Dr James Ross
PhD, CPhys, MInstP, MIPEM
Biomedical Physics Building
School of Medicine, Medical Sciences & Nutrition
University of Aberdeen
Dr Ross graduated from the University of St Andrews in 2009 with an MPhys(Hons) in Theoretical Physics. He then completed an MSc in Medical Physics at Aberdeen University in 2011 before completing a PhD in Medical Physics under the supervision of Professor David Lurie.
He joined Prof Lurie's team as a Research Assistant in 2015 on the EPSRC funded "Zero-Field MRI" project. He was appointed Research Fellow in 2016 on the EU Horizon-2020 funded "IDentIFY" project where he worked on developing Fast Field-Cycling MRI (FFC-MRI) techniques for biomedical and clinical applications.
He was appointed Lecturer in 2020 and joined the team of Professor Dana Dawson where he is currently leading the development of 31P magnetic resonance spectroscopy techniques for non-invasively probing cardiac energetics at 3T while continuing to work on new applications for FFC-MRI in heart, brain and breast imaging.
- MPhys Theoretical Physics2009 - University of St Andrews
- MSc Medical Physics2011 - University of Aberdeen
- PhD Medical Physics2016 - University of Aberdeen
My research is focused on a novel form of MRI, known as Fast Field-Cycling MRI (FFC-MRI) currently being developed at the University of Aberdeen. Unlike in conventional MRI where the static magnetic field B0 is held constant, in FFC-MRI the field is deliberately varied during the imaging sequence. This allows parameters such as the spin-lattice relaxation time, T1, to be studied as a function of B0. This "T1 dispersion" has demonstrated strong potential as a novel form of MRI contrast, and could find application in the diagnosis and characterisation of a wide range of pathologies.
I am interested in developing new imaging pulse sequences and reconstruction techniques for use with FFC-MRI with the aim of reducing scan time while still exploiting the unique T1 dispersion information that is accessible using FFC-MRI.
Applied Health SciencesSupervising
I am currently working on the development of phosphorus magnetic resonance spectroscopy (31P-MRS) techniques in the heart at 3T. Unlike conventional 1H techniques, 31P MRS allows the direct detection of metabolites involved in energy metabolism (for example PCr and ATP) which could make it a valuable tool in characterising conditions where there is impaired cardiac function.
Owing to the comparatively lower concentrations of phosphorus in-vivo, the lower gyromagnetic ratio and the added complications of respiratory and cardiac motion, cardiac 31P-MRS is a particuarly challenging technique which requires particular care in the choice of pulse sequence and acquisition parameters.
I reguarly take part in public engagement events aimed at explaining concepts in medical physics and electromagnetism to the wider community. Some past events include:
2019: Cell Block Science - an initiative started by St Andrews University aimed at educating inmates at prisons on ongoing research at local universities. In this event Prof David Lurie and I spent the day at HMP Grampian where we talked about the history of magnetic resonance imaging development at Aberdeen and demonstrated some of the fundamental physics that makes MRI possible.
2016, 2018, 2019: Doors Open Day is an event where usually closed buildings in Aberdeen are open to the public. This gives us an opportunity to show off what goes on in our labs at Aberdeen University. For the past few years I have given tours of the FFC-MRI labs to the public and hosted stalls in the IMS to talk about my research.
2019: I presented our work on FFC-MRI at the Scottish Parliament as part of the European Researcher's Night "Explorathon" event.
2018: I gave a public lecture on the history of MRI for MENSA Scotland.
