Professor Emad El-Omar


  Professor Emad El-Omar The University of Aberdeen School of Medicine & Dentistry Professor Emad El-Omar Chair in Gastroenterology (Clinical) work +44 (0)1224 437548 work fax +44 (0)1224 437348 pref Division of Applied Medicine School of Medicine & Dentistry University of Aberdeen Room 6.20 Institute of Medical Sciences Foresterhill Aberdeen AB25 2ZD University Secretary: Mrs Hazel Paterson 01224-437349

NHS Secretary: Mrs Roseanne McIntosh 01224-550924

Chair in Gastroenterology (Clinical)

BSc(Hons), MB ChB, MD (Hons), FRCP (Edin), FRSE

Professor Emad El-Omar

Contact Details

Telephone: +44 (0)1224 437548
Fax: +44 (0)1224 437348
Email:

e.el-omar@abdn.ac.uk

Address: Division of Applied Medicine
School of Medicine & Dentistry
University of Aberdeen
Room 6.20
Institute of Medical Sciences
Foresterhill
Aberdeen
AB25 2ZD

University Secretary: Mrs Hazel Paterson 01224-437349

NHS Secretary: Mrs Roseanne McIntosh 01224-550924

hCard

Biography

Professor Emad El-Omar graduated MB ChB from Glasgow University in 1988 having obtained an intercalated BSc (Hons) degree in Pathology in 1986. He trained in General Medicine and Gastroenterology in Glasgow and gained dual accreditation in both in 1997. In 1995 he was awarded the degree of MD with honours and Belahouston Medal, for his work on the effect of H. pylori infection on gastric acid secretion in man. In 1997, Professor El-Omar moved to the USA to carry out research on the role of bacterial and host genetic factors in the pathogenesis of gastric cancer. He spent one year in the Division of Infectious Diseases at Vanderbilt University School of Medicine, Nashville, Tennessee, and two years at the Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland. In July 2000, Professor El-Omar took up the newly created Chair of Gastroenterology at Aberdeen University. He is also an Honorary Consultant Physician with the Grampian University NHS Trust. Professor El-Omar leads a dedicated team of basic and clinical scientists studying the pathogenesis of gastrointestinal malignancies, inflammatory bowel disease and the role of chronic inflammation in cancer.

Professor El-Omar was elected Fellow of the Royal College of Physicians of Edinburgh in 2001 and Fellow of the Royal Society of Edinburgh in 2007.

Professor El-Omar is the Leader of the Immunity and Disease Programme in the Institute of Medical Sciences.

 

 


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Research Interests

The GI group is part of the Immunology and Inflammation Theme at the Institute of Medical Sciences. The main research interest of the GI group is the role of chronic inflammation in GI malignancy. The work is dedicated to understanding the pathogenesis of gastric cancer, colorectal cancer and inflammatory bowel disease. The common theme is the link between microbially-induced gastrointestinal inflammation and risk of malignant transformation. The main expertise is in molecular microbiology and molecular genetic research. The group has a special interest in studying Helicobacter pylori infection and the role of host genetic factors in upper GI cancer. The team also has special expertise in assessing the role of microbial diversity in inflammatory bowel disease and colorectal neoplasia. A major strength of the group is the full integration of the clinical GI service and the basic laboratory expertise, both based on the same campus. Institutional collaborations are strong with the Pathology, Immunology, Genetics and Microbiology groups and with the Rowett Research Institute. The group also has strong collaborations with national groups within the UK and several international groups in the US, Europe and Asia. 


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Current Research

 

Role of host genetic factors in gastric cancer (main collaborators: National Cancer Institute / NIH, Bethesda, USA; Nagoya Graduate School of Medicine, Nagoya, Japan; Hamamatsu Univesity School of Medicine, Hamamatsu, Japan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Mexcio) 

Pathogenesis of Helicobacyter pylori infection (main collaborators: New York University School of Medicine; National Cancer Institute / NIH, Bethesda, USA; Vanderbilt University School of Medicine, Nashville, Tennessee, USA; University of Toronto, Toronto, Canada; European Helicobacter Study Group) 

Role of chronic inflammation in pathogenesis of colorectal neoplasia (main collaborators: Rowett Research Institute) 

Study of bacterial diversity in pathogenesis of colorectal neoplasia 

Study of bacterial diversity and its functional consequences on pathogenesis of inflammatory bowel disease (main collaborators: Rowett Research Institute, Aberdeen

Role of anti-inflammatory diet on modulating risk of colorectal neoplasia (main collaborators: Rowett Research Institute) 


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Teaching Responsibilities

Professor El-Omar is the Academic Development Coordinator for the School of Medicine at Aberdeen University. He oversees a wide range of clinical academic initiatives for undergraduates and postgraduates including the Academic Foundation Programme and Clinical Lecturer posts.  


