Dr Alexander Ross

Dr Alexander Ross
Dr Alexander Ross
Dr Alexander Ross

Advanced Research Fellow

About
Research

Research Overview

In our research we are investigating how different foods and their constituents inform fullness and satiety to the brain. The objectives are to identify how cells of the gut and liver respond differently to different nutrients, and also how these nutrients may differentially affect metabolism to promote improved health. We are also interested in how diet-induced differences in the gut microbiome may alter host metabolism and health. The research results should provide evidence which, after validation in human trials, may be released as advice to the general public, or as product formulation advice to the food or drug industry aimed at healthy weight management. 

We use molecular biology and biochemical approaches including Next Generation Sequencing, Real-time PCR, in situ hybridization and Western blotting to identify target genes and exploit novel in vivo agonist/antagonist or antibody delivery in techniques aimed at addressing functional responses.

 

Research team

Prof Alexandra Johnstone

Claire Fyfe - Research Assistant

Gail Hepseed - Research assistant

 

 

Funding and Grants

Biotechnology and Biological Science Research Council (BBSRC) grant number BB/K001043/1 entitled: Inflammatory signals regulate neuroendocrine control of growth and energy balance through re-modelling of mammalian hypothalamus.

Publications

Page 4 of 6 Results 31 to 40 of 51

  • Photoperiodic regulation of hypothalamic retinoid signaling: Association of retinoid X receptor gamma with body weight

    Ross, A., Webster, C. A., Mercer, J., Moar, K., Ebling, F. J., Schuhler, S., Barrett, P., Morgan, P. J.
    Endocrinology, vol. 145, no. 1, pp. 13-20
    Contributions to Journals: Articles
  • Photoperiodic programming of body weight through the neuroendocrine hypothalamus

    Morgan, P. J., Ross, A., Mercer, J., Barrett, P.
    Journal of Endocrinology, vol. 177, no. 1, pp. 27-34
    Contributions to Journals: Articles
  • The pars tuberalis as a target of the central clock

    Ross, A. W., Morgan, P. J.
    Cell and Tissue Research, vol. 309, no. 1, pp. 163-171
    Contributions to Journals: Literature Reviews
  • How does the melatonin receptor decode a photoperiodic signal in the pars tuberalis?

    Morgan, P. J., Messager, S., Webster, C., Barrett, P., Ross, A.
    Advances in Experimental Medicine and Biology, vol. 460, pp. 165-174
    Contributions to Journals: Articles
  • Photoperiod regulates growth, puberty and hypothalamic neuropeptide and receptor gene expression in female Siberian hamsters

    Adam, C. L., Moar, K., Logie, T., Ross, A., Barrett, P., Morgan, P. J., Mercer, J.
    Endocrinology, vol. 141, no. 12, pp. 4349-4356
    Contributions to Journals: Articles
  • Regulation of leptin receptor, POMC and AGRP gene expression by photoperiod and food deprivation in the hypothalamic arcuate nucleus of the male Siberian hamster (Phodopus sungorus)

    Mercer, J., Moar, K. M., Morgan, P. J., Ross, A.
    Appetite, vol. 34, no. 1, pp. 109-111
    Contributions to Journals: Articles
  • Photoperiod regulates arcuate nucleus POMC, AGRP, and leptin receptor mRNA in Siberian hamster hypothalamus

    Mercer, J., Moar, K., Ross, A., Hoggard, N., Morgan, P. J.
    American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 278, no. 1, pp. R271-81
    Contributions to Journals: Articles
  • Decoding photoperiodic time through Per1 and ICER gene amplitude

    Messager, S., Ross, A., Barrett, P., Morgan, P. J.
    PNAS, vol. 96, no. 17, pp. 9938-9943
    Contributions to Journals: Articles
  • Melatonin receptors and signal transduction mechanisms

    Barrett, P., Morris, M., Choi, W. S., Ross, A., Morgan, P. J.
    Biological Signals and Receptors, vol. 8, no. 1-2, pp. 6-14
    Contributions to Journals: Articles
  • oPer1 is an early response gene under photoperiodic regulation in the ovine pars tuberalis

    Morgan, P. J., Ross, A., Graham, E. S., Adam, C. L., Messager, S., Barrett, P.
    Journal of Neuroendocrinology, vol. 10, no. 5, pp. 319-323
    Contributions to Journals: Articles
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