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Dr Laurent Trembleau

Dr Laurent Trembleau
Dr Laurent Trembleau
Dr Laurent Trembleau

PhD, Chemical Engineer

Senior Lecturer

About
Email Address
l.trembleau@abdn.ac.uk
Telephone Number
+44 (0)1224 272922
Office Address

Telephone: +44 (0)1224 272922 Address: School of Natural and Computing Sciences University of Aberdeen Meston Building, Room G95 Aberdeen AB24 3UE

School/Department
School of Natural and Computing Sciences

Biography

Laurent Trembleau received his undergraduate education at the "Institut Universitaire de Technologie" of Orléans (France) and obtained a "Diplôme d'Ingénieur" in Fine Chemistry and Engineering, and a "Diplôme d'Etudes Approfondies" (DEA) in Chemistry at the "Institut National des Sciences Appliquées" of Rouen, France (1993). In 1994, he moved to Louvain-la-Neuve (Belgium) to undertake a PhD in the group of Professor Léon Ghosez. His work, financed by Rhône-Poulenc Rorer, involved the development of new Diels-Alder reactions and methods towards the synthesis of ottelione A, a natural product inhibitor of tubulin polymerisation. In 2001, he moved to the Scripps Research Institute (USA) for a 2-year post-doctoral position in the group of Professor Julius Rebek where he designed a water-soluble receptor of acetylcholine, described the helical conformation of alkanes in synthetic receptors, and was involved in the synthesis of oxazole-based macrocycles. In 2004, he did a short post-doctoral position in the group of Dr Simon Webb, where he worked on the synthesis of novel lipids designed to mimic cell adhesion molecules. At the end of 2004, he accepted a Lectureship in Medicinal Chemistry at the University of Aberdeen, where he is currently studying the total synthesis and SAR of bioactive molecules, the development of organic catalysts and novel methods for application in Organic Synthesis and Medicinal Chemistry.

Research

Current Research

1) Methodology

Peptide Synthesis

We are interested in the development of efficient solution and solid-phase syntheses of peptides. We have recently optimized a repetitive procedure that contains features from both solid-phase and solution-phase methods, making it an effective method for the synthesis of short peptides. We are currently modifying resins to improve the synthesis of "difficult peptide sequences".

Supramolecular Chemistry

1) We are investigating the properties of novel organocatalysts that mimic the residues of enzymes involved in catalysis.

2) We are developing new foldamers with the aim to bind anions (especially fluoride) in aqueous media.

2) Medicinal Chemistry

Inhibitors of Protein-Protein Interactions (PPI): This project involves the design and synthesis of inhibitors of protein-protein interactions. We are developing macrocyclic molecules possessing large surface areas in the aim to inhibit specific protein-protein interactions (in collaboration with Prof M. Jaspars, Dr W. Houssen, and Prof J. Naismith).

Funding and Grants

  • European Commission "New Chemical Biology for Tayloring Novel Therapeutics - PDRA (2014-2019) (with Prof Marcel Jaspars and Prof Jim Naismith)
  • Scottish Enterprise "Validation of the Commercial Potential of Diversity-Oriented Biosynthesis to Create Novel Macrocycle Drugs" - (2015-2016) with Prof Marcel Jaspars, Prof Jim Naismith and Dr Wael Houssen.
Teaching

Teaching Responsibilities

Dr Trembleau teaches in the following courses

  • CM1022 Elements of Chemistry 1 (2 lectures)
  • CM2512 Organic and Biological Chemistry (8 lectures)
  • CM3521 Organic and Biological Chemistry (12 lectures)
  • CM4516 Honours/Advanced Chemistry (12 lectures)
  • CM5003 MChem Chemistry Applications (10 lectures)
Publications

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  • Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6+6+6+6]+[5+5] Spiro-Architecture

    Maglangit, F., Wang, S., Moser, A., Kyeremeh, K., Trembleau, L., Zhou, Y., Clark, D. J., Tabudravu, J., Deng, H.
    Journal of Natural Products
    Contributions to Journals: Articles

  • Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents

    Al-Wahaibi, L. H., Mohammed, A. F., Abdelrahman, M. H., Trembleau, L., Youssif, B. G.
    Pharmaceuticals, vol. 16, no. 7, 1039
    Contributions to Journals: Articles

  • Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors

    Al-Wahaibi, L. H., Mohammed, A. F., Abdel Rahman, F. E. Z. S., Abdelrahman, M. H., Gu, X., Trembleau, L., Youssif, B. G.
    Journal of enzyme inhibition and medicinal chemistry, vol. 38, no. 1, 2218602
    Contributions to Journals: Articles

  • Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action

    Mohamed, F. A., Alakilli, S. Y., El Azab, E. F., Baawad, F. A., Shaaban, E. I. A., Alrub, H. A., Hendawy, O., Gomaa, H. A., Bakr, A. G., Abdelrahman, M. H., Trembleau, L., Mohammed, A. F., Youssif, B. G.
    RSC Medicinal Chemistry, vol. 14, no. 4, pp. 734-744
    Contributions to Journals: Articles

  • Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways

    Al-Wahaibi, L. H., Mohammed, A. F., Abdelrahman, M. H., Trembleau, L., Youssif, B. G.
    Molecules, vol. 28, no. 3, 1269
    Contributions to Journals: Articles

  • A ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motif

    Wang, S., Lin, S., Fang, Q., Gyampoh, R., Lu, Z., Gao, Y., Clarke, D. J., Wu, K., Trembleau, L., Yu, Y., Kyeremeh, K., Milne, B. F., Tabudravu, J., Deng, H.
    Nature Communications, vol. 13, no. 1, 5044
    Contributions to Journals: Articles

  • Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors

    Al-Wahaibi, L. H., Mostafa, Y. A., Abdelrahman, M. H., El-Bahrawy, A. H., Trembleau, L., Youssif, B. G.
    Pharmaceuticals, vol. 15, no. 8, 1006
    Contributions to Journals: Articles

  • Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities

    Gomaa, H. A., Shaker, M. E., Alzarea, S. I., Hendawy, O. M., Mohamed, F. A., Gouda, A. M., Ali, A. T., Morcoss, M. M., Abdelrahman, M. H., Trembleau, L., Youssif, B. G.
    Bioorganic Chemistry, vol. 120, 105616
    Contributions to Journals: Articles

  • Characterization of a class II ketol-acid reductoisomerase from Mycobacterium tuberculosis

    Valera, A., Wang, S., Carr, R., Trembleau, L., Deng, H.
    RSC Advances, vol. 12, no. 17, pp. 10540-10544
    Contributions to Journals: Articles

  • Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease

    Al-Wahaibi, L. H., Mostafa, A., Mostafa, Y. A., Abou-Ghadir, O. F., Abdelazeem, A. H., Gouda, A. M., Kutkat, O., Abo Shama, N. M., Shehata, M., Gomaa, H. A., Abdelrahman, M. H., Mohamed, F. A., Gu, X., Ali, M. A., Trembleau, L., Youssif, B. G.
    Bioorganic Chemistry, vol. 116, 105363
    Contributions to Journals: Articles

  • Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects

    Hendawy, O. M., Gomaa, H. A., Alzarea, S. I., Alshammari, M. S., Mohamed, F. A., Mostafa, Y. A., Abdelazeem, A. H., Abdelrahman, M. H., Trembleau, L., Youssif, B. G.
    Bioorganic Chemistry, vol. 116, 105302
    Contributions to Journals: Articles

  • Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity

    Mohamed, F. A., Gomaa, H. A., Hendawy, O., Ali, A. T., Farghaly, H. S., Gouda, A. M., Abdelazeem, A. H., Abdelrahman, M. H., Trembleau, L., Youssif, B. G.
    Bioorganic Chemistry, vol. 112, 104960
    Contributions to Journals: Articles

