Dr Holly Spence
Research Fellow
- About
-
- Email Address
- holly.spence1@abdn.ac.uk
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Dr Spence is a research fellow who has worked extensively on the mechanistic relationship between brain iron, inflammatory processes, and cognition. Dr Spence completed her PhD at the University of Aberdeen investigating the links between brain iron, cognition and blood markers for iron and inflammation. She now works as a research fellow with a continued focus on heavy metals and lipid peroxidation in neurodegenerative diseases.
Latest Publications
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
Acta Neuropathologica, vol. 147, 50Contributions to Journals: ArticlesSOP and tick-sheet for using TDP-43 RNA aptamer (TDP-43APT) to detect pathological TDP-43 in FFPE-preserved human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica) v1
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.eq2lyjo4mlx9/v1
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides withSTMN-2cryptic splicing and precedes clinical manifestation in ALS
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2023.10.24.563701
Associations between sex, systemic iron and inflammatory status and subcortical brain iron
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2023.08.22.554249
Cognition and brain iron deposition in whole grey matter regions and hippocampal subfields
European Journal of Neuroscience, vol. 56, no. 11, pp. 6039-6054Contributions to Journals: Articles
- Publications
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Page 1 of 1 Results 1 to 6 of 6
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
Acta Neuropathologica, vol. 147, 50Contributions to Journals: ArticlesSOP and tick-sheet for using TDP-43 RNA aptamer (TDP-43APT) to detect pathological TDP-43 in FFPE-preserved human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica) v1
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.eq2lyjo4mlx9/v1
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides withSTMN-2cryptic splicing and precedes clinical manifestation in ALS
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2023.10.24.563701
Associations between sex, systemic iron and inflammatory status and subcortical brain iron
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2023.08.22.554249
Cognition and brain iron deposition in whole grey matter regions and hippocampal subfields
European Journal of Neuroscience, vol. 56, no. 11, pp. 6039-6054Contributions to Journals: ArticlesThe impact of brain iron accumulation on cognition: A systematic review
PloS ONE, vol. 15, no. 10, pp. e0240697Contributions to Journals: Articles