Professor Marcel Jaspars

  Professor Marcel Jaspars The University of Aberdeen Natural & Computing Sciences Professor Marcel Jaspars Chair in Chemistry work +44 (0)1224 272895 work fax 01224 272921 pref Meston Building Room G21

Chair in Chemistry

BA Hons (Cantab), PhD (Dublin), FRSC, CChem

Professor Marcel Jaspars

Contact Details

Telephone: +44 (0)1224 272895
Fax: 01224 272921
Email:

m.jaspars@abdn.ac.uk

Address: Meston Building Room G21
hCard

Marine Biodiscovery Centre


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Biography

Employment:

  • Professor of Organic Chemistry, University of Aberdeen, 2003-
  • Sabbatical at the Australian Institute of Marine Science, 2004
  • Senior Lecturer in Organic Chemistry, University of Aberdeen, 2000-2003
  • Lecturer in Organic Chemistry, University of Aberdeen, 1995-2000
  • Post-Doc, Crews Lab, University of California, Santa Cruz, 1993-1995
  • Post-Doc, Burgess Lab, Texas A & M University, 1992-1993

 

Education:

  • PhD in Davis group, Trinity College, Dublin, Eire entitled "Electrophilic Catalysis of the Sakurai Reaction", 1987-1991
  • BA (Hons) Cantab, Natural Sciences (Chemistry)

 

Fellowships/Awards:

  • Biotechnology and Biological Sciences Research Council Research Development Fellow, 2006-2009
  • American Society of Pharmacognosy Matt Suffness Award for young investigators, 2003
  • Fellow of the Royal Society of Chemistry, Chartered Chemist

 

Industrial Involvement:

  • Adviser to GlycoMar, Oban, CEO: Dr Charlie Bavington
  • Adviser to Aquapharm, Oban, CEO: Dr Andrew Mearns-Spragg 

Professional:

 


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Research Interests

"Some chemists, having synthesised a few compounds believe themselves to be better chemists than nature, which, in addition to synthesising compounds too numerous to mention, synthesised those chemists as well."

"Form follows function"

.....engineering benchmarks can serve as predictions for how Darwinian organisms ought to work. The more uncannily the engineering specifications for a system match the facts of the organism, the more confidently we can infer that the organism was selected to perform that function.

Steven Pinker, Nature 2000, 404, 441

It is often said that 'form follows function' and this can be shown to be true of many biological systems. We are particularly interested in showing the converse for those marine natural products whose functions have yet to be defined. My premise is that we can infer the true biological/ecological function of a natural product by careful study of its form using spectroscopic and physicochemical techniques. This type of investigation is the main theme of our research program. In addition we are taking examples from nature and modifying them in order to carry out alternative functions.

Visit the Marine Biodiscovery Centre website


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Teaching Responsibilities

Professor Jaspars teaches in the following courses: 

1st year General Chemistry (1st half session)

1st year Organic Chemistry (2nd half session)

3rd year Organic Spectroscopy

4th year Organic Spectroscopy

5th year Organic Spectroscopy


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External Responsibilities

2007-2012 Visiting Professor at MabCent, University of Tromsø, Norway 

2008-     On the Scientific Advisory Board of MabCent, Tromsø, Norway

2009-  Member of the International Union of Pure and Applied Chemistry Subcommittee on Biotechnology

2010- Member of the Industrial Biotechnology Sector Group of the Biosciences Knowledge Transfer Network

2010 -   UK member of the Marine Biotechnology working group of the European Science Foundation's Marine Board Marine Biotechnology Working Group that authored the report "Marine Biotechnology – A European Strategy"


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Textbook

"Organic Structure Analysis, 2nd Edition" Phillip Crews, Jaime Rodriguez and Marcel Jaspars. Oxford University Press, New York, 2010, 636 pp.

 