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External Responsibilities

Professor El-Omar is the Editor in Chief of the journal GUT (2011 IF 10.111). He also currently sits on the international editorial boards of several journals including Gastroenterology, Helicobacter, World Journal of Gastroenterology, Fibrogenesis & Tissue Repair and Journal of Digestive Diseases.

Professor El-Omar chairs the Scientific Advisory Board for the Singapore Gastric Cancer Consortium. He is also on the grant review board for the National Medical Research Council of Singapore.

Professor El-Omar is the Chair of the Gastroduodenal Section of the British Society of Gatsroenterology (since 2007) and sits on the BSG Council, the Education, Programme, and Clinical Services and Standards Committees of the BSG.


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Publications 

Contributions to Journals

Articles

  • Hold, GL., Smith, M., Grange, C., Watt, ER., El-Omar, EM. & Mukhopadhya, I. (2014). 'Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?'. World Journal of Gastroenterology, vol 20, no. 5, pp. 1192-1210.
    [Online] DOI: 10.3748/wjg.v20.i5.1192
  • Mactier, KE., Glaire, MA., Basavaraju, U., El-Omar, EM. & Hold, GL. (in press). 'MicroRNAs in gastrointestinal malignancy: a tool in cancer prevention?'. European Journal of Cancer Prevention.
    [Online] DOI: 10.1097/CEJ.0000000000000014
  • Kostic, AD., Chun, E., Robertson, L., Glickman, JN., Gallini, CA., Michaud, M., Clancy, TE., Chung, DC., Lochhead, P., Hold, GL., El-Omar, EM., Brenner, D., Fuchs, CS., Meyerson, M. & Garrett, WS. (2013). 'Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment'. Cell Host & Microbe, vol 14, no. 2, pp. 207-215.
    [Online] DOI: 10.1016/j.chom.2013.07.007
  • Hansen, R., Berry, SH., Mukhopadhya, I., Thomson, JM., Saunders, KA., Nicholl, CE., Bisset, WM., Loganathan, S., Mahdi, G., Kastner-Cole, D., Barclay, AR., Bishop, J., Flynn, DM., McGrogan, P., Russell, RK., El-Omar, EM. & Hold, GL. (2013). 'The microaerophilic microbiota of de-novo paediatric inflammatory bowel disease: the BISCUIT study'. PloS one, vol 8, no. 3, e58825.
    [Online] DOI: 10.1371/journal.pone.0058825
  • McLean, MH., Thomson, AJ., Murray, GI., Fyfe, N., Hold, GL. & El-Omar, EM. (2013). 'Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression: a marker of malignant potential?'. British Journal of Cancer, vol 108, no. 12, pp. 2537-2541.
    [Online] DOI: 10.1038/bjc.2013.264
  • Graf, N., McLean, MH., Capellino, S., Scholmerich, J., Murray, GI., El-Omar, EM. & Straub, RH. (2012). 'Loss of sensory and noradrenergic innervation in benign colorectal adenomatous polyps-a putative role of semaphorins 3F and 3A'. Neurogastroenterology and Motility, vol 24, no. 2, pp. 120-e83., 10.1111/j.1365-2982.2011.01818.x
    [Online] DOI: 10.1111/j.1365-2982.2011.01818.x
  • Raju, D., Hussey, S., Ang, M., Terebiznik, MR., Sibony, M., Galindo-Mata, E., Gupta, V., Blanke, SR., Delgado, A., Romero-Gallo, J., Ramjeet, MS., Mascarenhas, H., Peek, RM., Correa, P., Streutker, C., Hold, G., Kunstmann, E., Yoshimori, T., Silverberg, MS., Girardin, SE., Philpott, DJ., El Omar, E. & Jones, NL. (2012). 'Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans'. Gastroenterology, vol 142, no. 5, pp. 1160-1171.
    [Online] DOI: 10.1053/j.gastro.2012.01.043
    [Online] AURA: Raju_et_al_Gastroenterology_2012.pdf
