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Dr Lynda Constable

Dr Lynda Constable
Dr Lynda Constable
Dr Lynda Constable

BSc (Hons), PhD

Senior Trial Manager

About
Email Address
l.constable@abdn.ac.uk
School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I am a Senior Trials Manager working across the portfolio of clinical trials at the Centre for Healthcare Randomised Trials (CHaRT) clinical trials unit (CTU) within the Aberdeen Centre for Evaluation (ACE, formerly Health Services Research Unit (HSRU)). 

I have worked as the lead trial manager on the CHESS, PIP, DIAMOND, CATHETER II, VUE, MASTER and ASICA trials.

I graduated with a BSc in Biosciences and Chemistry and a PhD in Cancer cell and Molecular biology. Prior to joining the unit, I worked as a Research Fellow at Aberdeen University on a range of projects with an emphasis on cancer biomarkers.

External Memberships

Member of the Executive Committee of the UK Trial Managers Network (UKTMN)

Member of the Education Committee for the Society for Clinical Trials (2013 - 2020)

Chair of the Education Committee for the Society for Clinical Trials (2018-2019)

Co-Chair of the Education Committee for the Society for Clinical Trials (2017-2018)

Chair of the Webinar Committee for the Society for Clinical Trials (2017-2018)

Member of the Board of Directors for the Society for Clinical Trials (2016)

Latest Publications

  • Supporting the professional development of trial managers: how can you help?

    Mitchell, E. J., Arundel, C., Babalis, D., Connolly, S., Constable, L., Goodman, K., Stylianou, L., Taylor, J., Wakefield, N., Williams, S., Wolstenhulme, F.
    Trials, vol. 26, no. 1, 436
    Contributions to Journals: Articles

  • Protocol for a feasibility randomized control trial of the Supporting Toddlers with a connection to autism or ADHD to develop Strong Attention, Regulation, and Thinking skills (START) programme

    Hendry, A., Nosyk, M., Hulks, V., Hudson, J., Constable, L., Charman, T., Mathers, S., Rhodes, S., Scerif, G.
    Pilot and Feasibility Studies, vol. 11, no. 1, 122
    Contributions to Journals: Articles

  • CATHETER II, a Randomised Controlled Trial Comparing the Clinical and Cost Effectiveness of Various Washout Policies versus No Washout Policy in Preventing Catheter Associated Complications in Adults Living with Long Term Catheters

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Catheter II Team
    45th Congress of the Société Internationale d'Urologie
    Contributions to Conferences: Posters

  • Patients and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial

    Tripathee, S., Abdel-Fattah, M., Johnson, D., Constable, L., Cotton, S., Cooper, D., MacLennan, G., Evans, S., Young, A. J., Dimitropoulos, K., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., Murchie, P., Myint, P. K., N'Dow, J., Paterson, C., Powell, K., Scotland, G., Thiruchelvam, N., Norrie, J., Omar, M. I., MacLennan, S.
    BMJ Open, vol. 15, no. 4, e087206
    Contributions to Journals: Articles

  • CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Catheter II Team
    European Association of Urology Annual Congress 2025, pp. A0090
    Contributions to Conferences: Abstracts

View My Publications

Research

Research Overview

Clinical trials methodology

Clinical trial management

Research Areas

Applied Health Sciences

View Research Area

Current Research

VUE Trial: Vault or Uterine prolapse surgery evaluation: Two parallel randomised controlled trials of surgical options for upper compartment (vault or uterine) pelvic organ prolapse.

MASTER Trial: investigating the surgical treatment of male stress incontinence after prostate surgery.

ASICA: Achieving Self-Directed Integrated Cancer Aftercare (ASICA) in melanoma: A randomised patient-focused trial of delivering the ASICA intervention as a means to earlier detection of recurrent and second primary melanoma

CATHETER II Trial: evaluating the effect of weekly saline or acidic prophylactic catheter washout policies with standard care on catheter related complications.

Teaching

Teaching Responsibilities

I have supervised a number of BSc and MSc student research projects, including topics such as understanding patient's decision making to participate in clinical trials; rapid introduction of new cancer therapies; personalised cancer therapies; and investigation of the mode of action novel cancer therapeutics.

Publications

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  • Supporting the professional development of trial managers: how can you help?