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Publications 

Contributions to Journals

Articles

  • Leirós, M., Alonso, E., Sanchez, JA., Rateb, MEM., Ebel, R., Houssen, WE., Jaspars, M., Alfonso, A. & Botana, LM. (2014). 'Mitigation of ROS Insults by Streptomyces Secondary Metabolites in Primary Cortical Neurons'. ACS Chemical Neuroscience, vol 5, no. 1, pp. 71-80.
    [Online] DOI: 10.1021/cn4001878
  • Qin, Z., Wang, X., Rateb, M., Ass'ad, LA., Jaspars, M., Deng, Z., Yu, Y. & Deng, H. (2014). 'Disruption of a methyltransferase gene in actinomycin G gene cluster in Streptomyces iakyrus increases the production of phenazinomycin'. FEMS Microbiology Letters, vol 352, no. 1, pp. 62-68.
    [Online] DOI: 10.1111/1574-6968.12370
  • Kyeremeh, K., Acquah, K., Sazak, A., Houssen, WE., Tabudravu, J., Deng, H. & Jaspars, M. (2014). 'Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310'. Marine Drugs, vol 12, no. 2, 12, pp. 999-1012.
    [Online] DOI: 10.3390/md12020999
    [Online] AURA: marinedrugs_12_00999.pdf
  • Rateb, ME., Hassan, HM., Arafa, E-SA, Jaspars, M., Ebel, R. & Rateb, ME.M (2014). 'Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum'. Natural Product Communications, vol 9, no. 4, pp. 473-6.
  • Leirós, M., Sánchez, JA., Alonso, E., Rateb, ME., Houssen, WE., Ebel, R., Jaspars, M., Alfonso, A., Botana, LM. & Rateb, ME.M (2014). 'Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress'. Marine Drugs, vol 12, no. 2, pp. 700-18.
    [Online] DOI: 10.3390/md12020700
  • Koehnke, J., Morawitz, F., Bent, AF., Houssen, WE., Shirran, SL., Fuszard, MA., Smellie, IA., Botting, CH., Smith, MCM., Jaspars, M. & Naismith, JH. (2013). 'An enzymatic route to selenazolines'. ChemBioChem, vol 14, no. 5, pp. 564-567.
    [Online] DOI: 10.1002/cbic.201300037
  • Wang, X., Tabudravu, J., Rateb, M., Annand, KJ., Qin, Z., Jaspars, M., Deng, Z., Yu, Y. & Deng, H. (2013). 'Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus'. Molecular BioSystems, vol 9, no. 6, pp. 1286-1289.
    [Online] DOI: 10.1039/c3mb70081j
  • Qin, Z., Baker, AT., Raab, A., Huang, S., Wang, T., Yu, Y., Jaspars, M., Secombes, CJ. & Deng, H. (2013). 'The fish pathogen Yersinia ruckeri produces holomycin and uses an RNA methyltransferase for self-resistance'. The Journal of Biological Chemistry, vol 288, no. 21, pp. 14688-14697.
    [Online] DOI: 10.1074/jbc.M112.448415
  • Wang, X., Tabudravu, J., Jaspars, M. & Deng, H. (2013). 'Tianchimycins A-B, 16-membered macrolides from the rare actinomycete Saccharothrix xinjiangensis'. Tetrahedron, vol 69, no. 30, pp. 6060-6064.
    [Online] DOI: 10.1016/j.tet.2013.05.094
  • Bent, AF., Koehnke, J., Houssen, WE., Smith, MCM., Jaspars, M. & Naismith, JH. (2013). 'Structure of PatF from Prochloron didemni'. Acta crystallographica. Section F, Structural biology and crystallization communications, vol 69, no. 6, pp. 618-623.
    [Online] DOI: 10.1107/S1744309113012931
  • Rateb, M., Hallyburton, I., Houssen, WE., Bull, A., Goodfellow, M., Santhanam, R., Jaspars, M. & Ebel, R. (2013). 'Induction of diverse secondary metabolites in Aspergillus fumigatus by microbial co-culture'. RSC Advances, vol 34, no. 3, pp. 14444-14450.
    [Online] DOI: 10.1039/C3RA42378F
    [Online] AURA: RSC_Advances_2013.pdf
  • Koehnke, J., Bent, AF., Zollman, D., Smith, K., Houssen, WE., Zhu, X., Mann, G., Lebl, T., Scharff, R., Shirran, S., Botting, CH., Jaspars, M., Schwarz-Linek, U. & Naismith, JH. (2013). 'The Cyanobactin Heterocyclase Enzyme: A Processive Adenylase That Operates with a Defined Order of Reaction'. Angewandte Chemie International Edition, vol 52, no. 52, pp. 13991-13996.
    [Online] DOI: 10.1002/anie.201306302
    [Online] AURA: 201306302_ftp.pdf
  • Deflorio, G., Horgan, G., Jaspars, M. & Woodward, S. (2012). 'Defence response of Sitka spruce before and after artificial inoculation with Heterobasidion annosum: 1 H NMR fingerprinting of bark and sapwood metabolites'. Analytical and Bioanalytical Chemistry, vol 402, no. 10, pp. 3333-3344.
    [Online] DOI: 10.1007/s00216-011-5666-z
