Professor Claude Wischik
Chair in Mental Health (Clin)
- About
-
- Email Address
- c.m.wischik@abdn.ac.uk
- Office Address
TauRx Therapeutics Ltd
1st Floor, Sir Moir Lockhead Building
395 King Street
Aberdeen
AB24 5RP
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
- Research
-
Research Overview
Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology
- Publications
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Page 1 of 5 Results 1 to 25 of 112
Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease
Behavioural Pharmacology, pp. 64-69Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/FBP.0000000000000865
Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer’s disease
The Journal of Prevention of Alzheimer's Disease, vol. 13, no. 3, 100480Contributions to Journals: ArticlesInhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies
ACS Chemical Neuroscience, vol. 17, no. 1, pp. 124-138Contributions to Journals: ArticlesQuantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer’s disease
Scientific Reports, vol. 15, 41881Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41598-025-25864-x
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/82867189-e587-4cae-9b66-e8593ec53c83/download
- [ONLINE] View publication in Scopus
A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine
Journal of Molecular Biology, vol. 437, no. 17, 169231Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2025.169231
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7a09658e-98e2-46e0-b61c-ea4a48f823ab/download
- [ONLINE] View publication in Scopus
Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer’s disease: A meta-analysis 2015-2023
Journal of Alzheimer's Disease, vol. 107, no. 2, pp. 452-476Contributions to Journals: ArticlesRole of 18F-florzolotau PET in diagnostic and therapeutic decision-making for cognitive impairment
Alzheimer's & dementia : the journal of the Alzheimer's Association, vol. 21, no. 8, e70563Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/alz.70563
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/019992bc-c02d-48ce-afa4-a00b14c06599/download
FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning
Nuclear Medicine and Molecular Imaging, vol. 59, pp. 201-208Contributions to Journals: Articles- [ONLINE] https://pubmed.ncbi.nlm.nih.gov/40385367/
- [ONLINE] DOI: https://doi.org/10.1007/s13139-025-00908-2
Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain
FEBS Journal, vol. 292, no. 10, pp. 2602-2623Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/febs.70021
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/372a1f89-dc2a-4be5-a64e-19083dc6d8d6/download
- [ONLINE] View publication in Scopus
Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2025.02.05.636249
Obtaining personalized predictions from a randomized controlled trial on Alzheimer’s disease
Scientific Reports, vol. 15, 1671Contributions to Journals: ArticlesRivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia
Brain Research Bulletin, vol. 220, 111172Contributions to Journals: ArticlesHigh-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease
Alzheimer's Research & Therapy, vol. 16, 209Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13195-024-01561-1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/16d6fd7f-e75d-41e6-9988-873e405154e6/download
- [ONLINE] View publication in Scopus
Rescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine
Cellular Signalling, vol. 121, 111269Contributions to Journals: ArticlesHydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
Brain Research Bulletin, vol. 212, 110955Contributions to Journals: ArticlesConsiderations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease
Translational neurodegeneration, vol. 13, 25Contributions to Journals: Review articlesLETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy
European Journal of Pharmacology, vol. 970, 176505Contributions to Journals: ArticlesNeuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model
Cells, vol. 13, no. 7, 642Contributions to Journals: ArticlesAssays for the Screening and Characterization of Tau Aggregation Inhibitors
Tau Protein: Methods and Protocols. 2 edition, pp. 93-104, 12 pagesChapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)- [ONLINE] DOI: https://doi.org/10.1007/978-1-0716-3629-9_5
Solubility of α-synuclein species in the L62 mouse model of synucleinopathy
Scientific Reports, vol. 14, 6239Contributions to Journals: ArticlesApathy-like behaviour in tau mouse models of Alzheimer’s disease and frontotemporal dementia
Behavioural Brain Research, vol. 456, 114707Contributions to Journals: ArticlesA Meta-Analysis on Presynaptic Changes in Alzheimer's Disease
Journal of Alzheimer's Disease, vol. 97, no. 1, pp. 145-162Contributions to Journals: ArticlesSignificant dose-dependent reduction in neurofilament light chain concentration in plasma with oral tau aggregation inhibitor hydromethylthionine mesylate
Alzheimer's Dementia, vol. 19, no. S24, e083153Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/alz.083153
Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants
International Journal of Molecular Sciences, vol. 24, no. 18, 13747Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/ijms241813747
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/029b2654-85f4-47f9-9fbb-53ce74475240/download
- [ONLINE] View publication in Scopus
Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice
International Journal of Molecular Sciences, vol. 24, no. 13, 10810Contributions to Journals: Articles