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Dr Renato Coelho Dos Santos

Dr Renato Coelho Dos Santos
Dr Renato Coelho Dos Santos
Dr Renato Coelho Dos Santos

Advanced Research Fellow

About
Email Address
renato.santos@abdn.ac.uk
Telephone Number
+44 (0)1224 438577
Office Address

Liberty Building, Room GD07

Foresterhill Road

AB25 2ZP

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD
Scopus
Google Scholar
Pure

Biography

I obtained the BSc in Biology in 2008, and the Doctorate degree (Cell Biology) in 2014 from the Faculty of Sciences and Technology, University of Coimbra, Portugal. My work was focused on numerous aspects of cellular and, particularly, mitochondrial biology, namely, mitochondrial biogenesis, mitochondrial fission and fusion and also autophagy/mitophagy. The main subject of my work was to understand the relation between diabetes and the propensity do develop dementia, particularly Alzheimer's disease. In 2017, I joined the team of Dr. Charles Harrington at the Institute of Medical Sciences, University of Aberdeen. My research interests include the understanding of neuropathological processes, uncovering of therapeutic targets and study of efficient therapeutic approaches to tackle progression of neurodegenerative diseases.  

Qualifications

  • BSc Biology 
    2008 - University of Coimbra, Portugal 
  • PhD Cell Biology 
    2014 - University of Coimbra, Portugal 

Internal Memberships

03/2023-02/2025: Board Member - School Ethics Review Board (SERB), for the School of Medicine, Medical Sciences and Nutrition

Latest Publications

View My Publications

Research

Research Overview

Neurodegeneration

Alzheimer's disease

Tau protein

Mitochondria

Oxidative Stress

Autophagy/Mitophagy

Therapeutics

Publications

Page 1 of 1 Results 1 to 56 of 56

  • Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain

    Coelho Dos Santos, R., Lee, S. H., Lofthouse, R. A., Melis, V., Strachan, L., Leith, M., Dreesen, E., Armstrong, P., Vorley, T., Goatman, E., Hull, C., Riedel, G., Wischik, C., Harrington, C.
    FEBS Journal, vol. 292, no. 10, pp. 2602-2623
    Contributions to Journals: Articles

  • Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

    Kondak, C., Leith, M., Baddeley, T. C., Santos, R. X., Harrington, C. R., Wischik, C. M., Riedel, G., Klein, J.
    International Journal of Molecular Sciences, vol. 24, no. 13, 10810
    Contributions to Journals: Articles

  • HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

    Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.
    Biomedicines, vol. 10, no. 4, 867
    Contributions to Journals: Articles

  • Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

    Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R., Wischik, C. M.
    Current Alzheimer Research, vol. 17, no. 3, pp. 285-296
    Contributions to Journals: Articles

  • Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

    Candeias, E., Duarte, A. I., Sebastião, I., Fernandes, M. A., Plácido, A. I., Carvalho, C., Correia, S., Santos, R. X., Seiça, R., Santos, M. S., Oliveira, C. R., Moreira, P. I.
    Molecular Neurobiology, vol. 54, no. 8, pp. 6471-6489
    Contributions to Journals: Articles

  • Brain intracellular signaling, oxidative stress and Alzheimer’s disease-related hallmarks upon type 2 diabetes are differentially influenced by gender

    Duarte, A. I., Candeias, E., Sebastião, I., Carvalho, C., Correia, S. C., Plácido, A. I., Coelho Dos Santos, R. X., Fernandes, M. A., Seiça, R., Santos, M. S., Oliveira, C. R., da Silva Moreira, P. I.
    12th International Conference on Alzheimer's and Parkinson's diseases (AD/PD)
    Contributions to Conferences: Posters

  • Gender Influences Type 2 Diabetic-Related Intracellular Brain Signaling and Neurodegeneration Markers

    Duarte, A. I., Candeias, E., Sebastião, I., Plácido, A. I., Coelho Dos Santos, R. X., Carvalho, C., Correia, S. C., Fernandes, M. A., Seiça, R., Santos, M. S., Oliveira, C. R., da Silva Moreira, P. I.
    XIV Meeting of the Portuguese Society for Neuroscience
    Contributions to Conferences: Posters

  • Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

    Santos, R. X., Correia, S. C., Alves, M. G., Oliveira, P. F., Cardoso, S., Carvalho, C., Seiça, R., Santos, M. S., Moreira, P. I.
    Molecular & Cellular Biochemistry, vol. 394, no. 1-2, pp. 13-22
    Contributions to Journals: Articles

  • The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease

    Plácido, A., Pereira, C., Duarte, A., Candeias, E., Correia, S., Santos, R., Carvalho, C., Cardoso, S., Oliveira, C., Moreira, P.
    Biochimica et Biophysica Acta, vol. 1842, no. 9, pp. 1444-1453
    Contributions to Journals: Articles

  • Type 2 diabetic female rat brains are less vulnerable to oxidative stress and AD-related hallmarks: a role for insulin/IGF-1/estrogen signaling?

    Duarte, A. I., Candeias, E., Sebastião, I., Carvalho, C., Correia, S. C., Plácido, A. I., Coelho Dos Santos, R. X., Fernandes, M. A., Seiça, R., Santos, M. S., Oliveira, C. R., da Silva Moreira, P. I.
    9th FENS Forum of Neuroscience
    Contributions to Conferences: Posters

  • Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats.

    Santos, R., Correia, S. C., Alves, M., Oliveira, P., Cardoso, S., Carvalho, C., Duarte, A., Santos, M., Moreira, P.
    Biochimica et Biophysica Acta, vol. 1842, no. 7, pp. 1154-1166
    Contributions to Journals: Articles

  • Role of Mitochondria and Oxidative stress in Parkinson's disease

    Coelho Dos Santos, R. X., Correia, S. C., Cardoso, S., Carvalho, C., Candeias, E., Plácido, A. I., Duarte, A. I., Santos, M. S., da Silva Moreira, P. I.
    Role of Oxidative Stress in Chronic Diseases. Dichi, I., Breganó, J. W., Colado Simão, A. N., Cecchini, R. (eds.). CRC Press, pp. 521-548, 28 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)

  • The Janus Face of Insulin in Brain

    Duarte, A. I., Candeias, E., Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Plácido, A. I., Santos, M. S., Oliveira, C. R., da Silva Moreira, P. I.
    Metabolic Syndrome and Neurological Disorders. Farooqui, T., Farooqui, A. A. (eds.). John Wiley & Sons Ltd., pp. 85-113, 29 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease

    Santos, R. X., Correia, S. C., Zhu, X., Smith, M. A., Moreira, P. I., Castellani, R. J., Nunomura, A., Perry, G.
    Antioxidants & Redox Signaling, vol. 18, no. 18, pp. 2444–2457
    Contributions to Journals: Articles

  • Type 2 diabetic and Alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies.

    Carvalho, C., Machado, N., Mota, P. C., Correia, S. C., Cardoso, S., Santos, R. X., Santos, M. S., Oliveira, C. R., Moreira, P. I.
    Journal of Alzheimer's Disease, vol. 35, no. 3, pp. 623-635
    Contributions to Journals: Articles

  • Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins

    Cardoso, S., Correia, S., Santos, R., Carvalho, C., Candeias, E., Duarte, A., Plácido, A., Santos, M., Moreira, P.
    Current molecular medicine, vol. 13, no. 4, pp. 586-601
    Contributions to Journals: Articles

  • Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease.

    Correia, S. C., Santos, R. X., Santos, M. S., Casadesus, G., LaManna, J. C., Perry, G., Smith, M. A., Moreira, P. I.
    Current Alzheimer Research, vol. 10, no. 4, pp. 406-419
    Contributions to Journals: Articles

  • Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

    Duarte, A. I., Candeias, E., Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Plácido, A., Santos, M. S., Oliveira, C. R., Moreira, P. I.
    Biochimica et Biophysica Acta, vol. 1832, no. 4, pp. 527-541
    Contributions to Journals: Articles

  • Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

    Cardoso, S., Santos, R. X., Correia, S. C., Carvalho, C., Santos, M. S., Baldeiras, I., Oliveira, C. R., Moreira, P. I.
    Neurobiology of Disease, vol. 49, pp. 1-12
    Contributions to Journals: Articles

  • A insulina diminui os níveis de proteína tau fosforilada e modula a dinâmica mitocondrial no cérebro de ratos diabéticos tipo 1

    Coelho Dos Santos, R. X., Correia, S. C., Santos, M. S., da Silva Moreira, P. I.
    Annual Meeting of the Portuguese Society of Diabetology
    Contributions to Conferences: Posters

  • Defective HIF signaling pathway and brain response to hypoxia in neurodegenerative diseases: not an "iffy" question!