  • Discovery and biosynthetic investigation of a new antibacterial dehydrated non‐ribosomal tripeptide

    Wang, S., Fang, Q., Lu, Z., Gao, Y., Trembleau, L., Ebel, R., Andersen, J. H., Philips, C., Law, S., Deng, H.
    Angewandte Chemie International Edition, vol. 60, no. 6, pp. 3229-3237
    Contributions to Journals: Articles

  • A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models

    Mielnik, C. A., Sugamori, K. S., Finlay, D. B., Thorpe, H. H. A., Schapira, M., Sivananthan, N., Li, C. K., lam, V. M., Harrington, S., Abdelrahman, M. H., Trembleau, L. A., Burnham, W. M., Khokhar, J. Y., Salahpour, A., Ramsey, A. J., Glass, M., Greig, I. R., Ross, R. A.
    Neuropsychopharmacology, vol. 46, no. 2, pp. 413-422
    Contributions to Journals: Articles

  • Productive Syntheses of Privileged Scaffolds Inspired by the Recognition of a Diels–Alder Pattern Common to Three Classes of Natural Products

    Badarau, E., Reddy, K. H. V., Loudet, A., Simon, C., Trembleau, L., Claerhout, S., Pair, E., Massip, S., Breton, P., Lesur, B., Goldstein, S., Fourquez, J. M., Henlin, J. M., Ghosez, L.
    Chemistry - A European Journal, vol. 26, no. 67, pp. 15477-15481
    Contributions to Journals: Articles

  • Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors

    Al-Wahaibi, L. H., Gouda, A. M., Abou-Ghadir, O. F., Salem, O. I., Ali, A. T., Farghaly, H. S., Abdelrahman, M. H., Trembleau, L., Abdu-Allah, H. H., Youssif, B. G.
    Bioorganic Chemistry, vol. 104, 104260
    Contributions to Journals: Articles

  • A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms

    Schaefer, K., Dambuza, I. M., Dall'angelo, S., Trembleau, L., Zanda, M., Brown, G. D., Netea, M. G., Gow, N. A. R.
    Microorganisms, vol. 8, no. 7, 1066
    Contributions to Journals: Articles

  • Characterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis

    Maglangit, F., Alrashdi, S., Renault, J., Trembleau, L., Victoria, C., Tong, M. H., Wang, S., Kyeremeh, K., Deng, H.
    Organic & Biomolecular Chemistry, vol. 18, no. 12, pp. 2219-2222
    Contributions to Journals: Articles

  • Structure‐based design, synthesis and bioactivity of a new anti‐TNFα cyclopeptide

    Idress, M., Milne, B. F., Thompson, G. S., Trembleau, L., Jaspars, M., Houssen, W. E.
    Molecules, vol. 25, no. 4, 922
    Contributions to Journals: Articles

  • Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A

    Liu, Y., Su, L., Fang, Q., Tabudravu, J., Yang, X., Rickaby, K., Trembleau, L., Kyeremeh, K., Deng, Z., Deng, H., Yu, Y.
    Journal of Organic Chemistry, vol. 84, no. 24, pp. 16323-16328
    Contributions to Journals: Articles

  • Physicochemical Tools: Toward a Detailed Understanding of the Architecture of Targeted Radiotherapy Nanoparticles

    Cabello, G., Nwoko, K. C., Mingarelli, M., McLaughlin, A. C., Trembleau, L., Feldmann, J., Cuesta Ciscar, A., Smith, T. A. D.
    ACS Applied Bio Materials, vol. 1, no. 5, pp. 1639-1646
    Contributions to Journals: Articles

  • Cyclic Peptides – A Look to the Future

    Idress, M., Alexandru-Crivac, C. N., Jaspars, M., Trembleau, L. A. C., Houssen Ibrahim, W. E. M., Rickaby, K. A., Dalponte, L.
    Cyclic Peptides: From Bioorganic Synthesis to Applications. Koehnke, J., Naismith, J., van der Donk, W. A. (eds.). Royal Society of Chemistry (Great Britain), pp. 340-373, 34 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

