Chair in Human Nutrition
Professor Heisler investigates brain circuits regulating energy homeostasis in an effort to identify new targets amenable to obesity and type 2 diabetes medications. Professor Heisler received her PhD from Tufts University, USA in 1997 and held postdoctoral positions at the University of California, San Francisco USA from 1997-99 and Beth Israel Deaconess Medical Center, Harvard Medical School (HMS) USA from 1999-2001. In 2001, Professor Heisler was promoted to Instructor and set up her laboratory at HMS. She then relocated her group to the University of Cambridge, UK in 2004 where they worked until 2013. In 2013, the Heisler group moved to the Rowett Institute to take advantage of the Institute’s strengths in obesity research, ranging from molecules to man.
Professor Heisler was the recipient of the 2018 Outstanding Scientific Achievement Award (OSAA) from the American Diabetes Association. Professor Heisler received the OSAA prize for her research identifying a new type of medication to improve type 2 diabetes. This prestigious award recognises research in diabetes that demonstrates particular independence of thought and originality. Her career scientific contributions include seminal discoveries in the brain control of appetite and blood sugar that demonstrate her innovation.
Professor Heisler commented: “Diabetes is such a widespread problem and it is crucial that we as scientists continue to research this disease in order to find new ways to combat it. It is extremely humbling to be recognised for our contribution to diabetes research. I work alongside many talented colleagues."
Mechanisms underlying the pathophysiology of obesity and type 2 diabetes
The brain represents the master coordinator of appetite and energy expenditure, employing interwoven neurological circuits to continually appraise and respond to changes in energy state.
Our research aims to discover and characterise these brain circuits using cutting edge technology with the objective of locating points within the pathway that are amenable to manipulation with manmade (drug) or natural (hormone) substances.
We also examine the impact of diet and body weight on circuit rewiring and mechanisms restore appropriate system connectivity and activity.
The ultimate aim of our research is to identify new treatments for obesity and type 2 diabetes.
Cells in the brain that impact appetite Our work identifying a new treatment
for type 2 diabetes is on the journal cover
- Dr Delia Ramirez - Research fellow
- Dr Yuliia Martynova - Research fellow
- Dr Pablo Blanco Martinez de Morentin - Research fellow
- Dr Stefan Wagner - Research fellow
- Mr Alasdair Leeson Payne - Research fellow
- Miss Raffaella Chianese - Research assistant
- Miss Tania Pérez Márquez - Research assistant
- Mr Matevz Arcon - PhD Student
British Heart Foundation
Medical Research Scotland
Frontiers of Biomedical Science - SM3002
- Further Info
Deputy Editor, Molecular Metabolism
SAB, Keysone Symposia
Obesity and Food Choice Theme Lead
Page 1 of 4 Results 1 to 10 of 38
- Meakin, PJ, Jalicy, SM, Montagut, G, Allsop, DJP, Cavellini, DL, Irvine, SW, McGinley, C, Liddell, MK, McNeilly, AD, Parmionova, K, Liu, Y-R, Bailey, CLS, Dale, JK, Heisler, LK, McCrimmon, RJ & Ashford, MLJ 2018, 'Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice', Scientific Reports, vol. 8, 55. [Online] DOI: https://doi.org/10.1038/s41598-017-18388-6
- Chakera, AJ, Hurst, PS, Spyer, G, Ogunnowo-Bada, EO, Marsh, WJ, Riches, CH, Yueh, C-Y, Markkula, SP, Dalley, JW, Cox, RD, Macdonald, IA, Amiel, SA, MacLeod, KM, Heisler, LK, Hattersley, AT & Evans, ML 2018, 'Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes', Molecular Metabolism, vol. 17, pp. 17-27. [Online] DOI: https://doi.org/10.1016/j.molmet.2018.08.001
- d'Agostino, G, Lyons, D, Cristiano, C, Lettieri, M, Olarte-Sanchez, C, Burke, LK, Greenwald-Yarnell, M, Cansell, C, Doslikova, B, Georgescu, T, Blanco Martinez de Morentin, P, Myers Jr., MG, Rochford, JJ & Heisler, L 2018, 'Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake', Cell Metabolism, vol. 28, no. 4, pp. 619.-630.e5. [Online] DOI: https://doi.org/10.1016/j.cmet.2018.07.017
- Rupp, AC, Allison, MB, Jones, JC, Patterson, CM, Faber, CL, Bozadjieva, N, Heisler, LK, Seeley, RJ, Olson, DP & Myers Jr., MG 2018, 'Specific Subpopulations of Hypothalamic Leptin Receptor-Expressing Neurons Mediate the Effects of Early Developmental Leptin Receptor Deletion on Energy Balance', Molecular Metabolism, vol. 14, pp. 130-138. [Online] DOI: https://doi.org/10.1016/j.molmet.2018.06.001
- Xu, P, He, Y, Cao, X, Valencia-Torres, L, Yan, X, Saito, K, Wang, C, Yang, Y, Hinton Jr., A, Zhu, L, Shu, G, Myers Jr., MG, Wu, Q, Tong, Q, Heisler, LK & Xu, Y 2017, 'Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice', Biological Psychiatry, vol. 81, no. 9, pp. 737-747. [Online] DOI: https://doi.org/10.1016/j.biopsych.2016.06.005
- Valencia-Torres, L, Olarte-Sanchez, CM, Lyons, DJ, Georgescu, T, Greewald-Yarnell, M, Myers, MG, Bradshaw, CM & Heisler, LK 2017, 'Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation', Neuropsychopharmacology, vol. 42, no. 7, pp. 1511-1521. [Online] DOI: https://doi.org/10.1038/npp.2016.264
- Heisler, LK & Lam, DD 2017, 'An appetite for life: brain regulation of hunger and satiety', Current Opinion in Pharmacology, vol. 37, pp. 100-106. [Online] DOI: https://doi.org/10.1016/j.coph.2017.09.002
- Burke, LK, Ogunnowo-Bada, E, Georgescu, T, Cristiano, C, Martinez De Morentin, PB, Valencia-Torres, L, D'Agostino, G, Riches, C, Heeley, N, Ruan, Y, Rubinstein, M, Low, MJ, Myers, MG, Rochford, JJ, Evans, ML & Heisler, LK 2017, 'Lorcaserin improves glycemic control via a melanocortin neurocircuit', Molecular Metabolism, vol. 6, no. 10, pp. 1092-1102. [Online] DOI: https://doi.org/10.1016/j.molmet.2017.07.004
- Martin-Gronert, MS, Stocker, CJ, Wargent, ET, Cripps, RL, Garfield, AS, Jovanovic, Z, D'Agostino, G, Yeo, GSH, Cawthorne, MA, Arch, JRS, Heisler, LK & Ozanne, SE 2016, '5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats', Disease Models & Mechanisms, vol. 9, no. 4, pp. 401-412. [Online] DOI: https://doi.org/10.1242/dmm.023903
- Martin-Gronert, MS, Stocker, CJ, Wargent, ET, Cripps, RL, Garfield, AS, Jovanovic, Z, D'Agostino, G, Yeo, GSH, Cawthorne, MA, Arch, JRS, Heisler, LK & Ozanne, SE 2016, '5-HT2Aand 5-HT2Creceptors as hypothalamic targets of developmental programming in male rats', Development, vol. 143, no. 8, pp. 401-412. [Online] DOI: https://doi.org/10.1242/dev.138396