    Correia, S. C., Carvalho, C., Cardoso, S., Santos, R. X., Plácido, A. I., Candeias, E., Duarte, A. I., Moreira, P. I.
    Current Pharmaceutical Design, vol. 19, no. 38, pp. 6809-6822
    Contributions to Journals: Articles

  • Effects of type 1 diabetes and insulin therapy on brain mitochondrial dynamics and autophagy

    Coelho Dos Santos, R. X., Correia, S. C., Santos, M. S., da Silva Moreira, P. I.
    XIII Meeting of the Portuguese Society for Neuroscience
    Contributions to Conferences: Posters

  • Tolerância cerebral mediada pelo pré-condicionamento por hipoxia num modelo animal de insulinorresistência central

    Correia, S. C., Santos, R. X., Casadesus, G., Lamanna, J. C., Perry, G., Smith, M. A., da Silva Moreira, P. I.
    Annual Meeting of the Portuguese Society of Diabetology
    Contributions to Conferences: Posters

  • The impairment of insulin signaling in Alzheimer's disease

    Candeias, E., Duarte, A. I., Carvalho, C., Correia, S. C., Cardoso, S., Santos, R. X., Plácido, A. I., Perry, G., Moreira, P. I.
    IUBMB life, vol. 64, no. 12, pp. 951-957
    Contributions to Journals: Review articles

  • Alzheimer disease as a vascular disorder: where do mitochondria fit?

    Correia, S. C., Santos, R. X., Cardoso, S., Carvalho, C., Candeias, E., Duarte, A. I., Plácido, A. I., Santos, M. S., Moreira, P. I.
    Experimental Gerontology, vol. 47, no. 11, pp. 878-886
    Contributions to Journals: Review articles

  • Diabetes disturbs autophagy and mitochondrial dynamics in the brain

    Coelho Dos Santos, R. X., Santos, M. S., Seiça, R., Oliveira, C. R., da Silva Moreira, P. I.
    26th Meeting of the Portuguese group for the study of brain aging and dementia
    Contributions to Conferences: Posters

  • Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities

    Carvalho, C., Cardoso, S., Correia, S. C., Santos, R. X., Santos, M. S., Baldeiras, I., Oliveira, C. R., Moreira, P. I.
    Diabetes, vol. 61, no. 5, pp. 1234-1242
    Contributions to Journals: Articles

  • Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation

    Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Candeias, E., Santos, M. S., Oliveira, C. R., Moreira, P. I.
    Brain Research, vol. 1441, pp. 64-78
    Contributions to Journals: Review articles

  • Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1α

    Correia, S. C., Santos, R. X., Cardoso, S. M., Santos, M. S., Oliveira, C. R., Moreira, P. I.
    Neurobiology of Disease, vol. 45, no. 1, pp. 206-218
    Contributions to Journals: Articles

  • Diabetes unbalances autophagy and mitochondrial dynamics in the brain

    Coelho Dos Santos, R. X., Correia, S. C., Santos, M. S., Seiça, R., Oliveira, C. R., da Silva Moreira, P. I.
    12th FENS Forum
    Contributions to Conferences: Posters

  • Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases

    Correia, S. C., Santos, R. X., Perry, G., Zhu, X., Moreira, P. I., Smith, M. A.
    Advances in Experimental Medicine and Biology, vol. 724, pp. 205-221
    Contributions to Journals: Review articles

  • Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

    Santos, R. X., Correia, S. C., Zhu, X., Lee, H., Petersen, R. B., Nunomura, A., Smith, M. A., Perry, G., Moreira, P. I.
    FREE RADICAL RESEARCH, vol. 46, no. 4, pp. 565-576
    Contributions to Journals: Review articles

  • Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease

    Santos, R. X., Correia, S. C., Cardoso, S., Carvalho, C., Santos, M. S., Moreira, P. I.
    Journal of Neurochemistry, vol. 117, no. 6, pp. 927-936
    Contributions to Journals: Articles

  • Mitophagy in neurodegeneration: an opportunity for therapy?

