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Professor Anne Kiltie

Professor Anne Kiltie
Professor Anne Kiltie
Professor Anne Kiltie

MA DM DSc MRCP(UK) FRCR

Friends of ANCHOR Clinical Chair in Oncology

About
Email Address
anne.kiltie@abdn.ac.uk
Office Address

Room 5.053

School/Department
School of Medicine, Medical Sciences and Nutrition
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Linkedin

Biography

I qualified in medicine from the Universities of Cambridge and Oxford and trained in Clinical Oncology at the Christie Hospital, Manchester, and Cookridge Hospital, Leeds. I undertook my DM at the Paterson Institute, University of Manchester and was a Clinical Research Fellow at ICRF Clare Hall before taking up a Senior Lecturer/Honorary Consultant Clinical Oncologist appointment at the University of Leeds in 2001. I moved to the Department of Oncology, University of Oxford in 2009, and obtained my DSc and personal chair in 2016.

I took up my appointment as Friends of ANCHOR Clinical Chair of Oncology at the University of Aberdeen in June 2021.

My research focusses on exploiting dietary fibre manipulation and its effects on the gut microbiome as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.

 

Qualifications

  • DSc Medical Sciences 
    2016 - University of Oxford 
  • DM Medical Sciences 
    1999 - University of Oxford 
  • BM BCh Medicine 
    1988 - University of Oxford 
  • BA Medical Sciences 
    1985 - University of Cambridge 
  • MRCP(UK) General Medicine 
    1992 - Royal College of Physicians of England 
  • FRCR Clinical Oncology 
    1995 - Royal College of Radiologists 
  • MA Medicine 
    1989 - University of Cambridge 
  • MA Medicine 
    1999 - University of Oxford 

Memberships and Affiliations

Internal Memberships

Jul 2021 - present      Member of the Rowett Institute Ethics Panel

Oct 2021 - present     Member of Friends of ANCHOR Research Advisory Group

External Memberships

Jun 2023 - present    Member of RAIDER TrialTranslational Working Group 

Jan 2022 - present    Member of Scientific Review Group BCAN Bladder Cancer Research Innovation Award 2022

Jan 2022 - present    Member of Scottish Radiotherapy Research Forum Committee

Oct 2018 - present     Bladder Cancer Advocacy Network (BCAN) Bladder Cancer Network Management Committee

Dec 2017 - present    Member of Editorial Board of European Urology Oncology

Oct 2016 - present     Associate Editor of Bladder Cancer

2014 - present            Grant reviewer for Italian Association for Cancer Research (AIRC)

Sept 2012 - present   British Uro-oncology Group Executive Committee Trustee

Jan 2012 - present     Royal College of Radiologists representative on Advisory Appointments Committees

Research

Research Overview

Tumours in the pelvis, including bladder, prostate and colorectal cancer and gynaecological cancers may be treated by surgical removal or organ-preserving radiotherapy-based treatments. Current organ-preservation standard of care for most tumour sites includes addition of radiosensitising chemotherapy to improve tumour control. However, this often comes at the expense of increased radiotherapy-induced side effects to the surrounding normal tissues, including the intestines. Furthermore, such combined treatments are often not tolerated by elderly patients. With the proportion of over 75-year olds set to double by 2050, there is an urgent need to find alternative approaches to radiosensitisation.

Having worked on histone deacetylase inhibitors, which we showed to be effective tumour radiosensitisers without additional acute and late small intestinal toxicity in in vivo models, we are now working to exploit dietary fibre manipulation and the gut microbiome as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.

Research Areas

Applied Health Sciences

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Biomedical Sciences

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Nutrition and Health

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Research Specialisms

  • Medicine
  • Food Science
  • Bacteriology
  • Oncology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Supervision

Supervisees

  • MS MEREL VAN DEN HAAK
  • MR ADAM POTTER
  • MR DANIEL SESCU
  • MISS ANAM WAJID
Teaching

Teaching Responsibilities

ME3013 MBChB SSC2: supervisor

BM4501 BSc Honours project: supervisor

RN5504 Nutrition and Health through the Life Stages: lecture

RN5505 Clinical Nutrition: lecture and seminar

RN5503 Clinical Nutrition for Disease Prevention: lecture

Non-course Teaching Responsibilities

I am a Regent for the MB ChB Regent Scheme.

