The Centre is committed to the dissemination of research findings in the NHS in Scotland and beyond, in line with its remit to 'work for the implementation of proven changes in clinical activities'.
A variety of methods have been used to promote this. Active dissemination is pursued through presentations at conferences and publications in scientific journals and books.
Recent Publications
Academic articles
Abdel-Fattah, M, Chapple, C, Cooper, D, Breeman, S, Bell-Gorrod, H, Kuppanda, P, Guerrero, K, Dixon, S, Cotterill, N, Ward, K, Hashim, H, Monga, A, Brown, K, Drake, M, Gammie, A, Mostafa, A, Bruce, R, Bell, V, Kennedy, C, Evans, S, MacLennan, G, and Norrie, J. Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms (FUTURE) in the UK: a multicentre, superiority, parallel, open-label, randomised controlled trial. The Lancet 2025;[Online first]
Adam, R, Duncan, L, MacLennan, S, Locock, L, Kiltie, AE, Samuel, L, and Murchie, P. Co-Design of the Structured Personalised Assessment for Reviews After Cancer (SPARC) Intervention. Health Expect 2025;28(1):e70174.
Atter, M, Stoddart, A, Cotton, S, Vadiveloo, T, Innes, K, Balfour, A, Arnott, R, Aucott, L, Batham, Z, Foo, I, MacLennan, G, Nimmo, S, Speake, D, Norrie, J, and Paterson, H. Intravenous lidocaine for gut function recovery in colonic surgery: a health economic evaluation of the ALLEGRO randomised clinical trial. BMJ Open 2025;15(2):e088298.
Bell-Gorrod, H, Thokala, P, Breeman, S, Cooper, D, MacLennan, G, Abdel-Fattah, M, and Dixon, S. Long-term cost-effectiveness of invasive urodynamic studies for overactive bladder in women. BJU Int 2025;136(1):82-94.
Bolland, MJ, Avenell, A, and Grey, A. Accuracy and distribution of baseline categorical variables and p-values in spine randomized controlled trials. R Soc Open Sci 2025;12(1):240170.
Boxall, C, Bishop, FL, Alwan, NA, Treweek, S, Griffiths, G, Ekeke, N, McGavin, J, Thorp, J, and Bradbury, K. The role of intersectionality in shaping participant engagement with health research through digital methods: findings from a qualitative study. Trials 2025;26(1):218.
Bulmer, C, and Avenell, A. The effect of dietary weight-loss interventions on the inflammatory markers interleukin-6 and TNF-alpha in adults with obesity: A systematic review and meta-analysis of randomized controlled clinical trials. Obes Rev 2025:e13910.
Cardoso Borges, F, van der Graaf, WTA, Saesen, R, Aebi, S, Amariutei, AE, Bekelman, J, Gorlia, T, Hulstaert, F, Huys, I, Kluetz, P, Morris, MJ, Patil, V, Prindiville, SA, Schilsky, RL, Thomson, A, Treweek, S, Weller, M, Zuidgeest, M, Retel, V, and Lacombe, D. Defining the role of pragmatic clinical trials in cancer clinical research: outcomes of a collaborative workshop hosted by the European Organisation for Research and Treatment of Cancer. Lancet Oncol 2025;26(5):e253-e63.
Chan, AW, Boutron, I, Hopewell, S, Moher, D, Schulz, KF, Collins, GS, Tunn, R, Aggarwal, R, Berkwits, M, Berlin, JA, Bhandari, N, Butcher, NJ, Campbell, MK, Chidebe, RCW, Elbourne, DR, Farmer, AJ, Fergusson, DA, Golub, RM, Goodman, SN, Hoffmann, TC, Ioannidis, JPA, Kahan, BC, Knowles, RL, Lamb, SE, Lewis, S, Loder, E, Offringa, M, Ravaud, P, Richards, DP, Rockhold, FW, Schriger, DL, Siegfried, NL, Staniszewska, S, Taylor, RS, Thabane, L, Torgerson, DJ, Vohra, S, White, IR, and Hróbjartsson, A. SPIRIT 2025 statement: updated guideline for protocols of randomised trials. BMJ 2025;389:e081477.
