions to Journals: Articles

  • Defining and investigating occupational asthma: a consensus approach

    Francis, C., Prys-Picard, C. O., Fishwick, D., Stenton, C., Burge, P. S., Bradshaw, L. M., Ayres, J. G., Campbell, M., Niven, R. M.
    Occupational and Environmental Medicine, vol. 64, no. 6, pp. 361-365
    Contributions to Journals: Articles

  • Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: A randomised controlled trial

    McNeill, G., Avenell, A., Campbell, M. K., Cook, J. A., Hannaford, P. C., Kilonzo, M. M., Milne, A. C., Ramsay, C. R., Seymour, D. G., Stephen, A. I., Vale, L. D.
    Nutrition Journal, vol. 6, 10
    Contributions to Journals: Articles

  • The Trial Protocol Tool: the PRACTIHC software tool that supported the writing of protocols for pragmatic randomized controlled trials

    Treweek, S. P., McCormack, K., Abalos, E., Campbell, M. K., Ramsay, C. R., Zwarenstein, M., PRACTIHC Collaboration
    Journal of Clinical Epidemiology, vol. 59, no. 11, pp. 1127-1133
    Contributions to Journals: Articles

  • Genetic nurse counsellors can be an acceptable and cost-effective alternative to clinical geneticists for breast cancer risk genetic counselling: Evidence from two parallel randomised controlled equivalence trials

    Torrance, N., Mollison, J. A., Wordsworth, S., Gray, J., Miedzybrodzka, Z. H., Haites, N. E., Grant, A., Campbell, M. K., Watson, M., Clarke, A., Wilson, B.
    British Journal of Cancer, vol. 95, pp. 435-444
    Contributions to Journals: Articles

  • Protocol for stage 1 of the GaP study (Genetic testing acceptability for Paget's disease of bone): an interview study about genetic testing and preventive treatment: would relatives of people with Paget's disease want testing and treatment if they were available?

    Langston, A. L., Johnston, M., Robertson, C., Campbell, M. K., Entwistle, V. A., Marteau, T. M., McCallum, M., Ralston, S. H.
    BMC Health Services Research, vol. 6, no. 71, 71
    Contributions to Journals: Articles

  • What influences recruitment to randomised controlled trials?: A review of trials funded by two UK funding agencies

    McDonald, A. M., Knight, R. C., Campbell, M. K., Entwistle, V. A., Grant, A. M., Cook, J. A., Elbourne, D. R., Francis, D., Garcia, J., Roberts, I., Snowdon, C.
    Trials, vol. 7, pp. 9
    Contributions to Journals: Articles

  • A comparison of imputation methods for trial data collected by reminder. 2006 International Society for Quality of Life reserach meeting abstracts

    Fielding, S., Fayers, P., Ramsay, C. R., Campbell, M. K.
    Quality of Life Research
    Contributions to Journals: Articles

  • Cluster randomized trial of a multifaceted primary care decision-support intervention for inherited breast cancer risk

    Wilson, B., Torrance, N., Mollison, J. A., Watson, M., Douglas, A., Miedzybrodzka, Z. H., Gordon, R., Wordsworth, S., Campbell, M. K., Haites, N. E., Grant, A. M.
    Family Practice, vol. 23, no. 5, pp. 537-44
    Contributions to Journals: Articles

  • Financial considerations in the conduct of multi-centre randomised controlled trials: evidence from a qualitative study

    Snowdon, C., Elbourne, D. R., Garcia, J., Campbell, M. K., Entwistle, V. A., Francis, D., Grant, A. M., Knight, R. C., McDonald, A. M., Roberts, I.
    Trials, vol. 7, no. 34
    Contributions to Journals: Articles

  • Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial

    Avenell, A., Campbell, M. K., Cook, J. A., Hannaford, P. C., Kilonzo, M. M., McNeill, G., Milne, A. C., Ramsay, C. R., Seymour, D. G., Stephen, A. I., Vale, L. D., Writing Group on the MAVIS trial
    British Medical Journal, vol. 331, no. 7512, pp. 324-329
    Contributions to Journals: Articles

  • Frequency of administration of recombinant human erythropoietin for anaemia of end-stage renal disease in dialysis patients (Review)

