
FRSTMH, FHEA, FRSB, CBiol
Reader
- About
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- Email Address
- jsternberg@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272272
- Office Address
- School/Department
- School of Biological Sciences
Biography
Infectious disease immunologist with a particular focus on immunoepidemiology
Memberships and Affiliations
- Internal Memberships
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Old Aberdeen Biological Safety Advisor
- External Memberships
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FRSB CBiol
FRSTMH
Editorial Board, Parasite Immunology
- Research
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Research Overview
Immune-surveillance for Exposure to Arthropod Vectors of Disease
We have identified a diagnostic antigen that enables exposure monitoring for Triatoma infestans in peri-domestic animals, an important vector of Chagas disease (https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0000532). Current research is extending this method to probe human exposure to the vector.
We are using immune surveillance/serology to define sensitive markers for human exposure to ticks as part of the Northtick programme
Immunology and Pathogenesis in African trypanosome infections.
African trypanosomes are parasitic protozoans which cause sleeping sickness in man and ngana in domestic animals. These parasites are exquisite manipulators of the host immune-system. Recent research has focussed on understanding the pathogenesis of disease at a range of levels from the laboratory to the field and the application of novel diagnostic methods. This includes studies of macrophage activation by trypanosome molecules, studies of the immunological response to infections in patients in Malawi and Uganda, and research into novel diagnostic methods using immunological markers and metabolomic analysis. As of 2021 the lab is withdrawing from this research area.
Collaborations
Imperial College, Dept of Surgery and Cancer: Prof Elaine Holmes: Metabonomic discovery of diagnostic markers in sleeping sickness.
University of Glasgow, Dept of Neurology: Prof. Peter Kennedy: Models of CNS pathogenesis in trypanosomiasis
University of Glasgow, Wellcome Centre for Molecular Parasitology: Dr Annette MacLeod and Prof. Andy Tait: Molecular epidemiology of protozoan parasites
Vrije Universiteit Brussel, VIB Department of Molecular and Cellular Interactions: Prof. Stefan Magez: Immune responses to tsetse fly saliva
Makerere University, Kampala, Uganda: Dr Enock Matovu. Clinical epidemiology and immunology in African trypanosomiasis
Funding and Grants
Tick Borne Infections in the North Sea Region EU InterReg 2019-2023
CNS diagnostic markers in human African trypanosomiasis 2007-2008 FIND
Validation of lateral flow devices 2012-3 FIND
Defining the therapeutic role of IL-10 in African Trypanosomiasis. Wellcome Trust 2008-2012
Energetics of trypanosome infection BBSRC 2011-2015
- Teaching
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Teaching Responsibilities
School of Biological Sciences Honours Project/4th year convener
Course leader for BI4016, ZO4816, BI4027 & Wildlife Parasitology Field Course
- Publications
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Page 1 of 7 Results 1 to 10 of 64
Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections
PLoS Neglected Tropical Diseases, vol. 15, no. 9, e0009814Contributions to Journals: ArticlesRNAi gene knockdown in the poultry red mite, Dermanyssus gallinae (De Geer 1778), a tool for functional genomics
Parasites & Vectors, vol. 14, no. 1, 57Contributions to Journals: ArticlesRNA interference in the poultry red mite Dermanyssus gallinae
74th Association for Veterinary Teaching and Research Work Annual ConferenceContributions to Conferences: AbstractsInducible Germline IgMs Bridge Trypanosome Lytic Factor Assembly and Parasite Recognition
Cell Host & Microbe, vol. 28, no. 1, pp. 79-88.e4Contributions to Journals: ArticlesA Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metabolite
Molecules, vol. 25, no. 2, 256Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/molecules25020256
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13522/1/Maglangit_molecules_VOR.pdf
- [ONLINE] View publication in Scopus
Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense infection
The journal of infectious diseases, vol. 216, no. 10, pp. 1273-1280Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/infdis/jix466
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9692/1/jix466.pdf
The Relationship of Endotoxaemia to Peripheral and Central Nervous System Inflammatory Responses in Human African Trypanosomiasis
Parasitology, vol. 144, no. 4, pp. 557-562Contributions to Journals: ArticlesKynurenine Pathway Activation in Human African Trypanosomiasis
The journal of infectious diseases, vol. 215, no. 5, pp. 806-812Contributions to Journals: ArticlesCentral Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice.
PLoS Neglected Tropical Diseases, vol. 9, no. 10, 0004201Contributions to Journals: ArticlesCentral Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice
PLoS Neglected Tropical Diseases, vol. 9, no. 10, e0004201Contributions to Journals: Articles