Coffey, T, Young, N, and Gillies, K. A scoping review of how behavioural theories, models and frameworks have been applied to the design, conduct, analysis or reporting of clinical trials. Trials 2025;26(1):104.
Cruickshank, MD, Robertson, C, Brazzelli, MG, Ekong, AI, Ade Pgce, M, McDonagh Hull, P, Manson, PD, Bick, DE, Williams, DO, Taylor, G, Ward, LA, Kilonzo, MM, Fairley, TE, Bhattacharya, S, Locock, L, Rzewuska Diaz, M, and Black, ME. What are the influences on women’s preferences and decision-making when planning mode of birth in high-income countries? A qualitative systematic review. AJOG Global Reports 2025:100556.
Cupit, C, Finlay, T, Pope, C, and PACFiND Team. Chronicity rhetoric in health and welfare systems inhibits patient recovery: a qualitative, ethnographic study of fibromyalgia care. Soc Sci Med 2025;382:118313.
Daly, A, Treweek, S, Shiely Hayes, G, and Shiely, F. Tolerating bad health research (part 2): still as many bad trials, but more good ones too. Trials 2025;26(1):110.
Devereux, G, Cotton, S, Nath, M, McMeekin, N, Campbell, K, Chaudhuri, R, Choudhury, G, De Soyza, A, Fielding, S, Gompertz, S, Haughney, J, Lee, A, MacLennan, G, Morice, A, Norrie, J, Price, D, Short, P, Vestbo, J, Walker, P, Wedzicha, J, Wilson, A, Wu, O, and Lipworth, B. Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT. Health Technol Assess 2025;29(17):1-97.
Dick, S, Kyle, R, Wilson, P, Aucott, L, France, E, King, E, Malcolm, C, Hoddinott, P, and Turner, SW. Contact with the National Health Service in the week after an acute medical paediatric admission. Arch Dis Child 2025.
Dombrowski, SU, Hoddinott, P, Macaulay, L, O'Dolan, C, Swingler, J, Cotton, S, Avenell, A, Getaneh, AM, Gray, C, Hunt, K, Kee, F, MacLean, A, McKinley, MC, Torrens, C, Turner, K, van der Pol, M, and MacLennan, G. Secondary analysis of the Game of Stones trial for men with obesity: examining moderator effects and exploratory outcomes. Obesity (Silver Spring) 2025:1-15.
Farrow, L, Clement, ND, Smith, D, Dominic Meek, RM, Ryan, M, Gillies, K, and Anderson, L. Stakeholder prioritization preferences for individuals awaiting hip and knee arthroplasty. Bone Joint J 2025;107-b(1):89-96.
Getaneh, AM, van der Pol, M, Boyers, D, Avenell, A, Cotton, S, Dombrowski, SU, Gray, CM, Kee, F, Macaulay, L, McKinley, M, O'Dolan, C, Swingler, J, Torrens, C, Turner, K, MacLennan, G, and Hoddinott, P. Text messaging with or without financial incentives versus a waitlist control for weight loss in men: cost-effectiveness analysis of the Game of Stones randomised controlled trial. Lancet Reg Health Eur 2025;54:101328.
Goldstein, CE, du Toit, J, Murphy, NB, Nicholls, SG, Shaw, JF, Althabe, F, Binik, A, Brehaut, J, Eldridge, S, Ferrand, RA, Gillies, K, Giraudeau, B, van der Graaf, R, Hemkens, LG, Hemming, K, Johri, M, Kim, SYH, Largent, E, London, AJ, Mbuagbaw, L, Mitchell, SL, Smith, M, Tugwell, P, Treweek, S, Welch, VA, Taljaard, M, and Weijer, C. Gaps in the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials: a citation analysis reveals a need for updated ethics guidelines. Res Integr Peer Rev 2025;10(1):10.
Goulão, B, Boyers, D, Forbes, O, and Konnyu, K. Measuring the environmental impact of health interventions in randomized controlled trials - A scoping review. J Clin Epidemiol 2025;183:111751.
Grey, A, Avenell, A, Bolland, MJ, and Thornton, JG. The Fetal Pillow Deflates-Lessons for All. BJOG 2025;132(4):429-32.