  • Smith, C., Lochhead, P., Basavaraju, U., Hold, GL., Fyfe, N., Murray, GI. & El-Omar, EM. (2012). 'Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia: a case-control and immunohistochemical study'. BMC Research Notes, vol 5, no. 1, pp. 371.
    [Online] DOI: 10.1186/1756-0500-5-371
  • Palmer, AJ., Lochhead, P., Hold, GL., Rabkin, CS., Chow, W-H, Lissowska, J., Vaughan, TL., Berry, S., Gammon, MD., Risch, HA. & El-Omar, EM. (2012). 'Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations'. European Journal of Cancer Prevention, vol 21, no. 6, pp. 541-544.
    [Online] DOI: 10.1097/CEJ.0b013e3283529b79
  • Hansen, R., Russell, RK., Reiff, C., Louis, P., McIntosh, F., Berry, SH., Mukhopadhya, I., Bisset, WM., Barclay, AR., Bishop, J., Flynn, DM., McGrogan, P., Loganathan, S., Mahdi, G., Flint, HJ., El-Omar, EM. & Hold, GL. (2012). 'Microbiota of De-Novo Pediatric IBD: Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's But Not in Ulcerative Colitis'. American journal of gastroenterology, vol 107, no. 12, pp. 1913-1922.
    [Online] DOI: 10.1038/ajg.2012.335
    [Online] AURA: Microbiota_of_De_Novo_Pediatric_IBD.pdf
    [Link] http://www.nature.com/ajg/journal/v107/n12/full/ajg2012335a.html
  • McLean, MH., Murray, GI., Stewart, KN., Norrie, G., Mayer, C., Hold, GL., Thomson, J., Fyfe, N., Hope, M., Mowat, NAG., Drew, JE. & El-Omar, EM. (2011). 'The inflammatory microenvironment in colorectal neoplasia'. PLoS ONE, vol 6, no. 1, e15366.
    [Online] DOI: 10.1371/journal.pone.0015366
    [Online] AURA: McLean_et_al_PLoS_2011.pdf
    [Link] http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015366
  • Thomson, JM., Hansen, R., Berry, SH., Hope, ME., Murray, GI., Mukhopadhya, I., McLean, MH., Shen, Z., Fox, JG., El-Omar, E. & Hold, GL. (2011). 'Enterohepatic Helicobacter in ulcerative colitis: potential pathogenic entities?'. PLoS ONE, vol 6, no. 2, e17184.
    [Online] DOI: 10.1371/journal.pone.0017184
    [Online] AURA: Enterohepatic%20Helicobacter%20in%20ulcerative%20colitis-%20...
    [Link] http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017184
  • Lochhead, P., Ng, MTH., Hold, GL., Rabkin, CS., Vaughan, TL., Gammon, MD., Risch, HA., Lissowska, J., Mukhopadhya, I., Chow, W-H & El-Omar, EM. (2011). 'Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer'. European Journal of Cancer Prevention, vol 20, no. 1, pp. 54-57.
    [Online] DOI: 10.1097/CEJ.0b013e328341e320
  • Lochhead, P., Frank, B., Hold, GL., Rabkin, CS., Ng, MTH., Vaughan, TL., Risch, HA., Gammon, MD., Lissowska, J., Weck, MN., Raum, E., Müller, H., Illig, T., Klopp, N., Dawson, A., McColl, KE., Brenner, H., Chow, W-H & El-Omar, EM. (2011). 'Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals'. Gastroenterology, vol 140, no. 2, pp. 435-441.
    [Online] DOI: 10.1053/j.gastro.2010.11.001
  • Mukhopadhya, I., Thomson, JM., Hansen, R., Berry, SH., El-Omar, EM. & Hold, GL. (2011). 'Detection of Campylobacter concisus and other Campylobacter species in colonic biopsies from adults with ulcerative colitis'. PLoS ONE, vol 6, no. 6, e21490.
    [Online] DOI: 10.1371/journal.pone.0021490
    [Online] AURA: Detection_of_Campylobacter_concisus_and_Other_Campylobacter_...
  • Mukhopadhya, I., Hansen, R., Nicholl, CE., Alhaidan, YA., Thomson, JM., Berry, SH., Pattinson, C., Stead, DA., Russell, RK., El-Omar, EM. & Hold, GL. (2011). 'A comprehensive evaluation of colonic mucosal isolates of Sutterella wadsworthensis from inflammatory bowel disease'. PLoS ONE, vol 6, no. 10.
    [Online] DOI: 10.1371/journal.pone.0027076
    [Online] AURA: A_Comprehensive_Evaluation_of_Colonic_Mucosal_Isolates_of_Su...