Funding and Grants
British Heart Foundation: The Next Leap in Cardiac Magnetic Resonance Imaging: Cycling the Field; D Dawson, D Lurie, L Broche, J Ross, H Abbas: , 2020-2023, £278k
SINAPSE Innovation Partnership: Towards a Cardiac Magnetic Resonance Protocol for Fast Field-Cycling MRI; J Ross, D Dawson, D Lurie, A Mezincescu: 2020-2021, £10k
Northwood Trust PhD Scholarship: Detecting Cardiac Fibrosis using T1 rho Magnetic Resonance Imaging; J Ross, D Dawson: 2022-2026, £70k
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Joint multi-field T1 quantification for fast field-cycling MRIMagnetic Resonance in Medicine, vol. 86, no. 4, pp. 2049-2063Contributions to Journals: Articles
A New Method for Investigating Osteoarthritis using Fast Field Cycling Nuclear Magnetic ResonancePhysica Medica, vol. 88, pp. 142-147Contributions to Journals: Articles
Monitoring tissue implants by field-cycling H-1-MRI via the detection of changes in the N-14-quadrupolar-peak from imidazole moieties incorporated in a "smart" scaffold materialJournal of Materials Chemistry B, vol. 9, no. 24, pp. 4863-4872Contributions to Journals: Articles
A novel class of 1H-MRI Contrast Agents based on the relaxation enhancement induced on water protons by 14N imidazole moietiesAngewandte Chemie International Edition, vol. 60, no. 8, pp. 4208-4214Contributions to Journals: Articles
Fast field-cycling magnetic resonance detection of intracellular ultra-small iron oxide particles in vitro: Proof-of-conceptJournal of Magnetic Resonance, vol. 313, 106722Contributions to Journals: Articles
A whole-body Fast Field-Cycling scanner for clinical molecular imaging studiesScientific Reports, vol. 9, 10402Contributions to Journals: Articles
Bilateral Breast coil for Fast Field-Cycling Relaxometric MRI27th Annual Meeting, International Society for Magnetic Resonance in MedicineContributions to Conferences: Abstracts
Comparison of fast field-cycling magnetic resonance imaging methods and future perspectivesMolecular Physics, vol. 117, no. 7-8, pp. 832-848Contributions to Journals: Articles
Techniques and Applications of Field-cycling Magnetic Resonance in MedicineField-cycling NMR Relaxometry. Kimmich, R. (ed.). Royal Society of Chemistry, pp. 358-384, 27 pagesChapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)
Fast Field-Cycling MRI technology: prototype human scanner and first clinical resultsRadiological Society of North America Annual MeetingContributions to Conferences: Abstracts
A Fast Field-Cycling MRI system for clinical applications2018 ISMRM British Chapter Annual meetingContributions to Conferences: Abstracts
Simple algorithm for the correction of MRI image artefacts due to random phase fluctuationsThe ISMRM 26th Annual Meeting & Exhibition, pp. 2710Contributions to Conferences: Abstracts
Simple algorithm for the correction of MRI image artefacts due to random phase fluctuationsMagnetic Resonance Imaging, vol. 44, pp. 55-59Contributions to Journals: Articles
A Fast Field-Cycling MRI system for clinical applications34th Annual Congress of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), pp. 56Contributions to Conferences: Abstracts
Fast Field-cycling Magnetic Resonance ImagingItalian Magnetic Resonance Group XLVI National Congress, pp. 11Contributions to Conferences: Abstracts
Fast Field-cycling Magnetic Resonance ImagingEuropean Conress on Magnetic Resonance (EUROMAR 2017), pp. 378Contributions to Conferences: Abstracts
Design and commissioning of a whole-body 0.2 T fast field-cycling MRI magnet10th Conference on Fast Field-Cycling NMR Relaxometry, pp. 7Contributions to Conferences: Abstracts
Fast Field-Cycling Magnetic Resonance Imaging10th Conference on Fast Field-Cycling NMR Relaxometry, pp. 6Contributions to Conferences: Abstracts
Fast Field-cycling MRI: T1-Dispersion for Enhanced Medical DiagnosisAMPERE NMR School (2017), pp. 19Contributions to Conferences: Abstracts
A new human-scale fast Field-cycling MRI system for clinical applicationsThe ISMRM 25th Annual Meeting & Exhibition, pp. 2677Contributions to Conferences: Abstracts
A Fast Field-Cycling MRI system for clinical applicationsSINAPSE Annual Scientific Meeting 2017Contributions to Conferences: Abstracts