    Alexandru-Crivac, C. N., Umeobika, C., Leikoski, N., Jokela, J., Rickaby, K. A., Grilo, A. M., Sjö, P., Plowright, A. T., Idress, M., Siebs, E., Nneoyi-Egbe, A., Wahlsten, M., Sivonen, K., Jaspars, M., Trembleau, L., Fewer, D. P., Houssen, W. E.
    Chemical Communications, vol. 53, no. 77, pp. 10656-10659
    Contributions to Journals: Articles

  • A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize

    Booth, J., Alexandru-Crivac, C., Rickaby, K. A., Nneoyiegbe, A. F., Umeobika, U., McEwan, A. R., Trembleau, L., Jaspars, M., Houssen, W. E., Shalashilin, D. V.
    The Journal of Physical Chemistry Letters, vol. 8, no. 10, pp. 2310-2315
    Contributions to Journals: Articles

  • Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

    Greig, I. R., Baillie, G. L., Abdelrahman, M. H., Trembleau, L., Ross, R. A.
    Bioorganic & Medicinal Chemistry Letters, vol. 26, no. 18, pp. 4403-4407
    Contributions to Journals: Articles

  • Weak interactions in the crystal structures of two indole derivatives

    Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L., Harrison, W. T. A.
    Acta Crystallographica Section E: Crystallographic Communications, vol. 72, no. 7, pp. 964-968
    Contributions to Journals: Articles

  • Different N—H···π interactions in two indole derivatives

    Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L., Harrison, W. T. A.
    Acta Crystallographica Section E: Crystallographic Communications, vol. 72, no. 5, pp. 699-703
    Contributions to Journals: Articles

  • A Unique Tryptophan C‐Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

    Parajuli, A., Kwak, D. H., Dalponte, L., Leikoski, N., Galica, T., Umeobika, U., Trembleau, L., Bent, A., Sivonen, K., Wahlsten, M., Wang, H., Rizzi, E., De Bellis, G., Naismith, J., Jaspars, M., Liu, X., Houssen, W., Fewer, D. P.
    Angewandte Chemie International Edition, vol. 55, no. 11, pp. 3596-3599
    Contributions to Journals: Articles

  • Crystal structures of four indole derivatives with a phenyl substituent at the 2-position and a carbonyl group at the 3-position: the C(6) N-H⋯O chain remains the same, but the weak reinforcing inter-actions are different

    Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L., Harrison, W. T. A.
    Acta Crystallographica Section E: Crystallographic Communications, vol. 72, no. 3, pp. 363-369
    Contributions to Journals: Articles

  • Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins

    Huang, S., Tabudravu, J., Elsayed, S. S., Travert, J., Peace, D., Tong, M. H., Kyeremeh, K., Kelly, S. M., Trembleau, L., Ebel, R., Jaspars, M., Yu, Y., Deng, H.
    Angewandte Chemie International Edition, vol. 54, no. 43, pp. 12697-12701
    Contributions to Journals: Articles

  • Crystal structures of four indole derivatives as possible cannabinoid allosteric antagonists

    Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 71, no. 6, pp. 654-659
    Contributions to Journals: Articles

  • In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

    Gamage, T. F., Ignatowska-Jankowska, B. M., Wiley, J. L., Abdelrahman, M., Trembleau, L., Greig, I. R., Thakur, G. A., Tichkule, R., Poklis, J., Ross, R. A., Pertwee, R. G., Lichtman, A. H.
    Behavioural Pharmacology, vol. 25, no. 2, pp. 182-185
    Contributions to Journals: Articles

  • Isolation and Synthesis of Pulmonarins A and B, Acetylcholinesterase Inhibitors from the Colonial Ascidian Synoicum pulmonaria

    Tadesse, M., Svenson, J., Sepicic, K., Trembleau, L., Engqvist, M., Andersen, J. H., Jaspars, M., Stensvag, K., Haug, T.
    Journal of Natural Products, vol. 77, no. 2, pp. 364-369
    Contributions to Journals: Articles