    [Link] http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027076
  • Ng, MTH., Van't Hof, R., Crockett, JC., Hope, ME., Berry, S., Thomson, J., McLean, MH., McColl, KEL., El-Omar, EM. & Hold, GL. (2010). 'Increase in NF-κB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease'. Infection and Immunity, vol 78, no. 3, pp. 1345-1352.
    [Online] DOI: 10.1128/IAI.01226-09
  • Demaria, S., Pikarsky, E., Karin, M., Coussens, LM., Chen, Y-C, El-Omar, EM., Trinchieri, G., Dubinett, SM., Mao, JT., Szabo, E., Krieg, A., Weiner, GJ., Fox, BA., Coukos, G., Wang, E., Abraham, RJ., Carbone, M. & Lotze, MT. (2010). 'Cancer and Inflammation: health sciences journal'. Journal of Immunotherapy, vol 33, no. 4, pp. 335-351.
    [Online] DOI: 10.1097/CJI.0b013e3181d32e74
  • El-Omar, EM. (2010). 'Gut's golden anniversary and a new editor-in-chief'. Gut, vol 59, no. 3, pp. 281.
    [Online] DOI: 10.1136/gut.2010.208801
  • Bain, G., Murray, G., Denison, A., Brooks, M., Collie-Duguid, E., McKiddie, F., Gilbert, F., El-Omar, E., Park, K., McAteer, D., Phull, P., Qadir, A. & Petty, R. (2010). 'Aberdeen Microarray and PET in Optimising Oesophagogastric Cancer Response-1 (AMPETOOR-1). Preliminary Results: Preliminary Results'. Annals of Oncology, vol 21, pp. 43.
  • Hold, GL., Rabkin, CS., Gammon, MD., Berry, SH., Smith, MG., Lissowska, J., Risch, HA., Chow, W-H, Mowat, AG., Vaughan, TL. & El-Omar, EM. (2009). 'CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations'. European Journal of Cancer Prevention, vol 18, no. 2, pp. 117-119.
    [Online] DOI: 10.1097/CEJ.0b013e3283101292
  • Hold, GL., Untiveros, P., Saunders, KA. & El-Omar, EM. (2009). 'Role of host genetics in fibrosis'. Fibrogenesis & Tissue Repair, vol 2, 6.
    [Online] DOI: 10.1186/1755-1536-2-6
  • Shanks, A-M & El-Omar, EM. (2009). 'Helicobacter pylori infection, host genetics and gastric cancer'. Journal of Digestive Diseases, vol 10, no. 3, pp. 157-164.
    [Online] DOI: 10.1111/j.1751-2980.2009.00380.x
  • Jeffery, N., McLean, MH., El-Omar, EM. & Murray, GI. (2009). 'The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers'. Histopathology, vol 54, no. 7, pp. 820-828.
    [Online] DOI: 10.1111/j.1365-2559.2009.03301.x
  • McLean, MH. & El-Omar, EM. (2009). 'Genetic aspects of inflammation'. Current Opinion in Pharmacology, vol 9, no. 4, pp. 370-374.
    [Online] DOI: 10.1016/j.coph.2009.06.003
  • Watanabe, O., Ando, T., El-Omar, EM., Shimada, M., Ina, K., Ishiguro, K., Hasegawa, M., Miyake, N., Nakamura, M., Miyahara, R., Ohmiya, N., Niwa, Y. & Goto, H. (2009). 'Role of endoscopic ultrasonography in predicting the response to cyclosporin A in ulcerative colitis refractory to steroids'. Digestive and Liver Disease, vol 41, no. 10, pp. 735-739.
    [Online] DOI: 10.1016/j.dld.2009.03.014
  • Mbulaiteye, SM., Hisada, M. & El-Omar, EM. (2009). 'Helicobacter Pylori associated global gastric cancer burden'. Frontiers in Bioscience, vol 14, pp. 1490-1504.
    [Online] DOI: 10.2741/3320
  • Mahajan, R., El-Omar, EM., Lissowska, J., Grillo, P., Rabkin, CS., Baccarelli, A., Yeager, M., Sobin, LH., Zatonski, W., Channock, SJ., Chow, W-H & Hou, L. (2008). 'Genetic variants in t helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population'. Japanese Journal of Clinical Oncology, vol 38, no. 9, pp. 626-633.
    [Online] DOI: 10.1093/jjco/hyn075
    [Link] http://beta.ukpmc.ac.uk/abstract/PMC/2528891
