Last modified: 05 Aug 2021 13:04
This course will cover the principles of toxicology including molecular toxicology and target organ toxicity, mechanisms of cell death, molecular carcinogenesis and safety evaluation of carcinogens, adverse outcome pathways (AOPs) and new alternative methods (NAMs). These elements will be taught around the processes involved in drug discovery and development and will include advanced learning on drug metabolism and drug transporters. The course will also provide the principles and practice of risk assessment and regulatory toxicology. External experts are invited to provide their unique expertise on a range of topics, which include regulatory aspects as well as an industrial perspective on the drug discovery process.
|Session||First Sub Session||Credit Points||15 credits (7.5 ECTS credits)|
Topics - Principles of toxicology; target organ toxicity and oxidative stress; molecular toxicology; mechanisms of cell death; molecular and chemical carcinogenesis; use of biomarkers; safety evaluation of carcinogens; drug metabolism and transporters; Risk Assessment; regulatory toxicology.
Information on contact teaching time is available from the course guide.
|Assessment Weeks||17||Feedback Weeks||19|
|Assessment Weeks||14||Feedback Weeks||16|
|Assessment Weeks||17||Feedback Weeks||18|
There are no assessments for this course.
|Knowledge Level||Thinking Skill||Outcome|
|Procedural||Understand||Understand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity|
|Reflection||Evaluate||Evaluating industrial drug research and development and risk assessment|
|Conceptual||Evaluate||Describe various types of biomarkers particularly in relation to cancer and cancer therapies|
|Procedural||Evaluate||Discuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies|
|Reflection||Create||improved scientific communication|