Professor Martin Collinson
BA Natural Sciences (Cantab. 1991), MA (Cantab. 1994), PhD (Edinburgh 1996)
J. Martin Collinson
Graduated in Natural Sciences (Genetics) from Fitzwilliam College, University of Cambridge, in 1991. Obtained a PhD at the University of Edinburgh, working in the MRC Human Genetics Unit studying the roles of homeobox gene family members (Msx genes) in vertebrate embryological development.
Postdoctoral positions at the University of Edinburgh 1996-2002, studying the roles of cell adhesion molecules (Neurofascin) and transcription factors (Pax6) in vertebrate development and disease.
Appointed Lecturer at Aberdeen University, 2002.
Senior Lecturer from October 2005. Reader 2008. Personal Chair 2012
Vice-chair of the Editorial Board of the journal British Birds.
Former Chair of the British Ornithologists’ Union Records Committee
FOR BIRD/DNA enquiries, contact firstname.lastname@example.org
MEMBERSHIP OF PROFESSIONAL ORGANISATIONS
British Society for Developmental Biology
Former Chair of the BOU records Committee and Convenor of the Taxonomic Committee
EDITORIAL BOARD MEMBERSHIP
Ibis 2009 - present
The major foci of work in the lab are:
THE GENETIC BASIS OF HUMAN BIRTH ABNORMALITIES AND DEGENERATIVE DISEASE
STEM CELL BIOLOGY IN HUMAN DEVELOPMENT AND DISEASE
We study the genetic basis of normal embryonic development (mostly eyes and limbs) and the processes that can go wrong in humans. We also study stem cell activity in adults, focusing on degenerative disease and fertility problems.
1) The development and evolution of eyes. There are several projects on the go.
a) The roles of a transcription factor, Pax6, in eye development and disease . We examine how mutations in Pax6 change the cell surface properties of mutant cells, and how this may impact on the eye.
Patients with mutations in the PAX6 gene develop multiple eye abnormalities, including any or all of: aniridia (absence of iris), corneal opacity (aniridia-related keratopathy), cataract (lens clouding), glaucoma and long-term retinal degeneration. We are interested in developing new therapeutic strategies
Figure 1: The eye of a PAX6+/- aniridic patient (photograph kindly provided by Dr K, Ramaesh, University of Edinburgh). Note the corneal opacity associated with vascularisation.
b) The development of eyes in true moles (Talpa). Moles live most of their lives underground and over evolutionary time we expect their eyes to degenerate. We study the Iberian Mole Talpa occidentalis, in which the eyes are permanently closed, and determine how the genetic pathways that underlie eye development are breaking down in this species.
Figure 2: An adult Iberian Mole
2) The genetic control of axon guidance and epithelial cell migration. What pushes a cell or a growth cone from point A to point B? We examine the relative contribution of chemical and contact mediated guidance cues in vivo.
Figure 3. Swirling patterns of cell migration in the corneal epithelium, visualised in eyes that are mosaic for LacZ expression.
3) The genetics and etiology of Congenital Talipes Equinovarus (clubfoot)
We study the genetic and environmental factors that underlie clubfoot - an extremely common birth abnormality (1 in 500 babies) for which virtually nothing is clear about the causes.
Figure 4. Human bilateral clubfoot.
28th August 2011 - Interview with the Naked Scientists about the clubfoot project - see
POTENTIAL PHD STUDENT?
We are looking for motivated, funded PhD students for studies in any of the above fields, e.g.
1) Genetics and molecular biology of motor neurone development and disease
2) Eye Evolution
3) Control of cell migration and wound healing
4) Genetics of human disease
5) Adult Stem Cells
Biological and Environmental Sciences
Funding and Grants
MRC Principal Applicant. The genetic basis of clubfoot. £515,000 from October 2008
BBSRC Principal Applicant – coholders Dr Ann Rajnicek (Univ of Aberdeen), Prof Min Zhao (UC Irvine), Prof Colin McCaig (Univ of Aberdeen) The genetic control of epithelial cell migration and wound healing physiology £643,000 from February 2007
WELLCOME TRUST Corneal dysgenesis in the Pax6-mutant mouse – shoddy workmanship or sabotage? £245,000 from 1/9/04.
Dr James Alexander Mearns Trust Molecular basis of gene dosage effects of Pax6 mutants £51,660 from 01/10/07.
NHS GRAMPIAN ENDOWMENT FUND Vascularisation of the cornea £2688 from 01/04/07
NEWLIFE (Birth Defects Foundation) Aetiology and therapy of congenital corneal opacity £80,000 from July 2005
TEACHING - BSc Programmes in Biomedical Sciences, Genetics, Human Embryology and Developmental Biology.