    Santos, R. X., Correia, S. C., Carvalho, C., Cardoso, S., Santos, M. S., Moreira, P. I.
    Current Drug Targets, vol. 12, no. 6, pp. 790-799
    Contributions to Journals: Articles

  • Hyperglycemia potentiates apoptosis and autophagy in primary cortical neurons

    Coelho Dos Santos, R. X., Santos, M. S., Oliveira, C. R., da Silva Moreira, P. I.
    XII Meeting of the Portuguese Society for Neuroscience
    Contributions to Conferences: Posters

  • Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?

    Correia, S. C., Santos, R. X., Perry, G., Zhu, X., Moreira, P. I., Smith, M. A.
    Ageing Research Reviews, vol. 10, no. 2, pp. 264-273
    Contributions to Journals: Articles

  • Oxidative stress, mitochondria and insulin signaling dysfunction: a redoubtable trio in Alzheimer’s disease pathogenesis

    Correia, S. C., Coelho Dos Santos, R. X., Carvalho, C., Cardoso, S., da Silva Moreira, P. I.
    Dementia. McNamara, P. (ed.). ABC-CLIO Greenwood
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)

  • Association of Mitochondrial Signaling in Alzheimer’s Disease and Hypoxia

    Carvalho, C., Correia, S. C., Coelho Dos Santos, R. X., Cardoso, S., da Silva Moreira, P. I., Zhu, X., Smith, M. A., Perry, G.
    Molecular Aspects of Neurodegeneration and Neuroprotection. Farooqui, A. A., Farooqui, T. (eds.). Bentham Science Publishers B.V., pp. 50-61, 12 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)

  • Diabetes, Mitochondria and brain endothelium dysfunction: a dangerous triad for neurodegeneration?

    Carvalho, C., Correia, S. C., Coelho Dos Santos, R. X., Cardoso, S., Santos, M. S., da Silva Moreira, P. I.
    Mitochondria: Structure, Functions and Dysfunctions. Svensson, O. L. (ed.). Nova Science Publishers Inc, pp. 553-578, 26 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)

  • New Insights into the Mechanisms of Mitochondrial Preconditioning-Triggered Neuroprotection

    Correia, S. C., Cardoso, S., Santos, R. X., Carvalho, C., Santos, M. S., Perry, G., Smith, M. A., Moreira, P. I.
    Current Pharmaceutical Design, vol. 17, no. 31, pp. 3381-3389
    Contributions to Journals: Articles

  • Mitochondrial preconditioning: a potential neuroprotective strategy

    Correia, S. C., Carvalho, C., Cardoso, S., Santos, R. X., Santos, M. S., Oliveira, C. R., Perry, G., Zhu, X., Smith, M. A., Moreira, P. I.
    Frontiers in Genetics, vol. 2, 138
    Contributions to Journals: Articles

  • Mitochondrial reactive oxygen species preconditioning protects brain cells against hyperglycemia

    Correia, S. C., Coelho Dos Santos, R. X., Santos, M. S., Moreira, P. I.
    Alzheimer's Association International Conference on Alzheimer's Disease (ICAD)
    Contributions to Conferences: Posters

  • Autophagy in Alzheimer's disease

    Moreira, P. I., Santos, R. X., Zhu, X., Lee, H., Smith, M. A., Casadesus, G., Perry, G.
    Expert Review Neurotherapeutics, vol. 10, no. 7, pp. 1209-1218
    Contributions to Journals: Articles

  • Effects of Estrogen in the Brain: Is it a Neuroprotective Agent in Alzheimers Disease?

    Correia, S. C., Santos, R. X., Cardoso, S., Carvalho, C., Santos, M. S., Oliveira, C. R., Moreira, P. I.
    Current Aging Science, vol. 3, no. 2, pp. 113-126
    Contributions to Journals: Articles

  • A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease

    Santos, R. X., Correia, S. C., Wang, X., Perry, G., Smith, M. A., Moreira, P. I., Zhu, X.
    Journal of Alzheimer's Disease, vol. 20, no. s2, pp. S401-S412
    Contributions to Journals: Articles

  • Alzheimer's disease: diverse aspects of mitochondrial malfunctioning

    Santos, R. X., Correia, S. C., Wang, X., Perry, G., Smith, M. A., Moreira, P. I., Zhu, X.
    International journal of clinical and experimental pathology, vol. 3, no. 6, pp. 570-581
    Contributions to Journals: Articles

  • Targeting autophagy in the brain: a promising approach?

