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CM5046: DRUG METABOLISM AND PHARMACOKINETICS (DMPK) (2021-2022)

Last modified: 31 May 2022 13:05


Course Overview

This course introduces a core discipline within drug discovery, namely drug metabolism and pharmacokinetics (DMPK). DMPK is primarily concerned with safety evaluation, drug absorption and how a drug is metabolised. The course will combine an introduction to basic pathways of enzymatic xenobiotic metabolism, the measurement and modelling of drug and metabolite concentrations and the regulatory framework overseeing this stage of drug development.

Course Details

Study Type Postgraduate Level 5
Session First Sub Session Credit Points 15 credits (7.5 ECTS credits)
Campus Aberdeen Sustained Study No
Co-ordinators
  • Dr Rainer Ebel
  • Dr Rebecca Walker

What courses & programmes must have been taken before this course?

  • Any Postgraduate Programme

What courses cannot be taken with this course?

  • CM5546 Drug Metabolism and Pharmacokinetics (Dmpk) (Studied)

Are there a limited number of places available?

No

Course Description

This course provides an introduction to drug metabolism and pharmacokinetics (DMPK). DMPK is primarily concerned with safety evaluation in drug development. In recent times DMPK has become a core discipline within drug discovery, development and post-marketing.

Basic pathways of enzymatic xenobiotic metabolism will be explained. The course will go on to explain standard methodologies for measuring drug and metabolite concentrations in biological fluids (bioanalysis) and to promote an understanding of how this data is modelled using pharmacokinetics. The course will conclude by covering the regulatory requirements and guidance set out by the main government and international agencies that are relevant to conducting this work during pharmaceutical development.


Details for second half-session courses, including assessments, may be subject to change until 23 December 2022.

Contact Teaching Time

Information on contact teaching time is available from the course guide.

Teaching Breakdown

More Information about Week Numbers


Details for second half-session courses, including assessments, may be subject to change until 23 December 2022.

Summative Assessments

Essay

Assessment Type Summative Weighting 25
Assessment Weeks 16 Feedback Weeks 18

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Written

Word Count 1000
Learning Outcomes
Knowledge LevelThinking SkillOutcome
ConceptualUnderstandUnderstand the origins and development of DMPK.
ConceptualUnderstandUnderstand the key metabolic pathways in vivo.
ProceduralApplyUnderstand the application of DMPK to drug development.
ProceduralApplyUnderstand the key analytical methodology to obtain relevant data for DMPK
ProceduralEvaluateBasic understanding of DMPK statistical analysis including evaluation of data.

Exam

Assessment Type Summative Weighting 75
Assessment Weeks 19,20 Feedback Weeks

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Written

Learning Outcomes
Knowledge LevelThinking SkillOutcome
ConceptualUnderstandUnderstand the origins and development of DMPK.
ConceptualUnderstandUnderstand the key metabolic pathways in vivo.
ProceduralApplyUnderstand the key analytical methodology to obtain relevant data for DMPK
ProceduralApplyUnderstand the application of DMPK to drug development.
ProceduralEvaluateBasic understanding of DMPK statistical analysis including evaluation of data.

Formative Assessment

There are no assessments for this course.

Resit Assessments

Essay

Assessment Type Summative Weighting 25
Assessment Weeks Feedback Weeks

Look up Week Numbers

Feedback

Written

Word Count 1000
Learning Outcomes
Knowledge LevelThinking SkillOutcome
ConceptualUnderstandUnderstand the origins and development of DMPK.
ConceptualUnderstandUnderstand the key metabolic pathways in vivo.
ProceduralApplyUnderstand the application of DMPK to drug development.
ProceduralApplyUnderstand the key analytical methodology to obtain relevant data for DMPK
ProceduralEvaluateBasic understanding of DMPK statistical analysis including evaluation of data.

Exam

Assessment Type Summative Weighting 75
Assessment Weeks Feedback Weeks

Look up Week Numbers

Feedback

Written.

Learning Outcomes
Knowledge LevelThinking SkillOutcome
ConceptualUnderstandUnderstand the origins and development of DMPK.
ConceptualUnderstandUnderstand the key metabolic pathways in vivo.
ProceduralApplyUnderstand the key analytical methodology to obtain relevant data for DMPK
ProceduralApplyUnderstand the application of DMPK to drug development.
ProceduralEvaluateBasic understanding of DMPK statistical analysis including evaluation of data.

Course Learning Outcomes

Knowledge LevelThinking SkillOutcome
ProceduralApplyUnderstand the key analytical methodology to obtain relevant data for DMPK
ConceptualUnderstandUnderstand the origins and development of DMPK.
ProceduralEvaluateBasic understanding of DMPK statistical analysis including evaluation of data.
ConceptualUnderstandUnderstand the key metabolic pathways in vivo.
ProceduralApplyUnderstand the application of DMPK to drug development.

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