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Aberdeen Centre for Arthritis and Musculoskeletal Health

Selected Publications

Selected Publications

Arthritis and Regenerative Medicine Laboratory Selected Publications

Peer-reviewed research articles
  • Collins FL, Roelofs AJ, Symons RA, Kania K, Campbell E, Collie-Duguid ESR, Riemen AHK, Clark SM, De Bari C. The taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution. Ann Rheum Dis., in press.
     
  • Symons R, Colella F, Collins FL, Rafipay AJ, Kania K, McClure J, White N, Cunningham I, Ashraf S, Hay E, MacKenzie KS, Howard KA, Riemen AHK, Manzo A, Clark SM, Roelofs AJ, De Bari C. Targeting the IL6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis. Ann Rheum Dis. 2022, 81 (2), 214-224.
     
  • Gadomski S, Fielding C, García-García A, Korn C, Kapeni C, Ashraf S, Villadiego J, Toro RD, Domingues O, Skepper JN, Michel T, Zimmer J, Sendtner R, Dillon S, Poole KES, Holdsworth G, Sendtner M, Toledo-Aral JJ, De Bari C, McCaskie AW, Robey PG, Méndez-Ferrer S. A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise. Cell Stem Cell. 2022 7;29(4):528-544.e9.
     
  • Perry J, Roelofs AJ, Mennan C, McCarthy HS, Richmond A, Clark SM, Riemen AHK, Wright K, De Bari C, Roberts S. Human mesenchymal stromal cells enhance cartilage healing in a murine joint surface injury model. Cells 2021, 10(8): 1999.
     
  • Karabayas M, Dospinescu P, Fluck N, Kidder D, Fordyce G, Hollick RJ, De Bari C, Basu N. Evaluation of adjunctive mycophenolate for large vessel giant cell arteritis. Rheumatol Adv Pract. 2020, 19;4(2):rkaa069.
     
  • Karabayas M, Dospinescu P, Locherty M, Moulindu P, Sobti M, Hollick R, De Bari C, Robinson S, Olson J, Basu N. Stratified glucocorticoid monotherapy is safe and effective for most cases of giant cell arteritis. Rheumatol Adv Pract. 2020, 12;4(2):rkaa024.
     
  • Roelofs AJ, Kania K, Rafipay AJ, Sambale M, Kuwahara ST, Collins FL, Smeeton J, Serowoky MA, Rowley L,  Wang H, Gronewold R, Kapeni C, Méndez-Ferrer S, Little CB, Bateman JF, Pap T, Mariani FV, Sherwood J, Crump JG, De Bari C. Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis. Ann Rheum Dis. 2020, 79(12): 1625-1634.
     
  • Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, Guan Z, Lydon H, Thomas BL, Thorup AS,  Fernandez BF, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford JR, Henson F, McCaskie AW, De Bari C, Dell’Accio F. Agrin induces long term osteochondral regeneration by supporting repair morphogenesis. Sci Transl Med. 2020; 12(559): eaax9086.
     
  • Kania K, Colella F, Riemen AHK, Wang H, Howard KA, Aigner T, Dell'Accio F, Capellini TD, Roelofs AJ, De Bari C. Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis. Sci Rep. 2020; 10(1): 157-167.
     
  • Karabayas M, Dospinescu P, Locherty M, Moulindu P, Sobti MM, Hollick R, De Bari C, Robinson S, Olson J & Basu N. Stratified glucocorticoid monotherapy is safe and effective for most cases of giant cell arteritis. Rheumatol Adv Pract. 2020; 4(2).
     
  • Mcilroy GD, Suchacki K, Roelofs AJ, Yang W, Fu Y, Bai B, Wallace RJ, De Bari C, Cawthorn WP, Han W, Delibegović M, Rochford JJ. Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease. Mol Metab. 2018; 10: 55-65.
  • Roelofs AJ, Zupan J, Riemen AHK, Kania K, Ansboro S, White N, Clark SM, De Bari C. Joint morphogenetic cells in the adult mammalian synovium. Nat Commun. 2017; 8: 15040
     
  • Sergijenko A, Roelofs AJ, Riemen AHK, De Bari C. Bone marrow contribution to synovial hyperplasia following joint surface injury. Arthritis Res Ther. 2016; 18: 166-176.
     