  • Argent, RH., Hale, JL., El-Omar, EM. & Atherton, JC. (2008). 'Differences in Helicobacter pylori CagA tyrosine phosphorylation motif patterns between western and East Asian strains, and influences on interleukin-8 secretion'. Journal of Medical Microbiology, vol 57, no. 9, pp. 1062-1067.
    [Online] DOI: 10.1099/jmm.0.2008/001818-0
  • Rugge, M., Correa, P., Di Mario, F., El-Omar, E., Fiocca, R., Geboes, K., Genta, RM., Graham, DY., Hattori, T., Malfertheiner, P., Nakajima, S., Sipponen, P., Sung, J., Weinstein, W. & Vieth, M. (2008). 'OLGA staging for gastritis: A tutorial'. Digestive and Liver Disease, vol 40, no. 8, pp. 650-658.
    [Online] DOI: 10.1016/j.dld.2008.02.030
  • McNamara, D. & El-Omar, E. (2008). 'Helicobacter pylori infection and the pathogenesis of gastric cancer: a paradigm for host-bacterial interactions'. Digestive and Liver Disease, vol 40, no. 7, pp. 504-509.
    [Online] DOI: 10.1016/j.dld.2008.02.031
  • McLean, MH., Murray, GI., Fyfe, N., Hold, GL., Mowat, NAG. & El-Omar, EM. (2008). 'COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics'. Histopathology, vol 52, no. 7, pp. 806-815.
    [Online] DOI: 10.1111/j.1365-2559.2008.03038.x
  • Argent, RH., Thomas, RJ., Aviles-Jimenez, F., Letley, DP., Limb, MC., El-Omar, EM. & Atherton, JC. (2008). 'Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families'. Clinical Cancer Research, vol 14, no. 7, pp. 2227-2235.
    [Online] DOI: 10.1158/1078-0432.CCR-07-2022
  • Lochhead, P. & El-Omar, EM. (2008). 'Gastric cancer'. British Medical Bulletin, vol 85, no. 1, pp. 87-100.
    [Online] DOI: 10.1093/bmb/ldn007
  • Thomson, JM., Louis, P., Hold, GL., Mowat, NG., Flint, HJ. & El-Omar, EM. (2008). 'Changes in the mucosally adherent microbial community in ulcerative colitis'. Gut, vol 57, no. Supplement 1, pp. A150-A150.
  • Snaith, AC. & El-Omar, EM. (2008). 'Helicobacter pylori: host genetics and disease outcomes'. Expert Review of Gastroenterology & Hepatology, vol 2, no. 4, pp. 577-585.
    [Online] DOI: 10.1586/17474124.2.4.577
  • Rugge, M., Correa, P., Di Mario, F., El-Omar, EM., Fiocca, R., Geboes, K., Genta, RM., Graham, DY., Hattori, T., Malfertheiner, P., Nakajima, S., Sipponen, P., Sung, J., Weinstein, W. & Vieth, M. (2008). 'OLGA staging for gastritis: a tutorial'. Digestive and Liver Disease, vol 40, no. 8, pp. 650-658.
    [Online] DOI: 10.1016/j.dld.2008.02.030
  • McLean, MH., Murray, GI., Stewart, KN., Hold, GL., Fyfe, N., Mowat, NAG. & El-Omar, EM. (2008). 'Role of chronic inflammation in sporadic colorectal neoplasia'. Gastroenterology, vol 134, no. 4 Supplement 1, pp. A293-A294.
    [Online] DOI: 10.1016/S0016-5085(08)61366-9
  • Hold, GL., Rabkin, CS., Chow, W-H, Smith, MG., Gammon, MD., Risch, HA., Vaughan, TL., McColl, KEL., Lissowska, J., Zatonski, W., Schoenberg, JB., Blot, WJ., Mowat, NAG., Fraumeni, JF. & El-Omar, EM. (2007). 'A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors'. Gastroenterology, vol 132, no. 3, pp. 905-912.
    [Online] DOI: 10.1053/J.GASTRO.2006.12.026
  • Malfertheiner, P., Megraud, F., O'Morain, C., Bazzoli, F., El-Omar, E., Graham, D., Hunt, R., Rokkas, T., Vakil, N., Kuipers, EJ. & EHSG Study Grp (2007). 'Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report'. Gut, vol 56, no. 6, pp. 772-781.
    [Online] DOI: 10.1136/gut.2006.101634
  • Lochhead, P. & El-Omar, EM. (2007). 'Helicobacter pylori infection and gastric cancer'. Best Practice & Research Clinical Gastroenterology, vol 21, no. 2, pp. 281-297.
    [Online] DOI: 10.1016/j.bpg.2007.02.002