    Cody, J. D., Daly, C., Campbell, M. K., Donaldson, C., Khan, I., Wallace, S. A., Vale, L., Macleod, A. M.
    Cochrane Database of Systematic Reviews, no. 3, CD003895
    Contributions to Journals: Articles

  • Recombinant human erythropoietin for chronic renal failure anaemia in pre-dialysis patients

    Cody, J. D., Daly, C., Campbell, M. K., Khan, I., Rabindranath, K. S., Vale, L., Wallace, S. A., MacLeod, A. M., Grant, A. M., Pennington, S., Nistor, I., Bolignano, D., Webster, A. C.
    Cochrane Database of Systematic Reviews, no. 3, CD003266
    Contributions to Journals: Literature Reviews

  • A centralised public information resource for randomised trials: a scoping study to explore desirability and feasibility

    Langston, A. L., Campbell, M. K., Entwistle, V. A., Skea, Z.
    BMC Health Services Research, vol. 5, 39
    Contributions to Journals: Articles

  • Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial

    Grant, A. M., Anderson, F. H., Avenell, A., Campbell, M. K., Cooper, C., Donaldson, C., Francis, R., Gillespie, W. J., Robinson, C. M., Torgerson, D. J., Wallace, W. A., RECORD Trial Group
    The Lancet, vol. 365, no. 9471, pp. 1621-1628
    Contributions to Journals: Articles

  • Determinants of the intracluster correlation coefficient in cluster randomized trials: the case of implementation research

    Campbell, M. K., Fayers, P., Grimshaw, J. M.
    Clinical Trials, vol. 2, no. 2, pp. 99-107
    Contributions to Journals: Articles

  • Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women

    MacDonald, H. M., New, S. A., Fraser, W. D., Campbell, M. K., Reid, D. M.
    The American Journal of Clinical Nutrition, vol. 81, no. 4, pp. 922-933
    Contributions to Journals: Articles

  • Issues in data monitoring and interim analysis of trials

    Grant, A. M., Altman, D. G., Babiker, A., Campbell, M. K., Clemens, F., Darbyshire, J., Elbourne, D. R., Mcleer, S. K., Parmar, M., Pocock, S., Spiegelhalter, D., Sydes, M., Walker, A. E., Wallace, S. A.
    Health Technology Assessment, vol. 9, no. 7, pp. 1-238
    Contributions to Journals: Articles

  • An integrated approach to consumer representation and involvement in a multicentre randomised controlled trial

    Langston, A. L., McCallum, M., Campbell, M. K., Robertson, C., Ralston, S.
    Clinical Trials, vol. 2, no. 1, pp. 1-8
    Contributions to Journals: Articles

  • An integrated approach to consumer representation and involvement in a multicentre randomized controlled trial

    Langston, A. L., McCallum, M., Campbell, M. K., Robertson, C., Ralston, S. H.
    Clinical Trials, vol. 2, pp. 80-87
    Contributions to Journals: Articles

  • An investigation into People's perceptions of 'Quality of Life' when completing health-related quality of life questionnaires

    Robertson, C., Langston, A. L., McColl, E., Fayers, P., Campbell, M. K.
    1 page.
    Other Contributions: Other Contributions

  • A proposed charter for clinical trial data monitoring committees: helping them to do their job well.

    Campbell, M. K., Grant, A. M., McCann, S. K., Walker, A. E., Wallace, S. A., The DAMOCLES Study Group
    The Lancet, vol. 365, no. 9460, pp. 711-722
    Contributions to Journals: Articles

  • Cluster randomised trials of professional and organisational behaviour change interventions in health care settings.

    Eccles, M., Campbell, M. K., Elbourne, D.
    Annals of the American Academy of Political and Social Science, vol. 599, pp. 71-93
    Contributions to Journals: Articles

  • Data monitoring in randomised controlled trials: surveys of recent practice and policies

    Clemens, F., Elbourne, D., Darbyshire, J., Pocock, S., Grant, A. M., Campbell, M. K., McCann, S. K., Walker, A. E., Wallace, S. A., DAMOCLES Group
    Clinical Trials, vol. 2, pp. 22-33
    Contributions to Journals: Articles