  • Redelinghuys P, Whitehead L, Augello A, Drummond RA, Levesque JM, Vautier S, Reid DM, Kerscher B, Taylor JA, Nigrovic PA, Wright J, Murray GI, Willment JA, Hocking LJ, Fernandes MJ, De Bari C, Mcinnes IB, Brown GD. MICL controls inflammation in rheumatoid arthritis. MICL controls inflammation in rheumatoid arthritis. Ann Rheum Dis. 2016; 75(7): 1386-1391.
     
  • Karystinou A, Roelofs AJ, Neve A, Cantatore FP, Wackerhage H, De Bari C. Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells. Arthritis Res Ther. 2015; 17: 147-160.
     
  • Sherwood J, Bertrand J, Nalesso G, Poulet B, Pitsillides A, Brandolini L, Karystinou A, De Bari C, Luyten FP, Pitzalis C, Pap T, Dell’Accio F. A homeostatic function of CXCR2 signalling in articular cartilage. Ann Rheum Dis. 2015; 74 (12): 2207-2215.
     
  • Tremblay AM, Missiaglia E, Galli GG, Hettmer S, Urcia R, Carrara M, Judson RN, Thway K, Nadal G, Selfe JL, Murray G, Calogero RA, De Bari C, Zammit PS, Delorenzi M, Wagers AJ, Shipley J, Wackerhage H, Camargo FD. The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation. Cancer Cell 2014; 26 (2): 273-287.
     
  • Cherry HM, Roelofs AJ, Kurth TB, De Bari C. In vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum. Eur Cell Mater. 2014; 27:185-195.
     
  • Gullo F, De Bari C: Prospective purification of a subpopulation of human synovial mesenchymal stem cells with enhanced chondro-osteogenic potency. Rheumatology 2013; 52 (10): 1758-1768.
     
  • Judson R, Walker C, Carroll A, Itzstein C, Gray SD, Lionikas A, Zammit P, De Bari C, Wackerhage H. Constitutive expression of Yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy. PLOS One 2013;8 (3): e59622.
     
  • Judson RN, Tremblay AM, Knopp P, White RB, Urcia R, De Bari C, Zammit PS, Camargo FD, Wackerhage H: The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells. J Cell Sci. 2012; 125 (Pt 24): 6009-6019.
     
  • Zhao Z, Watt C, Karystinou A, Roelofs AJ, McCaig CD, Gibson IR, De Bari C: Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field. Eur Cell Mater. 2011; 22:344-358.
     
  • Kurth TB, Dell’Accio F, Crouch V, Augello A, Sharpe PT, De Bari C: Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo. Arthritis Rheum. 2011; 63 (5): 1289-1300.
     
  • Feng J, Mantesso A, De Bari C, Nishiyama A, Sharpe PT: Dual origin of mesenchymal stem cells contributing to organ growth and repair. Proc Natl Acad Sci U S A. 2011; 108 (16): 6503-6508.
     
  • Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell’Accio F: WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. J Cell Biol. 2011; 193 (3): 551-564.
     
  • Watt KI, Judson R, Medlow P, Reid K, Kurth TB, Burniston JG, Ratkevicius A, De Bari C, Wackerhage H: Yap is a novel regulator of C2C12 myogenesis. Biochem Biophys Res Commun. 2010; 393 (4): 619-624.
     
  • Karystinou A, Dell’Accio F, Kurth TB, Wackerhage H, Khan IM, Archer CW, Jones EA, Mitsiadis TA, De Bari C: Progenitor cell subsets revealed by clonal analysis of human synovial membrane mesenchymal stem cells. Rheumatology (Oxford). 2009; 48 (9):1057-1064.
     
  • De Bari C, Dell’Accio F, Karystinou A, Guillot PV, Fisk NM, Khan IM, Archer CW, Jones EA, McGonagle D, Mitsiadis TA, Donaldson AN, Luyten FP, Pitzalis C: A biomarker-based mathematical model to predict bone forming potency of human synovial and periosteal mesenchymal stem cells. Arthritis Rheum. 2008; 58 (1): 240-250.
     
  • De Bari C, Dell’Accio F, Vanlauwe J, Eyckmans J, Khan I, Archer CW, Jones E, McGonagle D, Pitzalis C, Luyten FP: Mesenchymal multipotency of adult human periosteal cells demonstrated by single cell lineage analysis. Arthritis Rheum. 2006; 54 (4): 1209-1221.
     
  • De Bari C, Dell’Accio F, Luyten FP: Failure of in vitro-differentiated mesenchymal stem cells from the synovial membrane to form ectopic stable cartilage in vivo. Arthritis Rheum. 2004; 50 (1): 142-150.
     
