TOPKAT is a multicentre randomised controlled trial, funded by the NIHR HTA Programme. TOPKAT aims to compare the effectiveness and cost-effectiveness of total versus uni-compartmental knee replacement for the management of knee osteoarthritis. TOPKAT recruited 529 participants from 27 different UK orthopaedic units over a two year period. The study incorporates a standard randomised design for surgeons willing to randomise between the two interventions and an expertise-based design for surgeons who have an approach of choice.

The primary outcome is the Oxford Knee Score at five years post randomisation.

TOPKAT is led by Professor David Beard based at the University of Oxford.

For more information please see the TOPKAT Study Website



Ongoing - long term follow up complete; in analysis


TOPKAT protocol was published and is available here -