  • Houssen, WE., Koehnke, J., Bent, A., Zollman, D., Morawitz, F., Shirran, S., Vendome, J., Nneoyiegbe, AF., Trembleau, L., Botting, CH., Smith, MCM., Jaspars, M. & Naismith, JH. (2012). 'The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain'. Nature Structural & Molecular Biology, vol 19, no. 8, pp. 767-772.
    [Online] DOI: 10.1038/nsmb.2340
  • Zovko, A., Gabric, MV., Sepcic, K., Pohleven, F., Jaklic, D., Gunde-Cimerman, N., Lu, Z., Edrada-Ebel, R., Houssen, WE., Mancini, I., Defant, A., Jaspars, M. & Turk, T. (2012). 'Antifungal and antibacterial activity of 3-alkylpyridinium polymeric analogs of marine toxins'. International Biodeterioration & Biodegradation, vol 68, pp. 71-77.
    [Online] DOI: 10.1016/j.ibiod.2011.10.014
  • Houssen, WE. & Jaspars, M. (2012). 'Isolation of marine natural products'. Methods in Molecular Biology, vol 864, pp. 367-392.
    [Online] DOI: 10.1007/978-1-61779-624-1_14
  • Qin, Z., McNee, D., Gleisner, H., Raab, A., Kyeremeh, K., Jaspars, M., Krupp, E., Deng, H. & Feldmann, J. (2012). 'Fluorine speciation analysis using reverse phase liquid chromatography coupled off-line to continuum source molecular absorption spectrometry (CS-MAS): identification and quantification of novel fluorinated organic compounds in environmental and biological samples'. Analytical Chemistry, vol 84, no. 14, pp. 6213-6219.
    [Online] DOI: 10.1021/ac301201y
  • Houssen, WE., Koehnke, J., Zollman, D., Vendome, J., Raab, A., Smith, MCM., Naismith, JH. & Jaspars, M. (2012). 'The discovery of new cyanobactins from Cyanothece PCC 7425 defines a new signature for processing of patellamides'. ChemBioChem, vol 13, no. 18, pp. 2683-2689.
    [Online] DOI: 10.1002/cbic.201200661
  • Hanssen, KO., Schuler, B., Williams, AJ., Demissie, TB., Hansen, E., Andersen, JH., Svenson, J., Blinov, K., Repisky, M., Mohn, F., Meyer, G., Svendsen, J-S, Ruud, K., Elyashberg, M., Gross, L., Jaspars, M. & Isaksson, J. (2012). 'A combined atomic force microscopy and computational approach for the structural elucidation of Breitfussin A and B: highly modified halogenated dipeptides from Thuiaria breitfussi'. Angewandte Chemie International Edition, vol 51, no. 49, pp. 12238-12241.
    [Online] DOI: 10.1002/anie.201203960
  • Rateb, ME., Houssen, WE., Arnold, M., Abdelrahman, MH., Deng, H., Harrison, WTA., Okoro, CK., Asenjo, JA., Andrews, BA., Ferguson, G., Bull, AT., Goodfellow, M., Ebel, R. & Jaspars, M. (2011). 'Chaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp'. Journal of Natural Products, vol 74, no. 6, pp. 1491-1499.
    [Online] DOI: 10.1021/np200320u
  • Rateb, ME., Houssen, WE., Harrison, WTA., Deng, H., Okoro, CK., Asenjo, JA., Andrews, BA., Bull, AT., Goodfellow, M., Ebel, R. & Jaspars, M. (2011). 'Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment'. Journal of Natural Products, vol 74, no. 9, pp. 1965-1971.
    [Online] DOI: 10.1021/np200470u
  • Schumacher, M., Cerella, C., Eifes, S., Chateauvieux, S., Morceau, F., Jaspars, M., Dicato, M. & Diederich, M. (2010). 'Heteronemin, a spongean sesterterpene, inhibits TNF alpha-induced NF-kappa B activation through proteasome inhibition and induces apoptotic cell death (vol 79, pg 610, 2010)'. Biochemical Pharmacology, vol 79, no. 12, pp. 1837-1837.
    [Online] DOI: 10.1016/j.bcp.2010.02.021
  • Schumacher, M., Cerella, C., Eifes, S., Chateauvieux, S., Morceau, F., Jaspars, M., Dicato, M. & Diederich, M. (2010). 'Heteronemin, a spongean sesterterpene, inhibits TNFa-induced NF-¿B activation through proteasome inhibition and induces apoptotic cell death'. Biochemical Pharmacology, vol 79, no. 4, pp. 610-622.
    [Online] DOI: 10.1016/j.bcp.2009.09.027
  • Tadesse, M., Strom, MB., Svenson, J., Jaspars, M., Milne, BF., Torfoss, V., Andersen, JH., Hansen, E., Stensvag, K. & Haug, T. (2010). 'Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria'. Organic Letters, vol 12, no. 21, pp. 4752-4755.
    [Online] DOI: 10.1021/ol101707u
  • Houssen, WE., Wright, SH., Kalverda, AP., Thompson, GS., Kelly, SM. & Jaspars, M. (2010). 'Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE1–34'. ChemBioChem, vol 11, no. 13, pp. 1867-1873.
    [Online] DOI: 10.1002/cbic.201000305