Publications

Page 3 of 4 Results 51 to 75 of 96

  • Using gene polymorphisms to assess bladder cancer risk: Progress and challenges

    Kiltie, A. E.
    Journal of Urology, vol. 187, no. 2, pp. 379-380
    Contributions to Journals: Editorials

  • European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

    Rafnar, T., Vermeulen, S. H., Sulem, P., Thorleifsson, G., Aben, K. K., Witjes, J. A., Grotenhuis, A. J., Verhaegh, G. W., van de Kaa, C. A., Besenbacher, S., Gudbjartsson, D., Stacey, S. N., Gudmundsson, J., Johannsdottir, H., Bjarnason, H., Zanon, C., Helgadottir, H., Jonasson, J. G., Tryggvadottir, L., Jonsson, E., Geirsson, G., Nikulasson, S., Petursdottir, V., Bishop, D. T., Chung-Sak, S., Choudhury, A., Elliott, F., Barrett, J. H., Knowles, M. A., de Verdier, P. J., Ryk, C., Lindblom, A., Rudnai, P., Gurzau, E., Koppova, K., Vineis, P., Polidoro, S., Guarrera, S., Sacerdote, C., Panadero, A., Sanz-Velez, J. I., Sanchez, M., Valdivia, G., Garcia-Prats, M. D., Hengstler, J. G., Selinski, S., Gerullis, H., Ovsiannikov, D., Khezri, A., Kiltie, A. E.
    Human Molecular Genetics, vol. 20, no. 21, pp. 4268-4281
    Contributions to Journals: Articles

  • Radiotherapy for node positive penile cancer: Experience of the leeds teaching hospitals

    Franks, K. N., Kancherla, K., Sethugavalar, B., Whelan, P., Eardley, I., Kiltie, A. E.
    Journal of Urology, vol. 186, no. 2, pp. 524-529
    Contributions to Journals: Articles

  • Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients

    Qiao, B., Scott, G. B., Elliott, F., Vaslin, L., Bentley, J., Hall, J., Bishop, D. T., Knowles, M. A., Kiltie, A. E.
    BMC Medical Genetics, vol. 12, 84
    Contributions to Journals: Articles

  • In vitro functional effects of XPC gene rare variants from bladder cancer patients

    Qiao, B., Ansari, A. H., Scott, G. B., Sak, S. C., Chambers, P. A., Elliott, F., Teo, M. T., Bentley, J., Churchman, M., Hall, J., Taylor, C. F., Bishop, T. D., Knowles, M. A., Kiltie, A. E.
    Carcinogenesis, vol. 32, no. 4, pp. 516-521
    Contributions to Journals: Articles

  • Phase II study of conformal hypofractionated radiotherapy with concurrent gemcitabine in muscle-invasive bladder cancer

    Choudhury, A., Swindell, R., Logue, J. P., Elliott, P. A., Livsey, J. E., Wise, M., Symonds, P., Wylie, J. P., Ramani, V., Sangar, V., Lyons, J., Bottomley, I., McCaul, D., Clarke, N. W., Kiltie, A. E., Cowan, R. A.
    Journal of Clinical Oncology, vol. 29, no. 6, pp. 733-738
    Contributions to Journals: Articles

