- Course Code
- BI 20M3
- Credit Points
- 15
- Course Coordinator
- Dr A MacKenzie
Pre-requisites
BI 1004, BI 1507 and CM 1010. TS 1001 strongly recommended for students with C or less at Higher (or equivalent) in Mathematics or Physics.
Overview
With the sequencing of the human genome there has never been a more exciting time to study modern molecular biology. This course consists of four main modules that provide an understanding of the processes that convert the one-dimensional information contained within genomes into three-dimensional organisms including humans.
Module 1 provides an overview of nucleic acid biochemistry with emphasis on the dynamic structure of human DNA and the way in which it is packaged into chromosomes. The basic principles of modern recombinant DNA technologies are also covered.
Module 2 provides a comprehensive introduction to protein biochemistry and gives details of the chemistry of amino-acids and peptides. The properties of proteins are described using a number of examples of globular and fibrous proteins.
Module 3 describes how the genetic information contained in the genome is transcribed into RNA and then translated into proteins. In this module, a basic introduction to gene regulation in human development, health and physiology is provided.
Module 4 explains how the human genome can be compromised by mutation and chromosomal rearrangements leading to disorders such as Downs syndrome, cystic fibrosis, fragile-X syndrome and cancer.
Structure
3 one-hour lectures per week; a total of 4 three-hour practical classes; a total of 4 one-hour tutorials.
Assessment
1st Attempt: 1 two-hour written examination (80%); in-course assessment (4 practical reports) (20%).
Resit: 1 two-hour written examination (80%); in-course assessment (4 practical reports) (20%).