FRSTMH, FHEA, FRSB, CBiol
Infectious disease immunologist with a particular focus on immunoepidemiology
Immune-surveillance for Exposure to Arthropod Vectors of Disease
We have identified a diagnostic antigen that enables exposure monitoring for Triatoma infestans in peri-domestic animals, an important vector of Chagas disease (https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0000532). Current research is extending this method to probe human exposure to the vector.
We are using immune surveillance/serology to define sensitive markers for human exposure to ticks as part of the Northtick programme
Immunology and Pathogenesis in African trypanosome infections.
African trypanosomes are parasitic protozoans which cause sleeping sickness in man and ngana in domestic animals. These parasites are exquisite manipulators of the host immune-system. Recent research has focussed on understanding the pathogenesis of disease at a range of levels from the laboratory to the field and the application of novel diagnostic methods. This includes studies of macrophage activation by trypanosome molecules, studies of the immunological response to infections in patients in Malawi and Uganda, and research into novel diagnostic methods using immunological markers and metabolomic analysis. As of 2021 the lab is withdrawing from this research area.
Imperial College, Dept of Surgery and Cancer: Prof Elaine Holmes: Metabonomic discovery of diagnostic markers in sleeping sickness.
University of Glasgow, Dept of Neurology: Prof. Peter Kennedy: Models of CNS pathogenesis in trypanosomiasis
University of Glasgow, Wellcome Centre for Molecular Parasitology: Dr Annette MacLeod and Prof. Andy Tait: Molecular epidemiology of protozoan parasites
Vrije Universiteit Brussel, VIB Department of Molecular and Cellular Interactions: Prof. Stefan Magez: Immune responses to tsetse fly saliva
Makerere University, Kampala, Uganda: Dr Enock Matovu. Clinical epidemiology and immunology in African trypanosomiasis
Funding and Grants
Tick Borne Infections in the North Sea Region EU InterReg 2019-2023
CNS diagnostic markers in human African trypanosomiasis 2007-2008 FIND
Validation of lateral flow devices 2012-3 FIND
Defining the therapeutic role of IL-10 in African Trypanosomiasis. Wellcome Trust 2008-2012
Energetics of trypanosome infection BBSRC 2011-2015
School of Biological Sciences Honours Project/4th year convener
Course leader for BI4016, ZO4816, BI4027 & Wildlife Parasitology Field Course
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Autoimmunity to phosphatidylserine and anemia in African Trypanosome infectionsPLoS Neglected Tropical Diseases, vol. 15, no. 9, e0009814Contributions to Journals: Articles
RNAi gene knockdown in the poultry red mite, Dermanyssus gallinae (De Geer 1778), a tool for functional genomicsParasites & Vectors, vol. 14, no. 1, 57Contributions to Journals: Articles
RNA interference in the poultry red mite Dermanyssus gallinae74th Association for Veterinary Teaching and Research Work Annual ConferenceContributions to Conferences: Abstracts
Inducible Germline IgMs Bridge Trypanosome Lytic Factor Assembly and Parasite RecognitionCell Host & Microbe, vol. 28, no. 1, pp. 79-88.e4Contributions to Journals: Articles
A Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid MetaboliteMolecules, vol. 25, no. 2, 256Contributions to Journals: Articles
Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense infectionThe journal of infectious diseases, vol. 216, no. 10, pp. 1273-1280Contributions to Journals: Articles
The Relationship of Endotoxaemia to Peripheral and Central Nervous System Inflammatory Responses in Human African TrypanosomiasisParasitology, vol. 144, no. 4, pp. 557-562Contributions to Journals: Articles
Kynurenine Pathway Activation in Human African TrypanosomiasisThe journal of infectious diseases, vol. 215, no. 5, pp. 806-812Contributions to Journals: Articles
Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice.PLoS Neglected Tropical Diseases, vol. 9, no. 10, 0004201Contributions to Journals: Articles
Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected MicePLoS Neglected Tropical Diseases, vol. 9, no. 10, e0004201Contributions to Journals: Articles