  • Hou, L., El-Omar, EM., Chen, J., Grillo, P., Rabkin, CS., Baccarelli, A., Yeager, M., Chanock, SJ., Zatonski, W., Sobin, LH., Lissowska, J., Fraumeni, JF. & Chow, WH. (2007). 'Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancer'. Carcinogenesis, vol 28, no. 1, pp. 118-123.
    [Online] DOI: 10.1093/carcin/bgl130
  • Ando, T., El-Omar, EM., Goto, Y., Nobata, K., Watanabe, O., Maeda, O., Ishiguro, K., Minami, M., Hamajima, N. & Goto, H. (2006). 'Interleukin 1ß proinflammatory genotypes protect against gastro-oesophageal reflux disease through induction of corpus atrophy'. Gut, vol 55, no. 2, pp. 158-164.
    [Online] DOI: 10.1136/GUT.2005.072942
  • El-Omar, EM. (2006). 'Role of host genes in sporadic gastric cancer'. Best Practice & Research Clinical Gastroenterology, vol 20, no. 4, pp. 675-686.
    [Online] DOI: 10.1016/j.bpg.2006.04.006
  • Baccarelli, A., Hou, L., Chen, J., Lissowska, J., El-Omar, EM., Grillo, P., Giacomini, SM., Yaeger, M., Bernig, T., Zatonski, W., Fraumeni, JF., Chanock, SJ. & Chow, W-H (2006). 'Mannose-binding lectin-2 genetic variation and stomach cancer risk'. International Journal of Cancer, vol 119, no. 8, pp. 1970-1975.
    [Online] DOI: 10.1002/ijc.22075
  • Tseng, F-C, Brown, EE., Maiese, EM., Yeager, M., Welch, R., Gold, BD., Owens, M., Cranston, B., Hanchard, B., El-Omar, E. & Hisada, M. (2006). 'Polymorphisms in cytokine genes and risk of Helicobacter pylori infection among jamaican children'. Helicobacter, vol 11, pp. 425-430.
  • McLean, MH., Murray, GI., Fyfe, N., Hold, GL., Mowat, AG. & El-Omar, EM. (2006). 'Assessment of inflammation within sporadic colorectal polyps'. Gut, vol 55, no. Suppl. 2, pp. A23.
  • McLean, MH., Murray, GI., Fyfe, N., Hold, GL., Mowat, AG. & El-Omar, EM. (2006). 'Expression of cyclooxygenase-2 in human sporadic colorectal adenomas'. Gut, vol 55, no. Suppl. 2, pp. A23-A24.
  • Hold, GL., Smith, MG., Berry, SH., McColl, KE. & El-Omar, EM. (2006). 'Innate immune response gene polymorphisms and their role in H pylori induced precancerous changes'. Gut, vol 55, no. Suppl. 2, pp. A26-A27.
  • Garza-Gonzalez, E., Bosques-Padilla, FJ., El-Omar, EM., Hold, GL., Tijerina-Menchaca, R., Maldonado-Garza, HJ. & Perez-Perez, GI. (2005). 'Role of the polymorphic IL-1B, IL-1RN and TNF-A genes in distal gastric cancer in Mexico'. International Journal of Cancer, vol 114, no. 2, pp. 237-241.
    [Online] DOI: 10.1002/ijc.20718
  • Macarthur, M., sharp, L., hold, G., little, J. & El-Omar, EM. (2005). 'The Role of Cytokine Gene Polymorphisms in Colorectal Cancer and their interaction with Aspirin Use in the North East of Scotland'. Cancer Epidemiology, Biomarkers and Prevention, vol 14, no. 7, pp. 1613-1618.
    [Online] DOI: 10.1158/1055-9965.EPI-04-0878
  • Ando, T., Minami, M., Mizuno, T., Watanabe, O., Ishiguro, K., Ina, K., Kusugami, K., Nobata, K., Nishiwaki, T., Tsuzuki, T., Shimada, M., El-Omar, E. & Goto, H. (2005). 'Long-term follow-up after eradication of Helicobacter pylori with omeprazole, clarithromycin, and tinidazole (OCT regimen) in a Japanese population'. Helicobacter, vol 10, pp. 379-384.
  • Cooper, IAM., Hold, GL., Shen, Z., Fox, JG. & El-Omar, EM. (2005). 'Development of a Helicobacter genus DNA probe for fluorescent in situ hybridization in gastrointestinal clinical samples'. Helicobacter, vol 10, no. 5, pp. 520.
  • Cooper, IAM., Hold, GL., Smith, MG., Vijayan, B., Fyfe, N., Shen, Z., Fox, JG. & El-Omar, EM. (2005). 'Detection of Helicobacter species in archival human UC colorectal tissue by fluorescent in situ hybridization (FISH)'. Helicobacter, vol 10, no. 5, pp. 549-549.