  • Experimental evaluations of change and improvements strategies

    Eccles, M., Campbell, M. K., Ramsay, C. R.
    Improving patient care: the implementation of change in clinical practice., pp. 235-247, 12 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Improving the referral process for familial breast cancer genetic counselling: findings of three randomised controlled trials of two interventions - Introduction

    Wilson, B. J., Torrance, N., Mollison, J., Wordsworth, S., Gray, J. R., Haites, N. E., Grant, A., Campbell, M. K., Miedyzbrodzka, Z., Clarke, A., Watson, M. S.
    Health Technology Assessment, vol. 9, pp. 1
    Contributions to Journals: Literature Reviews

  • The CONSORT statement for cluster randomised trials

    Campbell, M. K., Elbourne, D. R., Altman, D. G.
    Medicina ClĂ­nica, vol. 125, no. Suppl. 1, pp. 28-31
    Contributions to Journals: Articles

  • Low Back Pain: Influence of Early MR Imaging or CT on Treatment and Outcome—Multicenter Randomized Trial

    Gilbert, F., Gillan, M., Grant, A., Vale, L., Campbell, M., Scott, N., Knight, D., Wardlaw, D.
    Radiology, vol. 231, no. 2, pp. 343-351
    Contributions to Journals: Articles

  • Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement

    Avenell, A., Broom, J., Brown, T. J., Poobalan, A. S., Aucott, L. S., Stearns, S. C., Smith, W. C. S., Jung, R. T., Campbell, M. K., Grant, A. M.
    Health Technology Assessment, vol. 8, no. 21, pp. 1-182
    Contributions to Journals: Articles

  • Intracluster correlation coefficients in cluster randomized trials: empirical insights into how should they be reported

    Campbell, M. K., Grimshaw, J. M., Elbourne, D. R.
    BMC Medical Research Methodology, vol. 4, 9
    Contributions to Journals: Articles

  • Cervical screening in women over the age of fifty: results of a population based multicentre study

    Flannelly, G., Monaghan, J., Cruickshank, M., Duncan, I., Johnston, J., Jordan, J., Campbell, M. K., Patnick, J.
    British Journal of Obstetrics and Gynaecology, vol. 111, no. 4, pp. 362-368
    Contributions to Journals: Articles

  • Lower estimates of net endogenous noncarbonic acid production are positively associated with indexes of bone health in premenopausal and perimenopausal women

    New, S. A., MacDonald, H. M., Campbell, M. K., Martin, J., Garton, M. J., Robins, S. P., Reid, D. M.
    The American Journal of Clinical Nutrition, vol. 79, no. 1, pp. 131-138
    Contributions to Journals: Articles

  • Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids

    MacDonald, H. M., New, S. A., Golden, M. H. N., Campbell, M. K., Reid, D. M.
    The American Journal of Clinical Nutrition, vol. 79, no. 1, pp. 155-165
    Contributions to Journals: Articles

  • Aminobisphosphonate versus other active treatment for Paget's disease of the bone in adults

    Langston, A. L., Campbell, M. K., Ralston, S., Robertson, C.
    Other Contributions: Other Contributions

  • CONSORT statement: extension to cluster randomised trials

    Campbell, M. K., Elbourne, D. R., Altman, D. G., CONSORT Group
    British Medical Journal, vol. 328, no. 7441, pp. 702-708
    Contributions to Journals: Articles

  • Continuous ambulatory peritoneal dialysis (CAPD) versus hospital or home haemodialysis for end-stage renal disease in adults

    Vale, L., Cody, J., Wallace, S., Daly, C., Campbell, M., Grant, A., Khan, I., Donaldson, C., Macleod, A.
    Cochrane Database of Systematic Reviews, no. 4, pp. CD003963
    Contributions to Journals: Articles

  • Delivering clinical trial supplies by post to elderly trial participants: a feasibility study

    McDonald, A. M., Campbell, M. K., Ross, S.
    Applied Clinical Trials, no. Feb, pp. 58-59
    Contributions to Journals: Articles

  • Does early magnetic resonance imaging influence management or improve outcome in patients referred to secondary care with low back pain? A pragmatic randomised controlled trial

    Gilbert, F. J., Grant, A. M., Gillan, M. G. C., Vale, L., Scott, N. W., Campbell, M. K., Wardlaw, D., Knight, D., McIntosh, E., Porter, R. W.
    Health Technology Assessment, vol. 8, pp. 1
    Contributions to Journals: Literature Reviews

  • Influence of weight and weight change on bone loss in perimenopausal and early postmenopausal Scottish women

    MacDonald, H. M., New, S. A., Campbell, M. K., Reid, D. M.
    Osteoporosis International, vol. 16, no. 2, pp. 163-171
    Contributions to Journals: Articles

  • Quality of life data: What to do when it is missing?