    Santos, R., Cardoso, S., Correia, S., Carvalho, C., Santos, M., Moreira, P.
    Central nervous system agents in medicinal chemistry, vol. 10, no. 2, pp. 158-168
    Contributions to Journals: Articles

  • Diabetes as a trigger of neurodegeneration: from pathophysiological mechanisms to therapeutic approaches

    Correia, S. C., Carvalho, C., Coelho Dos Santos, R. X., Cardoso, S., Santos, M. S., da Silva Moreira, P. I.
    Advances in Molecular Mechanisms and Pharmacology of Diabetic Complications. Stefek, M. (ed.). Research Signpost, pp. 175-198, 24 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)

  • Mitochondrial Uncoupling Proteins: Therapeutic Targets in Neurodegeneration?

    Cardoso, S., Carvalho, C., Correia, S. C., Coelho Dos Santos, R. X., Santos, M. S., da Silva Moreira, P. I.
    Neurodegeneration: Theory, Disorders and Treatments. McNeill, A. S. (ed.). Nova Science Publishers Inc, pp. 107-124, 18 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)

  • Insulin is a Two-Edged Knife on the Brain

    Cardoso, S., Correia, S., Santos, R. X., Carvalho, C., Santos, M. S., Oliveira, C. R., Perry, G., Smith, M. A., Zhu, X., Moreira, P. I.
    Journal of Alzheimer's Disease, vol. 18, no. 3, pp. 483-507
    Contributions to Journals: Articles

  • Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia

    Carvalho, C., Correia, S. C., Santos, R. X., Cardoso, S., Moreira, P. I., Clark, T. A., Zhu, X., Smith, M. A., Perry, G.
    Journal of bioenergetics and biomembranes, vol. 41, 433
    Contributions to Journals: Articles

  • Food Deprivation Promotes Oxidative Imbalance in Rat Brain

    Santos, R., Cardoso, S., Silva, S., Correia, S., Carvalho, C., Crisóstomo, J., Rodrigues, L., Amaral, C., Louro, T., Matafome, P., Santos, M., Proença, T., Duarte, A., Seiça, R., Moreira, P.
    Journal of Food Science, vol. 74, no. 1, pp. H8-H14
    Contributions to Journals: Articles

  • Doxorubicin: The Good, the Bad and the Ugly Effect

    Carvalho, C., Santos, R., Cardoso, S., Correia, S., Oliveira, P., Santos, M., Moreira, P.
    Current Medicinal Chemistry, vol. 16, no. 25, pp. 3267-3285
    Contributions to Journals: Articles

  • Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage

    Cardoso, S., Santos, R. X., Carvalho, C., Correia, S., Pereira, G. C., Pereira, S. S., Oliveira, P. J., Santos, M. S., Proença, T., Moreira, P. I.
    Free Radical Biology and Medicine, vol. 45, no. 10, pp. 1395-1402
    Contributions to Journals: Articles

  • Doxorubicin increases the susceptibility of brain mitochondria to oxidative stress and permeability transition pore opening

    Cardoso, S., Coelho Dos Santos, R. X., Carvalho, C., Correia, S. C., Pereira, G. C., Pereira, S. S., Oliveira, P. J., Santos, M. S., Proença, T., Seiça, R., Oliveira, C. R., da Silva Moreira, P. I.
    SFRR-E Free Radical Summer School
    Contributions to Conferences: Posters

  • Brain mitochondria as a potential target of doxorubicin action

    Cardoso, S., Coelho Dos Santos, R. X., Carvalho, C., Correia, S. C., Silva, S., Pereira, G. C., Pereira, S. S., Oliveira, P. J., Santos, M. S., Proença, T., Seiça, R., Oliveira, C. R., da Silva Moreira, P. I.
    International Courses on Toxicology 2008
    Contributions to Conferences: Posters

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