  • Smith, MG., Hold, GL., Rabkin, C., Chow, WH., Fraumeni, JF., Mowat, AG., Ando, T., Goto, H. & El-Omar, EM. (2005). 'IL-8-251 promoter polymorphism and risk of gastric cancer in white and Japanese populations'. Gut, vol 54, pp. A9.
  • Smith, MG., Hold, GL., MacArthur, M., McLean, MH., Hope, M., Mowat, AG., McColl, KE. & El-Omar, EM. (2005). 'COX-2 gene polymorphisms and association with premalignant changes in the stomach'. Gut, vol 54, no. Suppl. 2.
  • Furuta, T., Shirai, N., Xiao, F., El-Omar, EM., Rabkin, CS., Sugimura, H., Ishizaki, T. & Ohashi, K. (2004). 'Polymorphism of interleukin-1beta affects the eradication rates of Helicobacter pylori by triple therapy'. Clinical Gastroenterology and Hepatology, vol 2, no. 1, pp. 22-30.
    [Online] DOI: 10.1016/S1542-3565(03)00288-X
  • de Sanjose, S., Dickie, A., Alvaro, T., Romagosa, V., Garcia Villanueva, M., Domingo-Domenech, E., Fernandez de Sevilla, A. & El-Omar, EM. (2004). 'Helicobacter pylori and malignant lymphoma in Spain'. Cancer Epidemiology, Biomarkers and Prevention, vol 13, no. 6, pp. 944-948.
  • Macarthur, M., Hold, GL. & El-Omar, EM. (2004). 'Inflammation and Cancer: II. Role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy'. American journal of physiology. Gastrointestinal and liver physiology, vol 286, no. 4, pp. G515-G520.
    [Online] DOI: 10.1152/ajpgi.00475.2003
  • Ando, T., Tsuzuki, T., Mizuno, T., Minami, M., Ina, K., Kusugami, K., Takamatsu, J., Adachi, K., El-Omar, E., Ohta, M. & Goto, H. (2004). 'Characteristics of Helicobacter pylori-induced gastritis and the effect of H-pylori eradication in patients with chronic idiopathic thrombocytopenic purpura'. Helicobacter, vol 9, pp. 443-452.
  • MacArthur, M., Sharp, L., Hold, GL., Little, J. & El-Omar, EM. (2004). 'Role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the north east of Scotland'. Gut, vol 53, pp. A17.
  • Hold, GL., Smith, MG., Chow, WH., Rabkin, CS. & El-Omar, EM. (2004). 'A functional toll like receptor 4 polymorphism increases risk of gastric cancer'. Gut, vol 53, no. Suppl. 3, pp. A23.
  • El-Omar, EM., Rabkin, CS., Gammon, MD., Vaughan, TL., Risch, HA., Schoenberg, JB., Stanford, JL., Mayne, ST., Goedert, J., Blot, WJ., Fraumeni, JF. & Chow, WH. (2003). 'Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms'. Gastroenterology, vol 124, no. 5, pp. 1193-1201.
    [Online] DOI: 10.1016/S0016-5085(03)00157-4
  • Troost, E., Hold, GL., Smith, MG., Chow, WH., Rabkin, CS., McColl, KE. & El-Omar, EM. (2003). 'The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk'. Canadian Journal of Gastroenterology, vol 17, no. Suppl B, pp. 8B-12B.
  • Furuta, T., El-Omar, EM., Xiao, F., Shirai, N., Takashima, M. & Sugimura, H. (2002). 'Interleukin 1 ß polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan'. Gastroenterology, vol 123, no. 1, pp. 92-105.
    [Online] DOI: 10.1053/gast.2002.34156
  • Takata, T., El-Omar, EM., Camorlinga, M., Thompson, SA., Minohara, Y., Ernst, PB. & Blaser, MJ. (2002). 'Helicobacter pylori does not require Lewis X or Lewis Y expression to colonize C3H/HeJ mice'. Infection and Immunity, vol 70, no. 6, pp. 3073-3079.
    [Online] DOI: 10.1128/IAI.70.6.3073-3079.2002
  • Garza-Gonzalez, E., Hold, GL., Perez Perez, GI., Martinez-Padilla, J., Tijerina-Menchaca, R. & El-Omar, EM. (2002). 'Role of the polymorphic cytokines genes in gastric cancer in Mexico'. Gut, vol 51, pp. A23.

