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The Institute of Medical Sciences

Professor Nuala Booth

Professor Nuala Booth
Professor Nuala Booth
Professor Nuala Booth

PhD, FRSE

Emeritus Professor

About
Email Address
n.a.booth@abdn.ac.uk
Office Address

Institute of Medical Sciences University of Aberdeen Aberdeen AB25 2ZD UK

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Membership of Learned Societies:

  • International Society on Thrombosis and Haemostasis (Elected to Council, 2008-2014, Chairman Finance Committee 2009 to 2014),; formerly Chairman of Scientific Standardization Committee (2006-2008), chairman of the Subcommittee on Fibrinolysis (1997-2000) and Hon Secretary of the Council on Thrombosis (1998-2002)
  • International Society for Fibrinolysis and Proteolysis (on Council 1996-2005; Chairman 2002-2004)
  • British Society for Thrombosis and Haemostasis (President 1997; Treasurer 1991-96)
  • International Fibrinogen Research Society
  • The Biochemical Society
  • British Atherosclerosis Society
  • Scottish Cardiovascular Forum
Research

Research Overview

Our research is directed at a better understanding of fibrin and its stabilization, which is relevant to thrombosis and atherosclerosis. We focus on the plasmin system, which is central to the degradation of blood clots and extracellular matrix and to the activation of growth factors. Our studies include characterization of the major proteins of this pathway, the plasminogen activators, tPA and uPA, and the inhibitors, PAI-1, PAI-2 and að2-antiplasmin. Our work includes structure-function relationships in these proteins, their cellular roles and their importance in thrombus lysis and in the protection of the vessel wall from atherosclerosis. Localization of these and related proteins by transglutaminases is a particular interest. We also have a broad interest in microbial proteases in relation to pathogenic mechanisms.

Publications

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  • Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets

    Whyte, C. S., Morrow, G. B., Baik, N., Booth, N. A., Jalal, M. M., Parmer, R., Miles, L., Mutch, N. J.
    Blood, vol. 137, no. 2, pp. 248–257
    Contributions to Journals: Articles

  • Plasmin-antiplasmin system

    Mutch, N. J., Booth, N. A.
    Trauma Induced Coagulopathy. Gonzalez, E., Moore, H. B., Moore, E. E. (eds.). Springer International Publishing, pp. 31-51, 21 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Functional factor XIII-A is exposed on the stimulated platelet surface

    Mitchell, J. L., Lionikiene, A. S., Fraser, S. R., Whyte, C. S., Booth, N. A., Mutch, N. J.
    Blood, vol. 124, no. 26, pp. 3982–3990
    Contributions to Journals: Articles

  • Protease concentration in amniotic fluid at term and early childhood respiratory symptoms

    Turner, S. W., Carter, J., Danielian, P., Chalmers, I., McConaghy, L., Pacitti, N., Booth, N.
    Journal of Maternal-Fetal & Neonatal Medicine, vol. 27, no. 4, pp. 416-420
    Contributions to Journals: Articles

  • Measurement of fibrin concentration by fast field-cycling NMR

    Broche, L. M., Ismail, S. R., Booth, N. A., Lurie, D. J.
    Magnetic Resonance in Medicine, vol. 67, no. 5, pp. 1453–1457
    Contributions to Journals: Articles

  • Are the fractal skeletons the explanation for the narrowing of arteries due to cell trapping in a disturbed blood flow?

    Schelin, A. B., Karolyi, G., de Moura, A. P. S., Booth, N., Grebogi, C.
    Computers in Biology and Medicine, vol. 42, no. 3, pp. 276-281
    Contributions to Journals: Articles

  • Salt bridges regulate both dimer formation and monomeric flexibility in HdeB and may have a role in periplasmic chaperone function

    Wang, W., Rasmussen, T., Harding, A. J., Booth, N., Booth, I., Naismith, J.
    Journal of Molecular Biology, vol. 415, no. 3, pp. 538-546
    Contributions to Journals: Articles

  • The antifibrinolytic function of factor XIII is exclusively expressed through α2-antiplasmin cross-linking

    Fraser, S. R., Booth, N. A., Mutch, N. J.
    Blood, vol. 117, no. 23, pp. 6371-6374
    Contributions to Journals: Articles

  • Fractal structures in stenoses and aneurysms in blood vessels

    Schelin, A. B., Karolyi, G., de Moura, A. P. S., Booth, N. A., Grebogi, C.
    Philosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences, vol. 368, no. 1933, pp. 5605-5617
    Contributions to Journals: Articles

  • Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

    Mutch, N. J., Koikkalainen, J. S., Fraser, S. R., Duthie, K. M., Griffin, M., Mitchell, J., Watson, H. G., Booth, N. A.
    Journal of Thrombosis and Haemostasis, vol. 8, no. 9, pp. 2017-2024
    Contributions to Journals: Articles

  • Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets

    Baeten, K. M., Richard, M. C., Kanse, S. M., Mutch, N. J., Degen, J. L., Booth, N. A.
    Journal of Thrombosis and Haemostasis, vol. 8, no. 6, pp. 1313-1322
    Contributions to Journals: Articles

  • Fast field-cycling magnetic resonance imaging: Imagerie de resonance magnétique en champ cyclé

    Lurie, D. J., Aime, S., Baroni, S., Booth, N. A., Broche, L. M., Choi, C., Davies, G. R., Ismail, S., O Hogain, D., Pine, K. J.
    Comptes Rendus. Physique, vol. 11, no. 2, pp. 136-148
    Contributions to Journals: Articles

  • Chaotic advection in blood flow

    Schelin, A. B., Karolyi, G., de Moura, A. P. S., Booth, N. A., Grebogi, C.
    Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 80, no. 1, 016213
    Contributions to Journals: Articles

  • Bispecific targeting of thrombin activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 by a heterodimer diabody

    Develter, J., Booth, N. A., Declerck, P. J., Gils, A.
    Journal of Thrombosis and Haemostasis, vol. 6, no. 11, pp. 1884-1891
    Contributions to Journals: Articles

  • Plasminogen binding by oral streptococci from dental plaque and inflammatory lesions

    Kinnby, B., Booth, N. A., Svensaeter, G.
    Microbiology , vol. 154, no. 3, pp. 924-931
    Contributions to Journals: Articles

  • The use of the Chandler loop to examine the interaction potential of NXY-059 on the thrombolytic properties of rtPA on human thrombi in vitro

    Mutch, N. J., Moore, N. R., Mattsson, C., Jonasson, H., Green, A. R., Booth, N. A.
    British Journal of Pharmacology, vol. 153, no. 1, pp. 124-131
    Contributions to Journals: Articles

  • TAFIa, PAI-1 and α2-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots

    Mutch, N. J., Thomas, L., Moore, N. R., Lisiak, K. M., Booth, N. A.
    Journal of Thrombosis and Haemostasis, vol. 5, no. 4, pp. 812-817
    Contributions to Journals: Articles

  • The C-terminus of α2-antiplasmin interacts with endothelial cells

    Thomas, L., Moore, N. R., Miller, S., Booth, N. A.
    British Journal of Haematology, vol. 136, no. 3, pp. 472-479
    Contributions to Journals: Articles

  • The influence of anti-endothelial/antiphospholipid antibodies on fibrin formation and lysis on endothelial cells

    Patterson, A. M., Ford, I., Graham, A., Booth, N., Greaves, M.
    British Journal of Haematology, vol. 133, no. 3, pp. 323-330
    Contributions to Journals: Articles

  • Intraluminal thrombus enhances proteolysis in abdominal aortic aneurysms

    Carrell, T. W. G., Burnand, K. G., Booth, N., Humphries, J., Smith, A.
    Vascular Medicine, vol. 14, no. 1, pp. 9-16
    Contributions to Journals: Articles

  • Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI

    Mutch, N. J., Moore, N. R., Wang, E., Booth, N. A.
    Journal of Thrombosis and Haemostasis, vol. 1, no. 9, pp. 2000-2007
    Contributions to Journals: Articles

  • Candida albicans binds human plasminogen: identification of eight plasminogen-binding proteins

    Crowe, J. D., Sievwright, I. K., Auld, G. C., Moore, N. R., Gow, N. A. R., Booth, N. A.
    Molecular Microbiology, vol. 47, no. 6, pp. 1637-1651
    Contributions to Journals: Articles

  • Localization and identification of thrombin and plasminogen activator activities in model human thrombi by in situ zymography

    Mutch, N. J., Moir, E., Robbie, L. A., Berry, S. H., Bennett, B., Booth, N. A.
    Thrombosis and Haemostasis, vol. 88, no. 6, pp. 996-1003
    Contributions to Journals: Articles

  • Polymorphonuclear leucocytes have two opposing roles in fibrinolysis

    Moir, E., Robbie, L. A., Booth, N. A., Bennett, B.
    Thrombosis and Haemostasis, vol. 87, no. 6, pp. 1006-1010
    Contributions to Journals: Articles

  • The symbiosis of Bacillus subtilis L-forms with Chinese cabbage seedlings inhibit conidial germination of Botrytis cinerea

    Walker, R., Ferguson, C. M. J., Booth, N. A., Allan, E. J.
    Letters in Applied Microbiology, vol. 34, pp. 42-45
    Contributions to Journals: Articles
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