Hopewell, S, Chan, AW, Collins, GS, Hróbjartsson, A, Moher, D, Schulz, KF, Tunn, R, Aggarwal, R, Berkwits, M, Berlin, JA, Bhandari, N, Butcher, NJ, Campbell, MK, Chidebe, RCW, Elbourne, D, Farmer, A, Fergusson, DA, Golub, RM, Goodman, SN, Hoffmann, TC, Ioannidis, JPA, Kahan, BC, Knowles, RL, Lamb, SE, Lewis, S, Loder, E, Offringa, M, Ravaud, P, Richards, DP, Rockhold, FW, Schriger, DL, Siegfried, NL, Staniszewska, S, Taylor, RS, Thabane, L, Torgerson, D, Vohra, S, White, IR, and Boutron, I. CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials. BMJ 2025;389:e081124.
Howard, J, Forrest Keenan, K, Mazanderani, F, Turner, MR, and Locock, L. Experiences of predictive genetic testing in inherited motor neuron disease: Findings from a qualitative interview study. J Genet Couns 2025;34(1):e1904.
Howick, J, Lantos, JD, Treweek, S, Svobodova, M, Jacob, N, Edwards, A, Bostock, J, Bower, P, Gillies, K, and Hood, K. Variation in the extent to which patient information leaflets describe potential benefits and harms of trial interventions: a commentary. Trials 2025;26(1):132.
Hróbjartsson, A, Boutron, I, Hopewell, S, Moher, D, Schulz, KF, Collins, GS, Tunn, R, Aggarwal, R, Berkwits, M, Berlin, JA, Bhandari, N, Butcher, NJ, Campbell, MK, Chidebe, RCW, Elbourne, DR, Farmer, AJ, Fergusson, DA, Golub, RM, Goodman, SN, Hoffmann, TC, Ioannidis, JPA, Kahan, BC, Knowles, RL, Lamb, SE, Lewis, S, Loder, E, Offringa, M, Ravaud, P, Richards, DP, Rockhold, FW, Schriger, DL, Siegfried, NL, Staniszewska, S, Taylor, RS, Thabane, L, Torgerson, DJ, Vohra, S, White, IR, and Chan, AW. SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials. BMJ 2025;389:e081660
Hudson, J, Imamura, M, Robertson, C, Whibley, D, Aucott, L, Gillies, K, Manson, P, Dulake, D, Abhishek, A, Tang, NKY, Macfarlane, GJ, and Brazzelli, M. Effects of pharmacological and non-pharmacological interventions for the management of sleep problems in people with fibromyalgia: systematic review and network meta-analysis of randomised controlled trials. Arthritis Care Res (Hoboken) 2025. [Online first]
Getaneh, AM, van der Pol, M, Boyers, D, Avenell, A, Cotton, S, Dombrowski, SU, Gray, CM, Kee, F, Macaulay, L, McKinley, M, O'Dolan, C, Swingler, J, Torrens, C, Turner, K, MacLennan, G, and Hoddinott, P. Text messaging with or without financial incentives versus a waitlist control for weight loss in men: cost-effectiveness analysis of the Game of Stones randomised controlled trial. Lancet Reg Health Eur 2025;54:101328.
Imamura, M, Robertson, C, Hudson, J, Whibley, D, Aucott, L, Gillies, K, Beasley, M, Stevens, MJ, Manson, P, Dulake, D, Abhishek, A, Tang, NK, Macfarlane, GJ, and Brazzelli, M. Effects of pharmacological and non-pharmacological interventions for the management of sleep problems in people with fibromyalgia: a multi-methods evidence synthesis. Health Technol Assess 2025;29(20):1-228.
Kahan, BC, Juszczak, E, Beller, E, Birchenall, M, Chan, AW, Hall, S, Little, P, Fletcher, J, Golub, RM, Goulao, B, Hopewell, S, Islam, N, Zwarenstein, M, Elbourne, D, and Montgomery, A. Guidance for protocol content and reporting of factorial randomised trials: explanation and elaboration of the CONSORT 2010 and SPIRIT 2013 extensions. BMJ 2025;388:e080785.
