Dr Wenbo Zhan
Dr Wenbo Zhan

Dr Wenbo Zhan

Lecturer

About

R353, Fraser Noble Building

School of Engineering

King's College

University of Aberdeen

Aberdeen AB24 3UE, UK

Biography

Wenbo Zhan is a Lecturer in Biological Engineering in the School of Engineering. He received his undergraduate degrees from Xi’an Jiatong University in 2008 and a master degree from Harbin Institute of Technology in 2010. He graduated from Imperial College London with his PhD degree in 2014 and then worked as a project consultant at Imperial College London and a postdoctoral research fellow at the National University of Singapore until 2016. Prior to joining the University of Aberdeen in 2019, he was a research associate at Imperial College London.

Qualifications

  • PhD Chemical Engineering 
    2014 - Imperial College London 
  • MSc Thermal Energy and Power Engineering 
    2010 - Harbin Institute of Technology 
  • BEng Thermal Energy and Power Engineering 
    2008 - Xi'an Jiaotong University 
  • BEc Finance 
    2008 - Xi'an Jiaotong Univerisity 

Memberships and Affiliations

Internal Memberships
  • Coordinator of the School MSc individual projects
  • Deputy coordinator of MSc Biomedical Engineering programme
  • Member of School of Engineering Postgraduate Learning and Teaching Committee
External Memberships
  • Guest editor for special issue of Pharmaceutical Research, 2021/22
  • Grant reviewer for the French National Research Agency, 2021
  • Adjunct to the chair of the 18th CAOS Annual Conference, 2018 
  • Assistant to the editor for theme issue of Advanced Drug Delivery Review, 2017/18
  • Executive manager of the 8th GCCES Conference, 2016 
  • Local organising committee member of the 21st CLSS-UK Annual Conference, 2015
  • Reviewer for journals, including Journal of Controlled Release, Fuel, Applied Energy, Pharmaceutical Research, International Journal of Pharmaceutics, Powder Technology, Scientific Reports, PLoS One, International Journal of Hydrogen Energy, Journal of the Royal Society Interface and Materials Today Bio, etc.
Research

Research Overview

Wenbo Zhan's research centres on biological engineering and bioprocessing, with a particular focus on the biomechanics and transport processes in biological and physiological systems.

  •  Multiscale modelling of drug delivery processes 
  •  Soft tissue deformation
  •  Image-based analysis of cardiovascular fluid mechanics

Funding and Grants

  • Image-based modelling and optimisation of convection-enhanced delivery for combination therapy against heterogeneous human brain tumour, The Royal Society, PI, 12/08/2022 - 11/08/2024
  • Gender differences in sex hormone transport in abdominal aortic aneurysm, The Royal Society, PI, 31/03/2022 - 30/03/2024
  • Optimisation of infusion catheter posture for improving convection-enhanced drug delivery to brain cancer, Children's Brain Tumour Drug Delivery Consortium, Children with Cancer UK, PI, 01/03/2022 - 30/09/2022
  • Novel nanoparticle-embedded membranes for long-term bioactive SARS-CoV2 prevention, Grampian University Hospitals NHS Trust, Co-I, 01/04/2021 - 31/03/2023
  • Multifunctional liquid crystals stabilised by hydrogen-bounding and their integration in new devices for energy harvesting, conversion and storage, Royal Society of Edinburgh Scotland Foundation, Co-I, 23/10/2020 - 30/12/2021 
Teaching

Teaching Responsibilities

Course coordinator

  • EG555L - Modelling of Biological Systems
  • EG504Q - Introduction to Engineering for Life Scientists
  • EG555N,EG59F1,EG59F2,EG59M2 - MSc Individual Project (all MSc programmes)

Course contributor  

  • EG555J - Research Methods for Bioengineers
  • EG4578 - Group Design Project (Chemical Engineering)
Publications

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  • Pore-Scale Modelling of Elastic Properties in Hydrate-Bearing Sediments Using 4-D Synchrotron Radiation Imaging

    Li, R., Zhou, Y., Zhan, W., Yang, J.
    Marine and Petroleum Geology
    Contributions to Journals: Articles
  • On the microstructurally driven heterogeneous response of brain white matter to drug infusion pressure

    Yuan, T., Zhan, W., Jamal, A., Dini, D.
    Biomechanics and Modeling in Mechanobiology, vol. 21, pp. 1299–1316
    Contributions to Journals: Articles
  • Multiphysics Simulation in Drug Development and Delivery

    Zhan, W., Wang, C.
    Pharmaceutical Research
    Contributions to Journals: Articles
  • Effects of tissue hydraulic permeability on intracerebral transport of interstitial fluid and nanoparticle-encapsulated drugs upon convection-enhanced delivery