  • Abdel-Mageed, WM., Milne, BF., Wagner, M., Schumacher, M., Sandor, P., Pathom-aree, W., Goodfellow, M., Bull, AT., Horikoshi, K., Ebel, RP., Diederich, M., Fiedler, H-P & Jaspars, M. (2010). 'Dermacozines, a new phenazine family from deep-sea dermacocci isolated from a Mariana Trench sediment'. Organic & Biomolecular Chemistry, vol 8, no. 10, pp. 2352-2362.
    [Online] DOI: 10.1039/c001445a
  • Houssen, WE., Lu, Z., Edrada-Ebel, R., Chatzi, C., Tucker, SJ., Sepcic, K., Turk, T., Zovko, A., Shen, S., Mancini, I., Scott, RH. & Jaspars, M. (2010). 'Chemical synthesis and biological activities of 3-alkyl pyridinium polymeric analogues of marine toxins'. Journal of Chemical Biology, vol 3, no. 3, pp. 113-125.
    [Online] DOI: 10.1007/s12154-010-0036-4
  • Solano, G., Motti, CA. & Jaspars, M. (2009). 'New iodotyramine derivatives from Didemnum rubeum'. Tetrahedron, vol 65, no. 36, pp. 7482-7486.
    [Online] DOI: 10.1016/j.tet.2009.07.002
  • Rateb, M., Houssen, WE., Schumacher, M., Harrison, WTA., Diederich, M., Ebel, RP. & Jaspars, M. (2009). 'Bioactive Diterpene Derivatives from the Marine Sponge Spongionella sp'. Journal of Natural Products, vol 72, no. 8, pp. 1471-1476.
    [Online] DOI: 10.1021/np900233c
  • Folmer, F., Jaspars, M., Solano, G., Cristofanon, S., Henry, E., Tabudravu, J., Black, K., Green, DH., Kuepper, FC., Aalbersberg, W., Feussner, K., Dicato, M. & Diederich, M. (2009). 'The inhibition of TNF-alpha-induced NF-kappa B activation by marine natural products'. Biochemical Pharmacology, vol 78, no. 6, pp. 592-606.
    [Online] DOI: 10.1016/j.bcp.2009.05.009
  • Solano, G., Rojas-Jimenez, K., Jaspars, M. & Tamayo-Castillo, G. (2009). 'Study of the diversity of culturable actinomycetes in the North Pacific and Caribbean coasts of Costa Rica'. Antonie van Leeuwenhoek, vol 96, no. 1, pp. 71-78.
    [Online] DOI: 10.1007/s10482-009-9337-4
  • Latifi, R., Bagherzadeh, M., Milne, BF., Jaspars, M. & de Visser, SP. (2008). 'Density functional theory studies of oxygen and carbonate binding to a dicopper patellamide complex'. Journal of Inorganic Biochemistry, vol 102, no. 12, pp. 2171-2178.
    [Online] DOI: 10.1016/j.jinorgbio.2008.08.009
  • Wright, SH., Raab, A., Tabudravu, JN., Feldmann, J., Long, PF., Battershill, CN., Dunlap, WC., Milne, BF. & Jaspars, M. (2008). 'Marine metabolites and metal ion chelation: intact recovery and identification of an iron(II) complex in the extract of the ascidian Eudistoma gilboviride'. Angewandte Chemie International Edition, vol 47, no. 42, pp. 8090-8092.
    [Online] DOI: 10.1002/anie.200802060
  • Folmer, F., Schumacher, M., Diederich, M. & Jaspars, M. (2008). 'Finding NEMO (inhibitors) the search for marine pharmacophores targeting the nuclear factor-kappa B'. Chimica Oggi, vol 26, no. 4, pp. 40-46.
  • Folmer, F., Harrison, WTA., Tabudravu, JN., Jaspars, M., Aalbersberg, W., Feussner, K., Wright, AD., Dicato, M. & Diederich, M. (2008). 'NF-kappa B-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus'. Journal of Natural Products, vol 71, no. 1, pp. 106-111.
    [Online] DOI: 10.1021/np070290y
  • Shoeb, M., MacManus, SM., Jaspars, M., Nahar, L., Kong-Thoo-Lin, P., Celik, S. & Sarker, SD. (2007). 'Lignans and Flavonoids from the Seeds of Centaurea bornmuelleri Hausskn. Ex. Bornm. and Centaurea huber-morathii Wagenitz'. Polish Journal of Chemistry, vol 81, no. 1, pp. 39-44.
  • Starcevic, A., Jaspars, M., Cullum, J., Hranueli, D. & Long, PF. (2007). 'Predicting the Nature and Timing of Epimerisation on a Modular Polyketide Synthase'. ChemBioChem, vol 8, no. 1, pp. 28-31.
    [Online] DOI: 10.1002/cbic.200600399
  • Shoeb, M., Macmanus, SM., Kong-Thoo-Lin, P., Celik, S., Jaspars, M., Nahar, L. & Sarker, SD. (2007). 'Bioactivity of the extracts and isolation of lignans and a sesquiterpene from the aerial parts of Centaurea pamphylica (Asteraceae)'. DARU, vol 15, no. 3, pp. 118-122.
    [Link] http://journals.tums.ac.ir/abs/3896
  • Kumarasamy, Y., Byres, M., Cox, PJ., Jaspars, M., Nahar, L. & Sarker, SD. (2007). 'Screening seeds of some Scottish plants for free radical scavenging activity'. Phytotherapy Research, vol 21, no. 7, pp. 615-621.
    [Online] DOI: 10.1002/ptr.2129
