PhD, FRSE
Emeritus Professor
- About
-
- Email Address
- n.a.booth@abdn.ac.uk
- Office Address
Institute of Medical Sciences University of Aberdeen Aberdeen AB25 2ZD UK
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Membership of Learned Societies:
- International Society on Thrombosis and Haemostasis (Elected to Council, 2008-2014, Chairman Finance Committee 2009 to 2014),; formerly Chairman of Scientific Standardization Committee (2006-2008), chairman of the Subcommittee on Fibrinolysis (1997-2000) and Hon Secretary of the Council on Thrombosis (1998-2002)
- International Society for Fibrinolysis and Proteolysis (on Council 1996-2005; Chairman 2002-2004)
- British Society for Thrombosis and Haemostasis (President 1997; Treasurer 1991-96)
- International Fibrinogen Research Society
- The Biochemical Society
- British Atherosclerosis Society
- Scottish Cardiovascular Forum
- Research
-
Research Overview
Our research is directed at a better understanding of fibrin and its stabilization, which is relevant to thrombosis and atherosclerosis. We focus on the plasmin system, which is central to the degradation of blood clots and extracellular matrix and to the activation of growth factors. Our studies include characterization of the major proteins of this pathway, the plasminogen activators, tPA and uPA, and the inhibitors, PAI-1, PAI-2 and að2-antiplasmin. Our work includes structure-function relationships in these proteins, their cellular roles and their importance in thrombus lysis and in the protection of the vessel wall from atherosclerosis. Localization of these and related proteins by transglutaminases is a particular interest. We also have a broad interest in microbial proteases in relation to pathogenic mechanisms.
- Publications
-
Page 2 of 5 Results 11 to 20 of 44
Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets
Journal of Thrombosis and Haemostasis, vol. 8, no. 6, pp. 1313-1322Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2010.03813.x
Fast field-cycling magnetic resonance imaging: Imagerie de resonance magnétique en champ cyclé
Comptes Rendus. Physique, vol. 11, no. 2, pp. 136-148Contributions to Journals: ArticlesChaotic advection in blood flow
Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 80, no. 1, 016213Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1103/PhysRevE.80.016213
Bispecific targeting of thrombin activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 by a heterodimer diabody
Journal of Thrombosis and Haemostasis, vol. 6, no. 11, pp. 1884-1891Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2008.03137.x
Plasminogen binding by oral streptococci from dental plaque and inflammatory lesions
Microbiology , vol. 154, no. 3, pp. 924-931Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1099/mic.0.2007/013235-0
The use of the Chandler loop to examine the interaction potential of NXY-059 on the thrombolytic properties of rtPA on human thrombi in vitro
British Journal of Pharmacology, vol. 153, no. 1, pp. 124-131Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.bjp.0707543
TAFIa, PAI-1 and α2-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots
Journal of Thrombosis and Haemostasis, vol. 5, no. 4, pp. 812-817Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/J.1538-7836.2007.02430.X
The C-terminus of α2-antiplasmin interacts with endothelial cells
British Journal of Haematology, vol. 136, no. 3, pp. 472-479Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2141.2006.06452.x
The influence of anti-endothelial/antiphospholipid antibodies on fibrin formation and lysis on endothelial cells
British Journal of Haematology, vol. 133, no. 3, pp. 323-330Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2141.2006.05994.x
Intraluminal thrombus enhances proteolysis in abdominal aortic aneurysms
Vascular Medicine, vol. 14, no. 1, pp. 9-16Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2310/6670.2006.00008