    Yang, Y., Zhan, W.
    9th World Congress of Biomechanics
    Contributions to Conferences: Abstracts
  • Numerical modelling of nanoparticle-mediated drug delivery across blood-brain barrier using focused ultrasound

    Yang, Y., Zhan, W.
    9th World Congress of Biomechanics
    Contributions to Conferences: Abstracts
  • Role of Tissue Hydraulic Permeability in Convection-Enhanced Delivery of Nanoparticle-Encapsulated Chemotherapy Drugs to Brain Tumour

    Yang, Y., Zhan, W.
    Pharmaceutical Research, vol. 39, no. 5, pp. 877-892
    Contributions to Journals: Articles
  • Effect of particle size and surface charge on nanoparticles diffusion in the brain white matter

    Yuan, T., Gao, L., Zhan, W., Dini, D.
    Pharmaceutical Research, vol. 39, pp. 767–781
    Contributions to Journals: Articles
  • Mathematical modelling of nanoparticle-mediated topical drug delivery to skin tissue

    McLean, K., Zhan, W.
    International Journal of Pharmaceutics, vol. 611, 121322
    Contributions to Journals: Articles
  • Effect of tissue permeability on drug transport in brain tumour after pressure-driven infusion

    Yang, Y., Zhan, W.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Convection Enhanced Delivery of Light Responsive Antigen Capturing Oxygen Generators for Chemo-Phototherapy Triggered Adaptive Immunity

    Sunil, V., Mozhi, A., Zhan, W., Teoh, J. H., Wang, C.
    AIChE 2021
    Contributions to Conferences: Abstracts
  • Anti-angiogenic effect on convection-enhanced delivery of cytotoxic drugs

    Zhan, W.
    BioMedEng21
    Contributions to Conferences: Abstracts
  • Effect of brain tissue anisotropy on convection-enhanced delivery of nanoparticles encapsulated carmustine

    Zhan, W.
    BioMedEng21
    Contributions to Conferences: Abstracts
  • Convection enhanced delivery of light responsive antigen capturing oxygen generators for chemo-phototherapy triggered adaptive immunity

    Sunil, V., Mozhi, A., Zhan, W., Teoh, J. H., Wang, C.
    Biomaterials, vol. 275, 120974
    Contributions to Journals: Articles
  • Characterization of Transport Properties of Drugs in Brain Tissue Using Computational Fluid Dynamics

    Yuan, T., Zhan, W., Dini, D.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Particle velocity measurement of binary mixtures in the riser of a circulating fluidized bed by the combined use of electrostatic sensing and high-speed imaging

    Zhang, W., Wang, T., Liu, Y., Zhan, W., Wang, C.
    Petroleum Science, vol. 17, no. 4, pp. 1159-1170
    Contributions to Journals: Articles
  • Enhanced penetration of pro-apoptotic and anti-angiogenic micellar nanoprobe in 3D multicellular spheroids for chemophototherapy

    Mozhi, A., Sunil, V., Zhan, W., Ghode, P. B., Thakor, N. V., Wang, C.
    Journal of Controlled Release, vol. 323, pp. 502-518
    Contributions to Journals: Articles
  • A pilot study of aortic hemodynamics before and after thoracic endovascular repair with a double-branched endograft

    Zhu, Y., Zhan, W., Hamady, M., Xu, X. Y.
    Medicine in Novel Technology and Devices, vol. 4, 100027
    Contributions to Journals: Articles
  • Effects of Focused-Ultrasound-and-Microbubble-Induced Blood-Brain Barrier Disruption on Drug Transport under Liposome-Mediated Delivery in Brain Tumour: a Pilot Numerical Simulation Study

    Zhan, W.
    Pharmaceutics, vol. 12, no. 1, 69
    Contributions to Journals: Articles
  • Convection enhanced delivery of anti-angiogenic and cytotoxic agents in combination therapy against brain tumour

    Zhan, W.
    European Journal of Pharmaceutical Sciences, vol. 141, 105094
    Contributions to Journals: Articles
  • Convection Enhanced Delivery of Light Responsive Antigen Capturing Oxygen Generators for Photoimmunotherapy of Hypoxic Tumors

    Sunil, V., Mozhi, A., Zhan, W., Wang, C.
    Contributions to Conferences: Papers
  • Effect of Enhanced Cerebrospinal Fluid Flow on Drug Penetration in Convection Enhanced Delivery

    Zhan, W., Tan, Z., Bernardini, A., Dini, D., Baena, F. R. y.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration Into Brain Tissue