Human Embryology and Developmental Biology Degrees at the University of Aberdeen
The degrees are suitable for students wanting to learn about embryology, stem cells, bioengineering, reproductive biology, wound healing, evolution and cancer. Graduates can move on to jobs in academic and commercial jobs in embryology, clinical genetics, molecular biology and many biomedical fields.
'T-Club' - the Developmental Biology newsletter for University of Aberdeen.TClubDec12.pdf
Are you thinking about a degree in Developmental biology? Have a look at this.
Page 1 of 2 Results 1 to 50 of 92
Pathophysiology of aniridia-associated keratopathy: developmental aspects and unanswered questionsThe Ocular Surface, vol. 22, pp. 245-266Contributions to Journals: Articles
Systematic placement of the bee hummingbird (mellisuga helenae) (aves: Trochilidae) and potential consequences for nomenclature of the mellisuginiOrnitologia Neotropical, vol. 32, no. 1, pp. 45-50Contributions to Journals: Articles
Morphological and genetic analyses reveal the first Mediterranean occurrence of American Herring Gull Larus smithsonianusRevista catalana d'ornitologia = Catalan journal of ornithology, vol. 37, pp. 1-9Contributions to Journals: Articles
Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMAAnnals of Clinical and Translational Neurology, vol. 7, no. 9, pp. 1580-1593Contributions to Journals: Articles
Taxonomic status of the extinct Canary Islands Oystercatcher Haematopus meadewaldoiIbis, vol. 162, no. 3, pp. 1068-1074Contributions to Journals: Articles
Phylogeny of the Eurasian Wren Nannus troglodytes (Aves: Passeriformes: Troglodytidae) reveals deep and complex diversification patterns of Ibero-Maghrebian and Cyrenaican populationsPloS ONE, vol. 15, no. 3, e0230151Contributions to Journals: Articles
Dense active matter model of motion patterns in confluent cell monolayersNature Communications, vol. 11, 1405Contributions to Journals: Articles
Geographic patterns of mtDNA and Z-linked sequence variation in the Common Chiffchaff and the ‘chiffchaff complex’PloS ONE, vol. 14, no. 1, e0210268Contributions to Journals: Articles
The core Planar Cell Polarity gene, Vangl2, maintains apical-basal organisation of the corneal epitheliumJournal of Anatomy, vol. 234, no. 1, pp. 106-119Contributions to Journals: Articles
Limbal epithelial stem cell activity and corneal epithelial cell cycle parameters in adult and aging miceStem Cell Research, vol. 33, pp. 185-198Contributions to Journals: Articles
Lens-regulated retinoic acid signalling controls expansion of the developing eyeDevelopment, vol. 145, no. 19, dev167171Contributions to Journals: Articles
A conditional Pax6 depletion study with no morphological effect on the adult mouse corneal epitheliumBMC Research Notes, vol. 11, 705Contributions to Journals: Articles
Computer simulation of neutral drift among limbal epithelial stem cells of mosaic miceStem Cell Research, vol. 30, pp. 1-11Contributions to Journals: Articles
Endogenous bioelectric currents promote differentiation of the mammalian lensJournal of Cellular Physiology, vol. 233, no. 3, pp. 2202-2212Contributions to Journals: Articles
The developmental and genetic basis of ‘clubfoot’ in the peroneal muscular atrophy mutant mouseDevelopment, vol. 145, no. 3, dev160093Contributions to Journals: Articles
Taxonomic status of the Liberian Greenbul Phyllastrephus leucolepis and the conservation importance of the Cavalla Forest, LiberiaJournal of Ornithology, vol. 159, no. 1, pp. 19-27Contributions to Journals: Articles
When morphology is not reflected by molecular phylogeny: the case of three ‘orange-billed terns’ Thalasseus maximus, T. bergii and T. bengalensis (Charadriiformes: Laridae).Biological Journal of the Linnean Society, vol. 121, no. 2, pp. 439-445Contributions to Journals: Articles
Multi-locus barcoding confirms the occurrence of Elegant Tern in Western EuropeJournal of Ornithology, vol. 158, no. 2, pp. 351–361Contributions to Journals: Articles
Requirement of Pax6 for the integration of guidance cues in cell migrationRoyal Society Open Science, vol. 4, 170625Contributions to Journals: Articles
The taxonomic position and breeding range of Golden Nightjar Caprimulgus eximius (Caprimulgidae)Ostrich: Journal of African Ornithology, vol. 88, no. 3, pp. 281-286Contributions to Journals: Articles
The core planar cell polarity gene, Vangl2, directs adult corneal epithelial cell alignment and migrationRoyal Society Open Science, vol. 3, no. 10, 160658Contributions to Journals: Articles