  • A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

    Rothman, N., Garcia-Closas, M., Chatterjee, N., Malats, N., Wu, X., Figueroa, J. D., Real, F. X., Van Den Berg, D., Matullo, G., Baris, D., Thun, M., Kiemeney, L. A., Vineis, P., De Vivo, I., Albanes, D., Purdue, M. P., Rafnar, T., Hildebrandt, M. A., Kiltie, A. E., Cussenot, O., Golka, K., Kumar, R., Taylor, J. A., Mayordomo, J. I., Jacobs, K. B., Kogevinas, M., Hutchinson, A., Wang, Z., Fu, Y. P., Prokunina-Oolsson, L., BurdeT, L., Yeager, M., Wheeler, W., Tardón, A., Serra, C., Carrato, A., García-Cclosas, R., Loreta, J., Johnson, A., Schwenn, M., Karagas, M. R., Schned, A., Andriole, G., Grubb, R., Black, A., Jacobs, E. J., Diver, W. R., Gapstur, S. M., Weinstein, S. J., Virtamo, J.
    Nature Genetics, vol. 42, no. 11, pp. 978-984
    Contributions to Journals: Articles

  • MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer

    Choudhury, A., Nelson, L. D., Teo, M. T., Chilka, S., Bhattarai, S., Johnston, C. F., Elliott, F., Lowery, J., Taylor, C. F., Churchman, M., Bentley, J., Knowles, M. A., Harnden, P., Bristow, R. G., Bishop, D. T., Kiltie, A. E.
    Cancer Research, vol. 70, no. 18, pp. 7017-7026
    Contributions to Journals: Articles

  • Common predisposition alleles for moderately common cancers: Bladder cancer

    Kiltie, A. E.
    Current Opinion in Genetics and Development, vol. 20, no. 3, pp. 218-224
    Contributions to Journals: Review articles

  • A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer

    Kiemeney, L. A., Sulem, P., Besenbacher, S., Vermeulen, S. H., Sigurdsson, A., Thorleifsson, G., Gudbjartsson, D. F., Stacey, S. N., Gudmundsson, J., Zanon, C., Kostic, J., Masson, G., Bjarnason, H., Palsson, S. T., Skarphedinsson, O. B., Gudjonsson, S. A., Witjes, J. A., Grotenhuis, A. J., Verhaegh, G. W., Bishop, D. T., Sak, S. C., Choudhury, A., Elliott, F., Barrett, J. H., Hurst, C. D., De Verdier, P. J., Ryk, C., Rudnai, P., Gurzau, E., Koppova, K., Vineis, P., Polidoro, S., Guarrera, S., Sacerdote, C., Campagna, M., Placidi, D., Arici, C., Zeegers, M. P., Kellen, E., Gutierrez, B. S., Sanz-Velez, J. I., Sanchez-Zalabardo, M., Valdivia, G., Garcia-Prats, M. D., Hengstler, J. G., Blaszkewicz, M., Dietrich, H., Ophoff, R. A., Van Den Berg, L. H., Kiltie, A. E.
    Nature Genetics, vol. 42, no. 5, pp. 415-419
    Contributions to Journals: Articles

  • Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: Findings from the International Consortium of Bladder Cancer

    Stern, M. C., Lin, J., Figueroa, J. D., Kelsey, K. T., Kiltie, A. E., Yuan, J. M., Matullo, G., Fletcher, T., Benhamou, S., Taylor, J. A., Placidi, D., Zhang, Z. F., Steineck, G., Rothman, N., Kogevinas, M., Silverman, D., Malats, N., Chanock, S., Wu, X., Karagas, M. R., Andrew, A. S., Nelson, H. H., Bishop, D. T., Sei, C. S., Choudhury, A., Barrett, J. H., Elliot, F., Corral, R., Joshi, A. D., Gago-Dominguez, M., Cortessis, V. K., Xiang, Y. B., Gao, Y. T., Vineis, P., Sacerdote, C., Guarrera, S., Polidoro, S., Allione, A., Gurzau, E., Koppova, K., Kumar, R., Rudnai, P., Porru, S., Carta, A., Campagna, M., Arici, C., Park, S. S. L., Garcia-Closas, M.
    Cancer Research, vol. 69, no. 17, pp. 6857-6864
    Contributions to Journals: Articles

  • Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer

    Wu, X., Ye, Y., Kiemeney, L. A., Sulem, P., Rafnar, T., Matullo, G., Seminara, D., Yoshida, T., Saeki, N., Andrew, A. S., Dinney, C. P., Czerniak, B., Zhang, Z. F., Kiltie, A. E., Bishop, D. T., Vineis, P., Porru, S., Buntinx, F., Kellen, E., Zeegers, M. P., Kumar, R., Rudnai, P., Gurzau, E., Koppova, K., Mayordomo, J. I., Sanchez, M., Saez, B., Lindblom, A., De Verdier, P., Steineck, G., Mills, G. B., Schned, A., Guarrera, S., Polidoro, S., Chang, S. C., Lin, J., Chang, D. W., Hale, K. S., Majewski, T., Grossman, H. B., Thorlacius, S., Thorsteinsdottir, U., Aben, K. K., Witjes, J. A., Stefansson, K., Amos, C. I., Karagas, M. R., Gu, J.
    Nature Genetics, vol. 41, no. 9, pp. 991-995
    Contributions to Journals: Articles

  • Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities

    Bentley, J., L'Hôte, C., Platt, F., Hurst, C. D., Lowery, J., Taylor, C., Sak, S. C., Harnden, P., Knowles, M. A., Kiltie, A. E.
    Genes Chromosomes and Cancer, vol. 48, no. 4, pp. 310-321
    Contributions to Journals: Articles

  • Sequence variants at the TERT-CLPTM1L locus associate with many cancer types

    Rafnar, T., Sulem, P., Stacey, S. N., Geller, F., Gudmundsson, J., Sigurdsson, A., Jakobsdottir, M., Helgadottir, H., Thorlacius, S., Aben, K. K., Blöndal, T., Thorgeirsson, T. E., Thorleifsson, G., Kristjansson, K., Thorisdottir, K., Ragnarsson, R., Sigurgeirsson, B., Skuladottir, H., Gudbjartsson, T., Isaksson, H. J., Einarsson, G. V., Benediktsdottir, K. R., Agnarsson, B. A., Olafsson, K., Salvarsdottir, A., Bjarnason, H., Asgeirsdottir, M., Kristinsson, K. T., Matthiasdottir, S., Sveinsdottir, S. G., Polidoro, S., Höiom, V., Botella-Estrada, R., Hemminki, K., Rudnai, P., Bishop, D. T., Campagna, M., Kellen, E., Zeegers, M. P., De Verdier, P., Ferrer, A., Isla, D., Vidal, M. J., Andres, R., Saez, B., Juberias, P., Banzo, J., Navarrete, S., Tres, A., Kan, D., Lindblom, A., Gurzau, E., Koppova, K., De Vegt, F., Schalken, J. A., Van Der Heijden, H. F., Smit, H. J., Termeer, R. A., Oosterwijk, E., Van Hooij, O., Nagore, E., Porru, S., Steineck, G., Hansson, J., Buntinx, F., Catalona, W. J., Matullo, G., Vineis, P., Kiltie, A. E., Mayordomo, J. I., Kumar, R., Kiemeney, L. A., Frigge, M. L., Jonsson, T., Saemundsson, H., Barkardottir, R. B., Jonsson, E., Jonsson, S., Olafsson, J. H., Gulcher, J. R., Masson, G., Gudbjartsson, D. F., Kong, A., Thorsteinsdottir, U., Stefansson, K.
    Nature Genetics, vol. 41, no. 2, pp. 221-227
    Contributions to Journals: Articles

  • Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity

    Choudhury, A., Zhao, H., Jalali, F., Al Rashid, S., Ran, J., Supiot, S., Kiltie, A. E., Bristow, R. G.
    Molecular Cancer Therapeutics, vol. 8, no. 1, pp. 203-213
    Contributions to Journals: Articles

  • Cancer biomarkers associated with damage response genes

    Kiltie, A. E., Fernet, M., Hall, J.
    The DNA Damage Response: Implications on Cancer Formation and Treatment. Springer Netherlands, pp. 307-330, 24 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Molecular epidemiology of DNA repair genes in bladder cancer

