PhD, FRSE
Emeritus Professor
- About
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- Email Address
- n.a.booth@abdn.ac.uk
- Office Address
Institute of Medical Sciences University of Aberdeen Aberdeen AB25 2ZD UK
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Membership of Learned Societies:
- International Society on Thrombosis and Haemostasis (Elected to Council, 2008-2014, Chairman Finance Committee 2009 to 2014),; formerly Chairman of Scientific Standardization Committee (2006-2008), chairman of the Subcommittee on Fibrinolysis (1997-2000) and Hon Secretary of the Council on Thrombosis (1998-2002)
- International Society for Fibrinolysis and Proteolysis (on Council 1996-2005; Chairman 2002-2004)
- British Society for Thrombosis and Haemostasis (President 1997; Treasurer 1991-96)
- International Fibrinogen Research Society
- The Biochemical Society
- British Atherosclerosis Society
- Scottish Cardiovascular Forum
- Research
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Research Overview
Our research is directed at a better understanding of fibrin and its stabilization, which is relevant to thrombosis and atherosclerosis. We focus on the plasmin system, which is central to the degradation of blood clots and extracellular matrix and to the activation of growth factors. Our studies include characterization of the major proteins of this pathway, the plasminogen activators, tPA and uPA, and the inhibitors, PAI-1, PAI-2 and að2-antiplasmin. Our work includes structure-function relationships in these proteins, their cellular roles and their importance in thrombus lysis and in the protection of the vessel wall from atherosclerosis. Localization of these and related proteins by transglutaminases is a particular interest. We also have a broad interest in microbial proteases in relation to pathogenic mechanisms.
- Publications
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Page 3 of 5 Results 21 to 30 of 44
Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI
Journal of Thrombosis and Haemostasis, vol. 1, no. 9, pp. 2000-2007Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/J.1538-7836.2003.00383.X
Candida albicans binds human plasminogen: identification of eight plasminogen-binding proteins
Molecular Microbiology, vol. 47, no. 6, pp. 1637-1651Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/j.1365-2958.2003.03390.x
Localization and identification of thrombin and plasminogen activator activities in model human thrombi by in situ zymography
Thrombosis and Haemostasis, vol. 88, no. 6, pp. 996-1003Contributions to Journals: ArticlesPolymorphonuclear leucocytes have two opposing roles in fibrinolysis
Thrombosis and Haemostasis, vol. 87, no. 6, pp. 1006-1010Contributions to Journals: ArticlesThe symbiosis of Bacillus subtilis L-forms with Chinese cabbage seedlings inhibit conidial germination of Botrytis cinerea
Letters in Applied Microbiology, vol. 34, pp. 42-45Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/j.1472-765x.2002.01037.x
Human thrombi contain an abundance of active thrombin
Thrombosis and Haemostasis, vol. 86, no. 4, pp. 1028-1034Contributions to Journals: ArticlesThrombin upregulates tissue transglutaminase in endothelial cells: a potential role for tissue transglutaminase in stability of atherosclerotic plaque
Arteriosclerosis Thrombosis and Vascular Biology, vol. 21, no. 10, pp. 1689-1694Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1161/HQ1001.097063
Plasminogen activator inhibitor-1 and haemostasis in obesity
Proceedings of the Nutrition Society, vol. 60, no. 3, pp. 341-347Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1079/PNS200199
Characterization of crosslinking sites in fibrinogen for plasminogen activator inhibitor 2 (PAI-2)
Annals of the New York Academy of Sciences, vol. 936, pp. 215-218Contributions to Journals: ArticlesPolymorphonuclear leucocytes mediate endogenous thrombus lysis via a u-PA-dependent mechanism
British Journal of Haematology, vol. 113, no. 1, pp. 72-80Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/j.1365-2141.2001.02696.x