  • Shoeb, M., MacManus, SM., Kumarasamy, Y., Jaspars, M., Nahar, L., Thoo-Lin, PK., Nazemiyeh, H. & Sarker, SD. (2006). 'Americanin, a bioactive dibenzylbutyrolactone lignan, form the seeds of Centaurea americana'. Phytochemistry, vol 67, no. 21, pp. 2370-2375.
    [Online] DOI: 10.1016/j.phytochem.2006.08.012
  • Urbaniak, MD., Tabudravu, JN., Msaki, A., Mansfield Matera, K., Brenk, R., Jaspars, M. & Ferguson, MAJ. (2006). 'Identification of novel inhibitors of UDP-Glc4 / -epimerase, a validated drug target for african sleeping sickness'. Bioorganic & Medicinal Chemistry, vol 16, pp. 5744-5747.
    [Online] DOI: 10.1016/j.bmcl.2006.08.091
  • Kumarasamy, Y., Nahar, L., Kong-Thu-Lin, P., Jaspars, M. & Sarker, SD. (2006). 'Hederacine A and Hederacine B from Glechoma hederaceae Inhibit the growth of Colorectal Cancer Cells in vitro'. Natural Product Communications, vol 1, no. 1, pp. 33-35.
  • Temraz, TA., Houssen, WE., Jaspars, M., Woolley, DR., Wease, KN., Davies, SN. & Scott, RH. (2006). 'A pyridinium derivative from Red Sea soft corals inhibited voltage-activated potassium conductances and increased excitability of rat cultured sensory neurones'. BMC Pharmacology, vol 6, 10.
    [Online] DOI: 10.1186/1471-2210-6-10
  • Houssen, WE., Jaspars, M., Wease, KN. & Scott, RH. (2006). 'Acute actions of marine toxin latrunculin A on the electrophysiological properties of cultured dorsal root ganglion neurones'. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol 142, no. 1-2, pp. 19-29.
    [Online] DOI: 10.1016/j.cbpc.2005.09.006
  • Kyeremeh, K., Baddeley, T., Stein, BK. & Jaspars, M. (2006). 'A homologous series of eunicellin-based diterpenes from Acalycigorgia sp. characterised by tandem mass spectrometry'. Tetrahedron, vol 62, pp. 8770-8778.
    [Online] DOI: 10.1016/j.tet.2006.06.102
  • Shoeb, M., MacManus, SM., Jaspars, M., Tabudravu, JN., Nahar, L., Thoo-Lin, PK. & Sarker, SD. (2006). 'Montamine, a unique dimeric indole alkaloid, from the seeds of Centaurea montana (Asteraceae), and its in vitro cytotoxic activity against the CaCo2 colon cancer cells'. Tetrahedron, vol 62, pp. 11172-11177.
    [Online] DOI: 10.1016/j.tet.2006.09.020
  • Dunlap, WC., Jaspars, M., Hranueli, D., Battershill, CN., Peric-Concha, N., Zucko, J., Wright, SH. & Long, PF. (2006). 'New Methods for Medicinal Chemistry - Universal Gene Cloning and Expression Systems for Production of Marine Bioactive Metabolites'. Current Medicinal Chemistry, no. 13, pp. 697-710.
    [Online] DOI: 10.2174/092986706776055643
  • Milne, BF., Long, PF., Starcevic, A., Hranueli, D. & Jaspars, M. (2006). 'Spontaneity in the patellamide biosynthetic pathway'. Organic & Biomolecular Chemistry, no. 4, pp. 631-638.
    [Online] DOI: 10.1039/b515938e
  • Folmer, FJ., Blasius, R., Morceau, F., Tabudravu, JN., Dicato, M., Jaspars, M. & Diedrich, M. (2006). 'Inhibition of TNFa-induced activation of nuclear factor ¿B by kava ( Piper methysticum ) derivatives'. Biochemical Pharmacology, vol 71, no. 71, pp. 1206-1218.
    [Online] DOI: 10.1016/j.bcp.2005.12.032
  • McLaggan, D., Adjimatera, N., Sepcic, K., Jaspars, M., MacEwan, DJ., Blagbrough, IS. & Scott, RH. (2006). 'Pore forming polyalkylpyridinium salts from marine sponges versus synthetic lipofection systems: distinct tools for intracellular delivery of cDNA and siRNA'. BMC Biotechnology, vol 6.
    [Online] DOI: 10.1186/1472-6750-6-6
  • Kumarasamy, Y., Cox, PJ., Jaspars, M., Nahar, L. & Sarker, SD. (2006). 'Bioactivity of Hirsutanolol, Oregonin and Genkwanin, Isolated from the Seeds of Alnus glutinosa (Betulaceae)'. Natural Product Communications, vol 1, no. 8, pp. 641-644.
  • Tabudravu, JN. & Jaspars, M. (2005). 'Anticancer activities of constituents of kava ( Piper methysticum )'. The South Pacific Journal of Natural Science, vol 23, pp. 26-29.
  • Long, PF., Dunlap, WC., Battershill, CN. & Jaspars, M. (2005). 'Shotgun Cloning and Heterologous Expression of the Patellamide Gene Cluster as a Strategy to Achieving Sustained Metabolite Production'. ChemBioChem, vol 6, no. 6, pp. 1760-1765.
    [Online] DOI: 10.1002/cbic.200500210
  • Shoeb, M., Celik, S., Jaspars, M., Kumarasamy, Y., MacManus, SM., Nahar, L., Thoo-Lin, PK. & Sarker, SD. (2005). 'Isolation, structure elucidation and bioactivity of schischkiniin, a unique indole alkaloid from the seeds of Centaurea schischkinii'. Tetrahedron, vol 61, pp. 9001-9006.
