Last modified: 31 Jul 2023 11:19
|First Sub Session
|30 credits (15 ECTS credits)
The first part of the course deals with the basic biochemistry of genetic material, including an examination of DNA replication, including cell cycle, chromosome organisation, recombination and repair. We progress into the core central dogma by dealing with both prokaryotic and eukaryotic mechanisms for the transcription of DNA into RNA and the subsequent synthesis of proteins encoded in mRNA. The focus then moves first to protein molecules, dealing with protein processing, targeting and turnover, and then to cell biological aspects of protein trafficking, membrane transduction and cell signalling. The course concludes with a discussion of cell structure. Laboratory work and assignments are designed to complement and extend the lecture topics. Additional learning opportunities are provided in the staged series of Workshops, which allow the opportunity to actively employ understanding of a topic in a workshop/small group learning environment.
Information on contact teaching time is available from the course guide.
Essay analysis and essay 20%
Lab report 20%
Open book assessment 20%
Open book assessment 40%
There are no assessments for this course.
|Students will be able to describe the main features of transcription, including post-transcriptional processing, and translation in both prokaryotes and eukaryotes.
|Students will gain an understanding of, and training in, laboratory skills and how to observe and record scientific data.
|Students will be able to describe the main features of chromosomal organisation, recombination and repair.
|Students will be able to describe various selected aspects of protein biochemistry including protein folding, turnover, targeting and trafficking within the cell.
|Students will be able to describe the structure and propagation of mobile genetic elements (mobile DNA).
|Student will be able to describe the main features of DNA structure and replication.
|Students will be able to abstract information and understanding from complex literature and analyse and interpret data.
|Students will be able to describe the complex intracellular architecture of higher eukaryotic cells.
|Describe aspects of cell signalling in both prokaryotes and eukaryotes. This will include kinases, G-proteins, Ras, nuclear receptor, steroids, 2-component systems in microorganisms.