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Dr Thomas Baddeley

Dr Thomas Baddeley
Dr Thomas Baddeley
Dr Thomas Baddeley

PhD, BSc Hons

Senior Research Fellow

About
Telephone Number
+44 (0)1224 274238
School/Department
School of Natural and Computing Sciences
Linkedin
Google Scholar
Pure

North East Analytical Research (NEAR) Symposium

Link to the NEAR Symposium Website

NEAR Symposium

Qualifications

  • PhD Chemistry 
    2002 - University of Aberdeen 
  • BSc Hons Chemistry 
    1998 - University of Aberdeen 

External Memberships

  • Head of DMPK / Analytical Chemistry for TauRx Therapeutics
  • Cofounder of the North East Analytical Research (NEAR) Symposium

Latest Publications

View My Publications

Research

Research Overview

My focus is on the analytical pathways involved in pharmaceutical drug development.

  • This starts early during R and D looking at physical chemical testing of novel compounds and early analytical development to determine material purity and its impurities.
  • As the candidates progress further, bioanalytical methods, initial metabolism and material characterisation are developed.
  • Once into non clinical and clinical development validation according to ICH Q3 is required for material assays and ICH M7 for bioanalytical methods

 

 

Current Research

The development and use of new analytical methods in the study of small organic molecules undergoing clinical evaluation.

The development and use of bioanalytical methods used in clinical and non clinical studies

DMPK studies supporting novel pharmaceutical development

Past Research

The synthesis and study of novel organic compounds for use as potential drug candidates and excipients.

The study of the physical properties of novel oligosaccharides

Knowledge Exchange

Speaker at NEAR Symposium 2024 in Aberdeen

Speaker at REID bioanalytical Forum 2019, Cambridge

Speaker at INFORM 2018 in Copenhagen

 

Publications

Page 1 of 1 Results 1 to 35 of 35

  • Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

    Kondak, C., Leith, M., Baddeley, T. C., Santos, R. X., Harrington, C. R., Wischik, C. M., Riedel, G., Klein, J.
    International Journal of Molecular Sciences, vol. 24, no. 13, 10810
    Contributions to Journals: Articles

  • Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography

    Delbono, V., Larch, C. P., Newlands, K. C., Rhydderch, S., Baddeley, T. C., Storey, J. M. D.
    International journal of analytical chemistry, vol. 2022, 9171836
    Contributions to Journals: Articles

  • HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

    Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.
    Biomedicines, vol. 10, no. 4, 867
    Contributions to Journals: Articles

  • Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

    Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
    Contributions to Journals: Articles

  • Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

    Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946
    Contributions to Journals: Articles

  • Crystal structures and Hirshfeld surface analyses of a des-A-B-aromatic steroidal compound, and two of its derivatives, having a trans-2,3,4,5-tetrahydro-3a-methyl-7-methoxybenz[e]indane skeleton-structural comparisons with reported tetrahydrobenz[e]indene derivatives

    Gomes, L. R., Low, J. N., Turner, A. B., Nowicki, A. W., Baddeley, T. C., Wardell, J. L.
    Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, vol. 74, no. 9, pp. 649-663
    Contributions to Journals: Articles

  • N′-(1,3-Benzo­thia­zol-2-yl) benzene­sulfono­hydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry

    Baddeley, T. C., de Souza, M. V. N., Wardell, J. L., Jotani, M. M., Tiekink, E. R. T.
    Acta Crystallographica Section E: Crystallographic Communications, vol. 75, no. 4, pp. 516-523
    Contributions to Journals: Articles

  • Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives

    Pinheiro, A. C., de Souza, M. V. N., Lourenco, M. C. S., da Costa, C. F., Baddeley, T. C., Low, J. N., Wardell, S. M. S. V., Wardell, J. L.
    Journal of Molecular Structure, vol. 1178, pp. 655-668
    Contributions to Journals: Articles

  • Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements

    Gomes, L. R., Low, J. N., Turner, A. B., Baddeley, T. C., Wardell, J. L.
    Steroids, vol. 140, pp. 92-103
    Contributions to Journals: Articles

  • Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

    Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131
    Contributions to Journals: Articles

  • A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

    Schwab, K., Frahm, S., Horsley, D., Rickard, J. E., Melis, V., Goatman, E. A., Magbagbeolu, M., Douglas, M., Leith, M. G., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M., Harrington, C. R., Theuring, F.
    Frontiers in Molecular Neuroscience, vol. 10, 447
    Contributions to Journals: Articles

