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MT5003: DRUG METABOLISM & TOXICOLOGY (2016-2017)

Last modified: 28 Jun 2018 10:27


Course Overview

This course provides advanced level drug metabolism and includes the importance of drug transporters in the drug discovery process, dealing with molecular toxicology and pharmacology at an advanced level. Mechanisms of drug and oxidative stress and immunopharmacology are described. External experts are invited to provide their unique expertise on a range of topics which can include toxicopathology, immunotoxicology, risk assessment and an industrial perspective on the drug discovery process.

Course Details

Study Type Postgraduate Level 5
Session First Sub Session Credit Points 15 credits (7.5 ECTS credits)
Campus None. Sustained Study No
Co-ordinators
  • Professor Heather Wallace

Qualification Prerequisites

None.

What courses & programmes must have been taken before this course?

  • One of MRes Drug Discovery (Studied) or MSc Clinical Pharmacology (Studied) or MSc Drug Discovery and Development (Studied) or MSc Bio-Business and Medical Sciences (Studied)
  • Any Postgraduate Programme (Studied)

What other courses must be taken with this course?

None.

What courses cannot be taken with this course?

None.

Are there a limited number of places available?

No

Course Description

Topics - absorption, distribution, metabolism and excretion of drugs. Human drug metabolism - cytochrome P450. Induction/inhibition of cytochrome P450. Identification of cytochrome P450 at an early stage in drug discovery. Mechanisms of drug induced toxicity: reactive metabolites; cytoprotective mechanisms; agents conferring protection against drug toxicity - clinical applications; mechanisms of cell death; apoptosis and necrosis. Immunotoxicology and risk assessment. Pathology of drug toxicity. Haematological indices of drug toxicity.


In light of Covid-19 this information is indicative and may be subject to change.

Contact Teaching Time

Information on contact teaching time is available from the course guide.

Teaching Breakdown

None.

More Information about Week Numbers


Summative Assessments

Continues assessment 50% (essay (15%), practical 1 (10%), practical 2 (15%), presentation (10%); written examination 50%.

Formative Assessment

There are no assessments for this course.

Feedback

None.

Course Learning Outcomes

None.

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