PhD, AFHEA
Advanced Research Fellow
- About
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- Email Address
- c.s.whyte@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437897
- Office Address
Lab 1.33 Office 3.47:6
Institute of Medical Sciences
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I am an Advanced Research Fellow at the Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Science. I obtained my PhD in Medical Sciences at Rowett Research Institute of Nutrition and Health through the University of Aberdeen. My research to date has focused on cellular regulation of fibrinolysis with a particular interest in the role of platelets in directing this process. I have also investigated fibrinolytic dysregulation in disease situations including COVID-19, DVT and stroke. I have recently started on a Transition to Independence Fellowship funded by Friends of Anchor to investigate dysregulated fibrinolysis in cancer associated thrombosis.
Qualifications
- PhD Medical Sciences2009 - University of Aberdeen
Memberships and Affiliations
- Internal Memberships
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Univeristy Research Committee - ECR Representative
Nvision Researcher Development Network Committee
Postdoctoral Research Committee - Institute of Medical Sciences Representative
School of Medicine, Medical Sciences & Nutrition Health and Safety Committee - ECR Representative
- External Memberships
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British Society for Haemostasis and Thrombosis Committee
Council Member (Class of 2027) - International Society for Fibrinolysis and Proteolysis
Membership Committee - International Society on Thrombosis and Haemostasis
Latest Publications
Cancer-Associated Thrombosis (CAT); mechanisms and treatment options
Thrombosis Journal, vol. 23, no. 1, 116Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12959-025-00795-9
Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment
Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929Contributions to Journals: ArticlesAcute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V
Blood Advances, vol. 9, no. 11, pp. 2751-2762Contributions to Journals: ArticlesActivated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation
Blood Advances, vol. 8, no. 19, pp. 5072–5085.Contributions to Journals: ArticlesFibrinogenolysis and fibrinolysis in Vaccine-induced Immune Thrombocytopenia and Thrombosis (VITT)
Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3589-3596Contributions to Journals: Articles
Prizes and Awards
D. Collen Young Investigator Award runner up 2023
D. Collen Young Investigator Award runner up 2018
- Research
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Funding and Grants
Current Funding:
Contribution of the fibrinolytic system to breast cancer associated thrombosis. Principal Investigator, Co-I Prof Valerie Speirs. Mentor Prof Nicola Mutch. Friends of Anchor Transition to Independence Fellowship.
Determining whether breast cancer cells alter endothelial fibrinolytic regulation. Daisy Duncan Legacy Fund.
S100A8/A9 as a novel regulator of fibrinolysis in thromboinflammation. Co-I, PI: Prof Nicola Mutch, Co-Is Dr Julie Rayes and Dr Alexander Brill.
The role of vascular endothelial cells in dictating local fibrinolytic potential and thrombo-inflammatory complications. Co-I, PI: Prof Nicola Mutch. MRS.
- Teaching
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- Publications
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Page 3 of 4 Results 21 to 30 of 31
Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19
Journal of Thrombosis and Haemostasis, vol. 18, no. 7, pp. 1548-1555Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/jth.14872
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/3ec643dc-6c96-4d9c-a043-8d6a21a80c23/download
- [ONLINE] View publication in Scopus
Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation
Haematologica, vol. 105, no. 5Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3324/haematol.2019.230367
- [ONLINE] Open Access license
Platelet-Mediated Modulation of Fibrinolysis
Seminars in Thrombosis and Hemostasis, vol. 43, no. 2, pp. 115-128Contributions to Journals: Review articlesPolyphosphate delays fibrin polymerisation and alters the mechanical properties of the fibrin network
Thrombosis and Haemostasis, vol. 116, no. 5, pp. 897-903Contributions to Journals: ArticlesAltered fibrinolysis in autosomal dominant thrombomodulin-associated coagulopathy
Blood, vol. 128, no. 14, pp. 1879-1883Contributions to Journals: ArticlesPlasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow
Blood, vol. 125, no. 16, pp. 2568 - 2578Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2014-09-599480
Functional factor XIII-A is exposed on the stimulated platelet surface
Blood, vol. 124, no. 26, pp. 3982–3990Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2014-06-583070
A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo
Immunology, vol. 141, no. 1, pp. 96-110Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/imm.12173
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/79b345ca-99a9-4adc-9975-33bcebac9fe4/download
N-3 long-chain polyunsaturated fatty acids inhibit smooth muscle cell migration by modulating urokinase plasminogen activator receptor through MEK/ERK-dependent and -independent mechanisms
The Journal of Nutritional Biochemistry, vol. 23, no. 11, pp. 1378-1383Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jnutbio.2011.08.005
Impact of fibrin structure on fibrinolysis by different plasminogen activators: studies using fluorescent confocal microscopy
Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E24Contributions to Journals: Reviews of Books, Films and Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2012.04749.x