  • De Bari C, Dell’Accio F, Vandenabeele F, Vermeesch JR, Raymackers JM, Luyten FP: Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane. J Cell Biol. 2003; 160 (6): 909-918.
     
  • De Bari C, Dell’Accio F, Tylzanowski P, Luyten FP: Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum. 2001; 44 (8): 1928-1942.
     
  • De Bari C, Dell’Accio F, Luyten FP: Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age. Arthritis Rheum. 2001; 44 (1): 85-95. Figure in cover page.
Peer-reviewed review articles
  • Zelinka A, Roelofs AJ, Kandel RA, De Bari C. Cellular therapy and tissue engineering for cartilage repair. Osteoarthritis Cartilage. 2022: S1063-4584(22)00855-X.
     
  • Dickson BM, Roelofs AJ, Rochford JJ, Wilson HM, De Bari C. The burden of metabolic syndrome on osteoarthritic joints. Arthritis Res Ther. 2019; 21(1): 289-298.
     
  • Lolli A, Colella F, De Bari C, van Osch GJVM. Targeting anti-chondrogenic factors for the stimulation of chondrogenesis: A new paradigm in cartilage repair. J Orthop Res. 2019; 37 (1): 12-22.
     
  • De Bari C, Roelofs AJ. Stem Cell-based Therapeutic Strategies for Cartilage Defects and Osteoarthritis. Curr Opin Pharmacol. 2018;  40: 74-80.
     
  • Franceschetti T, De Bari C. The Potential role of adult stem cells in the management of the rheumatic diseases. Ther Adv Musculoskelet Dis. 2017; 9(7): 165-179.
     
  • Ansboro S, Roelofs AJ, De Bari C. Mesenchymal stem cells for the management of rheumatoid arthritis: immune modulation, repair or both? Curr Opin Rheumatol. 2017; 29(2): 201-207.
     
  • Van der Kraan PM, Berenbaum F, Blanco FJ, De Bari C, Lafeber F, Hauge E, Higginbottom A, Ioan-Facsinay A, Loughlin J, Meulenbelt I, Moilanen E, Pitsillidou I, Tsezou A, van Meurs J, Vincent T, Wittoek R, Lories R; EULAR Study group in OA. Translation of clinical problems in osteoarthritis into pathophysiological research goals. RMD Open. 2016; 2(1): 1-4.
     
  • De Bari C. Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys? Arthritis Res Ther. 2015; 17:113-121.
     
  • Eseonu O, De Bari C. Homing of mesenchymal stem cells: Mechanistic or stochastic? Implications for targeted delivery in arthritis. Rheumatology 2015; 54 (2): 210-218.
     
  • Roelofs AJ, Rocke JPJ, De Bari C. Cell-based approaches to joint surface repair: a research perspective. Osteoarthritis Cartilage 2013; 21:892-900.
     
  • Kurth TB, De Bari C: Immunostaining of skeletal tissues. Methods Mol Biol. 2012; 816:321-334.
     
  • MacDonald G, Augello A, De Bari C: Role of mesenchymal stem cells in reestablishing immunologic tolerance in autoimmune rheumatic diseases. Arthritis Rheum. 2011; 63 (9): 2547-2557.
     
  • Roberts S, Genever P, McCaskie A, De Bari C: Prospects of stem cell therapy in osteoarthritis. Regen Med. 2011; 6 (3): 351-366.
     
  • De Bari C, Kurth TB, Augello A: Mesenchymal stem cells from development to postnatal joint homeostasis, aging, and disease. Birth Defects Res C Embryo Today. 2010; 90 (4): 257-271.
     
  • Augello A, De Bari C: The regulation of differentiation in mesenchymal stem cells. Hum Gene Ther. 2010; 21 (10): 1226-1238.
     
  • Augello A, Kurth TB, De Bari C: Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches. Eur Cell Mater. 2010; 20: 121-133.
Book Chapters
  • De Bari C, Roelofs AJ. Stem and progenitor cells in synovium. In: “Encyclopaedia of Bone Biology”, 2020 (1st edition), Elsevier Science.
     
  • Luyten FP, De Bari C, Dell'Accio F. Regenerative Medicine and Tissue Engineering. In: “Kelley's Textbook of Rheumatology”, 2020 (11th Edition).
     
  • Roelofs AJ, De Bari C. Immunostaining of skeletal tissues. Methods Mol Biol. 2019; 1914: 437-450.