The HCA programme focuses on the rigorous evaluation of health care interventions.

The underlying philosophy of the programme is the generation of new knowledge through the application of, and interaction between, knowledge synthesis and primary research (particularly randomised controlled trials - RCTs).  The programme is supported by cross cutting methodological research and knowledge synthesis.

Current Project Highlights

  • C-GALL - A randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of laparoscopic cholecystectomy compared with observation/conservative management for preventing recurrent symptoms and complications in adults with uncomplicated symptomatic gallstones
  • PURE - The clinical and cost effectiveness of surgical interventions for stones in the lower calyx of the kidney: The PUrE RCT- Percutaneous Nephrolithotomy (PNL), Flexible Ureterorenoscopy (FURS) and Extracorporeal Lithotripsy (ESWL) for lower pole Calyceal Kidney Stones
  • THISTLE - Improving intrapartum outcomes for mothers and babies in Scotland: a stepped-wedge RCT of an intrapartum emergencies training package in 15 Scottish maternity units
  • EDNA - Early Detection of Neovascular Age-related macular degeneration 
  • RAACENO - Reducing Asthma Attacks in Children using Exhaled Nitric Oxide as a biomarker to inform treatment strategy - a randomised trial 
  • EuroFIT - Social innovation to improve physical activity and sedentary behaviour through elite European football 
  • PRioRITY II: Prioritising Retention in Randomised Trials

Completed Project Highlights

  • CLASS - Comparison of LAser, Surgery and foam Sclerotherapy
  • REFLUX - The place of minimal access surgery amongst people with gastro-oesophageal reflux disease
  • SUSPEND - Use of drug therapy in the management of symptomatic ureteric stones in hospitalised adults: a multicentre placebo controlled randomised trial of calcium channel blockers (nifedipine) and alpha blockers (tamsulosin)
  • RECORD - Randomised Evaluation of Calcium and / OR vitamin D
  • Difference ELicitation in TriAls (DELTA)