    [Online] DOI: 10.1016/j.tet.2005.07.047
  • Houssen, WE. & Jaspars, M. (2005). '4-Hydroxybenzoyl derivative from the aqueous extract of the hydroid Campanularia sp'. Journal of Natural Products, vol 68, no. 3, pp. 453-455.
    [Online] DOI: 10.1021/np049666n
  • Hansen, HR., Raab, A., Jaspars, M., Milne, BF. & Feldmann, J. (2004). 'Sulfur-containing arsenical mistaken for dimethylarsinous acid (DMA(III)) and identified as a natural metabolite in urine: Major implications for studies on assenic metabolism and toxicity'. Chemical Research in Toxicology, vol 17, pp. 1086-1091.
    [Online] DOI: 10.1021/tx049978q
  • Shoeb, M., Rahman, MM., Nahar, L., Delazar, A., Jaspars, M., MacManus, SM. & Sarker, SD. (2004). 'Bioactive Lignans from the Sees of Centaurea Macrocephala'. DARU, vol 12, no. 3, pp. 87-93.
    [Link] http://journals.tums.ac.ir/abs/12
  • Jaspars, M., Hansen, HR. & Feldmann, J. (2004). 'Arsinothioyl-sugars produced by in vitro incubation of seaweed extract with liver cytosol analysed by HPLC coupled simultaneously to ES-MS and ICP-MS'. Analyst, vol 129, no. 129, pp. 1058-1064.
    [Online] DOI: 10.1039/b409661b
  • Hansen, HR., Pickford, R., Thomas-Oates, J., Jaspars, M. & Feldmann, J. (2004). 'Dimethylarsinothioyl acetic acid identified in a biological sample: the first occurrence of a mammalian arsinothio(y)l metabolite'. Angewandte Chemie International Edition, vol 43, pp. 337-340.
    [Online] DOI: 10.1002/anie.200352740
  • Cox, PJ., Jaspars, M., Kumarasamy, Y. & Nahar, L. (2003). 'An anomalous racemate of naringenin at 120 K'. Acta Crystallographica Section E, Structure Reports Online, vol E59, pp. o46-o48.
  • Dzeha, T., Jaspars, M. & Tabudravu, JN. (2003). 'Clionasterol, a Triterpenoid from the Kenyan Marine Green Macroalga Halimeda macroloba'. Western Indian Ocean J. Mar. Sci, no. 2, pp. 157-161.
  • Jaspars, M. & Shoeb, M. (2003). 'Chlorinated C12 Fatty Acid Metabolites from the Red Alga Gracilaria verrucosa'. Journal of Natural Products, no. 66, pp. 1509-1511.
  • Jaspars, M., Morrison, BJ. & Musgrave, OC. (2003). 'Acid-induced dimerisation of 1,2-di(thien-2-yl)ethanone'. Tetrahedron, no. 59, pp. 4153-4155.
    [Online] DOI: 10.1016/S0040-4020(03)00581-7
  • Kumarasamy, Y., Nahar, L., Cox, PJ., Dinan, LN., Ferguson, CA., Finnie, DA., Jaspars, M. & Sarker, SD. (2003). 'Biological Activity of Lignans from the Seeds of Centaurea scabiosa'. Pharmaceutical Biology, vol 41, no. 3, pp. 203-206.
    [Online] DOI: 10.1076/phbi.41.3.203.15099
  • Cox, PJ., Jaspars, M., Kumarasamy, Y., Nahar, L., Sarker, SD. & Shoeb, M. (2003). 'A mixed crystal of imperatorin and phellopterin, with C¾H¼O, C¾H¼p and p-p interactions'. Acta Crystallographica Section C, Crystal Structure Communications, vol C59, pp. o520-o522.
  • Tucker, SJ., McClelland, D., Jaspars, M., Sepcic, K., MacEwan, DJ. & Scott, RH. (2003). 'The influence of alkyl pyridinium sponge toxins on membrane properties, cytotoxicity, transfection and protein expression in mammalian cells'. Biochimica et Biophysica Acta (BBA) - Biomembranes, vol 1614, no. 2, pp. 171-181.
    [Online] DOI: 10.1016/S0005-2736(03)00175-5
  • Lawton, LA., Robertson, PKJ., Benjamin, JPA., Marr, IJ. & Jaspars, M. (2003). 'Processes influencing surface interaction and photocatalytic destruction of microcystins on titanium dioxide photocatalysts'. Journal of Catalysis, no. 213, pp. 109-113.
    [Online] DOI: 10.1016/S0021-9517(02)00049-0
  • Kumarasamy, Y., Cox, PJ., Jaspars, M., Nahar, L. & Sarker, SD. (2003). 'Cyanogenic glycosids from Prunus spinosa (Rosaceae)'. Biochemical Systematics and Ecology, vol 31, no. 31, pp. 1063-1065.
    [Online] DOI: 10.1016/S0305-1978(03)00063-2
  • Kumarasamy, Y., Nahar, L., Cox, PJ., Jaspars, M. & Sarker, SD. (2003). 'Short Communication: Bioactivity of secoiridoid glycosides from Centaurium erythraea'. Phytomedicine, no. 10, pp. 344-347.
    [Online] DOI: 10.1078/094471103322004857
  • McClelland, D., Evans, RM., Abidin, I., Sharma, S., Choudhry, FZ., Jaspars, M., Sepcic, K. & Scott, RH. (2003). 'Irreversible and reversible pore formation by polymeric alkylpyridinium salts (poly-APS) from the sponge Reniera sarai'. British Journal of Pharmacology, vol 139, no. 8, pp. 1399-1408.
