Dr Andrew McEwan

Dr Andrew McEwan

Advanced Research Fellow

About

School/Department: School of Medicine, Medical Sciences and Nutrition

Publications

Page 1 of 1 Results 1 to 19 of 19

Exploring the roles of conserved context-dependent cis-regulatory elements (ccdCREs) in multicellularity, human health and disease
2025 - Published
McEwan, A. R., Rattray, A., Hutchings, G., Hay, E. A., Murgatroyd, C., MacKenzie, A.
FEBS Journal, vol. 292, no. 23, pp. 6163-6181
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/febs.70174
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/2c996e73-a60d-4020-a024-0fe503ad3ce7/download
Inhibitors of PTP1B/NCK1 interaction and methods of making and using same
2024 - Published
Delibegovic, M., Dall'Angelo, S., Hamer, M. M., Dekeryte, R., McEwan, A. R., Greig, I.
Patents: Patents
- [ONLINE] https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2024178250&_cid=P10-M0FOXW-70692-1
An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans
2024 - Published
McEwan, A. R., Hing, B., Erickson, J. C., Hutchings, G., Urama, C., Norton-Hughes, E., D'Ippolito, M., Berry, S., Delibegovic, M., Grassmann, F., MacKenzie, A.
Molecular Psychiatry, vol. 29, no. 3, pp. 660-670
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/s41380-023-02359-7
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/b8b46c95-65c6-480e-9fa8-ae3676605765/download
Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities
2022 - Published
MacKenzie, A., Hay, E. A., McEwan, A. R.
Addiction neuroscience, vol. 2, 100014
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.1016/j.addicn.2022.100014
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/e855b5d7-dcca-4363-bcad-1e3f1ecbd2a2/download
CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake
2021 - Published
McEwan, A. R., Davidson, C., Hay, E., Turnbull, Y., Erickson, J. C., Marini, P., Wilson, D., McIntosh, A., Adams, M. J., Murgatroyd, C., Barrett, P., Delibegovic, M., Clarke, T., MacKenzie, A.
Molecular Psychiatry, vol. 26, pp. 2263–2276
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/s41380-020-0707-7
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/e9355a7d-6af0-47aa-8a0d-fa85eaa84f50/download
- [ONLINE] View publication in Scopus
The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet
2021 - Published
McEwan, A., Erickson, J. C., Davidson, C., Heijkoop, J., Turnbull, Y., Delibegovic, M., Murgatroyd, C., MacKenzie, A.
Cellular and Molecular Life Sciences, vol. 78, no. 6, pp. 3045-3055
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1007/s00018-020-03705-6
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/790a7d4f-443b-4c16-bcf7-713c4ef74e76/download
- [ONLINE] View publication in Scopus
Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective?
2020 - Published
McEwan, A. R., MacKenzie, A.
International Journal of Molecular Sciences, vol. 21, no. 21, 7856
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms21217856
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/19f61556-ae2f-4175-a865-e7b0df699f5e/download
- [ONLINE] View publication in Scopus
Disease associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue specific activity of the cannabinoid‐1 receptor gene promoter; implications for cannabinoid pharmacogenetics
2020 - Published
Hay, E. A., Cowie, P., McEwan, A. R., Ross, R., Pertwee, R. G., MacKenzie, A.
Human Mutation, vol. 41, no. 1, pp. 291-298
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/humu.23931
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7909f0e8-3d91-45d2-8fdb-00370ec15102/download
- [ONLINE] View publication in Scopus
Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour
2019 - Published
Hay, E. A., McEwan, A., Wilson, D., Barrett, P., D'Agostino, G., Pertwee, R. G., MacKenzie, A.
Psychoneuroendocrinology, vol. 109, pp. 104407
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.psyneuen.2019.104407
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/d4cca040-cf9b-4d67-a10f-9a21f470dae1/download
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize
2017 - Published
Booth, J., Alexandru-Crivac, C., Rickaby, K. A., Nneoyiegbe, A. F., Umeobika, U., McEwan, A. R., Trembleau, L., Jaspars, M., Houssen, W. E., Shalashilin, D. V.
The Journal of Physical Chemistry Letters, vol. 8, no. 10, pp. 2310-2315
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1021/acs.jpclett.7b00848
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/5ec69daa-84b9-417b-94d2-3c2c42fc8d82/download
Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil
2017 - Published
Wichner, D., Idris, H., Houssen, W. E., McEwan, A. R., Bull, A. T., Asenjo, J. A., Goodfellow, M., Jaspars, M., Ebel, R., Rateb, M. E.
The Journal of antibiotics, vol. 70, pp. 448-453
