Dr Fiona Murray

Dr Fiona Murray
PhD Pharmacology

Senior Lecturer

I am currently accepting PhDs in Biomedical Sciences.

Overview
Dr Fiona Murray
Dr Fiona Murray

Contact Details


Biography

I moved to the University of Aberdeen from the University of California, San Diego, where I initially did my postdoctoral training with Professor Paul Insel in the Department of Pharmacology before joining the Department of Medicine as junior faculty.

The overall goal of my research is to examine the role of cyclic adenosine 3',5'-monophosphate (cAMP) signalling in disease, in particular the progression of pulmonary arterial hypertension (PAH) and B- and T-cell lymphomas, to uncover novel therapeutic targets. Model systems studied include cultured human lymphoma, pulmonary artery smooth muscle and pulmonary artery endothelial cells and models of disease. Current research focuses on the role of G protein-coupled receptors, in particular GPR75, which we believe could be a novel target and possible circulating biomarker for pulmonary arterial hypertension. In addition, we have an interest in re-purposing PDE1 inhibitors for pulmonary arterial hypertension.Current research focuses on the role of G protein-coupled receptors, in particular GPR75, which we believe could be a novel target and possible circulating biomarker for pulmonary arterial hypertension.


Qualifications

PhD, Pharmacology University of Glasgow 2003
BSc, Pharmacology University of Aberdeen 1998

Memberships and Affiliations

Internal

Active mentor in the University mentoring scheme

IMS Radiation Protection Supervisor

Athena SWAN committee member

Duly elected to serve as Senate members from the IMS

External

British Pharmacological Society Member

American Society for Pharmacology and Experimental Therapeutics Member

British Physiology Society Member

Committee member of the Scottish Cardiovascular forum

2009-2020 Editorial Board member of the British Journal of Pharmacology

2021-present Editor of Cellular Signalling 

 

 


Prizes and Awards

AHA CPCC Cournand & Comroe Young Investigator Award Finalist,

TiP’s Young Pharmacologist of the Year Finalist,

ASPET/Molecular Pharmacology Division Postdoctoral Winner,

APS respiratory section Hermann Rahn Award

Diagnosis and treatment of chronic lymphocytic leukaemia (CLL): United States Patent 7846664

G-protein coupled receptor-associated diagnosis and drug targets: United States Patent 10107816

Research

Research Areas

Please get in touch if you would like to discuss your research ideas further.

Email Me

Specialisms

  • Pharmacology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International


Research Overview

The overall goal of my research is to examine the role of cyclic adenosine 3',5'-monophosphate (cAMP) signalling in disease, in particular the progression of pulmonary arterial hypertension (PAH) and  B- and T-cell lymphomas, to uncover novel therapeutic targets.  Model systems studied include cultured human lymphoma, pulmonary artery smooth muscle and pulmonary artery endothelial cells and models of disease.


Current Research

My current research focuses on the role of G protein-coupled receptors, in partular GPR75, that we believe could be a novel target and possible circulating biomarker for pulmonary arterial hypertension.  In addition I have an interest in re-purposing PDE1 inhibitors for pulmonary arterial hypertension. 


Knowledge Exchange and Public Engagement

SHMU radio and science demonstrations at summer community fairs, local preschools (Scott et al., Primary School Children can Take the Lead in Teaching Anatomy and Physiology to their Peers, HAPS, 2020) and Physiology Friday, Doors open day (University of Aberdeen). University of Aberdeen YouTube channel.


Collaborations

Elasmogen to develop antibodies for the treatment of age-related-macular-degeneration.

European Lead Factory (GPR75-screen).

Consultant for Enthorin 


Supervision

My current supervision areas are: Biomedical Sciences.


Research Funding and Grants

A NOVEL G PROTEIN-COUPLED RECEPTOR TARGET FOR METABOLIC SYNDROME. 02/02/21-01/02/22, TENOVUS SCOTLAND

REPURPOSING OF A SELECTIVE PHOSPHODIESTERASE 1 INHIBITOR FOR LEUKAEMIA AND LYMPHOMA. 1/5/21 – 30/4/22, FRIENDS OF ANCHOR

GPR75: A NOVEL DRUG TARGET AND BIOMARKER FOR AGE RELATED MACULAR DEGENERATION Crane, I. J., Collinson, J. M. & Murray, F. 3/09/19 → 2/09/20, TENOVUS SCOTLAND

EXPLOITING THE BODY'S ENDOCANNABINOID SYSTEM IN CHRONIC LYMPHOCYTIC LEUKAEMIA Vickers, M. A., Murray, F. & Pertwee, R. 1/10/18 → 30/09/19 £14,648, FRIENDS OF ANCHOR

REPURPOSING OF A SELECTIVE PHOSPHODIESTERASE 1 INHIBITOR FOR PULMONARY ARTERIAL HYPERTENSION Murray, F. 1/04/18 → 31/03/19, NHS GRAMPIAN

UNCOVERING THE PHARMACOLOGY OF GPR75: ROLE IN PULMONARY ARTERIAL HYPERTENSION. Murray, F. 1/03/17 → 1/07/19,  WELLCOME TRUST

Teaching

Courses


Teaching Responsibilities

Course-coordinator - BM3501(Cardiovascular Physiology and Pharmacology)

Course-coordinator - MT5024/MT5524 (Molecular Pharmacology)

Lecturer - PA4005 (Molecular Pharmacology)

Lecturer - SM3002 (Frontiers of Biomedical Sciences)

Lecturer - BM5003 (Cardiovascular Health and Disease)


Non-Course Teaching Responsibilities

Lab supervisor for undergraduates and postgraduates 

Publications

Publications 

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  • Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

    Kalogriopoulos, N. A., Lopez-Sanchez, I., Lin, C., Ngo, T., Midde, K. K., Roy, S., Aznar, N., Murray, F., Garcia-Marcos, M., Kufareva, I., Ghassemian, M., Ghosh, P.

    Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 46, pp. 28763-28774

    Contributions to Journals: Articles

  • Primary School Children can Take the Lead in Teaching Anatomy and Physiology to their Peers

    Scott, D. A., Aitken, C., Murray, F.

    Contributions to Journals: Conference Articles

  • Endogenous IL-33 and Its Autoamplification of IL-33/ST2 Pathway Play an Important Role in Asthma

    Magat, J. M., Thomas, J. L., Dumouchel, J. P., Murray, F., Li, W. X., Li, J.

    The Journal of Immunology, vol. 204, no. 6, pp. 1592-1597

    Contributions to Journals: Articles

  • Deletion of caveolin scaffolding domain alters cancer cell migration

    Okada, S., Raja, S. A., Okerblom, J., Boddu, A., Horikawa, Y., Ray, S., Okada, H., Kawamura, I., Murofushi, Y., Murray, F., Patel, H. H.

    Cell Cycle, vol. 18, no. 11, pp. 1268-1280

    Contributions to Journals: Articles

  • Two Years On: How the Core Curriculum has Shaped Pharmacology Courses at the University of Aberdeen

    Tucker, S., Fleming, I. N., Hislop, J. N., Murray, F., Scott, D. A., Wallace, H. M.

    Contributions to Specialist Publications: Featured Articles

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