    Mitchell, E. J., Arundel, C., Babalis, D., Connolly, S., Constable, L., Goodman, K., Stylianou, L., Taylor, J., Wakefield, N., Williams, S., Wolstenhulme, F.
    Trials, vol. 26, no. 1, 436
    Contributions to Journals: Articles

  • Protocol for a feasibility randomized control trial of the Supporting Toddlers with a connection to autism or ADHD to develop Strong Attention, Regulation, and Thinking skills (START) programme

    Hendry, A., Nosyk, M., Hulks, V., Hudson, J., Constable, L., Charman, T., Mathers, S., Rhodes, S., Scerif, G.
    Pilot and Feasibility Studies, vol. 11, no. 1, 122
    Contributions to Journals: Articles

  • CATHETER II, a Randomised Controlled Trial Comparing the Clinical and Cost Effectiveness of Various Washout Policies versus No Washout Policy in Preventing Catheter Associated Complications in Adults Living with Long Term Catheters

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Catheter II Team
    45th Congress of the Société Internationale d'Urologie
    Contributions to Conferences: Posters

  • Patients and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial

    Tripathee, S., Abdel-Fattah, M., Johnson, D., Constable, L., Cotton, S., Cooper, D., MacLennan, G., Evans, S., Young, A. J., Dimitropoulos, K., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., Murchie, P., Myint, P. K., N'Dow, J., Paterson, C., Powell, K., Scotland, G., Thiruchelvam, N., Norrie, J., Omar, M. I., MacLennan, S.
    BMJ Open, vol. 15, no. 4, e087206
    Contributions to Journals: Articles

  • CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Catheter II Team
    European Association of Urology Annual Congress 2025, pp. A0090
    Contributions to Conferences: Abstracts

  • CATHETER II: a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Dimitropoulos, K., Evans, S., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., Murchie, P., Myint, P. K., N'Dow, J., Paterson, C., Powell, K., Scotland, G., Thiruchelvam, N., Young, A., Cotton, S., Norrie, J., MacLennan, G.
    BMJ Open, vol. 14, no. 12, e087203
    Contributions to Journals: Articles

  • RCT comparing the clinical and cost effectiveness of various catheter washout policies

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
    RCOG World Congress 2024, MTeP-42
    Contributions to Journals: Abstracts

  • CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
    The International Continence Society, 101602
    Contributions to Journals: Abstracts

  • Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G.
    RCOG World Congress 2024, pp. 171
    Contributions to Journals: Abstracts

  • Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial

    Tripathee, S., Abdel-Fattah, M., Johnson, D., Constable, L., Cotton, S., MacLennan, G., Norrie, J., Omar, M. I., MacLennan, S.
    The International Continence Society
    Contributions to Conferences: Posters

  • Male sling is as good as more complex surgery for incontinence after prostate surgery

    Saul, H., Deeney, B., Cassidy, S., Kwint, J., Constable, L., Abrams, P.
    BMJ (Clinical research ed.), vol. 381, pp. 1179
    Contributions to Journals: Articles

  • User Experiences of a Digital Intervention to Support Total-Skin-Self-Examination by Melanoma Survivors: Nested Qualitative Evaluation Embedded in a Randomized Controlled Trial

    Reilly, F., Wani, N., Hall, S., Morgan, H. M., Allan, J., Constable, L., Ntessalen, M., Murchie, P.
    JMIR Dermatology, vol. 6, e39544
    Contributions to Journals: Articles

  • Randomised controlled trial comparing the clinical and cost-effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long-term catheters: study protocol for the CATHETER II study

    Abdel-fattah, M., Johnson, D., Constable, L., Thomas, R., Cotton, S., Tripathee, S., Cooper, D., Boran, S., Dimitropoulos, K., Evans, S., Granitsiotis, P., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., MacLennan, S., Murchie, P., Myint, P., N’Dow, J., Norrie, J., Omar, M. I., Paterson, C., Scotland, G., Thiruchelvam, N., MacLennan, G.
    Trials, vol. 23, no. 1, 630
    Contributions to Journals: Articles

  • The Achieving Self-directed Integrated Cancer Aftercare Intervention for Detection of Recurrent and Second Primary Melanoma in Survivors of Melanoma: Pilot Randomized Controlled Trial

