Professor Nuala Booth
PhD, FRSE
Emeritus Professor
- About
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- Email Address
- n.a.booth@abdn.ac.uk
- Office Address
Institute of Medical Sciences University of Aberdeen Aberdeen AB25 2ZD UK
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Membership of Learned Societies:
- International Society on Thrombosis and Haemostasis (Elected to Council, 2008-2014, Chairman Finance Committee 2009 to 2014),; formerly Chairman of Scientific Standardization Committee (2006-2008), chairman of the Subcommittee on Fibrinolysis (1997-2000) and Hon Secretary of the Council on Thrombosis (1998-2002)
- International Society for Fibrinolysis and Proteolysis (on Council 1996-2005; Chairman 2002-2004)
- British Society for Thrombosis and Haemostasis (President 1997; Treasurer 1991-96)
- International Fibrinogen Research Society
- The Biochemical Society
- British Atherosclerosis Society
- Scottish Cardiovascular Forum
- Research
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Research Overview
Our research is directed at a better understanding of fibrin and its stabilization, which is relevant to thrombosis and atherosclerosis. We focus on the plasmin system, which is central to the degradation of blood clots and extracellular matrix and to the activation of growth factors. Our studies include characterization of the major proteins of this pathway, the plasminogen activators, tPA and uPA, and the inhibitors, PAI-1, PAI-2 and að2-antiplasmin. Our work includes structure-function relationships in these proteins, their cellular roles and their importance in thrombus lysis and in the protection of the vessel wall from atherosclerosis. Localization of these and related proteins by transglutaminases is a particular interest. We also have a broad interest in microbial proteases in relation to pathogenic mechanisms.
- Publications
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Page 1 of 1 Results 1 to 44 of 44
Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets
Blood, vol. 137, no. 2, pp. 248–257Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood.2020007263
- [ONLINE] View publication in Scopus
Plasmin-antiplasmin system
Trauma Induced Coagulopathy. Gonzalez, E., Moore, H. B., Moore, E. E. (eds.). Springer International Publishing, pp. 31-51, 21 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-3-319-28308-1_3
- [ONLINE] View publication in Scopus
Functional factor XIII-A is exposed on the stimulated platelet surface
Blood, vol. 124, no. 26, pp. 3982–3990Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2014-06-583070
Protease concentration in amniotic fluid at term and early childhood respiratory symptoms
Journal of Maternal-Fetal & Neonatal Medicine, vol. 27, no. 4, pp. 416-420Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3109/14767058.2013.818647
Measurement of fibrin concentration by fast field-cycling NMR
Magnetic Resonance in Medicine, vol. 67, no. 5, pp. 1453–1457Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mrm.23117
Are the fractal skeletons the explanation for the narrowing of arteries due to cell trapping in a disturbed blood flow?
Computers in Biology and Medicine, vol. 42, no. 3, pp. 276-281Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.compbiomed.2011.07.002
Salt bridges regulate both dimer formation and monomeric flexibility in HdeB and may have a role in periplasmic chaperone function
Journal of Molecular Biology, vol. 415, no. 3, pp. 538-546Contributions to Journals: ArticlesThe antifibrinolytic function of factor XIII is exclusively expressed through α2-antiplasmin cross-linking
Blood, vol. 117, no. 23, pp. 6371-6374Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2011-02-333203
Fractal structures in stenoses and aneurysms in blood vessels
Philosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences, vol. 368, no. 1933, pp. 5605-5617Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1098/rsta.2010.0268
Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis
Journal of Thrombosis and Haemostasis, vol. 8, no. 9, pp. 2017-2024Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2010.03963.x
Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets
Journal of Thrombosis and Haemostasis, vol. 8, no. 6, pp. 1313-1322Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2010.03813.x
Fast field-cycling magnetic resonance imaging: Imagerie de resonance magnétique en champ cyclé
Comptes Rendus. Physique, vol. 11, no. 2, pp. 136-148Contributions to Journals: ArticlesChaotic advection in blood flow
Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 80, no. 1, 016213Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1103/PhysRevE.80.016213
Bispecific targeting of thrombin activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 by a heterodimer diabody
Journal of Thrombosis and Haemostasis, vol. 6, no. 11, pp. 1884-1891Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2008.03137.x
Plasminogen binding by oral streptococci from dental plaque and inflammatory lesions
Microbiology , vol. 154, no. 3, pp. 924-931Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1099/mic.0.2007/013235-0
The use of the Chandler loop to examine the interaction potential of NXY-059 on the thrombolytic properties of rtPA on human thrombi in vitro
British Journal of Pharmacology, vol. 153, no. 1, pp. 124-131Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.bjp.0707543
TAFIa, PAI-1 and α2-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots
Journal of Thrombosis and Haemostasis, vol. 5, no. 4, pp. 812-817Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/J.1538-7836.2007.02430.X
The C-terminus of α2-antiplasmin interacts with endothelial cells
British Journal of Haematology, vol. 136, no. 3, pp. 472-479Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2141.2006.06452.x
The influence of anti-endothelial/antiphospholipid antibodies on fibrin formation and lysis on endothelial cells
British Journal of Haematology, vol. 133, no. 3, pp. 323-330Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2141.2006.05994.x
Intraluminal thrombus enhances proteolysis in abdominal aortic aneurysms
Vascular Medicine, vol. 14, no. 1, pp. 9-16Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2310/6670.2006.00008
Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI
Journal of Thrombosis and Haemostasis, vol. 1, no. 9, pp. 2000-2007Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/J.1538-7836.2003.00383.X
Candida albicans binds human plasminogen: identification of eight plasminogen-binding proteins
Molecular Microbiology, vol. 47, no. 6, pp. 1637-1651Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/j.1365-2958.2003.03390.x
Localization and identification of thrombin and plasminogen activator activities in model human thrombi by in situ zymography
Thrombosis and Haemostasis, vol. 88, no. 6, pp. 996-1003Contributions to Journals: ArticlesPolymorphonuclear leucocytes have two opposing roles in fibrinolysis
Thrombosis and Haemostasis, vol. 87, no. 6, pp. 1006-1010Contributions to Journals: ArticlesThe symbiosis of Bacillus subtilis L-forms with Chinese cabbage seedlings inhibit conidial germination of Botrytis cinerea
Letters in Applied Microbiology, vol. 34, pp. 42-45Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/j.1472-765x.2002.01037.x
Human thrombi contain an abundance of active thrombin
Thrombosis and Haemostasis, vol. 86, no. 4, pp. 1028-1034Contributions to Journals: ArticlesThrombin upregulates tissue transglutaminase in endothelial cells: a potential role for tissue transglutaminase in stability of atherosclerotic plaque
Arteriosclerosis Thrombosis and Vascular Biology, vol. 21, no. 10, pp. 1689-1694Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1161/HQ1001.097063
Plasminogen activator inhibitor-1 and haemostasis in obesity
Proceedings of the Nutrition Society, vol. 60, no. 3, pp. 341-347Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1079/PNS200199
Characterization of crosslinking sites in fibrinogen for plasminogen activator inhibitor 2 (PAI-2)
Annals of the New York Academy of Sciences, vol. 936, pp. 215-218Contributions to Journals: ArticlesPolymorphonuclear leucocytes mediate endogenous thrombus lysis via a u-PA-dependent mechanism
British Journal of Haematology, vol. 113, no. 1, pp. 72-80Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/j.1365-2141.2001.02696.x
TAFI meets the sticky ends
Thrombosis and Haemostasis, vol. 85, no. 1, pp. 1-2Contributions to Journals: ArticlesAn ELISA for the detection of Bacillus subtilis L-form bacteria confirms their symbiosis in strawberry
Letters in Applied Microbiology, vol. 31, pp. 390-394Contributions to Journals: ArticlesCross-linking of plasminogen activator inhibitor 2 and alpha(2)-antiplasmin to fibrin(ogen)
The Journal of Biological Chemistry, vol. 275, pp. 24915-24920Contributions to Journals: ArticlesEffective lysis of model thrombi by a t-PA mutant (A473S) that is resistant to alpha(2)-antiplasmin
British Journal of Haematology, vol. 111, pp. 517-523Contributions to Journals: ArticlesMyeloid leukaemic cells can lyse fibrin directly
British Journal of Haematology, vol. 111, pp. 524-529Contributions to Journals: ArticlesPlasminogen activator inhibitor 2 and urokinase-type plasminogen activator in plasma and leucocytes in patients with severe sepsis
British Journal of Haematology, vol. 109, pp. 342-348Contributions to Journals: ArticlesRegulation of fibrinolytic activity by localization of inhibitors to fibrin(ogen)
Fibrinolysis and Proteolysis, vol. 14, pp. 206-213Contributions to Journals: ArticlesRegulation of plasminogen activation by TGF-beta in cultured human retinal endothelial cells
British Journal of Ophthalmology, vol. 84, pp. 417-422Contributions to Journals: ArticlesCirculating tissue-type plasminogen activator and plasminogen activator inhibitor type 1 in proliferative diabetic retinopathy: a pilot study
Acta Diabetologica, vol. 36, pp. 155-158Contributions to Journals: ArticlesFibrinolysis and thrombosis
Best Practice & Research Clinical Obstetrics & Gynaecology, vol. 12, pp. 423-433Contributions to Journals: ArticlesMonocyte plasminogen activator inhibitor 2 (PAI-2) inhibits u-PA-mediated fibrin clot lysis and is cross-linked to fibrin
Journal of Thrombosis and Haemostasis, vol. 81, pp. 96-103Contributions to Journals: ArticlesUp regulation of plasminogen activator inhibitor 2 (PAI-2) in response to alpha-lactalbumin
Fibrinolysis and Proteolysis, vol. 13, pp. 17Contributions to Journals: ArticlesEvidence for an active fibrinolytic system in normal human bone marrow
British Journal of Haematology, vol. 93, no. 1, pp. 170-6Contributions to Journals: ArticlesTransforming growth factor beta (TGF-beta) regulates the matrix-associated plasminogen activator inhibitor 1 (PAI-1) in glomerular mesangial and epithelial cells
Nephron Experimental Nephrology, vol. 3, no. 2, pp. 141-2Contributions to Journals: Articles