Professor Sam Philip
Professor Sam Philip

Professor Sam Philip

MBBS, MD (Univ Kerala), FRCP (Edinburgh), MD (Univ Aberdeen)

Honorary Professor

About

Grampian Diabetes Research unit, JJR Macleod Centre for Diabetes, Endocrinology and Metabolism, David Anderson Building Aberdeen AB25 2ZP

Biography

Prof Sam Philip graduated from the Mahatma Gandhi University (India). He obtained his postgraduate degree in General (Internal) Medicine from Trivandrum Medical college (M Sivaraman Nair Gold Medal in 1999). Having obtained his MRCP(UK) from the Royal College of Physicians Edinburgh, he started his specialisation in Diabetes and Endocrinology at Aberdeen Royal Infirmary in 2001.

He is currently working as a Consultant Physician in the Department of Diabetes and Endocrinology and as an honorary Professor at the University of Aberdeen. He is the Training programme director for Diabetes and Endocrinology (North). He also heads the Grampian Diabetes Research Unit.

He is the national clinical lead for SCI-Diabetes. He is the current chair of the Scottish Study group for young people with diabetes.  He is the clinical lead (North) for Scottish health research register (SHARE) 

He worked as the clinical research fellow in Biomedical Physics on the automated retinopathy detection project as part of the 'Ophthalmic Imaging Group' led by Dr John Olson and Professor Peter Sharp and obtained an MD from the University of Aberdeen for his research. He won the Diabetes UK Young Diabetologist Award  2006 and Fould’s trophy (annual congress of the Royal College of Ophthalmologists 2005) for his work.

He is leading the development of teleconsultation service for people with diabetes in Orkney and Shetland and use of technology for supporting diabetes care in Grampian and the isles. He has a strong interest in research with clinical application and has won awards for projects on automated retinopathy detection, integrated screening (National Diabetes MCN Professional conference 2007), inpatient diabetes hypoglycaemia management (Service development prize at Diabetes in Scotland conference 2006, 2010), telemedicine consultation (RSM ehealth conference 2010).

Research

Research Overview

Diabetic Retinopathy, Medical Imaging, Telemedicine, Automation  and use of  information technology in health care.

Research Areas

Applied Health Sciences

Computing Science

Biomedical Sciences

Research Specialisms

  • Diagnostic Imaging
  • Databases
  • Health Informatics
  • Endocrinology
  • Diabetes

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

Diabetic retinopathy, Diabetes Telemedicine, Diabetes epidemiology, Information technology for Diabetes care,Functional MRI

Collaborations

Scottish Health Research Register 

Curator : Scottish Diabetes Register for  Young people with Diabetes

Funding and Grants

Research Activity

Academic

Principal investigator Can automated analysis of sequential retinal images of people attending diabetic retinopathy screening predict future referral to Ophthalmology? Funded by Chief Scientist Office, Scotland (£224,520) Dec
2012 to Nov 2015

Co-investigator Patterns of weight changes after diagnosis in patients with Type 2 Diabetes and their relationship with metabolic and cardiovascular outcomes. Funded by chief scientist office (£50,000) June 2012 May 2013

Co-investigator The Relationship between Diabetes and Stroke in an NHS Grampian Stroke Population June 2012 May 2013, NHS Grampian Endowments 3,000 Co -Investigator

Co-investigator CZG/2/536 - The value of automated grading of retinopathy to predict 5-year cardiovascular disease risk in people with diabetes in Scotland Funded by chief scientist office

Co-investigator in a (NHS Health Technology Assessment Programme) Improving the value of screening for diabetic macular oedema using surrogate photographic markers (Project No 06/402/49, January 2008- January 2010, £464,949).

Co-investigator in a Chief Scientist Office funded study- ‘The Role of Automated Level-Two Grading within The Diabetic Retinopathy Screening  Collaborative Network’ (CZH/4/316) £183743. A multi-centre study involving NHS Grampian, NHS Tayside, NHS Lothian, NHS Lanarkshire, NHS Greater Glasgow.