    Murchie, P., Constable, L., Hall, S., Brant, W., Allan, J., Johnston, M., Masthoff, J., Lee, A., Treweek, S., Ayansina, D., Proby, C., Rahman, K., Walter, F., Burrows, N., Durrani, A., Maclennan, G.
    JMIR cancer, vol. 8, no. 3, e37539
    Contributions to Journals: Articles

  • Synthetic sling or artificial urinary sphincter for men with urodynamic stress incontinence after prostate surgery: the MASTER non-inferiority RCT

    Constable, L., Abrams, P., Cooper, D., Kilonzo, M., Cotterill, N., Harding, C. K., Drake, M. J., Pardoe, M. N., McDonald, A., Smith, R., Norrie, J., McCormack, K., Ramsay, C., Uren, A., Mundy, T., Glazener, C., MacLennan, G.
    Health Technology Assessment, vol. 26, no. 36, 184
    Contributions to Journals: Articles

  • Achieving Integrated Self-Directed Cancer Aftercare (ASICA) for melanoma: How a digital intervention to support total skin self-examination was used by people treated for cutaneous melanoma

    Reilly, F., Constable, L., Brant, W., Rahman, K., Durrani, A., Burrows, N., Proby, C., Allan, J., Johnston, M., Johnston, D., Walter, F., Murchie, P.
    BMC Cancer, vol. 21, 1217
    Contributions to Journals: Articles

  • Outcomes of a non-inferiority randomised controlled trial of surgery for men with urodynamic stress incontinence after prostate surgery (MASTER)

    Abrams, P., Constable, L., Cooper, D., MacLennan, G., Drake, M. J., Harding, C., Mundy, A., McCormack, K., McDonald, A., Norrie, J., Ramsay, C., Smith, R., Cotterill, N., Kilonzo, M., Glazener, C., MASTER trial team
    European Urology, vol. 79, no. 6, pp. 812-823
    Contributions to Journals: Articles

  • Providing trial results to participants in Phase III pragmatic effectiveness RCTs: a scoping review

    Bruhn, H., Cowan, E., Campbell, M., Constable, L., Cotton, S., Entwistle, V., Humphreys, R., Innes, K., Jayacodi, S., Jayacodi, S., Knapp, P., South, A., Gillies, K.
    Trials, vol. 22, 361
    Contributions to Journals: Articles

  • It is unprecedented: trial management during the COVID-19 pandemic and beyond

    Mitchell, E. J., Ahmed, K., Breeman, S., Cotton, S., Constable, L., Ferry, G., Goodman, K., Hickey, H., Meakin, G., Mironov, K., Quann, N., Wakefield, N., McDonald, A.
    Trials, vol. 21, pp. 784
    Contributions to Journals: Articles

  • How to Deal with a Temporary Suspension and Restarting Your Trial: Our Experiences and lessons Learnt

    Constable, L., Davidson, T., Breeman, S., Cotton, S., McDonald, A., Wileman, S., Norrie, J.
    Trials, vol. 21, no. 1, pp. 765
    Contributions to Journals: Articles

  • Using systematic data categorisation to quantify the types of data collected in clinical trials: the DataCat project

    Crowley, E., Treweek, S., Banister, K., Breeman, S., Constable, L., Cotton, S., Duncan, A., El Feky, A., Gardner, H., Goodman, K., Lanz, D., McDonald, A., Ogburn, E., Starr, K., Stevens, N., Valente, M., Fernie, G.
    Trials, vol. 21, no. 1, pp. 535
    Contributions to Journals: Articles

  • Verifying participant-reported clinical outcomes: challenges and implications

    Breeman, S., Constable, L., Duncan, A., Starr, K., McDonald, A., Wileman, S., Cotton, S.
    Trials, vol. 21, no. 1, pp. 241
    Contributions to Journals: Articles

  • Surgical interventions for uterine prolapse and for vault prolapse: the two VUE RCTs

    Hemming, C., Constable, L., Goulao, B., Kilonzo, M., Boyers, D., Elders, A., Cooper, K., Smith, A., Freeman, R. M., Breeman, S., McDonald, A., Hagen, S., Montgomery, I., Norrie, J., Glazener, C.
    Health Technology Assessment, vol. 24, no. 13, pp. vii-xxxi, 1-220
    Contributions to Journals: Articles

  • Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells

    Bestwick, C. S., Milne, L., Dance, A. M., Cochennec, G., Cruickshank, G., Allain, E., Constable, L., Duthie, S. J., Thoo Lin, P. K.
    Toxicology in Vitro, vol. 52, pp. 342-350
    Contributions to Journals: Articles

  • Male synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): Study protocol for a randomised controlled trial

    Constable, L., Cotterill, N., Cooper, D., Glazener, C., Drake, M. J., Forrest, M., Harding, C., Kilonzo, M., MacLennan, G., McCormack, K., McDonald, A., Mundy, A., Norrie, J., Pickard, R., Ramsay, C., Smith, R., Wileman, S., Abrams, P., The MASTER Study Group
    Trials, vol. 19, pp. 1-17
    Contributions to Journals: Articles

  • Two parallel, pragmatic, UK multicentre, randomised controlled trials comparing surgical options for upper compartment (vault or uterine) pelvic organ prolapse (the VUE Study): study protocol for a randomised controlled trial

    Glazener, C., Constable, L., Hemming, C., Breeman, S., Elders, A., Cooper, K., Freeman, R., Smith, A. R. B., Hagen, S., McDonald, A., McPherson, G., Montgomery, I., Kilonzo, M., Boyers, D., Goulao, B., Norrie, J.
    Trials, vol. 17, pp. 1-18
    Contributions to Journals: Articles

  • How effective is mesh in pelvic organ prolapse surgery? An updated systematic review of randomised controlled trials

    Stewart, F., Constable, L. D., Cruickshank, M., Robertson, C., Glazener, C. M. A.
    Neurourology and Urodynamics, vol. 35, no. Suppl., pp. S299
    Contributions to Journals: Abstracts

  • The influence of bisnaphthalimidopropyl polyamines on DNA instability and repair in Caco-2 colon epithelial cells

    Bestwick, C. S., Ralton, L. D., Milne, L., Lin, P. K. T., Duthie, S. J.
    Cell Biology and Toxicology, vol. 27, no. 6, pp. 455-463
    Contributions to Journals: Articles

  • The proteomics of colorectal cancer: identification of a protein signature associated with prognosis

    O'Dwyer, D., Ralton, L. D., O'Shea, A., Murray, G. I.
    PloS ONE, vol. 6, no. 11, e27718
    Contributions to Journals: Articles

  • The use of formalin fixed wax embedded tissue for proteomic analysis

    Ralton, L. D., Murray, G. I.
    Journal of Clinical Pathology, vol. 64, no. 4, pp. 297-302
    Contributions to Journals: Articles

  • Biomarkers for colorectal cancer: identification through proteomics

    Ralton, L. D., Murray, G. I.
    Current Proteomics, vol. 7, no. 3, pp. 212-221
    Contributions to Journals: Articles

  • Bisnaphthalimidopropyl spermidine induces apoptosis within colon carcinoma cells

    Ralton, L. D., Bestwick, C. S., Milne, L., Duthie, S., Lin, P. K. T.
    Chemico-Biological Interactions, vol. 177, no. 1, pp. 1-6
    Contributions to Journals: Articles

  • Polyamine Analogues and Derivatives as Potential Anticancer Agents

    Ralton, L., Bestwick, C., Kong, P. T. L.
    Current Bioactive Compounds, vol. 3, no. 3, pp. 179-191
    Contributions to Journals: Articles

  • The synthesis and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer cells and parasite Leishmania infantum

    Oliveira, J., Ralton, L. D., Tavares, J., Codeiro-da-Silva, A., Bestwick, C., McPherson, A., Lin, P. K. T.
    Bioorganic & Medicinal Chemistry, vol. 15, no. 1, pp. 541-545
    Contributions to Journals: Articles

  • Synthesis and biological activities of bisnaphthalimido polyamines derivatives

    Dance, A. M., Ralton, L. D., Fuller, Z., Milne, L., Duthie, S. J., Bestwick, C., Lin, P. K. T.
    Biochemical Pharmacology, vol. 69, no. 1, pp. 19-27
    Contributions to Journals: Articles

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