UK Dementia Research Institute: Rethinking neurodegeneration: Could failing protein clearance provide the missing link?
-
This is a past event
External Event
Recent genome-wide association studies have revealed that most genetic risk factors for neurodegenerative diseases affect protein clearance pathways rather than directly causing disease. In this special UK DRI research webinar, Prof Sir John Hardy and Prof Valentina Escott-Price present evidence for how this insight could resolve several key questions in the field.
- Why do we often see multiple pathologies in ageing brains?
- Why can the same genetic variants lead to different pathologies?
- Why does disease penetrance vary?
- Why are these conditions so age-dependent?
Their framework suggests that failing protein clearance systems may provide a unifying mechanism for understanding neurodegeneration, with important implications for therapeutic development.
- Speaker
- Prof Sir John Hardy and Prof Valentina Escott-Price
- Hosted by
- Online