  • Receptor conformational change induces fluoride binding despite competitive water binding

    Trembleau, L., Smith, T. A. D., Abdelrahman, M. H.
    Chemical Communications, vol. 49, no. 52, pp. 5850-5852
    Contributions to Journals: Articles

  • The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

    Houssen, W. E., Koehnke, J., Bent, A., Zollman, D., Morawitz, F., Shirran, S., Vendome, J., Nneoyiegbe, A. F., Trembleau, L., Botting, C. H., Smith, M. C. M., Jaspars, M., Naismith, J. H.
    Nature Structural & Molecular Biology, vol. 19, no. 8, pp. 767-772
    Contributions to Journals: Articles

  • Development of 18F-fluorinatable dendrons and their application to cancer cell targeting

    Trembleau, L., Simpson, M., Cheyne, R. W., Escofet, I., Appleyard, M. V. C. L., Murray, K., Sharp, S., Thompson, A. M., Smith, T. A. D.
    New Journal of Chemistry, vol. 35, no. 11, pp. 2496-2502
    Contributions to Journals: Articles

  • 18F-PEG-biotin: Precursor (boroaryl-PEG-biotin) synthesis, 18F-labelling and an in-vitro assessment of its binding to NeutravidinTM -trastuzumab pre-treated cells

    Smith, T. A. D., Simpson, M., Cheyne, R. W., Trembleau, L. A. C.
    Applied Radiation and Isotopes, vol. 69, no. 10, pp. 1395-1400
    Contributions to Journals: Articles

  • Changes in 2-fluoro-2-deoxy-D-glucose incorporation, hexokinase activity and lactate production by breast cancer cells responding to treatment with the anti-HER-2 antibody trastuzumab

    Cheyne, R. W., Trembleau, L. A. C., McLaughlin, A., Smith, T. A. D.
    Nuclear Medicine and Biology, vol. 38, no. 3, pp. 339-346
    Contributions to Journals: Articles

  • N-(ARYLALKYL)-1H-INDOLE-2-SULFONIC ACID AMIDE COMPOUNDS AND THEIR THERAPEUTIC USE AS CANNABINOID ALLOSTERIC MODULATORS

    Greig, I. R., Ross, R. A., Trembleau, L. A. C., Pertwee, R. G., Abdelrahman, M. H.
    Patents: Patents

  • One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: Synthesis and radio-labelling of a PEGylated precursor

    Simpson, M., Trembleau, L. A. C., Cheyne, R. W., Smith, T. A. D.
    Applied Radiation and Isotopes, vol. 69, no. 2, pp. 418-422
    Contributions to Journals: Articles

  • Synthesis and characterisation of biologically compatible TiO2 nanoparticles

    Cheyne, R. W., Smith, T. A. D., Trembleau, L. A. C., McLaughlin, A.
    Nanoscale Research Letters, vol. 6, no. -, 423
    Contributions to Journals: Articles

  • Materials and methods for medical imaging

    Smith, T. A. D., Trembleau, L. A. C., McLaughlin, A., Simpson, M.
    Patents: Patents

  • Multigram-scale synthesis of short peptides via a simplified repetitive solution-phase procedure

    Meneses, C., Nicoll, S. L., Trembleau, L. A. C.
    Journal of Organic Chemistry, vol. 75, no. 3, pp. 564-569
    Contributions to Journals: Articles

  • 5-chloro-3-ethyl-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide

    Muirhead, K. E. A., Trembleau, L., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 8, o3389
    Contributions to Journals: Articles

  • 5-Chloro-3-ethyl-N-[3-(morpholin-4-yl)propyl]-1H-indole-2-carboxamide

    Muirhead, K. E. A., Trembleau, L., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 8, o3390
    Contributions to Journals: Articles