A new human-scale fast Field-cycling MRI system for clinical applicationsChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Progress on imaging using a 0.2 T whole-body Fast Field-Cycling system10th Conference on Fast Field-Cycling NMR RelaxometryContributions to Conferences: Abstracts
Field-Cycling Magnetic Resonance Imaging - a Curiosity or the Next Big Thing?AMPERE NMR School (2016), pp. 11Contributions to Conferences: Abstracts
Fast Field-Cycling MRI: Demonstration of New Technology for T1-Dispersion Contrast101st Scientific Assembly and Annual Meeting, Radiological Society of North America (RSNA), 2015, pp. SSJ23-02Contributions to Conferences: Abstracts
Accelerated Field-Cycling MRI using Keyhole ImagingESMRMB 2015 CongressContributions to Conferences: Abstracts
Detection of tissue remodelling by Fast Field-Cycling methodsESMRMB 2015 CongressContributions to Conferences: Abstracts
In vivo human brain imaging at 0.2 T with a whole body fast field-cycling systemESMRMB 2015 CongressContributions to Conferences: Abstracts
Molecular biomarkers in human pathologies from fast field-cycling MRIWorld Molecular Imaging Congress 2015Contributions to Conferences: Abstracts
In vivo human brain imaging at 0.2 T using a whole-body fast field-cycling MRI system9th Conference on Field-Cycling NMR Relaxometry, pp. 46Contributions to Conferences: Abstracts
Rapid Fast Field-Cycling Imaging using the Keyhole Technique9th Conference on Field-Cycling NMR Relaxometry, pp. 34Contributions to Conferences: Abstracts
Recent Progress in Fast Field-Cycling MRI9th Conference on Field-Cycling NMR Relaxometry, pp. 20Contributions to Conferences: Abstracts
Fast Field-Cycling MRI: A New Imaging ModalityAMPERE NMR School (2015), pp. 14Contributions to Conferences: Abstracts
Fast Field-Cycling NMR (FFC-NMR): A novel way to age thrombus in vivo?SINAPSE Annual Scientific Meeting 2015, pp. 34Contributions to Conferences: Abstracts
In vivo human brain imaging at 0.2 T with a whole body fast field-cycling systemSINAPSE Annual Scientific Meeting 2015Contributions to Conferences: Abstracts
Fast field-cycling magnetic resonance imaging: a new imaging modalityEuropean Congress of Radiology (2015), B-0315Contributions to Journals: Abstracts
Rapid field-cycling MRI using fast spin-echoMagnetic Resonance in Medicine, vol. 73, no. 3, pp. 1120-1124Contributions to Journals: Articles
Rapid Fast Field-Cycling MRI using Keyhole Imaging23rd Annual Meeting, International Society for Magnetic Resonance in Medicine (2015), pp. 2454Contributions to Conferences: Abstracts
Accelerated Field‐Cycling MRI using the Keyhole TechniqueAnnual Scientific Meeting of ISMRM British Chapter (2014), pp. PP1BContributions to Conferences: Abstracts
Clinical applications of Fast Field‐Cycling techniquesAnnual Scientific Meeting of ISMRM British Chapter (2014), pp. PP1AContributions to Conferences: Abstracts
Development of a voltage‐tuneable RF coil to enable double resonance experiments with Fast Field‐Cycling MRIAnnual Scientific Meeting of ISMRM British Chapter (2014), pp. P1CContributions to Conferences: Abstracts
Field-Cycling MRI: a New Imaging Modality?8th European Conference on Medical Physics (2014), pp. e8-e9Contributions to Conferences: Abstracts
A varactor-tuned RF coil for nuclear quadrupole double resonance with Fast Field-Cycling MRIAMPERE NMR School (2014), pp. P74Contributions to Conferences: Abstracts
Techniques and Bio-Medical Applications of Field-Cycling Magnetic ResonanceAMPERE NMR School (2014), pp. 21Contributions to Conferences: Abstracts
Translational studies with fast field-cycling MRIEuropean Congress of Radiology (2014), pp. 1-27Contributions to Conferences: Posters
Rapid multi-field T-1 estimation algorithm for Fast Field-Cycling MRIJournal of Magnetic Resonance, vol. 238, pp. 44-51Contributions to Journals: Articles
Analysis of musculoskeletal and breast tumours by fast field-cycling MRIESMRMB 2013 CongressContributions to Conferences: Abstracts
Techniques and Applications of Field-Cycling MRIAMPERE NMR School (2013)Contributions to Conferences: Abstracts
Field-Cycling Magnetic Resonance Imaging8th Conference on Field-Cycling NMR RelaxometryContributions to Conferences: Abstracts
Medical Applications of Fast Field Cycling MRI8th Conference on Field-Cycling NMR Relaxometry, pp. 23-23Contributions to Conferences: Abstracts