Last modified: 25 Sep 2019 09:58
This course provides advanced level learning in drug metabolism, discovery and development. It includes the importance of drug transporters in the drug discovery process, regulatory issues and molecular toxicology and pharmacology at an advanced level. Mechanisms of drug-induced and oxidative stress and immunopharmacology are described. External experts are invited to provide their unique expertise on a range of topics which can include toxicopathology, immunotoxicology, risk assessment and an industrial perspective on the drug discovery process.
|Session||First Sub Session||Credit Points||15 credits (7.5 ECTS credits)|
Topics - absorption, distribution, metabolism, excretion and transport of drugs. Human drug metabolism -cytochrome P450. Induction/inhibition of cytochrome P450. Identification of
cytochrome P450 and transporters at an early stage in drug discovery. Mechanisms of drug induced toxicity: reactive metabolites; cytoprotective mechanisms; agents conferring
protection against drug toxicity - clinical applications; mechanisms of cell death; apoptosis and necrosis. Immunotoxicology and risk assessment. Pathology of drug toxicity. Haematological indices of drug toxicity.
Information on contact teaching time is available from the course guide.
|Assessment Weeks||17||Feedback Weeks||19|
|Assessment Weeks||17||Feedback Weeks||18|
|Assessment Weeks||14||Feedback Weeks||16|
There are no assessments for this course.
|Knowledge Level||Thinking Skill||Outcome|
|Procedural||Evaluate||Discuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies|
|Procedural||Understand||Understand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity|
|Conceptual||Evaluate||Describe various types of biomarkers particularly in relation to cancer and cancer therapies|
|Reflection||Evaluate||Evaluating industrial drug research and development and risk assessment|
|Reflection||Create||improved scientific communication|