Scientific Reviews

  • Mukhopadhya, I., Hansen, R., El-Omar, EM. & Hold, GL. (2012). 'IBD-what role do Proteobacteria play?'. Nature Reviews Gastroenterology & Hepatology, vol 9, pp. 219-230.
    [Online] DOI: 10.1038/nrgastro.2012.14
  • Hansen, R., Thomson, J., El-Omar, EM. & Hold, GL. (2011). 'Could Helicobacter organisms cause inflammatory bowel disease?'. FEMS Immunology and Medical Microbiology, vol 61, no. 1, pp. 1-14.
    [Online] DOI: 10.1111/j.1574-695X.2010.00744.x
  • Hansen, R., Thomson, J., El-Omar, EM. & Hold, GL. (2010). 'The role of infection in the aetiology of inflammatory bowel disease'. Journal of Gastroenterology, vol 45, no. 3, pp. 266-276.
    [Online] DOI: 10.1007/s00535-009-0191-y
  • Hold, GL. & El-Omar, EM. (2008). 'Genetic aspects of inflammation and cancer'. Biochemical Journal, vol 410, pp. 225-235.
    [Online] DOI: 10.1042/BJ20071341
  • El-Omar, EM., Ng, MT. & Hold, GL. (2008). 'Polymorphisms in Toll-like receptor genes and risk of cancer'. Oncogene, vol 27, no. 2, pp. 244-252.
    [Online] DOI: 10.1038/sj.onc.1210912
  • Amieva, MR. & El-Omar, EM. (2008). 'Host-bacterial interactions in Helicobacter pylori infection'. Gastroenterology, vol 134, no. 1, pp. 306-323.
    [Online] DOI: 10.1053/j.gastro.2007.11.009
  • Smith, MG., Hold, GL., Tahara, E. & El-Omar, EM. (2006). 'Cellular and molecular aspects of gastric cancer'. World Journal of Gastroenterology, vol 12, no. 19, pp. 2979-2990.
  • Hope, ME., Hold, GL., Kain, R. & El-Omar, EM. (2005). 'Sporadic colorectal cancer: role of the commensal microbiota'. FEMS Microbiology Letters, vol 244, no. 1, pp. 1-7.
    [Online] DOI: 10.1016/j.femsle.2005.01.029

Editorials

  • McNamara, D. & El-Omar, EM. (2007). 'How accurate are fecal tests for determination of cure after Helicobacter pylori eradication therapy?'. Nature Reviews Gastroenterology & Hepatology, vol 4, no. 5, pp. 248-249.
    [Online] DOI: 10.1038/ncpgasthep0790
  • El-Omar, EM. (2006). 'What is the optimal therapy for the eradication of Helicobacter pylori?'. Nature Reviews Gastroenterology & Hepatology, vol 3, pp. 126-127.
    [Online] DOI: 10.1038/ncpgasthep0422
  • El-Omar, EM. (2001). 'The importance of interleukin 1beta in Helicobacter pylori associated disease'. Gut, vol 48, no. 6, pp. 743-747.
    [Online] DOI: 10.1136/gut.48.6.743

Abstracts

  • McLean, MH., Murray, GI., Fyfe, N., Hold, GL., Mowat, AG. & El-Omar, EM. (2007). 'Assessment of macrophage function within the stroma of sporadic colorectal polyps'. Gut, vol 56, no. Suppl 2, 153, pp. A51-A51.
    [Link] http://gut.bmj.com/content/56/suppl_2/a1.full.pdf
  • McLean, MH., Murray, GI., Fyfe, N., Hold, GL., Mowat, AG. & El-Omar, EM. (2007). 'Assessment of inflammatory cell phenotype in sporadic hyperplastic polyps'. Gut, vol 56, no. Suppl 2, 154, pp. A51-A51.
    [Link] http://gut.bmj.com/content/56/suppl_2/a1.full.pdf
  • Hope, M., Hold, GL., Kain, R. & El-Omar, EM. (2004). 'Microbial diversity and carbohydrate expression in healthy and neoplastic colonic tissue'. Gut, vol 53, no. Supplement 3, 264, pp. A68.

Chapters in Books, Reports and Conference Proceedings

Chapters

  • Troost, E., Hold, GL., Smith, MG., Chow, WH., Rabkin, CS., McColl, KE. & El-Omar, EM. (2003). 'The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk'. in RH Hunt & GN Tygat (eds), Helicobacter pylori: Basic mechanisms to clinical cure 2002. Kluwer Academic Publishers, Dordrecht, Netherlands, pp. 125-224.

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