Epithelial transport is essential for the
maintenance and propagation of life. In this course you will explore the
features of transporting epithelial cells which make them uniquely suited for
mediating the controlled, directional passage of ions, nutrients and water
across the walls of the alimentary, renal and respiratory systems. The
importance of these processes to the normal physiological function of these
organ systems is reflected by the pathophysiological symptoms which manifest
themselves when transport regulation breaks down. For example, infectious
diarrhoea occurs as a result of excessive intestinal fluid secretion and
accounts for more than five million child deaths per year in developing
countries. At the other extreme, the most common genetic disease of the
developed world, cystic fibrosis, is caused by a failure of epithelial tissues
to secrete any fluid at all resulting in malnutrition, infertility and
ultimately, respiratory failure and death. The course will initially examine
the common features of transporting epithelial cells and the technologies
available for their study. Following on from this, the role of epithelial cells
in the kidney, gastrointestinal tract and respiratory system will be examined
in detail. Emphasis is placed on understanding the cellular transport
mechanisms required for the normal physiological function of these systems in
health. Where insight into these processes has been enhanced by the study of
disease models, these will be highlighted.