    Kiltie, A. E.
    Cancer Epidemiology: Volume II: Modifiable Factors. Verma, M. (ed.), pp. 281-306, 26 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

    Kiemeney, L. A., Thorlacius, S., Sulem, P., Geller, F., Aben, K. K., Stacey, S. N., Gudmundsson, J., Jakobsdottir, M., Bergthorsson, J. T., Sigurdsson, A., Blondal, T., Witjes, J. A., Vermeulen, S. H., Hulsbergen-Van De Kaa, C. A., Swinkels, D. W., Ploeg, M., Cornel, E. B., Vergunst, H., Thorgeirsson, T. E., Gudbjartsson, D., Gudjonsson, S. A., Thorleifsson, G., Kristinsson, K. T., Mouy, M., Snorradottir, S., Placidi, D., Campagna, M., Arici, C., Koppova, K., Gurzau, E., Rudnai, P., Kellen, E., Polidoro, S., Guarrera, S., Sacerdote, C., Sanchez, M., Saez, B., Valdivia, G., Ryk, C., De Verdier, P., Lindblom, A., Golka, K., Bishop, D. T., Knowles, M. A., Nikulasson, S., Petursdottir, V., Jonsson, E., Geirsson, G., Kristjansson, B., Mayordomo, J. I., Steineck, G., Porru, S., Buntinx, F., Zeegers, M. P., Fletcher, T., Kumar, R., Matullo, G., Vineis, P., Kiltie, A. E., Gulcher, J. R., Thorsteinsdottir, U., Kong, A., Rafnar, T., Stefansson, K.
    Nature Genetics, vol. 40, no. 11, pp. 1307-1312
    Contributions to Journals: Articles

  • In Reply to Dr. Rosario et al.

    Kiltie, A. E., Choudhury, A., Johnston, C., Kotwal, S., Paul, A. B., Whelan, P.
    International Journal of Radiation Oncology Biology Physics, vol. 71, no. 5, pp. 1602
    Contributions to Journals: Letters

  • Analysis of variants in DNA damage signalling genes in bladder cancer

    Choudhury, A., Elliott, F., Iles, M. M., Churchman, M., Bristow, R. G., Timothy, D. T., Kiltie, A. E.
    BMC Medical Genetics, vol. 9, 69
    Contributions to Journals: Articles

  • Similar Treatment Outcomes for Radical Cystectomy and Radical Radiotherapy in Invasive Bladder Cancer Treated at a United Kingdom Specialist Treatment Center

    Kotwal, S., Choudhury, A., Johnston, C., Paul, A. B., Whelan, P., Kiltie, A. E.
    International Journal of Radiation Oncology Biology Physics, vol. 70, no. 2, pp. 456-463
    Contributions to Journals: Articles

  • DNA repair gene XRCC1 polymorphisms and bladder cancer risk

    Sak, S. C., Barrett, J. H., Paul, A. B., Bishop, D. T., Kiltie, A. E.
    BMC Genetics, vol. 8, 13
    Contributions to Journals: Articles

  • Comprehensive analysis of 22 XPC polymorphisms and bladder cancer risk

    Sak, S. C., Barrett, J. H., Paul, A. B., Bishop, D. T., Kiltie, A. E.
    Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 12, pp. 2537-2541
    Contributions to Journals: Articles

  • APE1 and XRCC1 protein expression levels predict cancer-specific survival following radical radiotherapy in bladder cancer

    Sak, S. C., Harnden, P., Johnston, C. F., Paul, A. B., Kiltie, A. E.
    Clinical Cancer Research, vol. 11, no. 17, pp. 6205-6211
    Contributions to Journals: Articles

  • The polyAT, intronic IVSII-6 and Lys939Gln XPC polymorphisms are not associated with transitional cell carcinoma of the bladder

    Sak, S. C., Barrett, J. H., Paul, A. B., Bishop, D. T., Kiltie, A. E.
    British Journal of Cancer, vol. 92, no. 12, pp. 2262-2265
    Contributions to Journals: Articles
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