Chair in Human Nutrition
Professor Heisler investigates brain circuits regulating energy homeostasis in an effort to identify new targets amenable to obesity and type 2 diabetes medications. Professor Heisler received her PhD from Tufts University, USA in 1997 and held postdoctoral positions at the University of California, San Francisco USA from 1997-99 and Beth Israel Deaconess Medical Center, Harvard Medical School (HMS) USA from 1999-2001. In 2001, Professor Heisler was promoted to Instructor and set up her laboratory at HMS. She then relocated her group to the University of Cambridge, UK in 2004 where they worked until 2013. In 2013, the Heisler group moved to the Rowett Institute to take advantage of the Institute’s strengths in obesity research, ranging from molecules to man.
Professor Heisler was the recipient of the 2018 Outstanding Scientific Achievement Award (OSAA) from the American Diabetes Association. Professor Heisler received the OSAA prize for her research identifying a new type of medication to improve type 2 diabetes. This prestigious award recognises research in diabetes that demonstrates particular independence of thought and originality. Her career scientific contributions include seminal discoveries in the brain control of appetite and blood sugar that demonstrate her innovation.
Professor Heisler commented: “Diabetes is such a widespread problem and it is crucial that we as scientists continue to research this disease in order to find new ways to combat it. It is extremely humbling to be recognised for our contribution to diabetes research. I work alongside many talented colleagues."
Mechanisms underlying the pathophysiology of obesity and type 2 diabetes
The brain represents the master coordinator of appetite and energy expenditure, employing interwoven neurological circuits to continually appraise and respond to changes in energy state.
Our research aims to discover and characterise these brain circuits using cutting edge technology with the objective of locating points within the pathway that are amenable to manipulation with manmade (drug) or natural (hormone) substances.
We also examine the impact of diet and body weight on circuit rewiring and mechanisms restore appropriate system connectivity and activity.
The ultimate aim of our research is to identify new treatments for obesity and type 2 diabetes.
Cells in the brain that impact appetite Our work identifying a new treatment
for type 2 diabetes is on the journal cover
- Dr Delia Ramirez - Research fellow
- Dr Yuliia Martynova - Research fellow
- Dr Pablo Blanco Martinez de Morentin - Research fellow
- Dr Stefan Wagner - Research fellow
- Mr Alasdair Leeson Payne - Research fellow
- Miss Raffaella Chianese - Research assistant
- Miss Tania Pérez Márquez - Research assistant
- Mr Matevz Arcon - PhD Student
British Heart Foundation
Medical Research Scotland
Frontiers of Biomedical Science - SM3002
- Further Info
Deputy Editor, Molecular Metabolism
SAB, Keysone Symposia
Obesity and Food Choice Theme Lead
Page 3 of 4 Results 21 to 30 of 38
- Cowley, M, Garfield, AS, Madon-Simon, M, Charalambous, M, Clarkson, RW, Smalley, MJ, Kendrick, H, Isles, AR, Parry, AJ, Carney, S, Oakey, RJ, Heisler, LK, Moorwood, K, Wolf, JB & Ward, A 2014, 'Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and Pup', PLoS Biology, vol. 12, no. 2, 1001799. [Online] DOI: https://doi.org/10.1371/journal.pbio.1001799
- Garfield, AS, Burke, LK, Shaw, J, Evans, ML & Heisler, LK 2014, 'Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia', Behavioural Brain Research, vol. 266, pp. 201-206. [Online] DOI: https://doi.org/10.1016/j.bbr.2014.02.018
- Flak, JN, Patterson, CM, Garfield, AS, D'Agostino, G, Goforth, PB, Sutton, AK, Malec, PA, Wong, J-MT, Germani, M, Jones, JC, Rajala, M, Satin, L, Rhodes, CJ, Olson, DP, Kennedy, RT, Heisler, LK & Myers, MG 2014, 'Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance', Nature Neuroscience, vol. 17, no. 12, pp. 1744-1750. [Online] DOI: https://doi.org/10.1038/nn.3861
- Doslikova, B, Garfield, AS, Shaw, J, Evans, ML, Burdakov, D, Billups, B & Heisler, LK 2013, '5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated', Journal of Neuroscience, vol. 33, no. 23, pp. 9800-9804. [Online] DOI: https://doi.org/10.1523/JNEUROSCI.4326-12.2013
- Stanley, S, Domingos, AI, Kelly, L, Garfield, A, Damanpour, S, Heisler, L & Friedman, J 2013, 'Profiling of glucose-sensing neurons reveals that ghrh neurons are activated by hypoglycemia', Cell Metabolism, vol. 18, no. 4, pp. 596-607. [Online] DOI: https://doi.org/10.1016/j.cmet.2013.09.002
- Osundiji, MA, Lam, DD, Shaw, J, Yueh, C-Y, Markkula, SP, Hurst, P, Colliva, C, Roda, A, Heisler, LK & Evans, ML 2012, 'Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion', Diabetes, vol. 61, no. 2, pp. 321-328. [Online] DOI: https://doi.org/10.2337/db11-1050
- Garfield, AS, Chan, WS, Dennis, RJ, Ito, D, Heisler, LK & Rochford, JJ 2012, 'Neuroanatomical characterisation of the expression of the lipodystrophy and motor-neuropathy gene Bscl2 in adult mouse brain', PloS ONE, vol. 7, no. 9, e45790. [Online] DOI: https://doi.org/10.1371/journal.pone.0045790
- Lam, DD, Leinninger, GM, Louis, GW, Garfield, AS, Marston, OJ, Leshan, RL, Scheller, EL, Christensen, L, Donato, J, Xia, J, Evans, ML, Elias, C, Dalley, JW, Burdakov, DI, Myers, MG & Heisler, LK 2011, 'Leptin does not directly affect CNS serotonin neurons to influence appetite', Cell Metabolism, vol. 13, no. 5, pp. 584-591. [Online] DOI: https://doi.org/10.1016/j.cmet.2011.03.016
- Marston, OJ, Hurst, P, Evans, ML, Burdakov, DI & Heisler, LK 2011, 'Neuropeptide Y cells represent a distinct glucose-sensing population in the lateral hypothalamus', Endocrinology, vol. 152, no. 11, pp. 4046-4052. [Online] DOI: https://doi.org/10.1210/en.2011-1307
- Rochford, JJ, Myers, MG & Heisler, LK 2011, 'Setting the tone: reactive oxygen species and the control of appetitive melanocortin meurons', Cell Metabolism, vol. 14, no. 5, pp. 573-574. [Online] DOI: https://doi.org/10.1016/j.cmet.2011.10.004