Latham, HA, Maclaren, AS, De Kock, JH, Locock, L, Murchie, P, and Skea, Z. Exploring rural Scottish GPs' migration decisions: a secondary qualitative analysis considering burnout. Br J Gen Pract 2025.
Locock, L, Maclaren, AS, Skea, Z, Angell, L, Cleland, J, Dawson, T, Denison, A, Dobson, C, Hollick, R, Murchie, P, Skätun, D, and Watson, V. "Come and work here!"; Qualitative research exploring community-led initiatives to improve healthcare recruitment and retention in remote and rural areas. Health and Social Care Delivery Research 2025;13(34).
Maclaren, A, Locock, L, Skea, Z, Angell, L, Cleland, J, Dawson, T, Denison, A, Dobson, C, Hollick, R, Murchie, P, Skåtun, D, and Watson, V. 'Come and work here!'' a qualitative exploration of local community-led initiatives to recruit and retain health care staff in remote and rural areas of the UK. J Health Serv Res Policy 2025:13558196251318607.
MacLennan, S, Wiseman, O, Smith, D, Starr, K, Aucott, L, Hernández, R, Manson, P, Thomas, R, Clark, CT, MacLennan, G, McRae, D, Bell, V, Cotton, S, Gall, Z, Turney, B, and McClinton, S. Updated Systematic Review and Meta-analysis of Extracorporeal Shock Wave Lithotripsy, Flexible Ureterorenoscopy, and Percutaneous Nephrolithotomy for Lower Pole Renal Stones. Eur Urol 2025.
Macleod, AD, Bolland, MJ, Balfour, A, Grey, A, Newmark, J, and Avenell, A. Biochemical osteomalacia in adults undergoing vitamin D testing in the North-East of Scotland. Ann Clin Biochem 2025:45632251315671.
Mohamed, S, Avenell, A, Douglas, F, and Keen, A. Investigating health professionals' perspectives and experiences of food security-related conversations in diabetes care. Diabet Med 2025;42(3):e15470.
Newhouse, N, Bartlett, YK, Simao, SC, Miles, L, Cholerton, R, Kenning, C, Locock, L, Williams, V, French, DP, Rea, R, and Farmer, A. Experiences of Using a Digital Text Messaging Intervention to Support Oral Medication Adherence for People Living With Type 2 Diabetes: Qualitative Process Evaluation. J Med Internet Res 2025;27:e70203.
Paterson, H, Vadiveloo, T, Innes, K, Balfour, A, Atter, M, Stoddart, A, Cotton, S, Arnott, R, Aucott, L, Batham, Z, Foo, I, MacLennan, G, Nimmo, S, Speake, D, and Norrie, J. Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery: A Randomized Clinical Trial. JAMA 2025;333(1):39-48.
Prowse, SR, Treweek, S, Brazzelli, M, and Bruhn, H. Improving Trial Informativeness: A Rapid Review of Global Research on How to Ensure Trials Are Useful. J Eval Clin Pract 2025;31(4):e70147.
Shaw, JF, Goldstein, CE, Mazzetti, T, Vieira Armond, AC, Marouf, Y, Lamprecht, K, Tran, E, Abdul, S, London, AJ, Weijer, C, Hemming, K, Mbuagbaw, L, Johri, M, Ferrand, R, Treweek, S, Nicholls, SG, and Taljaard, M. Randomization procedures in parallel-arm cluster randomized trials in low- and middle-income countries: a review of 300 trials published between 2017 and 2022. J Clin Epidemiol 2025;184:111825.
Singal, K, Douglas, F, Mackie, P, Paranjothy, S, and Brazzelli, M. Interventions to mitigate infant food insecurity in high-income countries: an overview of current evidence. Nutrire 2025;50(1):37.
Ssemaganda, HC, Davis, SE, Govindarajulu, US, Koola, JD, Mao, J, Westerman, DM, Perkins, AM, Speroff, T, Ramsay, CR, Sedrakyan, A, Ohno-Machado, L, Matheny, ME, and Resnic, FS. A Statistical Framework to Detect and Quantify Operator-Learning Curves in Medical Device Safety Evaluation. Med Devices (Auckl) 2025;18:361-75.