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/ja.2016.78
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/60fe75a0-cd1c-46f3-800a-71b8dfb64f36/download
Accurate quantification of modified cyclic peptides without the need for authentic standards
2016 - Published
Adaba, R. I., Mann, G., Raab, A., Houssen, W. E., McEwan, A. R., Thomas, L., Tabudravu, J., Naismith, J. H., Jaspars, M.
Tetrahedron, vol. 72, no. 52, pp. 8603-8609
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.tet.2016.11.040
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/c64e4277-4603-40e6-8fe6-87a3f0715975/download
An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides
2014 - Published
Houssen, W. E., Bent, A. F., McEwan, A. R., Pieiller, N., Tabudravu, J., Koehnke, J., Mann, G., Adaba, R. I., Thomas, L., Hawas, U. W., Liu, H., Schwarz-Linek, U., Smith, M. C. M., Naismith, J. H., Jaspars, M.
Angewandte Chemie International Edition, vol. 53, no. 51, pp. 14171-14174
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/anie.201408082
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/58306ec5-102b-4fd2-8437-ccdaa650968d/download
Gated rotation mechanism of site-specific recombination by ΦC31 integrase
2012 - Published
Olorunniji, F. J., Buck, D. E., Colloms, S. D., McEwan, A. R., Smith, M. C., Stark, W. M., Rosser, S. J.
Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 48, pp. 19661-19666
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1073/pnas.1210964109
- [ONLINE] View publication in Scopus
Zinc is essential for high-affinity DNA binding and recombinase activity of phi C31 integrase
2011 - Published
McEwan, A. R., Raab, A., Kelly, S. M., Feldmann, J., Smith, M. C. M.
Nucleic Acids Research, vol. 39, no. 14, pp. 6137-6147
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/nar/gkr220
Site-specific recombination by fC31 integrase and other large serine recombinases
2010 - Published
Smith, M. C. M., Brown, W. R. A., McEwan, A., Rowley, P. A.
Biochemical Society Transactions, vol. 38, no. 2, pp. 388-394
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1042/BST0380388
DNA binding and synapsis by the large C-terminal domain of ϕC31 integrase
2009 - Published
McEwan, A., Rowley, P. A., Smith, M. C.
Nucleic Acids Research, vol. 37, no. 14, pp. 4764-4773
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/nar/gkp485
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/e1b92841-b3db-4179-b3e7-aecdce578120/download
The fluorinase from Streptomyces cattleya is also a chlorinase
2006 - Published
Deng, H., Cobb, S. L., McEwan, A. R., McGlinchey, R. P., Naismith, J. H., O'hagan, D., Robinson, D. A., Spencer, J. B.
Angewandte Chemie International Edition, vol. 45, no. 5, pp. 759-762
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/anie.200503582
Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates
2006 - Published
Cobb, S. L., Deng, H., McEwan, A. R., Naismith, J. H., O'hagan, D., Robinson, D. A.
Organic & Biomolecular Chemistry, no. 8, pp. 1458-1460
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1039/B600574H

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Articles (17)

Review articles (1)

Patents

Patents (1)

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Exploring the roles of conserved context-dependent cis-regulatory elements (ccdCREs) in multicellularity, human health and disease

Inhibitors of PTP1B/NCK1 interaction and methods of making and using same

An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans

Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities

CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet

Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective?

Disease associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue specific activity of the cannabinoid‐1 receptor gene promoter; implications for cannabinoid pharmacogenetics

Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour

A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize

Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

Accurate quantification of modified cyclic peptides without the need for authentic standards

An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides

Gated rotation mechanism of site-specific recombination by ΦC31 integrase

Zinc is essential for high-affinity DNA binding and recombinase activity of phi C31 integrase

Site-specific recombination by fC31 integrase and other large serine recombinases

DNA binding and synapsis by the large C-terminal domain of ϕC31 integrase

The fluorinase from Streptomyces cattleya is also a chlorinase

Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates

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Patents