PhD, FRSE
Emeritus Professor
- About
-
- Email Address
- n.a.booth@abdn.ac.uk
- Office Address
Institute of Medical Sciences University of Aberdeen Aberdeen AB25 2ZD UK
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Membership of Learned Societies:
- International Society on Thrombosis and Haemostasis (Elected to Council, 2008-2014, Chairman Finance Committee 2009 to 2014),; formerly Chairman of Scientific Standardization Committee (2006-2008), chairman of the Subcommittee on Fibrinolysis (1997-2000) and Hon Secretary of the Council on Thrombosis (1998-2002)
- International Society for Fibrinolysis and Proteolysis (on Council 1996-2005; Chairman 2002-2004)
- British Society for Thrombosis and Haemostasis (President 1997; Treasurer 1991-96)
- International Fibrinogen Research Society
- The Biochemical Society
- British Atherosclerosis Society
- Scottish Cardiovascular Forum
- Research
-
Research Overview
Our research is directed at a better understanding of fibrin and its stabilization, which is relevant to thrombosis and atherosclerosis. We focus on the plasmin system, which is central to the degradation of blood clots and extracellular matrix and to the activation of growth factors. Our studies include characterization of the major proteins of this pathway, the plasminogen activators, tPA and uPA, and the inhibitors, PAI-1, PAI-2 and að2-antiplasmin. Our work includes structure-function relationships in these proteins, their cellular roles and their importance in thrombus lysis and in the protection of the vessel wall from atherosclerosis. Localization of these and related proteins by transglutaminases is a particular interest. We also have a broad interest in microbial proteases in relation to pathogenic mechanisms.
- Publications
-
Page 1 of 5 Results 1 to 10 of 44
Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets
Blood, vol. 137, no. 2, pp. 248–257Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood.2020007263
- [ONLINE] View publication in Scopus
Plasmin-antiplasmin system
Trauma Induced Coagulopathy. Gonzalez, E., Moore, H. B., Moore, E. E. (eds.). Springer International Publishing, pp. 31-51, 21 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-3-319-28308-1_3
- [ONLINE] View publication in Scopus
Functional factor XIII-A is exposed on the stimulated platelet surface
Blood, vol. 124, no. 26, pp. 3982–3990Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2014-06-583070
Protease concentration in amniotic fluid at term and early childhood respiratory symptoms
Journal of Maternal-Fetal & Neonatal Medicine, vol. 27, no. 4, pp. 416-420Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3109/14767058.2013.818647
Measurement of fibrin concentration by fast field-cycling NMR
Magnetic Resonance in Medicine, vol. 67, no. 5, pp. 1453–1457Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mrm.23117
Are the fractal skeletons the explanation for the narrowing of arteries due to cell trapping in a disturbed blood flow?
Computers in Biology and Medicine, vol. 42, no. 3, pp. 276-281Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.compbiomed.2011.07.002
Salt bridges regulate both dimer formation and monomeric flexibility in HdeB and may have a role in periplasmic chaperone function
Journal of Molecular Biology, vol. 415, no. 3, pp. 538-546Contributions to Journals: ArticlesThe antifibrinolytic function of factor XIII is exclusively expressed through α2-antiplasmin cross-linking
Blood, vol. 117, no. 23, pp. 6371-6374Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2011-02-333203
Fractal structures in stenoses and aneurysms in blood vessels
Philosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences, vol. 368, no. 1933, pp. 5605-5617Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1098/rsta.2010.0268
Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis
Journal of Thrombosis and Haemostasis, vol. 8, no. 9, pp. 2017-2024Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2010.03963.x