    Lei, C., Davoodi, P., Zhan, W., Chow, P. K., Wang, C.
    Journal of Pharmaceutical Sciences, vol. 108, no. 5, pp. 1736-1745
    Contributions to Journals: Articles
  • Delivery of liposome encapsulated temozolomide to brain tumour: Understanding the drug transport for optimisation

    Zhan, W.
    International Journal of Pharmaceutics, vol. 557, pp. 280-292
    Contributions to Journals: Articles
  • Effect of tissue permeability and drug diffusion anisotropy on convection-enhanced delivery

    Zhan, W., Baena, F. R. y., Dini, D.
    Drug Delivery, vol. 26, no. 1, pp. 773-781
    Contributions to Journals: Articles
  • Neurosurgical Convection Enhanced Drug Delivery: Experiments and Modelling

    Tan, Z., Zhan, W., Dini, D., Baena, F. R. y.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Optimising Nanoparticle Property and Treatment Regimen for Improving Convection Enhanced Delivery of Doxorubicin to Brain Tumour

    Zhan, W., Wang, C.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Towards a multiphysics modelling framework for thermosensitive liposomal drug delivery to solid tumour combined with focused ultrasound hyperthermia

    Zhan, W., Gedroyc, W., Xu, X. Y.
    Biophysics Reports, vol. 5, no. 1, pp. 43-59
    Contributions to Journals: Articles
  • Transport of Chemotherapeutic Agents in Anisotropic Tissue under Convection Enhanced Delivery for Localised Treatment

    Zhan, W., Dini, D., Baena, F. R. y.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Convection enhanced delivery of liposome encapsulated doxorubicin for brain tumour therapy

    Zhan, W., Wang, C.
    Journal of Controlled Release, vol. 285, pp. 212-229
    Contributions to Journals: Articles
  • Computational modelling of drug delivery to solid tumour: Understanding the interplay between chemotherapeutics and biological system for optimised delivery systems

    Zhan, W., Alamer, M., Xu, X. Y.
    Advanced Drug Delivery Reviews, vol. 132, pp. 81-103
    Contributions to Journals: Articles
  • Towards an Optimized Path Planner for the EDEN2020 Neurosurgical Steerable Needle

    Pinzi, M., Galvan, S., Zhan, W., Dini, D., Baena, F. R. y.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Convection enhanced delivery of chemotherapeutic drugs into brain tumour

    Zhan, W., Wang, C.
    Journal of Controlled Release, vol. 271, pp. 74-87
    Contributions to Journals: Articles
  • 3D-Bioprinting and Micro-/Nano-Technology: Emerging Technologies in Biomedical Sciences (Preface)

    Wang, C., Xu, X. Y., Zhan, W., Davoodi, P.
    Advanced Drug Delivery Reviews, vol. 132, pp. 1-2
    Contributions to Journals: Articles
  • A Multiphysics Model for Focused Ultrasound Activated Thermosentitive Liposome Drug Delivery to Tumour

    Huang, Y., Zhan, W., Liu, C., Xu, X. Y.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • A Pilot Study on Aortic Flow before and after Endovascular Repair with a Novel Branched Stent-Graft for Thoracic Aortic Aneurysm

    Zhu, Y., Zhan, W., Hamady, M., Xu, X. Y.
    Contributions to Conferences: Papers
  • Mathematical Modelling of Cerebral Infusion of Nanoparticle Encapsulated Anticancer Drugs for Brain Tumour Therapy

    Zhan, W.
    Contributions to Conferences: Papers
  • Micromechanical Modelling of Brain White Matter

    Bernardini, A., Zhan, W., Ge, S., Vidotto, M., Dini, D.
    Contributions to Conferences: Papers
  • Numerical Simulation of Convection Enhanced Delivery of Nano Drug Carriers into Brain Tumour

    Zhan, W., Baena, F. R. y.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Numerical Study on Cerebral Infusion Induced Backflow for Convection Enhanced Delivery

    Zhan, W., Bernardini, A., Konstantinou, I., Dini, D., Baena, F. R. y.
    Contributions to Conferences: Papers
  • The effect of tumour size on drug transport and uptake in 3-D tumour models reconstructed from magnetic resonance images

    Zhan, W., Gedroyc, W., Xu, X. Y.
    PloS ONE, vol. 12, no. 2, e0172276
    Contributions to Journals: Articles
  • Mathematical Modelling of Convection Enhanced Delivery of Carmustine and Paclitaxel for Brain Tumour Therapy

