Professor Claude Wischik
Chair in Mental Health (Clin)
- About
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- Email Address
- c.m.wischik@abdn.ac.uk
- Office Address
TauRx Therapeutics Ltd
1st Floor, Sir Moir Lockhead Building
395 King Street
Aberdeen
AB24 5RP
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
- Research
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Research Overview
Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology
- Publications
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Page 1 of 4 Results 1 to 25 of 97
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
Brain Research Bulletin, 110955Contributions to Journals: ArticlesNeuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model
Cells, vol. 13, no. 7, 642Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/cells13070642
Assays for the Screening and Characterization of Tau Aggregation Inhibitors
Tau Protein: Methods and Protocols. 2 edition, pp. 93-104, 12 pagesChapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)- [ONLINE] DOI: https://doi.org/10.1007/978-1-0716-3629-9_5
LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy
European Journal of Pharmacology, 176505Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ejphar.2024.176505
Solubility of α-synuclein species in the L62 mouse model of synucleinopathy
Scientific Reports, vol. 14, 6239Contributions to Journals: ArticlesApathy-like behaviour in tau mouse models of Alzheimer’s disease and frontotemporal dementia
Behavioural Brain Research, vol. 456, 114707Contributions to Journals: ArticlesA Meta-Analysis on Presynaptic Changes in Alzheimer's Disease
Journal of Alzheimer's Disease, vol. 97, no. 1, pp. 145-162Contributions to Journals: ArticlesSignificant dose-dependent reduction in neurofilament light chain concentration in plasma with oral tau aggregation inhibitor hydromethylthionine mesylate
Alzheimer's Dementia, vol. 19, no. S24, e083153Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/alz.083153
Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants
International Journal of Molecular Sciences, vol. 24, no. 18, 13747Contributions to Journals: ArticlesMitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice
International Journal of Molecular Sciences, vol. 24, no. 13, 10810Contributions to Journals: ArticlesUtility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer’s Disease: Systematic Review and Meta-Analysis
Cells, vol. 12, no. 8, 1184Contributions to Journals: Review articlesAn Additive-Free Model for Tau Self-Assembly
Methods in molecular biology (Clifton, N.J.), vol. 2551, pp. 163-188Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/978-1-0716-2597-2_12
- [ONLINE] View publication in Scopus
Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)
Frontiers in Neuroscience, vol. 16, 988074Contributions to Journals: ArticlesDityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro
Journal of Molecular Biology, vol. 434, no. 19, 167785Contributions to Journals: ArticlesOral Tau Aggregation Inhibitor for Alzheimer’s Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate
Journal of Prevention of Alzheimer's Disease, vol. 9, pp. 780-790Contributions to Journals: ArticlesGlutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine
Cellular Signalling, vol. 97, 110386Contributions to Journals: ArticlesStructural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis
Journal of Molecular Biology, vol. 434, no. 7, 167466Contributions to Journals: ArticlesHMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
Biomedicines, vol. 10, no. 4, 867Contributions to Journals: ArticlesCrossed cerebellar diaschisis in Alzheimer's disease
Nuclear Medicine Communications, vol. 43, no. 4, pp. 423-427Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/MNM.0000000000001531
- [ONLINE] View publication in Scopus
Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine
Journal of Neurochemistry, vol. 160, pp. 172-184Contributions to Journals: ArticlesDegeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia
Brain Communications, vol. 3, no. 4, fcab241Contributions to Journals: ArticlesLong-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier
Journal of Alzheimer's Disease, vol. 83, no. 3, pp. 1017-1023Contributions to Journals: ArticlesProteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks
Cells, vol. 10, no. 8, 2162Contributions to Journals: ArticlesOxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates
Cells, vol. 10, no. 3, 703Contributions to Journals: ArticlesDifferential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia
Journal of Biological Chemistry, vol. 295, no. 52, pp. 18508-18523Contributions to Journals: Articles