Sullivan, FM, Mair, FS, Anderson, W, Chew, C, Dorward, A, Haughney, J, Hogarth, F, Kendrick, D, Littleford, R, McConnachie, A, McCowan, C, McMeekin, N, Patel, M, Rauchhaus, P, Daly, F, Ritchie, L, Robertson, J, Sarvesvaran, J, Sewell, H, Taylor, T, Treweek, S, Vedhara, K, and Schembri, S. Five year mortality in an RCT of a lung cancer biomarker to select people for low dose CT screening. PLoS One 2025;20(1):e0306163.
Tripathee, S, Treweek, S, Van Hemelrijck, M, Ross, P, Watson, V, MacLennan, G, Guntupalli, A, Adams, J, Majmudar, B, Murchie, P, Bekheit, M, MacLennan, S, and null, n. ICANEQUAL multi-stakeholder partnership: Reducing inequalities in liver cancer (HCC) diagnosis, treatment and care across the UK NIHR Open Research 2025;5(5).
Tripathee, S, Abdel-Fattah, M, Johnson, D, Constable, L, Cotton, S, Cooper, D, MacLennan, G, Evans, S, Young, A, Dimitropoulos, K, Hashim, H, Kilonzo, M, Larcombe, JH, Little, P, Murchie, P, Myint, PK, J, ND, Paterson, C, Powell, K, Scotland, G, Thiruchelvam, N, Norrie, J, Omar, MI, and Maclennan, SJ. Patient and healthcare professionals' perception of weekly prophylactic catheter washout in adults living with long-term catheters: qualitative study of the CATHETER II trial. BMJ Open 2025;15(4):e087206.
Webster, J, Goldacre, R, Lane, JCE, Mafham, M, Campbell, MK, Johansen, A, and Griffin, XL. Facilitating clinical trials in hip fracture in the UK : the role and potential of the National Hip Fracture Database and routinely collected data. Bone Joint J 2025;107-b(2):229-38.
Weight, C, Vinette, B, Laritz, R, Mooney, M, Castiglione, SA, Maheu-Cadotte, MA, Argiropoulos, N, Konnyu, K, Cassidy, CE, Collins, SE, Semenic, S, Straiton, N, Middleton, S, Taylor, N, Gagnon, MP, Liang, S, Crump, L, Di Lalla, O, Meyers, T, Elakpa, DN, and Fontaine, G. How well are implementation strategies and target healthcare professional behaviors reported? A secondary analysis of 204 implementation trials using the TIDieR checklist and AACTT framework. Implement Sci 2025;20(1):28.
Wiseman, O, Smith, D, Starr, K, Aucott, L, Hernández, R, Thomas, R, MacLennan, S, Clark, CT, MacLennan, G, McRae, D, Bell, V, Cotton, S, Gall, Z, Turney, B, and McClinton, S. The PUrE randomised controlled trial 1: Clinical and cost effectiveness of flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones of ≤10 mm. Eur Urol 2025.
You, F, Coffey, T, Powell, D, Williamson, PR, and Gillies, K. Carbon emissions associated with clinical trials: A scoping review. J Clin Epidemiol 2025:111733
Other publications
Cooper, D, Imamura, M, Kennedy, C, Manson, P, Vadiveloo, T, Cruickshank, M, Preston, G, Brazzelli, M, and Boyers, D. Acalabrutinib with bendamustine and rituximab for untreated mantle cell lymphoma [ID6155]. Evidence Review Group report in support of NICE STA programme. University of Aberdeen: Aberdeen Centre for Evaluation; 2025
Kumar, S, Cruickshank, M, Ayansina, D, Shaukat, AA, Manson, P, Brazzelli, M, and Scotland, G. Tislelizumab for treating unresectable advanced oesophageal squamous cell cancer after platinum-based chemotherapy [ID4070]. Evidence Review Group report in support of NICE STA programme. University of Aberdeen: Aberdeen Centre for Evaluation; 2025
Robertson, C, Boyers, D, Vadiveloo, T, Cooper, D, Brewis, M, McCabe, C, Manson, P, Brazzelli, M, and Scotland, G. Sotatercept for treating pulmonary arterial hypertension [ID6163]. Evidence Review Group report in support of NICE STA programme. University of Aberdeen: Aberdeen Centre for Evaluation; 2025