  • Structural studies of (E)-2-(benzylidene)-1- tetralone derivatives: Crystal structures and Hirshfeld surface analysis

    Baddeley, T. C., Gomes, L. R., Low, J. N., Turner, A. B., Wardell, J. L., Watson, G. J.
    Zeitschrift fur Kristallographie - Crystalline Materials, vol. 232, no. 10, pp. 697-718
    Contributions to Journals: Articles

  • In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

    Steven, J., Müller, M. R., Carvalho, M. F., Ubah, O. C., Kovaleva, M., Donohoe, G., Baddeley, T., Cornock, D., Saunders, K., Porter, A. J., Barelle, C. J.
    Frontiers in Immunology, vol. 8, 1361
    Contributions to Journals: Articles

  • Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives

    Nogueira, T. C. M., Pinheiro, A. C., de Souza, M. V. N., Baddeley, T. C., Wardell, J. L., Wardell, S. M. S. V.
    Journal of Molecular Structure, vol. 1128, pp. 579-589
    Contributions to Journals: Articles

  • Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease

    Baddeley, T. C., McCaffrey, J., Storey, J. M. D., Cheung, J. K. S., Melis, V., Horsley, D., Harrington, C. R., Wischik, C. M.
    Journal of Pharmacology and Experimental Therapeutics, vol. 352, no. 1, pp. 110-118
    Contributions to Journals: Articles

  • Tautomers and polymorphs of pyrazolinone derivatives, generated from reactions of arylhydrazines, ArNHNH2, with 1,3-dicarbonyl compounds

    Baddeley, T. C., Howie, R. A., De Lima, G. M., Wardell, J. L., Wardell, S. M.
    Zeitschrift fur Kristallographie, vol. 228, no. 2, pp. 77-91
    Contributions to Journals: Articles

  • New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

    Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M., Wood, B. A.
    Patents: Patents

  • Variation in supramolecular arrangements of hydrazones, o-H2NC6H4CMe=NNHC6H4X (X = H, o-, m- and p-NO2), derived from o-aminoacetophenone and phenylhydrazines

    Howie, R. A., Baddeley, T. C., Wardell, J. L., Wardell, S. M. S. V.
    Journal of Molecular Structure, vol. 1020, pp. 16-22
    Contributions to Journals: Articles

  • 1,3-Diphenyl-4,5-dihydro-1H-pyrazol-5-one

    Baddeley, T., Wardell, S. M. S., Tiekink, E., Wardell, J.
    Acta Crystallographica Section E: Structure Reports Online, vol. E68, pp. o1016-o1017
    Contributions to Journals: Articles

  • 3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents

  • (Pyrazinecarbonyl)hydrazone halobenzaldehydes: Supramolecular arrays generated by face to face stacking of ribbons, formed from C-H-O interactions

    Baddeley, T. C., Alan Howie, R., Da Silva Lima, C. H., Kaiser, C. R., De Souza, M. V., Wardell, J. L., Wardell, S. M.
    Zeitschrift fur Kristallographie, vol. 224, no. 10, pp. 506-514
    Contributions to Journals: Articles

  • 2-Hydroxyacetophenone arylhydrazones. Supramolecular arrangements based on C–H · · · O(H), CH · · · O(NO), N–H · · · O(H), N–H · · · O(NO), C–H · · · π or π · · · π interactions

    Baddeley, T. C., Franca, L. d. S., Howie, R. A., de Lima, G. M., Skakle, J., de Souza, J. D., Wardell, J. L., Wardell, S. M. S. V.
    Zeitschrift für Kristallographie, vol. 224, no. 4, pp. 213-224
    Contributions to Journals: Articles

  • Synthesis of Per- and Poly Substituted Trehalose Derivatives: Studies of Properties Relevant to Their Use as Excipients for Controlled Drug Release

    Baddeley, T. C., Wardell, J. L.
    Journal of Carbohydrate Chemistry, vol. 28, no. 4, pp. 198-221
    Contributions to Journals: Articles