    Zhan, W., Arifin, D. Y., Lee, T. K., Wang, C.
    Pharmaceutical Research, vol. 34, pp. 860-873
    Contributions to Journals: Articles
  • Model for Focused Ultrasound-mediated Thermosentitive Liposome Drug Delivery to Tumour

    Huang, Y., Zhan, W., Liu, C., Xu, X. Y.
    Contributions to Conferences: Papers
  • Numerical Simulation of Thermosensitive Liposome-mediated Delivery of Doxorubicin to Solid Tumour under High Intensity Focused Ultrasound Heating

    Zhan, W., Gedroyc, W., Xu, X. Y.
    Contributions to Conferences: Papers
  • Numerical Study on Convection Enhanced Delivery of Anticancer Drugs into Brain Tumour

    Zhan, W.
    Contributions to Conferences: Papers
  • A Dual Tracer 18F-FCH/18F-FDG PET Imaging of an Orthotopic Brain Tumor Xenograft Model

    Fu, Y., Ong, L., Ranganath, S. H., Zheng, L., Kee, I., Zhan, W., Yu, S., Chow, P. K. H., Wang, C., Lonser, R. R. (ed.)
    PloS ONE, vol. 11, no. 2, e0148123
    Contributions to Journals: Articles
  • Numerical Simulation of Downdraft Biomass Gasifier: Influence of Structure Designs Using CFD Simulation

    Shen, Y., Yan, W., Zhan, W., Ng, Y. W., Luo, Z., Wang, C.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Numerical Study on the Hydrodynamics Behaviour in Bubbling Fluidized Bed for Sewage Sludge Gasification

    Zhan, W., Wang, C.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • The Effect of Infusion Position on Convection-Enhanced Delivery of Anticancer Drugs to Remnant Brain Tumour after Surgery

    Zhan, W., Arifin, D. Y., Lee, T. K., Wang, C.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Drug Delivery to Solid Tumour with High Intensity Focused Ultrasound Heating

    Zhan, W., Gedroyc, W., Xu, X. Y.
    21st CLSS-UK Annual Conference
    Contributions to Conferences: Abstracts
  • Effect of heterogeneous microvasculature distribution on drug delivery to solid tumour

    Zhan, W., Gedroyc, W., Xu, X. Y.
    Journal of Physics D: Applied Physics, vol. 47, no. 47, 475401
    Contributions to Journals: Articles
  • Mathematical Modelling of Drug Transport and Uptake in a Realistic Model of Solid Tumour

    Zhan, W., Gedroyc, W., Xu, X. Y.
    Protein & Peptide Letters, vol. 21, no. 11, pp. 1146-1156
    Contributions to Journals: Articles
  • Simulation of HIFU Heating in Solid Tumour: Comparison of Different Temperature Control Modes

    Zhan, W., Xu, X. Y.
    Contributions to Conferences: Papers
  • A Mathematical Model for Thermosensitive Liposomal Delivery of Doxorubicin to Solid Tumour

    Zhan, W., Xu, X. Y.
    Journal of Drug Delivery, vol. 2013, 172529
    Contributions to Journals: Articles
  • Computational Study of Drug Transport in Realistic Models of Solid Tumour

    Zhan, W., Gedroyc, W., Xu, X. Y.
    Contributions to Conferences: Papers
  • Computational Study of Drug Transport in Realistic Models of Solid Tumour

    Zhan, W., Gedroyc, W., Xu, X. Y.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Study on Hydrodynamic Characteristics in Liquid-Solid Reactor

    Jiang, Y., Zhan, W.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Prediction on immersed tubes erosion using two-fluid model in a bubbling fluidized bed

    He, Y., Zhan, W., Zhao, Y., Lu, H., Schlaberg, I.
    Chemical Engineering Science, vol. 64, no. 13, pp. 3072-3082
    Contributions to Journals: Articles
  • Potential of Clean Development Mechanism Projects in Heilongjiang Province

    Zhan, W., Liu, L., Liu, W., Wang, T., He, Y.
    Energy Conservation Technology, vol. 27, pp. 134-139
    Contributions to Journals: Articles
  • Study of the impact of the velocity inlet boundary condition to the bubbling fluidized bed

    He, Y., Zhan, W., Men, Y., Liu, W., Lu, H.
    Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics, vol. 30, no. 5, pp. 789-792
    Contributions to Journals: Articles
  • Simulation of Particle Segregation Behavior in Bubbling Fluidized Bed

    Peng, W., Zhan, W., Liu, W., He, Y.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Study on the Impact of Friction Model on Hydrodynamic Behavior in Bubbling Fluidized Bed

    Zhan, W., Zhang, S., Liu, W., He, Y.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings

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