  • Lipid fluorination enables phase separation from fluid phospholipid bilayers

    Webb, S. J., Greenway, K., Bayati, M., Trembleau, L. A. C.
    Organic & Biomolecular Chemistry, vol. 4, pp. 2399-2407
    Contributions to Journals: Articles

  • Galanin Agonists

    Bartfai, T., Conde Ceide, S., Haberhauer, G., Laszlo, S., Rebek, J. J., Trembleau, L. A. C.
    Patents: Patents

  • Membrane Composition Determines the Fate of Aggregated Vesicles

    Webb, S. J., Wang, X., Mart, R. J., Trembleau, L. A. C.
    Organic & Biomolecular Chemistry, vol. 3, pp. 3615-3617
    Contributions to Journals: Articles

  • Galmic, a nonpeptide galanin receptor agonist, affects behaviours in seizure, pain, and forced-swim tests

    Barfai, T., lu, X., Badie-Mahdavi, H., Barr, A. M., Mazarati, A., Hua, X. Y., Yaksh, T., Haberhauser, G., Ceide, S. C., Trembleau, L. A. C., Somogyi, L., Krock, L., Rebek Jnr, J.
    PNAS, vol. 101, pp. 10470-10475
    Contributions to Journals: Articles

  • Helical Folding of Alkanes in a Self-Assembled, Cylindrical Capsule

    Scarso, A., Trembleau, L. A. C., Rebek Jnr, J.
    Journal of the American Chemical Society, vol. 126, pp. 13512-13518
    Contributions to Journals: Articles

  • Interactions Between a Surfactant and Cavitand: Blur Distinctions Between Host and Guest

    Trembleau, L. A. C., Rebek Jnr, J.
    Chemical Communications, vol. 1, pp. 58-59
    Contributions to Journals: Articles

  • Kinetically Stable Complexes in Water: The Role of Hydration and Hydrophobicity

    Biros, S. M., Ullrich, E. C., Hof, F., Trembleau, L. A. C., Rebek Jnr, J.
    Journal of the American Chemical Society, vol. 126, pp. 2870-2876
    Contributions to Journals: Articles

  • Synthesis of galmic: A nonpeptide galanin receptor agonist

    Ceide, S. C., Trembleau, L. A. C., Haberhauer, G., Somogyi, L., Bartfai, T., Rebek Jnr, J.
    PNAS, vol. 101, no. 48, pp. 16727-16732
    Contributions to Journals: Articles

  • Acetylcholine Recognition by a Deep, Biomimetic Pocket

    Hof, F., Trembleau, L. A. C., Ulrich, E., Rebek Jnr, J.
    Angewandte Chemie International Edition, vol. 42, pp. 3150-3153
    Contributions to Journals: Articles

  • Encapsulation Induces Helical Folding of Alkanes

    Scarso, A., Trembleau, L. A. C., Rebek Jnr, J.
    Angewandte Chemie International Edition, vol. 42, pp. 5499-5502
    Contributions to Journals: Articles

  • Helical Conformation of Alkanes in a Hydrophobic Cavitand

    Trembleau, L. A. C., Rebek Jnr, J.
    Science, vol. 301, pp. 1219-1220
    Contributions to Journals: Articles

  • Crystal structure of (3R*,3aR*,4S*,7S*,7aR*)-4-(tert-butyldimethyl silyloxy)-4,7-epoxy-3-methoxy-7-methyloctahydro-1H-inden-1-one, C17H30O4Si

    Tinant, B., Trembleau, L. A. C., Ghosez, L.
    Zeitschrift für Kristallographie, vol. 215, no. 2, pp. 261-262
    Contributions to Journals: Articles

  • Diels-Alder reactions of activated furans to cyclopentenone derivatives: A regiodivergent Diels-Alder approach towards polyfunctionalised cis-hydrindanones

    Trembleau, L. A. C., Patiny, L., Ghosez, L.
    Tetrahedron Letters, vol. 41, no. 33, pp. 6377-6381
    Contributions to Journals: Articles

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