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Dr FIONA CLEGG

Dr FIONA CLEGG
Dr FIONA CLEGG
Dr FIONA CLEGG

BSc (BMedSci) MBChB MRCP (UK)

SCREDS Clinical Lecturer

About
Email Address
fiona.clegg@abdn.ac.uk
Office Address

Room 3.20
GI research group
Institute of Medical Sciences
University of Aberdeen

School/Department
School of Medicine, Medical Sciences and Nutrition

External Memberships

British Society of Gastroenterology

British Association for the Study of the Liver 

Royal College of Physicians Edinburgh 

Research

Research Overview

Fiona Clegg is a SCREDS Clinical Lecturer in Gastroenterology and commenced a CRANES Fellowship in 2018 "Defining the role of fibroblast growth factor 21 in chronic liver disease and hepatocellular carcinoma in humans".  Her current work focuses on the generation of in vitro models of chronic liver disease states including non-alcoholic steatohepatitis, using co-culture, 3D culture and human primary hepatic organoid culture. She has expertise in cell line and organoid culture, antibody production, qPCR and immunohistochemistry.

Research Areas

Nutrition and Health

View Research Area

Research Specialisms

  • Clinical Medicine
  • Pre-Clinical Medicine
  • Gastroenterology
  • Diabetes

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Funding and Grants

Cancer Research Aberdeen North-East Scotland (CRANES) Fellowship £150,000 "Liver Cancer Project" 2018

NHS Grampian Endowments Research Grant £11,999 " Primary human hepatic 3D organoid culture as a new method to study liver disease" 2022

University of Aberdeen Grants Academy SFC Covid-19 Grant Extension and Bridging Fund £35,301 "Characterising the role of Fibroblast Growth Factor 21 in hepatocarcinogenesis in humans" 2021

Tenovus Grampian Small Pilot Grant £19,925 "Characterising the role of Fibroblast Growth Factor 21 in hepatocarcinogenesis in humans" 2018

Wellcome Trust Institutional Strategic Support Fund (ISSF) @ Abdn Clinical Support Fund £9,970 "Defining the role of FGF21 in chronic liver disease using human 3D hepatic organoid cultures"  2018

 

Publications

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  • A refined method of adult tissue resident stem cell derived primary human hepatic organoid cultures

    Clegg, F., Thompson, D., McLean, M. H., Murray, G., Delibegovic, M.
    Contributions to Journals: Conference Articles

  • FGF21 sensitivity in hepatocellular carcinoma could be impaired through reduction in FGFR1 and KLB expression

    Clegg, F., McLean, M. H., Thompson, D., Murray, G., Delibegovic, M.
    Contributions to Journals: Conference Articles

  • P125: Development and Evaluation of a Novel Antibody to Human FGF21

    Clegg, F., Addawiyah Imawana, R., Alnabulsi, A., McLean, M. H., Thompson, D., Delibegovic, M., Murray, G.
    Journal of Pathology, vol. 261, no. S1, pp. S63
    Contributions to Journals: Abstracts

  • Generating a novel 3D primary human hepatic organoid model for study of metabolic diseases

    Clegg, F., Thompson, D., McLean, M. H., Murray, G., Delibegovic, M.
    Contributions to Journals: Conference Articles

  • Immunodeficiency

    Clegg, F.
    Chapters in Books, Reports and Conference Proceedings: Entries for Encyclopedias and Dictionaries

  • Ascitic drain insertion in practice – is our documentation up to scratch?

    Clegg, F., Gauci, J., Fraser, A., McLeman, L.
    Scottish Society of Physicians 61st Annual Meeting
    Contributions to Conferences: Posters

  • P615 Rescue infliximab for acute severe colitis: a single-centre experience

    Orpen-Palmer, J., Clegg, F., Basavaraju, U., Bain, G. H., Parnaby, C. N., Smith, M. G., McLean, M. H., Thomson, J. M.
    14th Congress of ECCO, pp. S424-S424
    Contributions to Journals: Abstracts

  • 21. Gastroenterology

    El-Omar, E., Clegg, C. F., McLean, M. H.
    Davidson's Self-assessment in Medicine. Wake, D., Cantley, P. (eds.). 1 edition. Elsevier, pp. 225-244, 20 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Molecular Analysis of the Microbiome in Colorectal Cancer

    Clegg, C. F., Berry, S. H., Hansen, R., Hold, G. L.
    Colorectal Cancer: Methods and Protocols. Beaulieu, J. (ed.). Humana Press, pp. 139-153, 15 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • PWE-105 Is there a correlation between severity of bile acid malabsorption (BAM) and response to treatment?

    Siu, W., Ko, I., McKiddle, F., Clegg, F., Bain, G., McKinlay, A. W.
    British Society of Gastroenterology (BSG) Annual Meeting 2018, pp. A170
    Contributions to Journals: Abstracts

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