  • Methods of synthesis and/or purification of diaminophenothiazinium compounds

    Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents

  • Studies of distannylated-1,2-dithiolato compounds: Synthesis of 4,5-bis[(triorganostannylmethyl)thiolato]-1,3-dithiole-2-thiones, (R3SnCH2)(2)(dmit), and 4,5-bis[(triorganostannylmethyl)thiolato]-1,3-dithiole-2-ones, (R3SnCH2)(2)(dmio) - Crystal structures of (Ph3SnCH2)(2)(dmit) and (Ph3SnCH2)(2)(dmio)

    Baddeley, T. C., Bordinhão, J., Comerlato, N. M., Cortás, L. d. C., Ferreira, G. B., Howie, R. A., Wardell, J. L.
    Journal of Organometallic Chemistry, vol. 692, no. 25, pp. 5583-5588
    Contributions to Journals: Articles

  • Co-crystallised alpha- and beta-Anomers of 2,3,4,6-Tetra-acetyl-D-glucopyranose, in which the alpha- and beta-Anomers are Randomly Distributed in the Hydrogen-bonded Chains of Molecules

    Baddeley, T. C., Harrison, W. T. A., Howie, R. A., Skakle, J. M. S., Wardell, J. L.
    Journal of Chemical Crystallography, vol. 37, no. 12, pp. 853-858
    Contributions to Journals: Articles

  • A homologous series of eunicellin-based diterpenes from Acalycigorgia sp. characterised by tandem mass spectrometry

    Kyeremeh, K., Baddeley, T., Stein, B. K., Jaspars, M.
    Tetrahedron, vol. 62, pp. 8770-8778
    Contributions to Journals: Articles

  • 1,2,3,4-Tetra-O-acetyl-beta-D-glucopyranuronic acid monohydrate at 120 K and anhydrous 1,2,3,4-tetra-O-acetyl-beta-D-glucopyranose at 292 K

    Baddeley, T. C., Howie, R. A., Skakle, J. M. S., Wardell, J. L.
    Acta Crystallographica Section C, Crystal Structure Communications, vol. 61, no. 12, pp. o711-o714
    Contributions to Journals: Articles

  • Supramolecular structures of substituted a,a'-trehalose derivatives

    Baddeley, T., Wardell, J. L., Skakle, J., Low, J., Glidewell, C., Davidson, I.
    Acta Crystallographica Section B, Structural Science, vol. B60, no. 4, pp. 461-471
    Contributions to Journals: Articles

  • Disordered 2,2 ',3,3 ',4,6,6 '-hepta-O-pivaloyl-alpha,alpha '-trehalose

    Baddeley, T. C., Clow, S. M., Cox, P. J., Davidson, I. G., Murdoch, A. M., Wardell, J. L.
    Acta Crystallographica Section E: Structure Reports Online, vol. 59, pp. 753-755
    Contributions to Journals: Articles

  • Disordered 4,4 '-di-O-isobutyroyl-2,2 ',-3,3 ',6,6 '-hex-O-acetyl-alpha,alpha '-trehalose

    Baddeley, T. C., Clow, S. M., Cox, P. J., Davidson, I. G., Ryder, C., Wardell, J. L.
    Acta Crystallographica Section E: Structure Reports Online, vol. 59, pp. o848-o850
    Contributions to Journals: Articles

  • Ethyl 1,2,3,4-tetra-O-acetyl-beta-D-glucopyranuronate

    Baddeley, T. C., Davidson, I. G., Skakle, J. M. S., Wardell, J. L.
    Journal of Chemical Crystallography, vol. 33, pp. 33-38
    Contributions to Journals: Articles

  • Ditrityl alpha,alpha-trehalose hexaacetate

    Baddeley, T. C., Clow, S. M., Cox, P. J., Davidson, I. G., Howie, R. A., Wardell, J. L.
    Acta Crystallographica Section E: Structure Reports Online, vol. 58, no. 5, pp. o476-o477
    Contributions to Journals: Articles

  • 1,2,3,4-Tetra-O-acetyl-alpha-D-glucopyranuronamide

    Baddeley, T. C., Davidson, I. G., Skakle, J. M. S., Wardell, J. L.
    Acta Crystallographica Section E: Structure Reports Online, vol. 58, no. 4, pp. o447-o449
    Contributions to Journals: Articles

  • alpha,alpha-trehalose octaacetate ethyl acetate solvate

    Baddeley, T. C., Clow, S. M., Cox, P. J., McLaughlin, A. M., Wardell, J. L.
    Acta Crystallographica Section E: Structure Reports Online, vol. 57
    Contributions to Journals: Articles

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