Unusual DNA of a Western Bonelli's warbler trapped on ShetlandBritish Birds, vol. 109, no. 10, pp. 637-638Contributions to Journals: Comments and Debates
Contact-mediated control of radial migration of corneal epithelial cellsMolecular vision, vol. 22, pp. 990-1004Contributions to Journals: Articles
Taxonomic recommendations for Western Palearctic birds: 11th reportIbis, vol. 158, no. 1, pp. 206-212Contributions to Journals: Articles
Lineage tracing in the adult mouse corneal epithelium supports the limbal epithelial stem cell hypothesis with intermittent periods of stem cell quiescenceStem Cell Research, vol. 15, no. 3, pp. 665-677Contributions to Journals: Articles
'Stejneger's Stonechat' in Dorset: New to BritainBritish Birds, vol. 108, no. 7, pp. 423-427Contributions to Journals: Review articles
'Eastern Grasshopper Warbler' on Fair Isle: New to BritainBritish Birds, vol. 108, no. 4, pp. 231-235Contributions to Journals: Articles
Första genetiskt bekräftade östlig rödstrupig sångare Sylvia cantillans i SverigeOrnis Svecica, vol. 25, no. 1-2, pp. 40-44Contributions to Journals: Articles
Water pipits: Three species rather than one?British Birds, vol. 108, no. 1, pp. 42-48Contributions to Journals: Articles
Taxonomic recommendations for Western Palaearctic birds: 10th reportIbis, vol. 157, no. 1, pp. 193-200Contributions to Journals: Articles
Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxPSitesPloS ONE, vol. 9, no. 10, pp. 1-19Contributions to Journals: Articles
The Expression and Roles of Nde1 and Ndel1 in the Adult Mammalian Central Nervous SystemNeuroscience, vol. 271, pp. 119-136Contributions to Journals: Articles
A genetic screen of the island races of Wren Troglodytes troglodytes in the North-east AtlanticBird Study, vol. 61, no. 2, pp. 135-142Contributions to Journals: Articles
Taxonomic recommendations for Western Palearctic birds: Ninth reportIbis, vol. 155, no. 4, pp. 898-907Contributions to Journals: Articles
CSI: Birding … barcoding the past, present and futureThe ConversationContributions to Specialist Publications: Articles
Genetic analysis of migrant Siberian Chiffchaffs in Britain and IrelandBritish Birds, vol. 106, no. 2, pp. 109-113Contributions to Journals: Articles
3D MRI analysis of the lower legs of treated idiopathic congenital talipes equinovarus (clubfoot)PloS ONE, vol. 8, no. 1, e54100Contributions to Journals: Articles
British records of 'Eastern Yellow Wagtail'British Birds, vol. 106, no. 1, pp. 36-41Contributions to Journals: Articles
Stem cells and corneal epithelial maintenance: Insights from the mouse and other animal modelsMouse Development, pp. 357-394, 38 pagesChapters in Books, Reports and Conference Proceedings: Chapters
Taxonomic recommendations for British birds: Eighth reportIbis, vol. 154, no. 4, pp. 874-883Contributions to Journals: Articles
What the eye doesn't see: The prevalence of fraud in ornithologyBritish Birds, vol. 105, no. 5, pp. 236-257Contributions to Journals: Review articles
Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epitheliumMolecular vision, vol. 18, pp. 139-150Contributions to Journals: Articles
Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasisPloS ONE, vol. 6, no. 12, e28895Contributions to Journals: Articles
Taxonomic recommendations for British birds: Seventh reportIbis, vol. 153, no. 4, pp. 883-892Contributions to Journals: Articles
The role of electrical signals in murine corneal wound re-epithelializationJournal of Cellular Physiology, vol. 226, no. 6, pp. 1544-1553Contributions to Journals: Articles
Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesisGene Expression Patterns, vol. 11, no. 3-4, pp. 221-232Contributions to Journals: Articles
A time-lapse and quantitative modelling analysis of neural stem cell motion in the absence of directional cues and in electric fieldsJournal of neuroscience research, vol. 88, no. 15, pp. 3267-3274Contributions to Journals: Articles
Development of the cornea of true moles (Talpidae): Morphogenesis and expression of PAX6 and cytokeratinsJournal of Anatomy, vol. 217, no. 5, pp. 488-500Contributions to Journals: Articles
Retinal development and function in a 'blind' moleProceedings of the Royal Society of London. B, Biological Sciences, vol. 277, no. 1687, pp. 1513-1522Contributions to Journals: Articles
Cytoskeletal and cell adhesion defects in wounded and Pax6+/- corneal epitheliaInvestigative Ophthalmology & Visual Science, vol. 51, no. 3, pp. 1415-1423Contributions to Journals: Articles