Last modified: 28 Jun 2018 10:27
This course provides advanced level drug metabolism and includes the importance of drug transporters in the drug discovery process, dealing with molecular toxicology and pharmacology at an advanced level. Mechanisms of drug and oxidative stress and immunopharmacology are described. External experts are invited to provide their unique expertise on a range of topics which can include toxicopathology, immunotoxicology, risk assessment and an industrial perspective on the drug discovery process.
|Session||First Sub Session||Credit Points||15 credits (7.5 ECTS credits)|
Topics - absorption, distribution, metabolism and excretion of drugs. Human drug metabolism - cytochrome P450. Induction/inhibition of cytochrome P450. Identification of cytochrome P450 at an early stage in drug discovery. Mechanisms of drug induced toxicity: reactive metabolites; cytoprotective mechanisms; agents conferring protection against drug toxicity - clinical applications; mechanisms of cell death; apoptosis and necrosis. Immunotoxicology and risk assessment. Pathology of drug toxicity. Haematological indices of drug toxicity.
Information on contact teaching time is available from the course guide.
Continues assessment 50% (essay (15%), practical 1 (10%), practical 2 (15%), presentation (10%); written examination 50%.
There are no assessments for this course.