    [Online] DOI: 10.1038/sj.bjp.0705374
  • Kumarasamy, Y., Cox, PJ., Jaspars, M., Neiland, MRM., Wilcock, CC. & Sarkar, SD. (2003). 'Biological activity of Euonymous eoropaeus'. Fitoterapia, vol 74, pp. 305-307.
    [Online] DOI: 10.1016/S0367-326X(03)00022-4
  • Harrison, WTA., Howie, RA., Jaspars, M., Wardell, SMSV. & Wardell, JL. (2003). 'Further studies of [omega-(haloalkylstannyl)alkyl]phosphine oxides.: Structures of bis[2-(bromodimethylstannyl)ethyl]phenylphosphine oxide and t-butyl[3-(iododimethylstannyl)propyl]phenylphosphine oxide'. Polyhedron, vol 22, no. 22, pp. 3277-3288.
    [Online] DOI: 10.1016/S0277-5387(03)00470-4
  • Middleton, M., Cox, PJ., Jaspars, M., Kumarasamy, Y., Nahar, L., Reid, RJ. & Sarker, SD. (2003). 'Dibenzylbutyrolactone lignans and indole alkaloids from the seeds of Centaurea nigra (Asteraceae)'. Biochemical Systematics and Ecology, vol 31, no. 31, pp. 653-656.
    [Online] DOI: 10.1016/S0305-1978(02)00227-2
  • Kumarasamy, Y., Cox, PJ., Jaspars, M., Nahar, L. & Sarker, SD. (2003). 'Isolation, structure elucidation and biological activity of hederacine A and B, two unique alkaloids from Glechoma hederaceae'. Tetrahedron, vol 59, no. 59, pp. 6403-6407.
    [Online] DOI: 10.1016/S0040-4020(03)01093-7
  • Engelke, CJ., Lawton, LA. & Jaspars, M. (2003). 'Elevated microcystin and nodularin levels in cyanobacteria growing in spent medium of Planktothrix agardhii'. Archiv für Hydrobiologie, vol 158, no. 158, pp. 541-550.
    [Online] DOI: 10.1127/0003-9136/2003/0158-0541
  • Kumarasamy, Y., Cox, PJ., Jaspars, M., Nahar, L. & Sarker, SD. (2002). 'Biological activity of Glechoma hederacea'. Fitoterapia, vol 73, pp. 721-723.
    [Online] DOI: 10.1016/S0367-326X(02)00237-X
  • Key, LN., Boyle, PR. & Jaspars, M. (2002). 'Novel activities of saliva from the octopus Eledone cirrhosa (Mollusca; Cephalopoda)'. Toxicon, pp. 677-683.
    [Online] DOI: 10.1016/S0041-0101(01)00254-9
  • Tabudravu, JN. & Jaspars, M. (2002). 'Purealidin S and Purpuramine J, Bromotyrosine Alkaloids from the Fijian Marine Sponge Druinella sp'. Journal of Natural Products, vol 65, pp. 1798-1801.
    [Online] DOI: 10.1021/np020275n
  • Tabudravu, JN., Morris, LA., Kettenes-van den Bosch, JJ. & Jaspars, M. (2002). 'Axinellin C, a proline-rich cyclic octapeptide isolated from the Fijian marine sponge Stylotella aurantium'. Tetrahedron, vol 58, pp. 7863-7868.
    [Online] DOI: 10.1016/S0040-4020(02)00898-0
  • Kumarasamy, Y., Cox, PJ., Jaspars, M., Nahar, L. & Sarker, SD. (2002). 'Screening seeds of Scottish plants for antibacterial activity'. Journal of Ethnopharmacology, vol 83, pp. 73-77.
    [Online] DOI: 10.1016/S0378-8741(02)00214-3
  • Morris, LA., Jaspars, M., Kettenes-van den Bosch, JJ., Versluis, K., Heck, AJR., Kelly, SM. & Price, NC. (2001). 'Metal binding of Lissclinum patella metabolites. Part 1: Patellamides A, C and ulithiacyclamide A'. Tetrahedron, vol 57, no. 15, pp. 3185-3197.
    [Online] DOI: 10.1016/S0040-4020(01)00177-6
  • Tabudravu, JN. & Jaspars, M. (2001). 'Stelliferin Riboside, a Triterpene Monosaccharide Isolated from the Fijian Sponge Geodia globostellifera'. Journal of Natural Products, vol 64, pp. 813-815.
    [Online] DOI: 10.1021/np010019v
  • Sarker, SD., Laird, A., Nahar, L., Kumarasamy, Y. & Jaspars, M. (2001). 'Indole alkaloids from the seeds of Centaurea cyanus (Asteraceae)'. Phytochemistry, vol 57, pp. 1273-1276.
    [Online] DOI: 10.1016/S0031-9422(01)00084-X
  • Tabudravu, JN., Morris, LA., Kettenes-van den Bosch, JJ. & Jaspars, M. (2001). 'Wainunuamide, a histidine-containing proline-rich cyclic heptapeptide isolated from the Fijian marine sponge Stylotella aurantium'. Tetrahedron Letters, vol 42, pp. 9273-9276.
    [Online] DOI: 10.1016/S0040-4039(01)01993-1
  • Morris, LA., Milne, BR., Jaspars, M., Kettenes-van den Bosch, JJ., Versluis, K., Heck, AJR., Kelly, SM. & Price, NC. (2001). 'Metal binding of Lissoclinum patella metabolites. Part 2: Lissoclinamides 9 and 10'. Tetrahedron, vol 57, no. 15, pp. 3199-3207.
    [Online] DOI: 10.1016/S0040-4020(01)00178-8