Co-investigator:   Muscle fat compartments and turnover as a determinant of insulin sensitivity: D Dawson (Chief Investigator), M Delibegovic, S Gray, S Philip, P Whitfield, F Thies, G Lobley, British Heart Foundation Project Grant no. PG/15/88/31780, £259,358, 2016-2019

 

Academic trials hosted

Local Principal investigator: Lowering Events in Non-proliferative Retinopathy in Scotland (LENS) NCT03439345

Local Principal investigator: Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial. UKCRN ID 12637, funded by Juvenile Diabetes Research Foundation Limited (JDRF) Diabetes Research & Wellness Foundation (DRWF) 

Local Principal investigator: Genetics of Diabetes Audit and Research in Tayside and Scotland. NCT02712632 Scottish Diabetes Research Network

Local Principal investigator: REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL) NCT01483560 Juvenile Diabetes Research Foundation.

 

Commercial

Principal investigator: A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes (SOUL) Expected date of closing 2024

Principal investigator: A Research Study to See How Semaglutide Works Compared to Placebo in People with Type 2 Diabetes and Chronic Kidney Disease (FLOW) Expected date of closing 2023

Principal investigator: Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus: (Harmony) Expected date of closed 2020

Principal investigator: SAGE-Observational study of glycaemic control & QoL in Type 1 diabetes. Sponsor: Sanofi closed 2019

Principal investigator: Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus NCT01144338, Sponsor: Amylin Pharmaceuticals, LLC.

Principal investigator:A European, Prospective, Controlled, Non-Interventional, Stratified Cluster Randomised Study to Assess the Frequency of Self-Monitoring of Blood Glucose, Quality of Life, and Patient-Reported Outcomes in Subjects with type I or type II Diabetes being Treated with Insulin. Study Number: RD001073 Sponsor Roche Pharmaceuticals

Co-investigator: Liraglutide Effect and Action in Diabetes: Evaluation of
Cardiovascular Outcome Results - A Long Term Evaluation (LEADER®). NCT01179048 Sponsor Novo Nordisk. 

Co-investigator: TECOS: A Randomized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes After Treatment With Sitagliptin in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control NCT00790205. Sponsor:Merck 

 

Teaching

Teaching Responsibilities

2008:  Supervisor for Medical student electives/ Intercalation ( BSc (Hons) in Medical Sciences)

2008:  Supporting Diabetes and Endocrinology undergraduate curriculum

2008: Supporting allied professional and postgraduate education

2008- present: Educational supervision of Registrars/ Specialty trainees 

2014 -2021 :Regional Training Programme Director for Diabetes and Endocrinology (North)

2015 -2018: National training programme director for Diabetes and Endocrinology (Scotland)

2008- 2014: Educational supervision of Foundation trainees 

 

Publications

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  • Flash monitor initiation is associated with improvements in HbA1c levels and DKA rates among people with type 1 diabetes in Scotland: a retrospective nationwide observational study

    Jeyam, A., Gibb, F. W., McKnight, J. A., O’Reilly, J. E., Caparrotta, T. M., Höhn, A., McGurnaghan, S. J., Blackbourn, L. A., Hatam, S., Kennon, B., McCrimmon, R. J., Leese, G., Philip, S., Sattar, N., McKeigue, P. M., Colhoun, H. M., Scottish Diabetes Research Network (SDRN) Epidemiology group
    Diabetologia, vol. 65, no. 1, pp. 159–172
    Contributions to Journals: Articles
  • Foot Ulcer and Risk of LowerLimb Amputation or Death in People With Diabetes: A National Population-Based Retrospective Cohort Study

    Chamberlain, R. C., Fleetwood, K., Wild, S. H., Colhoun, H. M., Lindsay, R. S., Petrie, J. R., McCrimmon, R. J., Gibb, F., Philip, S., Sattar, N., Kennon, B., Leese, G. P.
    Diabetes Care, vol. 45, no. 1, pp. 83-91
    Contributions to Journals: Articles
  • Marked improvements in glycaemic outcomes following insulin pump therapy initiation in people with type 1 diabetes: a nationwide observational study in Scotland

    Jeyam, A., Gibb, F. W., McKnight, J. A., Kennon, B., O'Reilly, J. E., Caparrotta, T. M., Höhn, A., McGurnaghan, S. J., Blackbourn, L. A. K., Hatam, S., McCrimmon, R. J., Leese, G., Lindsay, R. S., Petrie, J., Chalmers, J., Philip, S., Wild, S. H., Sattar, N., McKeigue, P. M., Colhoun, H. M., Scottish Diabetes Research Network (SDRN) Epidemiology group
    Diabetologia, vol. 64, no. 6, pp. 1320-1331
    Contributions to Journals: Articles
  • Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland

    McGurnaghan, S. J., Weir, A., Bishop, J., Kennedy, S., Blackbourn, L. A. K., McAllister, D. A., Hutchinson, S., Caparrotta, T. M., Mellor, J., Jeyam, A., O'Reilly, J. E., Wild, S. H., Hatam, S., Höhn, A., Colombo, M., Robertson, C., Lone, N., Murray, J., Butterly, E., Petrie, J., Kennon, B., McCrimmon, R., Lindsay, R., Pearson, E., Sattar, N., McKnight, J., Philip, S., Collier, A., McMenamin, J., Smith-Palmer, A., Goldberg, D., McKeigue, P. M., Colhoun, H. M., Public Health Scotland COVID-19 Health Protection Study Group, Scottish Diabetes Research Network–Epidemiology Group
    The lancet. Diabetes & endocrinology, vol. 9, no. 2, pp. 82-93
    Contributions to Journals: Articles
  • Prescribing Paradigm Shift?: Applying the 2019 European Society of Cardiology-Led Guidelines on Diabetes, Prediabetes, and Cardiovascular Disease to Assess Eligibility for Sodium-Glucose Cotransporter 2 Inhibitors or Glucagon-Like Peptide 1 Receptor Agonists as First-Line Monotherapy (or Add-on to Metformin Monotherapy) in Type 2 Diabetes in Scotland

    Caparrotta, T. M., Blackbourn, L. A. K., McGurnaghan, S. J., Chalmers, J., Lindsay, R., McCrimmon, R., McKnight, J., Wild, S., Petrie, J. R., Philip, S., McKeigue, P. M., Webb, D. J., Sattar, N., Colhoun, H. M., Scottish Diabetes Research Network–Epidemiology Group
    Diabetes Care, vol. 43, no. 9, pp. 2034-2041
    Contributions to Journals: Articles
  • Real-world user acceptability of the FreeStyle Libre: A pilot study on human factors and technology acceptance

    Gautam, A., Philip, S., MacLeod, M. J., Cadzow, A., Graveling, A. J.
    Diabetic Medicine, vol. 37, no. S1, pp. 106-107
    Contributions to Journals: Abstracts
  • Use of personalised risk-based screening schedules to optimise workload and sojourn time in screening programmes for diabetic retinopathy: A retrospective cohort study

    Ochs, A., McGurnaghan, S., Black, M. W., Leese, G. P., Philip, S., Sattar, N., Styles, C., Wild, S. H., McKeigue, P. M., Colhoun, H. M., Scottish Diabetes Research Network Epidemiology Group and the Diabetic Retinopathy Screening Collaborative
    PLoS Medicine, vol. 16, no. 10, e1002945
    Contributions to Journals: Articles
  • Factors associated with stillbirth in women with diabetes

    Mackin, S. T., Nelson, S. M., Wild, S. H., Colhoun, H. M., Wood, R., Lindsay, R. S., Gribble, S., Abubaker, A., Barnett, A., Fischbacher, C., Pearson, E., Leese, G., Chalmers, J., Mcknight, J., Petrie, J., Sattar, N., Wu, O., McCrimmon, R., Philip, S., Cunningham, S., SDRN Epidemiology Group, Scottish Diabetic Group Pregnancy
    Diabetologia, vol. 62, no. 10, pp. 1938-1947
    Contributions to Journals: Articles
  • Performance of Cardiovascular Disease Risk Scores in People Diagnosed With Type 2 Diabetes: External Validation Using Data From the National Scottish Diabetes Register

    Read, S. H., van Diepen, M., Colhoun, H. M., Halbesma, N., Lindsay, R. S., McKnight, J. A., McAllister, D. A., Pearson, E. R., Petrie, J. R., Philip, S., Sattar, N., Woodward, M., Wild, S. H., Scottish Diabetes Research Network (SDRN) Epidemiology group
    Diabetes Care, vol. 41, no. 9, pp. 2010-2018
    Contributions to Journals: Articles
  • Diabetes and pregnancy: national trends over a 15 year period

    Mackin, S. T., Nelson, S. M., Kerssens, J. J., Wood, R., Wild, S., Colhoun, H. M., Leese, G. P., Philip, S., Lindsay, R. S., SDRN Epidemiology Group
    Diabetologia, vol. 61, no. 5, pp. 1081-1088
    Contributions to Journals: Articles
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