    Fielding, S., Fayers, P., McDonald, A. M., McPherson, G. C., Campbell, M. K.
    Quality of Life Research, vol. 13, no. 9, pp. 1520-1520
    Contributions to Journals: Articles

  • Recruitment to multicentre trials

    Gates, S., Brocklehurst, P., Campbell, M. K., Elbourne, D.
    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 111, no. 1, pp. 3-5
    Contributions to Journals: Articles

  • Reported use of data monitoring committees in the main published reports of randomized controlled trials: a cross-sectional study

    Sydes, M., Spiegelhalter, D., Altman, D., Babiker, A., Parmar, M., Grant, A. M., Campbell, M. K., McCann, S. K., Walker, A. E., Wallace, S. A.
    Clinical Trials, vol. 1, no. 1, pp. 48-59
    Contributions to Journals: Articles

  • Sample size calculator for cluster randomized trials

    Campbell, M. K., Thomson, S., Ramsay, C. R., MacLennan, G. S.
    Computers in Biology and Medicine, vol. 34, no. 2, pp. 113-125
    Contributions to Journals: Articles

  • Small group processes relevant to data monitoring committees in controlled clinical trials: an overview of reviews

    Walker, A. E., McCann, S. K., Campbell, M. K., Grant, A. M., Wallace, S. A.
    Clinical Trials, vol. 1, no. 3, pp. 282-296
    Contributions to Journals: Articles

  • Systematic qualitative review of the literature on data monitoring committees for randomized controlled trials

    Sydes, M., Spiegelhalter, D., Altman, D., Babiker, A., Parmar, M., Grant, A. M., Campbell, M. K., McCann, S. K., Walker, A. E., Wallace, S. A.
    Clinical Trials, vol. 1, no. 1, pp. 60-79
    Contributions to Journals: Articles

  • The effects of an open design on trial participant recruitment, compliance and retention - a randomised controlled trial comparison with a blinded, placebo-controlled design

    Avenell, A., Grant, A. M., McGee, M., McPherson, G. C., Campbell, M. K., McGee, M.
    Clinical Trials, vol. 1, no. 6, pp. 490-498
    Contributions to Journals: Articles

  • What are the long-term benefits of weight reducing diets in adults? A systematic review of randomized controlled trials

    Avenell, A., Brown, T. J., McGee, M., Campbell, M. K., Grant, A. M., Jung, R. T., Smith, W. C. S., Broom, J.
    Journal of Human Nutrition and Dietetics, vol. 17, no. 4, pp. 317-335
    Contributions to Journals: Articles

  • What interventions should we add to weight reducing diets in adults with obesity? A systematic review of randomized controlled trials of adding drug therapy, exercise, behaviour therapy or combinations of these interventions

    Avenell, A., Brown, T. J., McGee, M., Campbell, M. K., Grant, A. M., Jung, R. T., Smith, W. C. S., Broom, J.
    Journal of Human Nutrition and Dietetics, vol. 17, no. 4, pp. 293-316
    Contributions to Journals: Articles

  • Determinants of the intracluster correlation coefficient in cluster randomised trials

    Campbell, M. K., Grimshaw, J. M., Fayers, P.
    Controlled Clinical Trials, vol. 24, no. 3, Suppl.1, pp. 174S-174S
    Contributions to Journals: Articles

  • Continuous ambulatory peritoneal dialysis (CAPD) versus hospital or home haemodialysis for end-stage renal disease in adults

    Vale, L., Cody, D. J., Wallace, S., Daly, C. L., Campbell, M. K., Grant, A. M., Khan, I., Donaldson, C., MacLeod, A.
    Cochrane Database of Systematic Reviews, no. 1, CD003963
    Contributions to Journals: Articles
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