Scientific Reviews

  • Houssen, WE. & Jaspars, M. (2010). 'Azole-Based Cyclic Peptides from the Sea Squirt Lissoclinum Patella: Old Scaffolds, New Avenues'. ChemBioChem, vol 11, no. 13, pp. 1803-1815.
    [Online] DOI: 10.1002/cbic.201000230
  • Jaspars, M. & Allen, MJ. (2009). 'Realizing the Potential of Marine Biotechnology: Challenges and Opportunities'. Industrial Biotechnology, vol 5, no. 2, pp. 77-83.
    [Online] DOI: 10.1089/ind.2009.5.077
    [Online] AURA: Realizing_the_potential.pdf
  • Battershill, CN., Bavington, C., Chahal, S., Jaspars, M., Littlechild, J. & Mearns-Spragg, A. (2008). 'Contributions of marine bioscience to industrial biotechnology'. Industrial Biotechnology, vol 3, no. 4, pp. 304-313.
    [Online] DOI: 10.1089/ind.2007.3.304

Editorials

  • Folmer, F., Jaspars, M., Dicato, M. & Diederich, M. (2008). 'Marine natural products as targeted modulators of the transcription factor NF-kappa B'. Biochemical Pharmacology, vol 75, no. 3, pp. 603-617.
    [Online] DOI: 10.1016/j.bcp.2007.07.044

Chapters in Books, Reports and Conference Proceedings

Conference Proceedings

  • Tucker, SJ., Jaspars, M. & Scott, RH. (2004). 'Cell membrane permeabilisation by alkylpyridinium sponge toxin preparations and their utilisation as novel transfection reagents'. in Neurotox' 2003: Neurotoxicological Targets from Functional: Chapter 5.

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